WO2003054020A3 - Human antibodies against human glycoprotein vi and their use - Google Patents
Human antibodies against human glycoprotein vi and their use Download PDFInfo
- Publication number
- WO2003054020A3 WO2003054020A3 PCT/GB2002/005755 GB0205755W WO03054020A3 WO 2003054020 A3 WO2003054020 A3 WO 2003054020A3 GB 0205755 W GB0205755 W GB 0205755W WO 03054020 A3 WO03054020 A3 WO 03054020A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antibody
- human
- glycoprotein
- domain
- chain variable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE60238556T DE60238556D1 (en) | 2001-12-20 | 2002-12-18 | HUMAN ANTIBODIES AGAINST THE HUMAN GLYCOPROTEIN VI AND ITS USE |
EP02788156A EP1458759B1 (en) | 2001-12-20 | 2002-12-18 | Human antibodies against human glycoprotein vi and their use |
AT02788156T ATE490983T1 (en) | 2001-12-20 | 2002-12-18 | HUMAN ANTIBODIES AGAINST HUMAN GLYCOPROTEIN VI AND THEIR USE |
CA002510745A CA2510745A1 (en) | 2001-12-20 | 2002-12-18 | Human antibodies against human glycoprotein vi and their use |
US10/499,266 US8853368B2 (en) | 2001-12-20 | 2002-12-18 | Human antibodies against human glycoprotein VI and their use |
AU2002352438A AU2002352438B2 (en) | 2001-12-20 | 2002-12-18 | Human antibodies against human glycoprotein VI and their use |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0130543.2A GB0130543D0 (en) | 2001-12-20 | 2001-12-20 | Human antibodies and their use |
GB0130543.2 | 2001-12-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003054020A2 WO2003054020A2 (en) | 2003-07-03 |
WO2003054020A3 true WO2003054020A3 (en) | 2003-12-18 |
Family
ID=9928080
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2002/005755 WO2003054020A2 (en) | 2001-12-20 | 2002-12-18 | Human antibodies against human glycoprotein vi and their use |
Country Status (8)
Country | Link |
---|---|
US (1) | US8853368B2 (en) |
EP (1) | EP1458759B1 (en) |
AT (1) | ATE490983T1 (en) |
AU (1) | AU2002352438B2 (en) |
CA (1) | CA2510745A1 (en) |
DE (1) | DE60238556D1 (en) |
GB (1) | GB0130543D0 (en) |
WO (1) | WO2003054020A2 (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7531178B2 (en) | 2002-06-07 | 2009-05-12 | Trigen Gmbh | Immunoadhesin comprising a glycoprotein VI domain |
US20070071744A1 (en) | 2002-06-07 | 2007-03-29 | Gotz Munch | Agents which bind to epitopes of glycoprotein VI |
EP1369128A1 (en) | 2002-06-07 | 2003-12-10 | Procorde GmbH | Inhibitors of glycoprotein VI and their therapeutic use |
CN100558895C (en) * | 2003-07-18 | 2009-11-11 | 持田制药株式会社 | Anti-platelet membrane glycoprotein vi monoclonal antibody |
EP1745076B1 (en) * | 2004-04-29 | 2012-06-13 | Otsuka Pharmaceutical Co., Ltd. | Antibodies specific for glycoprotein vi and methods of producing these antibodies |
US7645592B2 (en) | 2004-04-29 | 2010-01-12 | Otsuka Pharmaceutical Co., Ltd. | Glycoprotein VI antibodies and methods of use thereof |
CA2606450A1 (en) * | 2005-04-28 | 2006-11-09 | Mochida Pharmaceutical Co., Ltd. | Anti-platelet membrane glycoprotein vi monoclonal antibody |
US20090041783A1 (en) | 2005-04-28 | 2009-02-12 | Mochida Pharmaceutical Co., Ltd. | Anti-platelet membrane glycoprotein vi monoclonal antibody |
CA2646807A1 (en) * | 2006-03-31 | 2007-10-18 | Mochida Pharmaceutical Co., Ltd. | Novel platelet activation marker and method for determination thereof |
EP2212416A4 (en) * | 2007-10-31 | 2013-01-09 | Otsuka Pharma Co Ltd | Uses of a glycoprotein vi (gpvi) inhibitor |
EP2411416A1 (en) * | 2009-03-24 | 2012-02-01 | The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services | Anti-mesothelin antibodies |
UY33115A (en) * | 2009-12-18 | 2011-07-29 | Sanofi Aventis | NEW ANTAGONIST ANTIBODIES AND THEIR FRAGMENTS Fab AGAINST GPVI AND ITS USES |
EP2336188A1 (en) * | 2009-12-18 | 2011-06-22 | Sanofi-Aventis | Novel antagonist antibodies and their Fab fragments against GPVI and uses thereof |
EP2397495A1 (en) * | 2010-06-21 | 2011-12-21 | Sanofi | Novel antagonist antibodies and their Fab fragments against GPVI and uses thereof |
EP2615458A4 (en) | 2010-09-07 | 2014-01-01 | Mochida Pharm Co Ltd | Method for diagnosing alzheimer's disease using blood-soluble gpvi |
EP3331553B1 (en) | 2015-08-05 | 2022-06-29 | Acticor Biotech | Novel anti-human gpvi antibodies and uses thereof |
WO2018141909A1 (en) | 2017-02-03 | 2018-08-09 | Acticor Biotech | Inhibition of platelet aggregation using anti-human gpvi antibodies |
WO2019219765A1 (en) | 2018-05-16 | 2019-11-21 | Morphosys Ag | Antibodies targeting glycoprotein vi |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001000810A1 (en) * | 1999-06-30 | 2001-01-04 | Millennium Pharmaceuticals, Inc. | Glycoprotein vi and uses thereof |
WO2002080968A1 (en) * | 2001-04-09 | 2002-10-17 | Millennium Pharmaceuticals, Inc. | Glycoprotein vi and uses thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPS61134325A (en) | 1984-12-04 | 1986-06-21 | Teijin Ltd | Expression of hybrid antibody gene |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
EP1136556B1 (en) | 1991-11-25 | 2005-06-08 | Enzon, Inc. | Method of producing multivalent antigen-binding proteins |
ATE199392T1 (en) | 1992-12-04 | 2001-03-15 | Medical Res Council | MULTIVALENT AND MULTI-SPECIFIC BINDING PROTEINS, THEIR PRODUCTION AND USE |
GB9621295D0 (en) * | 1995-12-07 | 1996-11-27 | Cambridge Antibody Tech | Specific binding members,materials and methods |
US20020062010A1 (en) * | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
US6245527B1 (en) * | 1999-06-30 | 2001-06-12 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules encoding glycoprotein VI and recombinant uses thereof |
-
2001
- 2001-12-20 GB GBGB0130543.2A patent/GB0130543D0/en not_active Ceased
-
2002
- 2002-12-18 WO PCT/GB2002/005755 patent/WO2003054020A2/en not_active Application Discontinuation
- 2002-12-18 EP EP02788156A patent/EP1458759B1/en not_active Expired - Lifetime
- 2002-12-18 US US10/499,266 patent/US8853368B2/en not_active Expired - Fee Related
- 2002-12-18 DE DE60238556T patent/DE60238556D1/en not_active Expired - Lifetime
- 2002-12-18 CA CA002510745A patent/CA2510745A1/en not_active Abandoned
- 2002-12-18 AT AT02788156T patent/ATE490983T1/en not_active IP Right Cessation
- 2002-12-18 AU AU2002352438A patent/AU2002352438B2/en not_active Ceased
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001000810A1 (en) * | 1999-06-30 | 2001-01-04 | Millennium Pharmaceuticals, Inc. | Glycoprotein vi and uses thereof |
WO2002080968A1 (en) * | 2001-04-09 | 2002-10-17 | Millennium Pharmaceuticals, Inc. | Glycoprotein vi and uses thereof |
Non-Patent Citations (4)
Title |
---|
B. NIESWANDT ET AL.: "Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 31, 4 August 2000 (2000-08-04), BATIMORE, MD, US, pages 23998 - 24002, XP002174650 * |
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2002, QIAN MING D ET AL: "Anti GPVI human antibodies neutralizing collagen-induced platelet aggregation isolated from a combinatorial phage display library.", XP002253305, Database accession no. PREV200300060975 * |
HUMAN ANTIBODIES, vol. 11, no. 3, 2002, pages 97 - 105, ISSN: 1093-2607 * |
P.A. SMETHURST ET AL.: "Identification of the collagen binding surface of human glycoprotein VI and functional blockade by a novel human recombinant antibody.", BLOOD, vol. 100, no. 11, 16 November 2002 (2002-11-16), pages 474a, XP002253304 * |
Also Published As
Publication number | Publication date |
---|---|
CA2510745A1 (en) | 2003-07-03 |
AU2002352438B2 (en) | 2009-09-03 |
EP1458759A2 (en) | 2004-09-22 |
WO2003054020A2 (en) | 2003-07-03 |
GB0130543D0 (en) | 2002-02-06 |
ATE490983T1 (en) | 2010-12-15 |
US8853368B2 (en) | 2014-10-07 |
EP1458759B1 (en) | 2010-12-08 |
US20060088531A1 (en) | 2006-04-27 |
DE60238556D1 (en) | 2011-01-20 |
AU2002352438A1 (en) | 2003-07-09 |
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