WO2003065976A3 - Microfluidics apparatus and methods of use therefor - Google Patents
Microfluidics apparatus and methods of use therefor Download PDFInfo
- Publication number
- WO2003065976A3 WO2003065976A3 PCT/US2002/035990 US0235990W WO03065976A3 WO 2003065976 A3 WO2003065976 A3 WO 2003065976A3 US 0235990 W US0235990 W US 0235990W WO 03065976 A3 WO03065976 A3 WO 03065976A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- interaction
- methods
- cells
- sample fluid
- use therefor
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0663—Whole sensors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/054,760 US6926864B2 (en) | 2001-11-09 | 2001-11-13 | Microfluidics apparatus and methods for use thereof |
EP02805704A EP1487960A2 (en) | 2001-11-09 | 2002-11-08 | Microfluidics apparatus and methods of use therefor |
CA002464880A CA2464880A1 (en) | 2001-11-09 | 2002-11-08 | Microfluidics apparatus and methods of use therefor |
AU2002365434A AU2002365434A1 (en) | 2001-11-09 | 2002-11-08 | Microfluidics apparatus and methods of use therefor |
JP2003565402A JP2005517159A (en) | 2001-11-09 | 2002-11-08 | Microfluidic device and method of using the same |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3673301A | 2001-11-09 | 2001-11-09 | |
US10/036,733 | 2001-11-09 | ||
US10/054,760 US6926864B2 (en) | 2001-11-09 | 2001-11-13 | Microfluidics apparatus and methods for use thereof |
US10/054,760 | 2001-11-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003065976A2 WO2003065976A2 (en) | 2003-08-14 |
WO2003065976A3 true WO2003065976A3 (en) | 2004-09-30 |
Family
ID=27736746
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/035990 WO2003065976A2 (en) | 2001-11-09 | 2002-11-08 | Microfluidics apparatus and methods of use therefor |
Country Status (6)
Country | Link |
---|---|
US (2) | US6926864B2 (en) |
EP (1) | EP1487960A2 (en) |
JP (1) | JP2005517159A (en) |
AU (1) | AU2002365434A1 (en) |
CA (1) | CA2464880A1 (en) |
WO (1) | WO2003065976A2 (en) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1204842A4 (en) * | 1999-08-19 | 2003-04-02 | Univ California | Apparatus and method for visually identifying micro-forces with a palette of cantilever array blocks |
US7387889B2 (en) * | 2002-08-22 | 2008-06-17 | Massachusetts Institute Of Technology | Measurement of concentrations and binding energetics |
CA2504277A1 (en) | 2002-11-08 | 2004-05-27 | Protiveris, Inc. | Multiplex illuminator and device reader for microcantilever array |
US20040152211A1 (en) * | 2002-11-15 | 2004-08-05 | The Regents Of The University Of California | System and method for multiplexed biomolecular analysis |
US7344678B2 (en) * | 2002-11-15 | 2008-03-18 | The Regents Of The University Of California | Composite sensor membrane |
US20050255448A1 (en) * | 2004-05-13 | 2005-11-17 | Arun Majumdar | System for amplifying optical detection of cantilever deflection |
DE102004058828B4 (en) * | 2004-10-28 | 2010-08-19 | Progen Biotechnik Gmbh | Apparatus and method for parallel processing of biopolymers |
EP1889064B1 (en) * | 2005-06-02 | 2009-11-04 | Danmarks Tekniske Universitet | Sensor system with actuated structure releasing a coloured indicator |
US8068991B2 (en) | 2005-11-30 | 2011-11-29 | The Invention Science Fund I, Llc | Systems and methods for transmitting pathogen related information and responding |
US20080178692A1 (en) * | 2007-01-29 | 2008-07-31 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Fluidic methods |
US20080241909A1 (en) * | 2007-03-27 | 2008-10-02 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Microfluidic chips for pathogen detection |
US20080241935A1 (en) | 2007-03-27 | 2008-10-02 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Methods for pathogen detection |
US20080241000A1 (en) * | 2007-03-27 | 2008-10-02 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems for pathogen detection |
US20080179255A1 (en) * | 2007-01-29 | 2008-07-31 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Fluidic devices |
US10001496B2 (en) | 2007-01-29 | 2018-06-19 | Gearbox, Llc | Systems for allergen detection |
US20080181821A1 (en) * | 2007-01-29 | 2008-07-31 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Microfluidic chips for allergen detection |
US20080245740A1 (en) * | 2007-01-29 | 2008-10-09 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Fluidic methods |
US8617903B2 (en) | 2007-01-29 | 2013-12-31 | The Invention Science Fund I, Llc | Methods for allergen detection |
US20090050569A1 (en) * | 2007-01-29 | 2009-02-26 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Fluidic methods |
US8168120B1 (en) | 2007-03-06 | 2012-05-01 | The Research Foundation Of State University Of New York | Reliable switch that is triggered by the detection of a specific gas or substance |
US20090215157A1 (en) * | 2007-03-27 | 2009-08-27 | Searete Llc | Methods for pathogen detection |
US20080318242A1 (en) * | 2007-06-21 | 2008-12-25 | Ion Stiharu | Methods and devices for early detection of cancer cells and types through micromechanical interactions |
EP2217694A4 (en) | 2007-11-13 | 2011-08-31 | Univ California | Processes for rapid microfabrication using thermoplastics and devices thereof |
US20090325159A1 (en) * | 2008-06-30 | 2009-12-31 | Canon U.S. Life Sciences, Inc. | System and method to prevent cross-contamination in assays performed in a microfluidic channel |
US8122901B2 (en) | 2008-06-30 | 2012-02-28 | Canon U.S. Life Sciences, Inc. | System and method for microfluidic flow control |
WO2010059601A2 (en) * | 2008-11-18 | 2010-05-27 | Schlumberger Canada Limited | Fluid expansion in mud gas logging |
BRPI0924255A2 (en) | 2009-02-17 | 2016-01-26 | Medimate Holding B V | equipment for measuring a concentration of a species loaded in a sample |
GB0910569D0 (en) * | 2009-06-18 | 2009-07-29 | Cambridge Entpr Ltd | Fluid sensing, sensor apparatus, systems and methods |
US9140684B2 (en) * | 2011-10-27 | 2015-09-22 | University Of Washington Through Its Center For Commercialization | Device to expose cells to fluid shear forces and associated systems and methods |
CN104428671B (en) * | 2012-05-10 | 2017-04-26 | 华盛顿大学商业化中心 | Microfluidic devices for measuring platelet coagulation, and associated systems and methods |
USD733313S1 (en) * | 2013-03-19 | 2015-06-30 | Panasonic Healthcare Holdings Co., Ltd. | Chip for biochemical examination |
US9671350B2 (en) * | 2013-09-04 | 2017-06-06 | Applied Invention, Llc | Test mass compensation of mass measurement drift in a microcantilever resonator |
US10564122B1 (en) * | 2016-10-21 | 2020-02-18 | Iowa State University Research Foundation, Inc. | Electrophoretic soil nutrient sensor for agriculture |
US10191036B1 (en) * | 2018-03-22 | 2019-01-29 | NUB4U, Inc. | System for detecting and removing biological analytes in fluids |
CN115155688A (en) * | 2022-06-24 | 2022-10-11 | 北京莱芯生物技术有限公司 | Laboratory detects with application of sample liquid-transfering auxiliary operation platform |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6054277A (en) * | 1996-05-08 | 2000-04-25 | Regents Of The University Of Minnesota | Integrated microchip genetic testing system |
US6485690B1 (en) * | 1999-05-27 | 2002-11-26 | Orchid Biosciences, Inc. | Multiple fluid sample processor and system |
US6523392B2 (en) * | 2000-01-25 | 2003-02-25 | Arizona Board Of Regents | Microcantilever sensor |
US6620625B2 (en) * | 2000-01-06 | 2003-09-16 | Caliper Technologies Corp. | Ultra high throughput sampling and analysis systems and methods |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5846708A (en) * | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
US5807758A (en) * | 1995-07-21 | 1998-09-15 | Lee; Gil U. | Chemical and biological sensor using an ultra-sensitive force transducer |
US6118124A (en) * | 1996-01-18 | 2000-09-12 | Lockheed Martin Energy Research Corporation | Electromagnetic and nuclear radiation detector using micromechanical sensors |
US5763768A (en) * | 1997-03-17 | 1998-06-09 | Iowa State University Research Foundation, Inc. | Analytical method using modified scanning probes |
US5923421A (en) * | 1997-07-24 | 1999-07-13 | Lockheed Martin Energy Research Corporation | Chemical detection using calorimetric spectroscopy |
US6123819A (en) * | 1997-11-12 | 2000-09-26 | Protiveris, Inc. | Nanoelectrode arrays |
US6016686A (en) * | 1998-03-16 | 2000-01-25 | Lockheed Martin Energy Research Corporation | Micromechanical potentiometric sensors |
US6096559A (en) * | 1998-03-16 | 2000-08-01 | Lockheed Martin Energy Research Corporation | Micromechanical calorimetric sensor |
US6050722A (en) * | 1998-03-25 | 2000-04-18 | Thundat; Thomas G. | Non-contact passive temperature measuring system and method of operation using micro-mechanical sensors |
US5992226A (en) * | 1998-05-08 | 1999-11-30 | The United States Of America As Represented By The Secretary Of The Navy | Apparatus and method for measuring intermolecular interactions by atomic force microscopy |
US6287765B1 (en) * | 1998-05-20 | 2001-09-11 | Molecular Machines, Inc. | Methods for detecting and identifying single molecules |
US6041642A (en) * | 1998-06-04 | 2000-03-28 | Lockheed Martin Energy Systems, Inc. | Method and apparatus for sensing the natural frequency of a cantilevered body |
CA2372508C (en) | 1999-05-03 | 2009-09-29 | Cantion A/S | Sensor for microfluid handling system |
-
2001
- 2001-11-13 US US10/054,760 patent/US6926864B2/en not_active Expired - Fee Related
-
2002
- 2002-11-08 AU AU2002365434A patent/AU2002365434A1/en not_active Abandoned
- 2002-11-08 EP EP02805704A patent/EP1487960A2/en not_active Withdrawn
- 2002-11-08 JP JP2003565402A patent/JP2005517159A/en active Pending
- 2002-11-08 CA CA002464880A patent/CA2464880A1/en not_active Abandoned
- 2002-11-08 WO PCT/US2002/035990 patent/WO2003065976A2/en not_active Application Discontinuation
-
2004
- 2004-11-18 US US10/992,368 patent/US20050176034A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6054277A (en) * | 1996-05-08 | 2000-04-25 | Regents Of The University Of Minnesota | Integrated microchip genetic testing system |
US6485690B1 (en) * | 1999-05-27 | 2002-11-26 | Orchid Biosciences, Inc. | Multiple fluid sample processor and system |
US6620625B2 (en) * | 2000-01-06 | 2003-09-16 | Caliper Technologies Corp. | Ultra high throughput sampling and analysis systems and methods |
US6523392B2 (en) * | 2000-01-25 | 2003-02-25 | Arizona Board Of Regents | Microcantilever sensor |
Also Published As
Publication number | Publication date |
---|---|
AU2002365434A1 (en) | 2003-09-02 |
US6926864B2 (en) | 2005-08-09 |
US20030092016A1 (en) | 2003-05-15 |
EP1487960A2 (en) | 2004-12-22 |
JP2005517159A (en) | 2005-06-09 |
CA2464880A1 (en) | 2003-08-14 |
US20050176034A1 (en) | 2005-08-11 |
WO2003065976A2 (en) | 2003-08-14 |
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