WO2003055605A1 - Device for separating a component from a fluid - Google Patents

Device for separating a component from a fluid

Info

Publication number
WO2003055605A1
WO2003055605A1 PCT/DE2002/004701 DE0204701W WO03055605A1 WO 2003055605 A1 WO2003055605 A1 WO 2003055605A1 DE 0204701 W DE0204701 W DE 0204701W WO 03055605 A1 WO03055605 A1 WO 03055605A1
Authority
WO
Grant status
Application
Patent type
Prior art keywords
fluid
component
microfluidic
components
auxiliary
Prior art date
Application number
PCT/DE2002/004701
Other languages
German (de)
French (fr)
Inventor
Astrid Lohf
Original Assignee
Siemens Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40Concentrating samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/10Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00873Heat exchange
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00891Feeding or evacuation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00905Separation
    • B01J2219/00918Separation by adsorption
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781Aspects relating to microreactors
    • B01J2219/00905Separation
    • B01J2219/00921Separation by absorption
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N2030/009Extraction

Abstract

In order to separate a component from a fluid, a micro-fluidic component having a plurality of microstructured fluid paths is used. Alternately, the fluid is initially guided through the microfluidic component for enrichment of the component to be separated on the walls of the fluid paths, followed by an auxiliary fluid which is used to expel the enriched components from the microfluidic component. In order to ensure a continuous separation of the component from the fluid, at least one other microfluidic component (2, 21) is provided, said fluid being guided by one of the microfluidic components and the auxiliary fluid being simultaneously guided by at least one of the other microfluidic components (1, 2, 21).

Description

description

Device for separating a component from a fluid

The invention relates to an arrangement for separating a component from a fluid with a micro-fluidic component, extend in between two fluid Anschlussen a plurality of microstructured fluid paths, whose walls are formed for the enrichment of the component running a fluid supply, a fluid discharge, an auxiliary fluid supply and an auxiliary fluid removal as well as between these and the Fluidan ¬ losing the microfluidic component arranged controllable Ventilemrichtungen to alternately conduct the fluid to the enrichment of the component to be separated on the walls and the auxiliary fluid to the expulsion of the enriched components from the micro-fluidic component by this ,

In such known from WO 99/09042 known arrangement, the fluid is first directed to the component to be separated in the micro-fluidic component, wherein the component accumulates on the walls of the fluid paths. The accumulation can be allowed or by an appropriate structuring and / or coating of the walls, by electric charging of the walls or their exposure to ultrasonic be improved. The depleted from the component fluid over the

Fluid removal dissipated. dik-component is supplied as auxiliary fluid a suitable eluent, then by the Mikroflui- which solves the accumulated component of the walls of the fluid paths and abfuhrt via the auxiliary fluid discharge. The Ablosen of the component can be facilitated by electrical charging of the walls or their exposure to ultrasound by heating the microfluidic component and also, if necessary. Since the micro-fluidic component via the controllable valve means alternately to the first fluid supply and -abfuhr and is then switched to the Hilfsfluidzu- and discharge, a continuous separation process is not possible. The invention has the object to provide a continuous separation of the component from the fluid.

According to the invention the object is achieved in that in the arrangement of the aforementioned kind at least one further identically constructed microfluidic component is provided and that the valve means are adapted to at the same time the fluid through at least one and the auxiliary fluid through at least one other of the microfluidic directing components. Thereby, a continuous inflow of the fluid and continuous outflow of depleted fluid and the separated component is achieved.

Depending on the fluid and component separated is coming different separation method in question, so that the walls of the fluid paths may be formed in particular for the condensation or desublimation of the component from a gaseous fluid, for the adsorption or absorption of the component. In the latter case z. B. passing an absorbent in the fluid paths and fixed there, for example, by drying on the walls before the fluid is introduced with the component to be absorbed; then the absorbed component is expelled from the absorbent or the loaded absorbent from the micro-fluidic component Removing rinsed to separate the component in a subsequent processing step by means of the auxiliary fluid.

In order to allow the expulsion of the enriched in the microfluidic device component according to the separation method to facilitate or each of the microfluidic components is preferably in each case associated with a tempering device. Because the microfluidic devices are operated alternately for the enrichment of the component and for the expulsion of the enriched component, which tempering means preferably controllable as a heat pump, z are. B. thermoelectric heat pump (Peltier element) are formed, which cools the at least one micro-fluidic component flowed through by the fluid according to their control and heating the at least one micro-fluidic component flowed through by the auxiliary fluid. The direction of heat flow between the microfluidic components is reversed periodically.

To maintaining the continuous course of the separation of the component from the fluid rungs- different enrichment and to adjust Austreibungszeiten, wherein at least three microfluidic components, the number of traversed by the fluid microfluidic components different from the number of simultaneously from the auxiliary fluid perfused microfluidic components. For example, at five microfluidic components, the times for the enrichment and expulsion in the ratio 1: 4, 2: 3, 3: 2 and 4: 1 einge- provides.

In order to switch in the individual microfluidic components in an optimum manner between the enrichment of the component and the expulsion of the component enriched, means for detecting the loading of the microfluidic components are provided with the enriched component, which control the valve means. These devices may for example detect the flow of fluid through the microfluidic components, the pressure drop across the microfluidic components or the concentration of the component in the depleted fluid. Here, when an insufficient or too high loading of the respective microfluidic device is detected with the component, the valve means are switched to the expulsion of the component.

To further explain the invention reference is made hereinafter to the figures of the drawing; show in detail

1 shows a first embodiment of the arrangement according to the invention with two microfluidic components and figure 2 shows another exemplary embodiment of the erfmdungsge- reasonably arrangement having three microfluidic components.

Figure 1 shows two identical microfluidic components 1 and 2 with two fluid Anschlussen 3 and 4 or 5 and 6 between which microstructured fluid paths 7 and 8, m here form of parallel microchannels formed.

At their fluid Anschlussen 3 and 5, the microfluidic construction parts 1 and 2 are connected to a fluid supply 10 and an auxiliary fluid supply 11 via a first controllable valve device. 9 Depending on the switching position, connects the controllable valve means 9, either the fluid supply 10 to the fluid port 3 of the microfluidic device 1 and the auxiliary fluid supply 11 to the fluid port 5 of the microfluidic device 2 or, as shown in phantom, the fluid supply 10 to the fluid port 5 of the microfluidic device 2 and the auxiliary supply of fluid 11 with the fluid port 3 of the microfluidic device. 1

the microfluidic construction parts 1 and 2 are connected to a fluid discharge 13 and an auxiliary fluid discharge 14 via a second controllable valve means 12 at their fluid Anschlussen 4 and 6 respectively. Depending on the switching position 12 connects the second controllable Ventilemrichtung either the fluid port 4 of the microfluidic device 1 having the fluid discharge 13 and the fluid port 6 of the microfluidic device 2 with the auxiliary fluid discharge 14 or, as shown in phantom, the fluid port 4 of the microfluidic component 1 fluid discharge with the auxiliary 14 and the fluid port 6 of the microfluidic

be opposite to the fluid discharge 13. If the fluid stream and the auxiliary fluid flow through the microfluidic components 1 and 2 the component 2, so the auxiliary fluid supply can be 11 and auxiliary fluid discharge 14 reversed.

Each microF luidik component 1 and 2 [j in each case or a temperature-rier means 15th 16 is associated, which are formed here by a heat pump 17 with a heating circuit 18 and a cooling circuit 19, wherein by means of a controllable valve 20 is alternately switched between a heating and a cooling of one of the other microfluidic component. Instead of the illustrated heat pump 17 such can. As a

Peltier element for alternately cooling and heating of the microfluidic devices are provided. 1 and 2

For the separation of a component from a fluid that is led in the shown position of the valve means 9 and 12 via the fluid supply 10 into the first microfluidic component 1, which is cooled by the associated tempering device 15th The component to be separated is carried condensation, adsorption o. Ä. Enriched in the walls of the fluid paths 7, while the depleted fluid, the microfluidic device 1 leaves via the fluid discharge. 13 After reversal of the valve means 9 and 12 and the valve 20, the second microfluidic device 2 accepts the enrichment of the component to be separated, while the first microfluidic component 1 is heated and is flow-type on the auxiliary fluid supply 11 with an auxiliary fluid to the component from the microfluidic component 1 expel through the auxiliary fluid discharge fourteenth The auxiliary fluid may be preheated to himself. If the component is sucked only at the auxiliary fluid discharge 14, so the auxiliary fluid to the inflowing air corresponds.

In the example shown in Figure 2 embodiment of the inventive arrangement three identical microfluidic components 1, 2 and 21, each with two fluid Anschlussen 3 and 4, 5 and 6 or 22 and 23 are provided, between which microstructured fluid paths 7, 8 and 24, are formed here in the form of parallel microchannels.

The microfluidic components 1, 2 and 21 are on at their Fluidan- circuits 3, 5 and 22 via a first controllable valve device 25 on the fluid supply 10 and the auxiliary fluid supply 11 and at its fluid Anschlussen 4, 6 and 23 via a second controllable Ventilemrichtung 26 the fluid discharge 13 and the auxiliary fluid discharge 14 is connected. The controllable Ventilemrichtungen 25 and 26 turn always [two microfluidics components such. B. 1 and 2, between the fluid supply and discharge 10 and 13 and a micro-fluidic component, eg. B. 21, between the inlet and drainage Hilfsfluidzu- 11 and 14. Cyclic sequentially so the microfluidic components 1 and 2, 2 and 21 and 1 and 21 of the fluid and at the same time the microfluidic components 21, 1 and 2 of flows through the auxiliary fluid. The standing for the enrichment of the component in the microfluidic components for grouting time is twice as large as the time for the expulsion of the component. In still more than the three shown microfluidic components is more time ratios for the enrichment and expulsion of the component can be realized. For the enrichment of the component of the respective microfluidic components are cooled and heated to drive off, as this has been described using the example of Figure 1 and is therefore not shown here specifically.

Each microfluidic components 1, 2 and 21 is [a respective devices 27, 28, 29 assigned for detection of the loading of the respective microfluidic device with the enriched component. In the example shown this is done by sensing the pressure drop across the individual Mikroflui- dik components 1, 2 and 21. If the pressure drop a predetermined threshold, there is in addition the danger of clogging of the fluid paths in the relevant micro-fluidic component. By then a reversal of the valve means is made 25 and 26 for the expulsion of the component from the driving verstopfungsge- Deten microfluidic component via a control inputs direction 30th It can, at least temporarily, be changed for the enrichment and expulsion of the component was originally set time-encryption haltnis. In order to increase the separation performance, the arrangements shown can be switched in terms of a multi-stage arrangement, several times in succession.

Claims

claims
1. An arrangement for separating a component from a fluid with a micro-fluidic component (1), in which between two fluid Anschlussen (3, 4) extend a plurality of microstructured fluid paths (7) whose walls are formed for the enrichment of the component, with a fluid supply (10), a fluid discharge (13), an auxiliary fluid supply (11) and an auxiliary fluid discharge (14) as well as between these and the fluid Anschlussen (3, 4) of the microfluidic device disposed (1) the controllable valve means (9, 12; 25 , 26) to conduct alternately the fluid to the enrichment of the component to be separated on the walls and the auxiliary fluid to the expulsion of the enriched components from the microfluidic component (1) by this, since you rchgekennzeichnet that at least one further identically constructed microfluidic component (2; 21) is provided and that the valve means (9, 12; 25, 26) are adapted, simultaneously the fluid through at least one and the auxiliary fluid through slightest ns another of the microfluidic components (1, 2; directing 21).
2. Arrangement according to claim 1, characterized in that the walls of the fluid paths tion to condensation, sublimation, adsorption or absorption of the component are formed.
3. An arrangement according to one of the preceding claims, characterized in that each of the microfluidics components (1, 2) each comprise a tempering means (15, 16) is assigned.
4. An arrangement according to claim 3, characterized in that the tempering means are adapted (15, 16) as a controllable pump (17) which cools in accordance with their control the at least one micro-fluidic component flowed through by the fluid (eg. B. 1) and the at least one of the auxiliary fluid flowed through microfluidic component (z. B. 2) is heated.
5. An arrangement according to one of the preceding claims, du r ch geke nn zei chn et that at least three microfluidic components (1, 2, 21) the number of traversed by the fluid microfluidic components (eg., 1, 2) different (to the number of simultaneously flowed through by the auxiliary fluid microfluidic components z. B. 21).
6. Arrangement according to one of the preceding claims, as you that means (27, 28, 29) for detecting the loading of the microfluidic components (1, 2, 21) ensued with the component of the enriched see r ch geke nn zeic hn et, are that the valve means (25, 26) drive.
PCT/DE2002/004701 2001-12-21 2002-12-20 Device for separating a component from a fluid WO2003055605A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE2001163476 DE10163476A1 (en) 2001-12-21 2001-12-21 Device for separating a component from a fluid
DE10163476.5 2001-12-21

Publications (1)

Publication Number Publication Date
WO2003055605A1 true true WO2003055605A1 (en) 2003-07-10

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Family Applications (1)

Application Number Title Priority Date Filing Date
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Country Status (2)

Country Link
DE (1) DE10163476A1 (en)
WO (1) WO2003055605A1 (en)

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005011867A3 (en) * 2003-07-31 2005-04-21 Handylab Inc Processing particle-containing samples
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US8894947B2 (en) 2001-03-28 2014-11-25 Handylab, Inc. Systems and methods for thermal actuation of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US9028773B2 (en) 2001-09-12 2015-05-12 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US9040288B2 (en) 2006-03-24 2015-05-26 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using the same
US9051604B2 (en) 2001-02-14 2015-06-09 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US9080207B2 (en) 2006-03-24 2015-07-14 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
USD742027S1 (en) 2011-09-30 2015-10-27 Becton, Dickinson And Company Single piece reagent holder
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9217143B2 (en) 2007-07-13 2015-12-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9222954B2 (en) 2011-09-30 2015-12-29 Becton, Dickinson And Company Unitized reagent strip
US9238223B2 (en) 2007-07-13 2016-01-19 Handylab, Inc. Microfluidic cartridge
US9259735B2 (en) 2001-03-28 2016-02-16 Handylab, Inc. Methods and systems for control of microfluidic devices
US9259734B2 (en) 2007-07-13 2016-02-16 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9347586B2 (en) 2007-07-13 2016-05-24 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US9765389B2 (en) 2011-04-15 2017-09-19 Becton, Dickinson And Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
US9815057B2 (en) 2006-11-14 2017-11-14 Handylab, Inc. Microfluidic cartridge and method of making same

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Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9051604B2 (en) 2001-02-14 2015-06-09 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US9528142B2 (en) 2001-02-14 2016-12-27 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US9677121B2 (en) 2001-03-28 2017-06-13 Handylab, Inc. Systems and methods for thermal actuation of microfluidic devices
US8894947B2 (en) 2001-03-28 2014-11-25 Handylab, Inc. Systems and methods for thermal actuation of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US9259735B2 (en) 2001-03-28 2016-02-16 Handylab, Inc. Methods and systems for control of microfluidic devices
US9028773B2 (en) 2001-09-12 2015-05-12 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US9670528B2 (en) 2003-07-31 2017-06-06 Handylab, Inc. Processing particle-containing samples
WO2005011867A3 (en) * 2003-07-31 2005-04-21 Handylab Inc Processing particle-containing samples
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US9080207B2 (en) 2006-03-24 2015-07-14 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US9802199B2 (en) 2006-03-24 2017-10-31 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US9040288B2 (en) 2006-03-24 2015-05-26 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using the same
US9815057B2 (en) 2006-11-14 2017-11-14 Handylab, Inc. Microfluidic cartridge and method of making same
US9259734B2 (en) 2007-07-13 2016-02-16 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9347586B2 (en) 2007-07-13 2016-05-24 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US9701957B2 (en) 2007-07-13 2017-07-11 Handylab, Inc. Reagent holder, and kits containing same
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US9238223B2 (en) 2007-07-13 2016-01-19 Handylab, Inc. Microfluidic cartridge
US9217143B2 (en) 2007-07-13 2015-12-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US9765389B2 (en) 2011-04-15 2017-09-19 Becton, Dickinson And Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
US9480983B2 (en) 2011-09-30 2016-11-01 Becton, Dickinson And Company Unitized reagent strip
US9222954B2 (en) 2011-09-30 2015-12-29 Becton, Dickinson And Company Unitized reagent strip
USD742027S1 (en) 2011-09-30 2015-10-27 Becton, Dickinson And Company Single piece reagent holder

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