WO2003064416A1 - Heterocyclic tripeptides as hepatitis c inhibitors - Google Patents
Heterocyclic tripeptides as hepatitis c inhibitors Download PDFInfo
- Publication number
- WO2003064416A1 WO2003064416A1 PCT/CA2003/000091 CA0300091W WO03064416A1 WO 2003064416 A1 WO2003064416 A1 WO 2003064416A1 CA 0300091 W CA0300091 W CA 0300091W WO 03064416 A1 WO03064416 A1 WO 03064416A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- formula
- hcv
- butyl
- hepatitis
- Prior art date
Links
- JVSFQJZRHXAUGT-UHFFFAOYSA-N CC(C)(C)C(Cl)=O Chemical compound CC(C)(C)C(Cl)=O JVSFQJZRHXAUGT-UHFFFAOYSA-N 0.000 description 1
- JIQODWITGWWFJY-ZVPWSGANSA-N CC(C)(C)[C@@H](C(N(C[C@@H](C1)Oc2c(ccc(OC)c3)c3nc(-c3c[s]c(N)n3)c2)[C@@H]1C(N[C@](C1)(C1C=C)C(OC)=O)=O)O)NC(OC1CCCC1)=O Chemical compound CC(C)(C)[C@@H](C(N(C[C@@H](C1)Oc2c(ccc(OC)c3)c3nc(-c3c[s]c(N)n3)c2)[C@@H]1C(N[C@](C1)(C1C=C)C(OC)=O)=O)O)NC(OC1CCCC1)=O JIQODWITGWWFJY-ZVPWSGANSA-N 0.000 description 1
- IIXJVXQAIOWYSG-MRVPVSSYSA-N CC(C)(C)[C@@H](C(O)=O)NC(OC1CCC1)=O Chemical compound CC(C)(C)[C@@H](C(O)=O)NC(OC1CCC1)=O IIXJVXQAIOWYSG-MRVPVSSYSA-N 0.000 description 1
- 0 CC(C)(C)[C@@](C(N(C[C@@](C1)Oc2c(ccc(OC)c3)c3nc(-c3c[s]c(NC(C(C)(C)C)=O)n3)c2)[C@@]1C(N[C@](C1)(C1C=C)C(*)=O)=O)=O)NC(OC1CCCC1)=O Chemical compound CC(C)(C)[C@@](C(N(C[C@@](C1)Oc2c(ccc(OC)c3)c3nc(-c3c[s]c(NC(C(C)(C)C)=O)n3)c2)[C@@]1C(N[C@](C1)(C1C=C)C(*)=O)=O)=O)NC(OC1CCCC1)=O 0.000 description 1
- ZELMOAPJXIWIIE-LBPRGKRZSA-N OC([C@H](C1CCCCC1)NC(OC1CCCC1)=O)=O Chemical compound OC([C@H](C1CCCCC1)NC(OC1CCCC1)=O)=O ZELMOAPJXIWIIE-LBPRGKRZSA-N 0.000 description 1
- UJEQLSYCRUTGFR-ZDUSSCGKSA-N OC([C@H](C1CCCCC1)NC(OC1CCCCC1)=O)=O Chemical compound OC([C@H](C1CCCCC1)NC(OC1CCCCC1)=O)=O UJEQLSYCRUTGFR-ZDUSSCGKSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Description
Claims
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EA200400986A EA007739B1 (en) | 2002-02-01 | 2003-01-24 | Heterocyclic tripeptides as hepatitis c inhibitors |
UA20040807171A UA77757C2 (en) | 2002-02-01 | 2003-01-24 | Heterocyclic tripeptides as hepatitis c virus inhibitors |
AU2003202348A AU2003202348B2 (en) | 2002-02-01 | 2003-01-24 | Heterocyclic tripeptides as hepatitis c inhibitors |
JP2003564039A JP4073872B2 (en) | 2002-02-01 | 2003-01-24 | Heterocyclic tripeptides as hepatitis C inhibitors |
DE60315420T DE60315420T2 (en) | 2002-02-01 | 2003-01-24 | Heterocyclic tripeptides as hepatitis C inhibitors |
NZ534730A NZ534730A (en) | 2002-02-01 | 2003-01-24 | Heterocyclic tripeptides as hepatitis C inhibitors |
YU67104A RS67104A (en) | 2002-02-01 | 2003-01-24 | Heterocyclic tripeptides as hepatitis c inhibitors |
MXPA04007446A MXPA04007446A (en) | 2002-02-01 | 2003-01-24 | Heterocyclic tripeptides as hepatitis c inhibitors. |
EP03700745A EP1474423B1 (en) | 2002-02-01 | 2003-01-24 | Heterocyclic tripeptides as hepatitis c inhibitors |
CA2474031A CA2474031C (en) | 2002-02-01 | 2003-01-24 | Heterocyclic tripeptides as hepatitis c inhibitors |
BR0307517-6A BR0307517A (en) | 2002-02-01 | 2003-01-24 | Heterocyclic tripeptides as hepatitis c inhibitors |
KR10-2004-7011888A KR20040081167A (en) | 2002-02-01 | 2003-01-24 | Heterocyclic tripeptides as hepatitis C inhibitors |
HR20040696A HRP20040696A2 (en) | 2002-02-01 | 2004-07-30 | Heterocyclic tripeptides as hepatitis c inhibitors |
NO20043642A NO326421B1 (en) | 2002-02-01 | 2004-08-31 | Heterocyclic tripeptides, pharmaceutical compositions comprising such and the use thereof for the manufacture of medicaments for the treatment or prevention of disease |
HK05110947A HK1078870A1 (en) | 2002-02-01 | 2005-12-01 | Heterocyclic tripeptides as hepatitis c inhibitors |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002369970A CA2369970A1 (en) | 2002-02-01 | 2002-02-01 | Hepatitis c inhibitor tri-peptides |
CA2,369,970 | 2002-02-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003064416A1 true WO2003064416A1 (en) | 2003-08-07 |
Family
ID=27626567
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA2003/000091 WO2003064416A1 (en) | 2002-02-01 | 2003-01-24 | Heterocyclic tripeptides as hepatitis c inhibitors |
Country Status (30)
Country | Link |
---|---|
US (1) | US20030191067A1 (en) |
EP (1) | EP1474423B1 (en) |
JP (1) | JP4073872B2 (en) |
KR (1) | KR20040081167A (en) |
CN (1) | CN1304416C (en) |
AR (1) | AR038382A1 (en) |
AT (1) | ATE369364T1 (en) |
AU (1) | AU2003202348B2 (en) |
BR (1) | BR0307517A (en) |
CA (1) | CA2369970A1 (en) |
CO (1) | CO5611112A2 (en) |
DE (1) | DE60315420T2 (en) |
EA (1) | EA007739B1 (en) |
EC (1) | ECSP045224A (en) |
ES (1) | ES2290425T3 (en) |
HK (1) | HK1078870A1 (en) |
HR (1) | HRP20040696A2 (en) |
MX (1) | MXPA04007446A (en) |
MY (1) | MY133719A (en) |
NO (1) | NO326421B1 (en) |
NZ (1) | NZ534730A (en) |
PE (1) | PE20030854A1 (en) |
PL (1) | PL371283A1 (en) |
RS (1) | RS67104A (en) |
SA (1) | SA03240006B1 (en) |
TW (1) | TWI274056B (en) |
UA (1) | UA77757C2 (en) |
UY (1) | UY27638A1 (en) |
WO (1) | WO2003064416A1 (en) |
ZA (1) | ZA200406014B (en) |
Cited By (118)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6867185B2 (en) | 2001-12-20 | 2005-03-15 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
US6869964B2 (en) | 2002-05-20 | 2005-03-22 | Bristol-Myers Squibb Company | Heterocyclicsulfonamide hepatitis C virus inhibitors |
US6872805B2 (en) | 2000-11-20 | 2005-03-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2005030194A1 (en) * | 2003-09-30 | 2005-04-07 | Tibotec Pharmaceuticals Ltd. | Hcv inhibitiing sulfonamides |
US6878722B2 (en) | 2002-05-20 | 2005-04-12 | Bristol-Myers Squibb Company | Substituted cycloalkyl P1′ hepatitis C virus inhibitors |
WO2005037214A2 (en) | 2003-10-14 | 2005-04-28 | Intermune, Inc. | Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication |
WO2005080388A1 (en) | 2004-02-20 | 2005-09-01 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US6995174B2 (en) | 2002-05-20 | 2006-02-07 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2006020276A2 (en) | 2004-07-16 | 2006-02-23 | Gilead Sciences, Inc. | Antiviral compounds |
US7041698B2 (en) | 2002-05-20 | 2006-05-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7132504B2 (en) | 2003-11-12 | 2006-11-07 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7135462B2 (en) | 2003-11-20 | 2006-11-14 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2007019674A1 (en) | 2005-08-12 | 2007-02-22 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
WO2007044893A2 (en) | 2005-10-11 | 2007-04-19 | Intermune, Inc. | Compounds and methods for inhibiting hepatitis c viral replication |
WO2007009109A3 (en) * | 2005-07-14 | 2007-06-07 | Gilead Sciences Inc | Antiviral compounds |
JP2007531749A (en) * | 2004-03-30 | 2007-11-08 | インターミューン・インコーポレーテッド | Macrocyclic compounds as viral replication inhibitors |
US7309708B2 (en) | 2003-11-20 | 2007-12-18 | Birstol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7323447B2 (en) | 2005-02-08 | 2008-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
JP2008506720A (en) * | 2004-07-20 | 2008-03-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Hepatitis C inhibitor peptide analog |
JP2008506719A (en) * | 2004-07-20 | 2008-03-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Hepatitis C inhibitor peptide analog |
US7368452B2 (en) | 2003-04-18 | 2008-05-06 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
WO2008070358A2 (en) * | 2006-11-16 | 2008-06-12 | Phenomix Corporation | N-cyclopropyl-hydroxyproline-based tripeptidic hepatitis c serine protease inhibitors containing an isoindole, pyrrolopyridine, pyrrolopyrimidine or pyrrolopyrazine heterocycle in the side chain |
EP1944042A1 (en) | 2003-10-27 | 2008-07-16 | Vertex Pharmceuticals Incorporated | Combinations for HCV treatment |
WO2009005690A2 (en) * | 2007-06-29 | 2009-01-08 | Gilead Sciences, Inc. | Antiviral compounds |
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