WO2003069332A3 - Detection and/or monitoring of synuclein-related diseases - Google Patents

Detection and/or monitoring of synuclein-related diseases Download PDF

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Publication number
WO2003069332A3
WO2003069332A3 PCT/GB2003/000677 GB0300677W WO03069332A3 WO 2003069332 A3 WO2003069332 A3 WO 2003069332A3 GB 0300677 W GB0300677 W GB 0300677W WO 03069332 A3 WO03069332 A3 WO 03069332A3
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WO
WIPO (PCT)
Prior art keywords
synuclein
monitoring
detection
related diseases
patient
Prior art date
Application number
PCT/GB2003/000677
Other languages
French (fr)
Other versions
WO2003069332A2 (en
Inventor
David Allsop
Omar M A El-Agnaf
Sultan A Salem
Original Assignee
Univ Lancaster
David Allsop
Omar M A El-Agnaf
Sultan A Salem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9931023&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2003069332(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Lancaster, David Allsop, Omar M A El-Agnaf, Sultan A Salem filed Critical Univ Lancaster
Priority to CA2480466A priority Critical patent/CA2480466C/en
Priority to JP2003568402A priority patent/JP2005528588A/en
Priority to AT03709934T priority patent/ATE442592T1/en
Priority to EP03709934.8A priority patent/EP1476758B2/en
Priority to US10/503,416 priority patent/US20050176078A1/en
Priority to DE60329165T priority patent/DE60329165D1/en
Priority to AU2003214364A priority patent/AU2003214364A1/en
Publication of WO2003069332A2 publication Critical patent/WO2003069332A2/en
Publication of WO2003069332A3 publication Critical patent/WO2003069332A3/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention provides a method of diagnosing a synucleinopathy in a patient and also a method monitoring the effectiveness of a therapeutic agent that has been administered to a patient for the purpose of treating a synucleinopathy. The method comprises analysing a non-cerebral body fluid sample taken from the patient for the presence and/or amount of a synuclein in said sample.The synuclein may be an aggregated synuclein.
PCT/GB2003/000677 2002-02-14 2003-02-14 Detection and/or monitoring of synuclein-related diseases WO2003069332A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA2480466A CA2480466C (en) 2002-02-14 2003-02-14 Detection and/or monitoring of synuclein-related diseases
JP2003568402A JP2005528588A (en) 2002-02-14 2003-02-14 Detection and / or monitoring of synuclein-related diseases
AT03709934T ATE442592T1 (en) 2002-02-14 2003-02-14 DETECTION AND/OR MONITORING OF SYNUCLEIN-ASSOCIATED DISEASES
EP03709934.8A EP1476758B2 (en) 2002-02-14 2003-02-14 Detection and/or monitoring of synuclein-related diseases
US10/503,416 US20050176078A1 (en) 2002-02-14 2003-02-14 Detection and/or monitoring of synuclein-related diseases
DE60329165T DE60329165D1 (en) 2002-02-14 2003-02-14 DETECTION AND / OR OBSERVATION OF SYNUCLEIN ASSOCIATED DISEASES
AU2003214364A AU2003214364A1 (en) 2002-02-14 2003-02-14 Detection and/or monitoring of synuclein-related diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0203446.0 2002-02-14
GBGB0203446.0A GB0203446D0 (en) 2002-02-14 2002-02-14 Detection and/or monitoring of synuclein-related diseases

Publications (2)

Publication Number Publication Date
WO2003069332A2 WO2003069332A2 (en) 2003-08-21
WO2003069332A3 true WO2003069332A3 (en) 2004-01-08

Family

ID=9931023

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/000677 WO2003069332A2 (en) 2002-02-14 2003-02-14 Detection and/or monitoring of synuclein-related diseases

Country Status (9)

Country Link
US (1) US20050176078A1 (en)
EP (1) EP1476758B2 (en)
JP (1) JP2005528588A (en)
AT (1) ATE442592T1 (en)
AU (1) AU2003214364A1 (en)
CA (1) CA2480466C (en)
DE (1) DE60329165D1 (en)
GB (1) GB0203446D0 (en)
WO (1) WO2003069332A2 (en)

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US20040146521A1 (en) * 1999-06-01 2004-07-29 Schenk Dale B. Prevention and treatment of synucleinopathic disease
US9034337B2 (en) 2003-10-31 2015-05-19 Prothena Biosciences Limited Treatment and delay of outset of synucleinopathic and amyloidogenic disease
US20080014194A1 (en) * 2003-10-31 2008-01-17 Elan Pharmaceuticals, Inc. Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease
US8506959B2 (en) * 2002-11-01 2013-08-13 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
TW200509968A (en) * 2002-11-01 2005-03-16 Elan Pharm Inc Prevention and treatment of synucleinopathic disease
US8697082B2 (en) * 2002-11-01 2014-04-15 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
US7358331B2 (en) * 2003-05-19 2008-04-15 Elan Pharmaceuticals, Inc. Truncated fragments of alpha-synuclein in Lewy body disease
US7674599B2 (en) * 2003-11-08 2010-03-09 Elan Pharmaceuticals, Inc. Methods of using antibodies to detect alpha-synuclein in fluid samples
DE10361258A1 (en) 2003-12-24 2005-07-28 Schwarz Pharma Ag Use of substituted 2-aminotetralins for the preventive treatment of Parkinson's disease
DE102004014841B4 (en) 2004-03-24 2006-07-06 Schwarz Pharma Ag Use of rotigotine for the treatment and prevention of Parkinson-Plus syndrome
ES2310057B1 (en) * 2004-07-19 2009-11-17 Oryzon Genomics, S.A. METHOD OF MOLECULAR ANALYSIS AND TREATMENT IN DEMENTIA OF LEWY BODIES.
CN1752104B (en) * 2004-09-21 2010-05-05 北京市肿瘤防治研究所 Monoclonal antibody of synapse protein gamma and its application
WO2007011907A2 (en) * 2005-07-19 2007-01-25 University Of Rochester Alpha-synuclein antibodies and methods related thereto
IL199534A (en) 2007-01-05 2013-01-31 Univ Zuerich Isolated human antibody which is capable of selectively recognizing a neoepitope of a disorder-associated protein, a polynucleotide encoding the antibody, a vector comprising the polynucleotide, a host cell comprising the polynucleotide or the vector, a composition comprising the antibody and methods and uses associated therewith
US8147833B2 (en) * 2007-02-23 2012-04-03 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
EP2118300B1 (en) * 2007-02-23 2015-05-27 Prothena Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
GB0716885D0 (en) 2007-08-30 2007-10-10 United Arab Emirates Universit Diagnostic agent
JP5810413B2 (en) 2008-12-19 2015-11-11 バイオジェン インターナショナル ニューロサイエンス ゲーエムベーハー Human anti-alpha synuclein autoantibodies
WO2011033252A1 (en) * 2009-09-16 2011-03-24 United Arab Emirates University Diagnostic agent for parkinson's disease
CN101692092B (en) * 2009-09-24 2013-04-10 首都医科大学宣武医院 Method for quantitatively detecting alpha-synuclein auto-antibodies in human sera
US10989718B2 (en) * 2014-09-11 2021-04-27 Amprion, Inc. Detection of misfolded alpha synuclein protein
WO2012061789A2 (en) * 2010-11-05 2012-05-10 Brandeis University Tetrameric alpha-synuclein and use thereof
WO2012061786A1 (en) * 2010-11-05 2012-05-10 Brandeis University Ice cleaved alpha-synuclein a biomarker
WO2012074882A2 (en) * 2010-11-24 2012-06-07 Elan Pharmaceuticals, Inc. Phagocytic activity as a marker of synucleinopathic disease
WO2012177972A1 (en) 2011-06-23 2012-12-27 Biogen Idec International Neuroscience Gmbh Anti-alpha synuclein binding molecules
JP6263473B2 (en) * 2011-11-02 2018-01-31 バイオジェン インターナショナル ニューロサイエンス ゲーエムベーハー Use of anti-α-synuclein antibodies to diagnose high levels of α-synuclein in the brain
ES2481517B1 (en) * 2013-01-29 2015-06-01 Universidad De Sevilla Method for the diagnosis of parkinson's disease in early stages
HRP20231232T1 (en) * 2014-09-11 2024-01-19 Board Of Regents Of The University Of Texas System Detection of misfolded proteins
WO2016075516A1 (en) 2014-11-14 2016-05-19 United Arab Emirates University Compounds for use as imaging agents
MA41115A (en) 2014-12-02 2017-10-10 Biogen Int Neuroscience Gmbh ALZHEIMER'S DISEASE TREATMENT PROCESS
CN104711280B (en) * 2014-12-10 2018-04-13 中国医学科学院医学生物学研究所 The method that expression and purifying lack exon 3 and 5 α synapse nucleoprotein alternative splicing body proteins at the same time
MX2019013589A (en) 2017-05-16 2020-07-20 Claudio Soto Jara Detection of misfolded tau protein.
IL271359B2 (en) * 2017-06-19 2023-11-01 Kainos Medicine Inc Modulators of alpha-synuclein
SG11202001281WA (en) 2017-08-22 2020-03-30 Biogen Ma Inc Pharmaceutical compositions containing anti-beta amyloid antibodies
JP7173532B2 (en) * 2018-08-28 2022-11-16 学校法人順天堂 Diagnosis of α-Synucleinopathy
RU2703430C1 (en) * 2018-12-13 2019-10-16 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр глазных болезней имени Гельмгольца" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ГБ им. Гельмгольца" Минздрава России) Method for prediction of developing neurodegenerative diseases, underlying the pathogenesis of which is gamma-synucleinopathy
EP3779448A1 (en) * 2019-08-12 2021-02-17 Baden-Württemberg Stiftung gGmbH Novel diagnostic marker for creutzfeldt-jakob disease and alzheimer's disease
EP4111197A1 (en) * 2020-02-25 2023-01-04 Markus Otto Diagnosing a disease associated with synaptic degeneration using an elisa for determining a beta-synuclein concentration in csf
EP4252243A2 (en) 2020-11-30 2023-10-04 Enigma Biointelligence, Inc. Non-invasive assessment of alzheimer's disease

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WO2000002053A2 (en) * 1998-07-03 2000-01-13 Innogenetics N.V. Differential diagnosis of neurodegeneration

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WO2000002053A2 (en) * 1998-07-03 2000-01-13 Innogenetics N.V. Differential diagnosis of neurodegeneration

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Also Published As

Publication number Publication date
GB0203446D0 (en) 2002-04-03
DE60329165D1 (en) 2009-10-22
ATE442592T1 (en) 2009-09-15
EP1476758B2 (en) 2015-02-11
JP2005528588A (en) 2005-09-22
EP1476758B1 (en) 2009-09-09
AU2003214364A1 (en) 2003-09-04
WO2003069332A2 (en) 2003-08-21
CA2480466C (en) 2010-12-21
EP1476758A2 (en) 2004-11-17
US20050176078A1 (en) 2005-08-11
CA2480466A1 (en) 2003-08-21

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