WO2003053360A3 - Treatment of ebv and khsv infection and associated abnormal cellular proliferation - Google Patents

Treatment of ebv and khsv infection and associated abnormal cellular proliferation Download PDF

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Publication number
WO2003053360A3
WO2003053360A3 PCT/US2002/040853 US0240853W WO03053360A3 WO 2003053360 A3 WO2003053360 A3 WO 2003053360A3 US 0240853 W US0240853 W US 0240853W WO 03053360 A3 WO03053360 A3 WO 03053360A3
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WO
WIPO (PCT)
Prior art keywords
ebv
treatment
cellular proliferation
abnormal cellular
associated abnormal
Prior art date
Application number
PCT/US2002/040853
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French (fr)
Other versions
WO2003053360A2 (en
Inventor
Raymond F Schinazi
Junxing Shi
Joyce D Fingeroth
Erik Gustafson
Original Assignee
Pharmassett Ltd
Beth Israel Hospital
Univ Emory
Raymond F Schinazi
Junxing Shi
Joyce D Fingeroth
Erik Gustafson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmassett Ltd, Beth Israel Hospital, Univ Emory, Raymond F Schinazi, Junxing Shi, Joyce D Fingeroth, Erik Gustafson filed Critical Pharmassett Ltd
Priority to EP02795977A priority Critical patent/EP1569658A4/en
Priority to JP2003554120A priority patent/JP4651942B2/en
Priority to AU2002360697A priority patent/AU2002360697B2/en
Priority to CA002470938A priority patent/CA2470938A1/en
Publication of WO2003053360A2 publication Critical patent/WO2003053360A2/en
Publication of WO2003053360A3 publication Critical patent/WO2003053360A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an effective amount of a 5-substituted uracil nucleoside or its pharmaceutically acceptable salt or prodrug, optionally in a pharmaceutically acceptable diluent or excipient.
PCT/US2002/040853 2001-12-20 2002-12-19 Treatment of ebv and khsv infection and associated abnormal cellular proliferation WO2003053360A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP02795977A EP1569658A4 (en) 2001-12-20 2002-12-19 Treatment of ebv and khsv infection and associated abnormal cellular proliferation
JP2003554120A JP4651942B2 (en) 2001-12-20 2002-12-19 Treatment of EBV and KHSV infection and associated abnormal cell proliferation
AU2002360697A AU2002360697B2 (en) 2001-12-20 2002-12-19 Treatment of EBV and KHSV infection and associated abnormal cellular proliferation
CA002470938A CA2470938A1 (en) 2001-12-20 2002-12-19 Treatment of ebv and khsv infection and associated abnormal cellular proliferation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34513001P 2001-12-20 2001-12-20
US60/345,130 2001-12-20

Publications (2)

Publication Number Publication Date
WO2003053360A2 WO2003053360A2 (en) 2003-07-03
WO2003053360A3 true WO2003053360A3 (en) 2005-07-07

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/040853 WO2003053360A2 (en) 2001-12-20 2002-12-19 Treatment of ebv and khsv infection and associated abnormal cellular proliferation

Country Status (6)

Country Link
US (4) US7211570B2 (en)
EP (1) EP1569658A4 (en)
JP (1) JP4651942B2 (en)
AU (1) AU2002360697B2 (en)
CA (1) CA2470938A1 (en)
WO (1) WO2003053360A2 (en)

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PL3521297T3 (en) 2003-05-30 2022-04-04 Gilead Pharmasset Llc Modified fluorinated nucleoside analogues
WO2005027962A1 (en) * 2003-09-18 2005-03-31 Isis Pharmaceuticals, Inc. 4’-thionucleosides and oligomeric compounds
US20050171396A1 (en) * 2003-10-20 2005-08-04 Cyberheart, Inc. Method for non-invasive lung treatment
EP1674104A1 (en) * 2004-12-24 2006-06-28 Institut National De La Sante Et De La Recherche Medicale (Inserm) Uridine derivatives as antiviral drugs against a flaviviridae, especially HCV
JP5571947B2 (en) * 2006-03-14 2014-08-13 アルト ソリューションズ インコーポレーテッド Prevention and treatment of cancer and other diseases
WO2007122634A2 (en) * 2006-04-24 2007-11-01 Jubilant Biosys Limited Pyrimidinediones as tyrosine kinase inhibitors
PL2132215T3 (en) 2007-02-28 2016-04-29 Univ Alberta Compounds for preventing or treating viral infections and methods of use thereof
US20100330563A1 (en) * 2007-09-10 2010-12-30 Yamasa Corporation Medicinal agent for disease associated with epstein-barr virus, and method for screening of the medicinal agent
CN103467550B (en) * 2013-09-22 2015-05-27 河南师范大学 5-cyclohexyl uracil arabinoside, preparation method and application thereof
JP6351107B2 (en) * 2014-02-18 2018-07-04 富士フイルム株式会社 Method for producing thiolane skeleton type sugar compound and thiolane skeleton type sugar compound
EP3265102A4 (en) 2015-03-06 2018-12-05 ATEA Pharmaceuticals, Inc. Beta-d-2'-deoxy-2'alpha-fluoro-2'-beta-c-substituted-2-modified-n6-substituted purine nucleotides for hcv treatment
CN105566304B (en) * 2016-01-13 2019-04-30 大连大学 Sulfur-bearing uridine anticancer compound and its intermediate and preparation method
LU100724B1 (en) 2016-07-14 2018-07-31 Atea Pharmaceuticals Inc Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection
PT3512863T (en) 2016-09-07 2022-03-09 Atea Pharmaceuticals Inc 2'-substituted-n6-substituted purine nucleotides for rna virus treatment
SG10202012214WA (en) 2017-02-01 2021-01-28 Atea Pharmaceuticals Inc Nucleotide hemi-sulfate salt for the treatment of hepatitis c virus
TW202012001A (en) 2018-04-10 2020-04-01 美商亞堤製藥公司 Treatment of cirrhotic hcv infected patients
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19

Citations (7)

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US4542210A (en) * 1981-09-09 1985-09-17 Yamasa Shoyu Kabushiki Kaisha 1-β-D-Arabinofuranosyl-(E)-5-(2-halogenovinyl)-uracil-5'-phosphate, preparation thereof and use thereof
US4681933A (en) * 1986-05-01 1987-07-21 University Of Georgia Research Foundation, Inc. 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
US4841039A (en) * 1986-05-01 1989-06-20 Emory University 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
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US6022876A (en) * 1996-11-15 2000-02-08 Yale University L-β-dioxolane uridine analogs and methods for treating and preventing Epstein-Barr virus infections

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Also Published As

Publication number Publication date
JP2005528334A (en) 2005-09-22
US20030176392A1 (en) 2003-09-18
US7638502B2 (en) 2009-12-29
US20140336143A1 (en) 2014-11-13
JP4651942B2 (en) 2011-03-16
EP1569658A2 (en) 2005-09-07
AU2002360697B2 (en) 2009-04-23
CA2470938A1 (en) 2003-07-03
US20100168052A1 (en) 2010-07-01
WO2003053360A2 (en) 2003-07-03
US7211570B2 (en) 2007-05-01
US20070197462A1 (en) 2007-08-23
AU2002360697A1 (en) 2003-07-09
US9382286B2 (en) 2016-07-05
EP1569658A4 (en) 2007-05-30

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