WO2003044678A1 - Systeme de traitement de donnees utilisant des donnees relatives a une sequence de base - Google Patents

Systeme de traitement de donnees utilisant des donnees relatives a une sequence de base Download PDF

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Publication number
WO2003044678A1
WO2003044678A1 PCT/JP2002/012010 JP0212010W WO03044678A1 WO 2003044678 A1 WO2003044678 A1 WO 2003044678A1 JP 0212010 W JP0212010 W JP 0212010W WO 03044678 A1 WO03044678 A1 WO 03044678A1
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WO
WIPO (PCT)
Prior art keywords
polymorphism
information
base sequence
related information
pattern
Prior art date
Application number
PCT/JP2002/012010
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English (en)
Japanese (ja)
Inventor
Takamasa Kato
Takeo Morimoto
Original Assignee
Hitachi, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi, Ltd. filed Critical Hitachi, Ltd.
Priority to JP2003546248A priority Critical patent/JP3888999B2/ja
Publication of WO2003044678A1 publication Critical patent/WO2003044678A1/fr

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Classifications

    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F16/00—Information retrieval; Database structures therefor; File system structures therefor
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids

Definitions

  • the present invention relates to, for example, an information processing system that provides information via a communication network.
  • genomic base sequences of various organisms including humans are being rapidly determined, and genomic base sequence information is accumulated in various databases.
  • a system is being constructed that allows various research institutions and researchers to use genomic base sequence information stored in a database via an information communication network such as the Internet.
  • genomic drug discovery research and genetic information analysis have been actively conducted using the base sequences contained in such genomic base sequence information, and the Attention has been paid to differences in base sequences.
  • differences in the nucleotide sequence between individuals are defined as a polymorphism defined as having a predetermined base difference at a frequency of 1% or more in an individual species, and having a predetermined base difference of 1% in the individual species. Means a variation that is less than.
  • polymorphisms include single nucleotide polymorphism (SNP: Single Nucleotide Polymorphism), a single base difference between individuals, and deletion or deletion of one to several tens of bases (sometimes several thousand bases).
  • SNP Single Nucleotide Polymorphism
  • VNTR Very Number of Tandem Repeat
  • microsatellite polymorphism replicateated sequence of 2 to 4 Bases
  • Such polymorphism may affect the amino acid sequence of a protein between individuals, or the expression efficiency of a given gene between individuals. It is known that, due to such effects, for example, the susceptibility to a predetermined disease differs among individuals, and the sensitivity to a predetermined drug differs between individuals.
  • the present invention can utilize meaningful information useful for each individual by effectively utilizing differences in base sequence information between individuals, and can utilize the meaning information for each individual.
  • the purpose is to build an information processing system that can easily authenticate qualifications. Disclosure of the invention
  • the information processing method for a base sequence according to the present invention uses a position information and a base sequence-related information obtained from a requester side to request an authentication confirmation from the requester. And a method of requesting authentication confirmation using position information and base sequence-related information associated with the position information.
  • the nucleotide sequence-related information obtained from the requester matches the nucleotide sequence-related information included in the storage device that stores the position information and the nucleotide sequence-related information associated with the position information.
  • the authentication confirmation is performed by determining.
  • the position information is transmitted to the requester, the base sequence-related information associated with the transmitted position information is obtained from the requester, and the determination is made based on the obtained base sequence-related information. It can be carried out. Further, in this method, without sending the position information to the requester side, the authentication confirmation request and the base sequence-related information associated with the position information are obtained from the requester side, and based on the obtained base sequence-related information, A decision can be made.
  • the result of the determination can be sent to the requester side.
  • the present method records the position information and the base sequence-related information associated with the position information for each of a plurality of requesters who have usage qualifications or for each individual belonging to the requester side, and The method may include a step of constructing the storage contents.
  • the present method after sending the authentication confirmation request, position information is obtained, the base sequence-related information associated with the obtained position information is obtained, and the obtained base sequence-related information is transmitted in association with the position information. By doing so, authentication confirmation can be received. Further, in the present method, the salt associated with the location information can be obtained without acquiring the location information. By obtaining the base sequence-related information and associating the obtained base sequence-related information with the position information and sending it together with the authentication check request, the authentication can be confirmed. Further, the method may include a step of obtaining an authentication confirmation result. Note that the present method can be realized as a program that causes a computer including hardware such as a control device, a transmission / reception device, and a storage device to execute each step.
  • the present method can also be realized as a recording medium that records a program that causes a computer including hardware such as a control device, a transmission / reception device, and a storage device to execute each step.
  • the present method can also be realized as an information processing device including hardware such as a control device that executes each step, a transmission / reception device, and a storage device.
  • FIG. 1 is a schematic configuration diagram schematically showing a configuration of an information processing system to which the present invention is applied.
  • FIG. 2 is a schematic configuration diagram schematically showing the configuration of a shared computer.
  • FIG. 3 is a configuration diagram illustrating an example of data recorded in the main DB.
  • FIG. 4 is a schematic configuration diagram schematically showing the configuration of a personal computer.
  • FIG. 5 is a configuration diagram showing an example of data recorded on a genome-related information recording medium.
  • FIG. 6 is a configuration diagram illustrating an example of data recorded in the authentication polymorphism pattern database.
  • FIG. 7 is a flowchart showing processing in the authentication confirmation step.
  • FIG. 8 is a continuation of FIG. 7, and is a flowchart showing processing in the authentication confirmation step.
  • FIG. 9 is a flowchart showing a process performed by a shared computer and a personal computer in a system for providing morbidity for a predetermined disease.
  • Figure 10 is a continuation of Figure 9, which provides a system that provides morbidity for a given disease. In the system, it is a flowchart showing the processing on a shared computer and a personal computer.
  • Figure 1 1 is a system for providing a morbidity rate of a predetermined disease
  • Figure 1 2 flow is an Chiya one preparative showing another process in the shared computer and a personal computer, can suffer for a given disease
  • 5 is a flowchart showing still another processing in a shared computer and a personal computer in a system for providing a function.
  • FIG. 13 is a flowchart showing another process in the authentication confirmation step.
  • an information processing system for providing a user with a possibility of a predetermined disease will be described. That is, a case will be described as an example in which the user requests, as “request for goods and / or services”, for example, to teach his / her morbidity regarding a predetermined disease.
  • an information processing system for performing authentication of usage qualification and the like using base sequence-related information will be described, but for convenience of description, a simplified model will be described.
  • the “goods and / or services” are not limited to this, and include, for example, medicines, foods and luxury goods, etc. that match the constitution of the individual (individual), and the constitution and characteristics of the individual (individual). This includes services such as tailored information, membership-based information provision, and account use at financial institutions.
  • the information processing system includes a communication network 1 such as the Internet, a shared computer 2 connected to the communication network 1, and at least one or more individuals connected to the communication network 1. And a personal computer 3 via a communication network 1 to enable data communication between the shared computer 2 and the personal computer 3.
  • the shared computer 2 includes a CPU 4 for controlling all operations of the shared computer 2, an input device 5 such as a keyboard and a mouse for inputting information and an instruction to execute a program, a display device, and the like.
  • the memory 7 in the shared computer 2 has a memory section A 10 and a memory section B 11 1 for recording different types of information, respectively, and a screen memory 1 for recording image data to be displayed on, for example, the personal computer 3 and the display device 6. 2 and a processing program 13 for operating the present system.
  • the shared computer 2 does not have the screen memory 12 and the processing program 13 etc. in the internal memory 7, but has an external storage device (not shown) connected to the shared computer 2 via the communication network 1. ) May be included.
  • the database 8 (storage device) in the shared computer 2 includes a main DB 14 in which polymorphism addresses, polymorphism patterns, and semantic information are recorded, and a storage DB that stores information recorded in the memory A 10. It comprises an A 15, a storage DB-B 16 for storing information recorded in the memory section B 11, and an authentication polymorphism pattern database 17. As shown in Fig. 3, the main DB 14 records the polymorphism address, a plurality of polymorphism patterns that can be taken at the polymorphism address, and semantic information meaning each of the plurality of polymorphism patterns. Have been. Further, the main DB 14 may record semantic information indicating a combination of polymorphism patterns at a plurality of polymorphism addresses (for example, a haplotype).
  • polymorphism address means at least the position where the polymorphism exists in the nucleotide sequence.
  • polymorphism includes, for example, so-called single nucleotide polymorphism (SNP), restriction ion fragment length of polymorphism (RFLP), variable number of tandem repeat (VNTR), microsatellite, and the like. You.
  • SNP single nucleotide polymorphism
  • RFLP restriction ion fragment length of polymorphism
  • VNTR variable number of tandem repeat
  • microsatellite and the like.
  • polymorphism address refers to a base that occurs only at a frequency of less than 1% in an individual species and a change in the base sequence, including a position in the base sequence. You. That is, the “polymorphism address” represents a position indicating a polymorphism or the like by combining a numerical value, a character, a symbol, and the like. The polymorphism address is not particularly limited.
  • the polymorphism address can be represented by a combination of a chromosome number, a symbol indicating a gene in which the polymorphism exists, and a numerical value indicating the location of the polymorphism in the gene, May be a combination of a symbol indicating the gene in which the gene exists and a numerical value indicating the location of the polymorphism in the gene.
  • the polymorphism address may be a polymorphism-specific notation assigned to each polymorphism.
  • the polymorphism address does not directly indicate the position in the nucleotide sequence, but the position can be indirectly known based on the polymorphism-specific notation. Therefore, "polymorphism address" is meant to include notations specific to polymorphism.
  • Polymorphism pattern is information on a base sequence that differs between individuals, and includes at least a base or base sequence pattern in a polymorphism. Further, the term “polymorphism pattern” is meant to include not only polymorphisms but also patterns of bases and base sequences that occur at a frequency of less than 1% in an individual species. For example, at a polymorphism address known to take A or G, the “polymorphism pattern” is represented by either “A” or “G”.
  • the “polymorphism pattern” may indicate a heterozygote or a homozygote in a homologous chromosome.
  • the “polymorphism pattern” can be represented by any of “AA”, “GG”, and “AG”.
  • the “polymorphism pattern” does not directly represent a pattern that can be taken at a predetermined polymorphism address, but may be an indirect representation.
  • the “polymorphism pattern” is, for example, “allele 1” when taking “A” at a polymorphism address that is known to take A or G, and “allenore 2” when taking “G”. It may be written.
  • the “polymorphism pattern” can be expressed by any of “AA”, “GG” and “AG” as described above, for example, when it can be expressed by “AA”, it can be expressed by “HI” and “GG”. When it can be expressed by "
  • polymorphism pattern examples are numerical values representing the number of repetitions when the polymorphism is microsatellite, and “present / absent” when the polymorphism is an insertion or deletion type. It may be represented by a symbol.
  • the “polymorphism pattern” at each polymorphism address may be described as, for example, “polymorphism 1”, “polymorphism 2”, or “polymorphism 3” according to a predetermined rule or agreement.
  • polymorphism 1”, “polymorphism 2”, and “polymorphism 3” can be described in descending order of the possible frequency of “polymorphism pattern”.
  • each “polymorphism 1” at each polymorphism address does not necessarily represent the same content. That is, for example, a polymorphism address "polymorphism 1" represents the most likely frequency "AAJ", and another polymorphism address "polymorphism 1" represents the most likely frequency "GG”. Become.
  • the “semantic information” is information associated with the “polymorphism pattern”. Examples of such information include responsiveness to a drug, side effects to a drug, risk to a disease or a disorder, physical constitution, characteristics, characteristics, and the like. It refers to various information resulting from differences in “polymorphism patterns”, such as lifestyle advice based on protein interactions, and so on. As the “semantic information”, various information resulting from the difference of the “polymorphism pattern” may be directly expressed, or may be indirectly expressed using a symbol or the like indicating the information. “Semantic information” is information of a type that is increased and corrected as the research on genomes and genes progresses, and it is preferable to always upgrade the version.
  • polymorphism addresses are associated with polymorphism patterns that can be taken at the polymorphism addresses, and polymorphism addresses and polymorphism patterns that are not associated with semantic information are recorded. May be.
  • Information that is not directly related to “polymorphism pattern” but is further derived from “semantic information” is “information related to semantic information”. If the “semantic information” is “risk for disease”, when the risk exceeds a certain level, for example, a specific “medical examination item” is derived. This specific “medical examination item” is S “information related to semantic information”.
  • the semantic information is at least the main DB 14 as “annotation information for the polymorphism pattern” associated with the predetermined “polymorphism address” and “polymorphism pattern”. It is recorded in.
  • the semantic information includes a predetermined “polymorphism”. “Polymorphism classification” and “classification (disease name)” corresponding to the “address” are associated with each other. That is, when the predetermined “polymorphism address” is a predetermined “polymorphism pattern”, it is possible to obtain annotation information (semantic information) indicating the type of the disease name and the likelihood of being affected by the disease.
  • semantic information can be associated with each polymorphism pattern combination (eg, haplotype) corresponding to multiple polymorphism addresses. That is, for each combination of polymorphism patterns at a plurality of polymorphism addresses, it is possible to associate annotation information (semantic information) indicating a different morbidity of a given disease. In this case, when a plurality of polymorphism addresses are a combination of predetermined polymorphism patterns, it is possible to obtain annotation information (semantic information) indicating the likelihood of illness for a predetermined disease.
  • the "public level” determined according to a predetermined standard can be associated with the semantic information.
  • the criteria for determining the "disclosure level” are to take into account semantic information, that is, the unforeseen disadvantage to an individual by disclosing the morbidity of "classification (disease name)". Can be determined.
  • the shared computer 2 does not disclose semantic information that is not appropriate to the public in view of the law, rules, own standards of conduct, contracts with users, etc.
  • the system does not disclose to the user the annotation information that indicates the likelihood of morbidity that is associated with the “disclosure level”, which means that it cannot be disclosed.
  • the user can receive the semantic information associated with the predetermined “public level”.
  • the system may be open to the public.
  • the “disclosure level” can be set as three or more stages such as “1, 2, 3,...” Or “a, b, c,---J.”
  • the level can be set according to the type of the user, such as the age of the user, qualifications, and whether or not there is a contract with the user, on the side of the shared combination 2.
  • the specified level is determined by informed consent, etc.
  • a disease associated with a release level that is higher (or lower) than the release level The user can also select the disclosure level so that only the annotation information indicating the likelihood of the disease is provided to the user.
  • the storage DB-B16 for example, data such as base sequence-related information, which is genetic information of a requester who uses this system, can be recorded. Further, the storage DB-A 15 can record data such as, for example, information for identifying a requester who uses the system. In this way, by recording the genetic information of the individual and the information identifying the individual separately in the DB-A 15 for storage and the DB-B 16 for storage, the genetic information of the requester and the requester are recorded. It is difficult to associate with the data that specifies
  • the shared computer 2 is not limited to one having the database 8 therein, and may have an external database (not shown) connected to the shared computer 2 via the communication network 1. Further, shared computer 2 may have a plurality of databases 8 therein, or may have an internal database 8 and an external database connected to shared computer 2 via communication network 1. It may be something.
  • the personal computer 3 includes a CPU 20 for controlling all the operations of the personal computer 3 and an input device 2 such as a keyboard and a mouse for inputting information and an instruction to execute a program.
  • a display device such as a display device 22; a memory 23 for storing temporary information and rewritable information; a reading device 25 for reading data from a genome-related information recording medium 24;
  • the transmission / reception device 29 transmits / receives information to / from the shared computer 2 via the communication network 1.
  • the personal computer 3 is not limited to a normal computer, and may be in any form, such as a mobile phone, a personal mobile terminal, and other mobile communication devices.
  • the memory 23 in the personal computer 3 has a memory unit 26 for recording information and the like from the genome-related information recording medium 24, and stores a processing program 27 for operating the information processing system.
  • the genome-related information recording medium 24 records individual genome-related information 28.
  • Examples of the genome-related information recording medium 24 include a magnetic disk and a magnetic card. And the like, an optical recording medium to which a magneto-optical recording method, a phase change recording method, or the like is applied, a semiconductor memory, and the like.
  • the genome-related information recording medium 24 may be in any form such as a card, a disk, a stick, a tape, or a drum. Further, the genome-related information recording medium 24 may be a recording of the genome-related information 28 of a single individual (individual). 8 may be recorded.
  • the genome-related information 28 included in the genome-related information recording medium 24 is at least a “polymorphism address” and a “polymorphism” at a predetermined polymorphism address obtained as a result of analyzing the base sequence of an individual (individual). Pattern ".
  • the genome-related information 28 may include various kinds of information such as a history of a patient, characteristics, medical record information, and a result of a health examination.
  • the genome-related information recording medium 24 as the genome-related information 28, for example, as shown in FIG.
  • Record personal information such as date, record the polymorphism address and polymorphism pattern as data II, record the existing illness as data m , record the characteristics as data IV, and record the chart information as data V. That is, the genome-related information 28 is composed of data I, data II, data III, data IV, and data V.
  • Data I and Data II contain essential information, while Data III, Data IV and Data V consist of additional information.
  • the “polymorphism address” corresponding to the position on the nucleotide sequence and the “polymorphism pattern” at the polymorphism address are linked and recorded.
  • additional information at a predetermined polymorphism address may be recorded as a “comment” by linking to the “polymorphism address”.
  • the entire base sequence of a predetermined individual may be recorded in the data II. Even if the entire base sequence is recorded in data ⁇ ⁇ ⁇ , “polymorphism address” and “polymorphism pattern” will be included in data ⁇ .
  • the personal computer 3 and the genome-related information recording medium 24 are not limited to the configurations shown in FIGS. 4 and 5, respectively.
  • the genome-related information recording medium has a processing program.
  • a memory unit is provided so that a personal computer can load the genome-related information recording medium and operate the processing program. Configuration may be used.
  • the personal computer can operate in accordance with the processing program recorded in a part of the memory of the genome-related information recording medium.
  • the authentication polymorphism pattern database 17 stores, as shown in FIG. 6, a plurality of polymorphism addresses for each ⁇ .
  • the combination with the polymorphism pattern is recorded in association.
  • the usage qualification can be obtained by clearing predetermined conditions set by the shared computer 2 side. These conditions include the age of the user, the presence or absence of submitting a health diagnosis result, the terms of use and agreement to the terms and conditions, and the presence or absence of a contract.
  • the method of obtaining the use qualification is not particularly limited, but may be performed between the personal computer 3 and the shared computer 2 via the communication network 1.
  • the authentication polymorphism pattern database 17 allows the shared computer 2 to submit the polymorphism pattern and “Gno.” Related to a plurality of polymorphism addresses to the individual who has obtained the above-mentioned use qualification, and It can be produced by associating and recording the polymorphism pattern relating to the model number and “Gno.”. At this time, the plurality of polymorphism addresses that the individual is required to submit may be different for each of the individuals, or a C'3D may be common to the individuals.
  • polymorphism addresses it is preferable to use the polymorphism addresses to which the user is required to submit, to which the semantic information shown in the main DB 14 is not associated.
  • polymorphism pattern database for authentication 17 it is preferable to construct a polymorphism pattern database for authentication 17 in which polymorphism patterns and polymorphism addresses with no associated semantic information are associated with individuals who have obtained use qualifications.
  • each individual (hereinafter, requester) possessing the genome-related information recording medium 24 accesses the shared computer 2 via the communication network 1 using the personal computer 3.
  • the system uses semantic information recorded in the main DB 14 of the shared computer 2.
  • the information processing system uses a genome-related information recording medium 24 on which genome-related information 28 of a plurality of persons is recorded, and a system in which each individual accesses the genome-related information recording medium 24. It may be.
  • the processing program 13 recorded in the memory 7 of the shared computer 2 and the processing program 27 recorded in the memory 23 of the personal computer 3 For example, as shown in FIG. 7 and FIG.
  • an authentication confirmation step for confirming the use qualification of the requester is executed. Note that, in the flowcharts shown in FIGS. 7 and 8, the steps described as “(shared)” mean processing in the shared computer 2, and the steps described as “(pieces)” are performed in the personal computer 3. Process.
  • step 1 when the requester uses this system, it is recorded in the memory 23.
  • the processing program 27 is started, and the genome-related information recording medium 24 is accessed by the processing of the processing program 27. Specifically, the processing program 27 drives the reader 25 of the personal computer 3 Access the genome-related information recording medium 24.
  • step 2 the processing program 27 reads “Gno.” Recorded as data I on the genome-related information recording medium 24. The read “Gno.” Is stored in the memory unit 26.
  • step 3 the requester transmits “Gno.” Stored in the memory unit 26 from the personal computer 3 via the communication network 1 to the shared computer 2. In step 3, by transmitting "Gno.” To the shared computer 2, authentication of the requester having the genome-related information recording medium 24 of the "Gno.” Is requested (authentication confirmation request).
  • step 4 shared computer 2 receives “Gno.” (Authentication confirmation request) from personal computer 3.
  • the received “Gno.” Is stored in the memory section A10.
  • the processing program 13 is started.
  • step 5 the authentication polymorphism pattern database 17 is accessed according to the processing program 13 of the shared computer 2.
  • step 6 a plurality of polymorphism numbers enclosed by “Gno.” That match the “Gno.” Received in step 4 from the authentication polymorphism pattern database 17 according to the processing program 13 Read out the specified polymorphism address from the ground. The polymorphism address read in step 6 is the specified ⁇ Gno. '' All the polymorphism addresses recorded in the polymorphism pattern database for authentication 17 may be used, or even some polymorphism addresses recorded in the polymorphism pattern database 17 for authentication. good.
  • step 6 when reading out some polymorphism addresses, it may be some predetermined polymorphism addresses, or some polymorphism addresses randomly selected for each use. Further, in step 6, when a predetermined polymorphism address is read, a polymorphism pattern associated with the polymorphism address may be read at the same time. The read polymorphism address and the like are recorded in the memory unit A10 in a state of being associated with the requester's "Gno."
  • step 7 the “Gno.” And “polymorphism address” recorded in the memory section A 10 are transmitted to the personal computer 3 via the communication network 1 in accordance with the processing program 13. I do. That is, in step 7, the shared computer 2 transmits to the personal computer 3 the information instructing the submission of the polymorphism pattern associated with the predetermined polymorphism address.
  • step 8 the personal computer 3 receives “Gno.” And “polymorphism address” transmitted from the shared computer 2. The received “Gno.” And “polymorphism address” are recorded in the memory unit 26.
  • step 9 when the personal computer 3 receives “Gno” and “polymorphism address” from the shared computer 2, it drives the reading device 25 in accordance with the processing program 27 to drive the genome-related information. Access the recording medium 24.
  • step 10 the “polymorphism pattern” associated with the “polymorphism address” received in step 8 is read from the genome-related information recording medium 24 in accordance with the processing program 27. The read “polymorphism pattern” is recorded in the memory unit 26 in association with the “polymorphism address”.
  • step 11 the “polymorphism address” recorded in the memory unit 26 and the “polymorphism pattern” associated with the polymorphism address are set together with “Gno.” Together with the communication network 1 To shared computer 2 via. That is, in step 11, the “polymorphism address” included in the instruction information transmitted in step 7 and the “polymorphism pattern” associated with the polymorphism address are transmitted.
  • step 7 the shared computer 2
  • step 10 the personal computer 3 reads the polymorphism pattern from the genome-related information recording medium 24 in accordance with the command information.
  • the present system may be a system that does not transmit the instruction information in step 7.
  • the personal computer 3 searches the data II based on the polymorphism address received in step 8 according to the processing program 27, and reads out the polymorphism pattern of the received polymorphism address. Then, the personal computer 3 outputs the polymorphism pattern and the like to the shared computer 2 in step 11.
  • step 12 the shared computer 2 receives “Gno.”, “Polymorphism address” and “polymorphism pattern” transmitted from the personal computer 3.
  • the received “Gno.”, “Polymorphism address” and “polymorphism pattern” are stored in the memory unit A10.
  • step 13 when “Gno.”, “Polymorphism address”, and “polymorphism pattern” are received from the personal computer 3, the authentication polymorphism pattern is processed according to the processing program 13 of the shared computer 2.
  • Access database 17 is described in step 12 (S12).
  • step 14 in the authentication polymorphism pattern database 17, a search for a match with “Gno.” And “polymorphism address” received in step 12 is made, and the authentication polymorphism pattern is searched.
  • the “polymorphism pattern” associated with the “polymorphism address” retrieved from the database 17 is read.
  • the read polymorphism pattern is recorded in the memory section A10 in association with the polymorphism address. If, in step 6, the “polymorphism pattern” associated with the polymorphism address is read out together with the polymorphism address, these steps 13 and 14 are not performed. Go to step 15 later.
  • step 15 it is determined whether the “polymorphism pattern” read in step 14 and the “polymorphism pattern” received in step 12 all match. Specifically, for all the polymorphism addresses ordered to be submitted in step 7, the “polymorphism pattern” read out in step 14 matches the “polymorphism pattern” received in step 12. Is determined.
  • step 6 when the polymorphism pattern and the “polymorphism pattern” associated with the polymorphism address are read, the “polymorphism pattern” read in step 6 and the polymorphism pattern received in step 12 are received. Judge whether it matches or does not match with the “polymorphism pattern”.
  • step 15 As a result of the determination in step 15, when the “polymorphism pattern” read out in step 14 and the “polymorphism pattern” received in step 12 all match, the process proceeds to step 16 (S16), and 1 If any one does not match, go to step 1 (S17).
  • step 16 the personal computer 3 is notified that the authentication for the usage qualification has been confirmed. Specifically, screen data to the effect that authentication has been confirmed is transmitted to the personal computer 3.
  • step 18 the personal computer 3 receives the screen data and causes the display device 22 to display the screen data.
  • the shared computer 2 can confirm the use qualification of the requester when using the present system, and can prevent unauthorized use of the present system.
  • step 16 instead of transmitting the screen data to the personal computer 3, authentication confirmation data may be transmitted. In this case, the personal computer 3 displays an authentication confirmation completion screen on the display device 22 from the received authentication confirmation data.
  • step 17 the personal computer 3 is notified that the authentication of the usage qualification could not be confirmed, and the processing is stopped. Specifically, screen data for rejecting the authentication confirmation processing is transmitted to the personal computer 3, and the screen data is displayed on the display device 22.
  • step 17 instead of transmitting the screen data to the personal computer 3, the authentication unconfirmed data may be transmitted. In this case, the personal computer 3 displays an authentication uncompleted screen on the display device 22 from the received authentication unconfirmed data.
  • the requester may be an individual who possesses the genome-related information recording medium 24 or a person different from the individual to which the genome-related information 28 of the genome-related information recording medium 24 belongs.
  • the doctor becomes the requester and makes the above-described authentication confirmation request using the patient's genome-related information recording medium 24.
  • the present system performs an information processing operation according to, for example, the flowcharts shown in FIGS. 9 and 10.
  • Figure 9 Similarly, in the flowchart shown in FIG. 10, the steps described as “(shared)” mean the processing in the shared computer 2, and the steps described as “()” indicate the processing in the personal computer 3. Means.
  • step A1 the requester whose authentication has been verified for use qualification activates the processing program 27 recorded in the memory 23.
  • the processing program 27 drives the reader 25 of the personal computer 3 to access the genome-related information recording medium 24, and the ⁇ Gno. '' Recorded as data I on the genome-related information recording medium 24. Is read. The read "Gno.” Is stored in the memory unit 26.
  • step A2 based on the screen image displayed on the display device 22 by the processing program 27, the information requested by the requester, for example, "Possibility of colorectal cancer (Request information) is input to the personal computer 3 and the “possibility of colon cancer” and “Gno.” Are transmitted from the personal computer 3 to the shared computer 2 via the communication network 1. Alternatively, “possibility of colon cancer” and “Gno.” Are written from the personal computer 3 to the shared computer 2 via the communication network 1.
  • Step A3 the shared computer 2 receives “Possibility of colon cancer” and “Gno.”.
  • the received “colorectal cancer morbidity” and “Gno.” are stored as request information in the memory unit A10.
  • step A4 when the request information is received, the processing program 13 recorded in the memory 7 is started to access the main DB 14. The processing program 13 performs processing in the shared computer 2.
  • step A5 according to the processing program 13, the “classification (disease name)” recorded in the main DB 14 is searched, and the requested “possibility of colorectal cancer” ( ) Is extracted.
  • Step A6 among the data recorded in the main DB14, the “many” linked to “Classification (disease name)” (colorectal cancer) consistent with “possibility of colorectal cancer” Read the model number.
  • the read “polymorphism address” is stored in the memory section A 10 as position information associated with the request information. That is, in the memory section A 10, The “possibility of colon cancer” and “polymorphism address” for the specified “Gno.” Will be recorded.
  • step A7 the “Gno.” And “polymorphism address” recorded in the memory section A10 are transmitted to the personal computer 3, and the “polymorphism address” to be transmitted is corresponded.
  • Yes Send the instruction information to submit the “polymorphism pattern” to the personal computer 3.
  • it may be ordered to submit additional information such as pre-existing illness or characteristics as needed.
  • step A8 "Gno. J,” "polymorphism address” and command information transmitted from shared computer 2 are received.
  • the received “Gno.” And “polymorphism address” are recorded in the memory unit 26.
  • step A9 the data II recorded on the genome-related information recording medium 24 is accessed according to the received instruction information.
  • step A10 the data II recorded on the genome-related information recording medium 24 is searched according to the processing program 27, and the polymorphism pattern of the instructed polymorphism address is read. The pattern is recorded in the memory unit 26 in association with the pattern. At this time, it is preferable to access the data I and confirm whether the “Gno.” Received in step A8 is correct.
  • step A10 in addition to the polymorphism pattern, additional information recorded in data III, data IV, and data V is simultaneously read out, and may be recorded in the memory unit 26 as necessary. ,.
  • step All (SA11) the polymorphism pattern associated with the polymorphism address temporarily recorded in the memory unit 26 and the additional information recorded as necessary are
  • step A12 the shared computer 2 receives the polymorphism pattern associated with the polymorphism address and additional information recorded as necessary, and associates the received polymorphism pattern with the polymorphism address. To record in the memory section A10.
  • step A7 the shared computer 2 sends the instruction information for instructing the submission of the polymorphism pattern J, and in step A10, the personal computer 3 sends the polymorphism pattern in accordance with the instruction information. Is read from the genome-related information recording medium 24.
  • step A7 the A system that does not transmit information may be used.
  • step A10 the personal computer 3 searches the data II based on the polymorphism address received in step A8 according to the processing program 27, and finds the polymorphism pattern of the received polymorphism address. read out. Then, the personal computer 3 outputs the polymorphism pattern and the like to the shared computer 2 in step A11.
  • the shared computer 2 obtains the polymorphism pattern of the “polymorphism address” associated with the “classification (disease name)” corresponding to the “possibility of colorectal cancer” in step A 12. Can be.
  • step A13 the main DB 14 is accessed to search for a received polymorphism address and one that matches the polymorphism pattern.
  • the main DB 14 a plurality of polymorphism patterns are recorded for one polymorphism address, and the received polymorphism address and its polymorphism pattern are stored in the main DB 14. Search for a match.
  • step A14 (SA14), according to the processing program 13, the possibility of morbidity for colorectal cancer associated with the received polymorphism pattern is read. That is, in step A14, the susceptibility of the requester to colorectal cancer can be read out according to the polymorphism address and polymorphism pattern submitted by the requester. The read morbidity is stored in the memory part A10 in association with the requester's "Gno.” At this time, the likelihood of colorectal cancer may be stored in a form corrected with additional information, or other information obtained from the additional information may be associated with the requester's ⁇ Gno. '' It may be stored.
  • step A15 the requester's “Gno.” Stored in the memory unit A10 and the possibility of morbidity are sent to the personal computer 3 via the communication network 1 as semantic information. Send.
  • Step A16 the personal computer 3 receives the “Gno.” Of the requester and the morbidity (semantic information). The received semantic information is recorded in the memory unit 26.
  • step A 17 the possibility of colon cancer is displayed on the display device 22 based on the semantic information recorded in the memory unit 26 in accordance with the processing program 27.
  • the shared computer 2 reads (creates) a screen displaying semantic information according to the processing program 13, and It can also be displayed on the display device 22 of the personal computer 3 via the communication network 1. Also in this case, it is assumed that semantic information has been transmitted from the shared computer 2 to the personal computer 3. As a result, the requester can obtain the possibility of morbidity for colorectal cancer using the genome-related information 28 recorded on the genome-related information recording medium 24.
  • the genome-related information recording medium 24 that records the individual polymorphism pattern in association with the polymorphism address is used to record the information in the main DB 14.
  • the requested semantic information can be used by the requester by interposing the polymorphism address.
  • the authentication confirmation process is performed according to the flowcharts shown in FIGS. 7 and 8, so that unauthorized use can be reliably prevented.
  • a genome-related information recording medium 24 on which a decoded polymorphic pattern is recorded.
  • a polymorphic pattern for example, analyze the genomic DNA of an individual using a laboratory that performs genomic analysis, such as a clinical test company, and perform the genomic analysis on the resulting polymorphic pattern. Encrypted by the institution or another institution.
  • a random number is selected for each polymorphism address in a plurality of polymorphism addresses and combinations of polymorphism patterns obtained as a result of analyzing individual genomic DNA.
  • the random number may be randomly selected for a plurality of polymorphism addresses, or may be selected according to a predetermined rule.
  • a polymorphism pattern at a predetermined polymorphism address obtained by analysis is encrypted.
  • a combination of a polymorphism address and a polymorphism pattern obtained by analyzing an individual's genomic DNA can be a combination of a polymorphism address and an encrypted polymorphism pattern.
  • the genome-related information recording medium 24 has a polymorphism address and an encrypted polymorphism pattern.
  • the encrypted polymorphism pattern does not mean the nucleotide sequence at the actual polymorphism address. Therefore, by using the thus-encoded polymorphic pattern, the encrypted polymorphic pattern leaks to the outside due to an unexpected situation in the above-described authentication confirmation step and the subsequent steps.
  • a genome-related information recording medium 24 in which an encryption key such as a random number used for encrypting a polymorphism pattern is recorded can be used. That is, in the above-described example, a genome-related information recording medium 24 that records a “polymorphism address” and a “random number” associated with the polymorphism address for a predetermined “Gno. And associates the “encrypted polymorphism pattern” with the “polymorphism address” and records it in a database of a third party organization. In this case, authentication can be performed using the No. key in accordance with the flowcharts shown in FIGS. 7 and 8.
  • the information processing operation may be performed according to the flowchart shown in FIG. .
  • the steps described as “(shared)” mean the processing in the shared computer 2
  • the steps described as “(unit)” mean the processing in the personal computer 3. ing.
  • step B1 the requester, who has been verified for use qualification, activates the processing program 27 recorded in the memory 23 when the requester uses the present system.
  • the processing program 27 drives the reading device 25 of the personal computer 3 to access the genome-related information recording medium 24 and “Gno.” Recorded as data I on the information recording medium 24 is read. The read “Gno.” Is stored in the memory unit 26.
  • step B2 based on the screen image displayed on the display device 22 by the processing program 27, the information requested by the requestor, for example, "Possibility of colorectal cancer ) (Request information) to the personal computer 3, and transmit the “colorectal cancer morbidity” and “Gno.” From the personal computer 3 to the shared computer 2 via the communication network 1.
  • the main DB14 has a “polymorphism address” whose “classification (disease name)” is colorectal cancer, all “polymorphism patterns” associated with the “polymorphism address”, and all the “polymorphism patterns”.
  • step B2 the requester determines that the “classification (disease name)” of the main DB14 is “polymorphic address” of colon cancer and all “polymorphism patterns” associated with the “polymorphic address”. Request information that consists of all the “polymorphism patterns” and “morbidity” that implies each.
  • step B3 shared computer 2 receives the request information.
  • shared computer 2 activates processing program 13.
  • step B4 the main DB 14 is searched according to the processing program 13.
  • step B5 the “classification (disease name)” recorded in the main DB 14 is searched according to the processing program 13.
  • step B6 (Colorectal cancer).
  • the main DB 14 is accessed, and the “multiplicity” associated with the “classification (disease name)” (colorectal cancer) corresponding to “possibility of colorectal cancer” is determined.
  • the read “polymorphism address”, “polymorphism pattern”, and “possibility of disease” are stored in the memory unit A10 in association with the request information. That is, the memory section A 10 includes “polymorphism address”, “polymorphism pattern” and “polymorphism pattern” for a predetermined “Gno.”.
  • step B7 the “Gno.”, “Polymorphism address”, “polymorphism pattern” and “possibility” recorded in the memory section A10 are transmitted to the communication network 1. Through the pieces Sent to human computer 3.
  • step B8 “Gno.”, “Polymorphism address”, “polymorphism pattern”, and “possibility” are received from shared computer 2. The received “Gno.”, “Polymorphism address”, “polymorphism pattern”, and “possibility” are recorded in the memory unit 26.
  • step B9 access is made to the data II recorded on the genome-related information recording medium 24 according to the processing program 27. At this time, it is preferable to access the data I recorded on the genome-related information recording medium 24 and confirm whether the received “Gno.” Is correct.
  • step BIO a polymorphism pattern at a polymorphism address matching the received “polymorphism address” is extracted from the genome-related information 28 according to the processing program 27. Then, in step BIO (SB10), of all the “polymorphism patterns” associated with the received polymorphism address, the one that matches the extracted polymorphism pattern is searched.
  • step Bl l among all the “polymorphism patterns” associated with the received polymorphism address, the “morbidity” associated with the matched polymorphism pattern is extracted and extracted. "Possibility" is output. This allows the requester to obtain the likelihood (semantic information) of colorectal cancer.
  • step B11 the additional information recorded in data III, data IV, and data V is also read out at the same time, and the morbidity for colorectal cancer is corrected using the additional information. May be output.
  • the genome-related information recording medium 24 that records the individual polymorphism pattern in association with the polymorphism address is used to record it in the main DB14.
  • the requested semantic information can be used by the requester by interposing the polymorphism address. Also in this system, since the authentication confirmation process is performed according to the flowcharts shown in FIGS. 7 and 8, unauthorized use can be reliably prevented.
  • the requester instructs the shared computer 2 that the “classification (disease name)” of the main DB 14 is “polymorphic address” indicating that the subject is colorectal cancer. It requires submission of all “polymorphism patterns” for the “polymorphism address” and “possibility” for the “polymorphism pattern”. In other words, in the information processing operation according to the flowchart shown in FIG. 11, the requester determines that a predetermined “polymorphism address” and all “polymorphism patterns” related to the polymorphism address and the polymorphism pattern This will give you information on the likelihood of morbidity and useful value.
  • step CI the requester, who has been verified for use qualification, activates the processing program 27 recorded in the memory 23 when the requester uses the present system.
  • the processing program 27 drives the reading device 25 of the personal computer 3 to access the genome-related information recording medium 24, and the ⁇ Gno. ”And all“ polymorphism addresses ”and“ polymorphism patterns ”recorded as data II.
  • the read “Gno. J,” “polymorphism address,” and “polymorphism pattern” are stored in the memory unit 26.
  • step C 2 the processing program 27 Based on the displayed screen image, the requester inputs the information he or she wants to provide, for example, “Possibility to colorectal cancer” (request information) to the personal computer 3 and communicates from the personal computer 3 Sends “Possibility to colorectal cancer” and “Gno.”, “Polymorphism address j” and “polymorphism pattern” recorded in memory 26 to shared computer 2 via network 1 I do.
  • step C3 the shared computer 2 receives “Possibility of colon cancer”, “Gno.”, “Polymorphism address”, and “polymorphism pattern”.
  • the received "Possibility of colorectal cancer” is recorded in the memory part A10 as request information, and "Gno. J,” "polymorphism address” and “polymorphism pattern” are also stored in the memory part A10. Is done.
  • the shared computer 2 starts the processing program 13.
  • step C4 SC4
  • step C4 the main DB 14 is accessed according to the processing program 13.
  • step C5 the “classification (disease name)” recorded in the main DB14 is searched according to the processing program 13 and the requested “possibility of colorectal cancer” (colorectal cancer ) Is extracted.
  • step C6 the main DB 14 is accessed according to the processing program 13, and the “polymorphism address” classified as “colorectal cancer” from the main DB 14 and all of the polymorphism addresses for the polymorphism address Read “polymorphism pattern” and “possibility of morbidity” for the polymorphism pattern.
  • the read “polymorphism address”, “polymorphism pattern” and “possibility of morbidity” are stored in the memory part A 10.
  • Step C7 based on the “polymorphism address” and “polymorphism pattern” received in Step C3, the data stored in the memory unit A 10 in Step C6 was searched and received. The morbidity associated with the polymorphism pattern that matches the “polymorphism pattern” is extracted from the memory unit A 10.
  • step C8 the morbidity extracted based on the result of step C7, that is, which of the polymorphism patterns in the main DB 14 matches the polymorphism pattern included in the information received in step C3 Is transmitted to the personal computer 3 via the communication network 1.
  • the shared computer 2 transmits the extracted morbidity together with the “Gno.” Of the requester.
  • step C9 the ⁇ Gno. And "possibility” (semantic information).
  • the received “Gno.” And “possibility” are recorded in the memory unit 26. At this time, it is possible to access data I recorded on the genome-related information recording medium 24 and confirm whether the received “Gno.” Is correct.
  • Step CIO the possibility of colon cancer is displayed on the display device 22 from the semantic information recorded in the memory unit 26 in accordance with the processing program 27.
  • shared computer 2 reads out (creates) a screen displaying semantic information in accordance with processing program 13, and transmits the screen to personal computer 3 via communication network 1. It can also be displayed on the display device 22. Also in this case, it is assumed that semantic information has been transmitted from the shared computer 2 to the personal computer 3. As a result, the requester can obtain the morbidity for colorectal cancer using the genome-related information 28 recorded on the genome-related information recording medium 24.
  • the genome-related information recording medium 24 that records the individual polymorphism pattern in association with the polymorphism address is used to record it in the main DB14.
  • the requested semantic information can be used by the requester by interposing the polymorphism address. Also in this system, since the authentication confirmation process is performed according to the flowcharts shown in FIGS. 7 and 8, unauthorized use can be reliably prevented.
  • this system it is preferable to use a polymorphism address and a polymorphism pattern that are not associated with meaning information in the authentication confirmation process for use qualification. As a result, even if information leaks due to an unexpected situation in the steps after step 11, it is possible to prevent a third party from knowing the polymorphism address and the polymorphism pattern associated with the semantic information. Furthermore, also in this system, by using the genome-related information recording medium 24 on which the encrypted polymorphism pattern is recorded, the system becomes excellent in security.
  • the information provider uses the genomic-related information recording medium 24 to provide standardized semantic information corresponding to the polymorphism pattern and unified standards such as data transfer processing methods. Information can be provided in various ways without the need for
  • a third party or a third party can easily monitor and manage the shared computer 2 by checking the main DB 14. Therefore, the present system can perform, for example, administrative management on the side providing the semantic information, and thus can perform soundness and ethical management on the side providing the semantic information.
  • a storage medium having only the data I and additionally data III to V, which is obtained by removing the information included in the data II from the genome-related information recording medium may be used.
  • the information included in the data II is recorded in an external database (genome-related information recording medium) connected to the personal computer 3 via the communication network 1.
  • an external database is accessed via the communication network 1, and the polymorphism pattern of the instructed polymorphism address is read out.
  • the polymorphism pattern can be stored in the memory 26 in association with the pattern. Therefore, even in such a system, the requester can transmit the meaning information in the same manner as the flowcharts shown in FIGS. 9 and 10 and the flowcharts shown in FIGS. 11 and 12. Obtainable.
  • the requester has neither the genome-related information recording medium 24 nor the recording medium except for the information included in the data II from the genome-related information recording medium, and the communication network 1 is not provided. It may include a genome-related information recording medium 24 connected to the personal computer 3 via the personal computer 3. In such a system, the requester accesses the genome-related information recording medium 24 via the communication network 1 and obtains the “polymorphism address” and “polymorphism” recorded on the genome-related information recording medium 24. Information such as "patterns" can be downloaded to the personal computer 3. In this case, the genome-related information recording medium 24 may be a medium in which genome-related information on a plurality of individuals is recorded for each individual (for each “Gno.”).
  • the present invention is not limited to the configuration in which the shared computer 2 includes the main DB 14 as described above.
  • the main DB 14 connected to the shared computer 2 via the communication network 1
  • the shared computer 2 connects the communication network 1 to the main DB 14 in the flowchart shown in FIGS. 9 and 10, the flowchart shown in FIG. 11 or the flowchart shown in FIG. Access via Even in this case, according to the present information processing system, the requester can obtain the desired semantic information according to the flowcharts shown in FIGS. 9 and 10, the flowchart shown in FIG. 11 or the flowchart shown in FIG. Can be obtained.
  • the shared computer 2 accesses a plurality of main DBs 14 of different organizations or organizations via the communication network 1 and uses semantic information included in the plurality of main DBs 14.
  • information can be provided to the requestor. That is, in this information processing system, in step A5 in the flowcharts shown in FIGS. 9 and 10, in step B5 in the flowchart shown in FIG. 11, or in the flowchart shown in FIG. In step C5, the shared computer 2 accesses various main DBs 14 having information about the possibility of colon cancer as semantic information.
  • the requester can obtain information on the possibility of colon cancer based on the information contained in various main DBs 14.
  • the request information received from the personal computer 3 may be transmitted, and the semantic information (in this example, “possibility of colon cancer”) may be obtained via the agent.
  • the processing program 13 recorded in the memory 17 of the shared computer 2 and the processing program 27 recorded in the memory 23 of the personal computer 3 may be, for example, Information for performing the authentication confirmation process according to the flowchart shown in Fig. 13 It can also be applied to processing systems.
  • the steps described as “(shared)” indicate the processing in the shared computer 2
  • the steps described as “()” indicate the processing in the personal computer 3. ing.
  • step D1 when the requester uses the present system, the processing program 27 recorded in the memory 23 is activated, and the genome is processed by the processing program 27.
  • Related information recording medium 24 Access Specifically, the processing program 27 drives the reader 25 of the personal computer 3 to access the genome-related information recording medium 24.
  • step D 2 the “Gno.” Recorded as data I and the predetermined “polymorphism address” recorded as data II in the genome-related information recording medium 24 by the processing program 27 And the “polymorphism pattern” associated with the polymorphism address.
  • the read “Gno. J,” “polymorphism address,” and “polymorphism pattern” are stored in the memory unit 26.
  • “polymorphism address” and the “polymorphism pattern” read out in step D2 “polymorphism address” recorded in advance in the authentication polymorphism pattern database 17 is selected. That is, the requester has “polymorphism address” recorded in the authentication polymorphism pattern database 17 as information in advance.
  • step D 3 the requester sends the “Gno.”, “Polymorphism address” and “polymorphism” stored in the memory 26 from the personal computer 3 via the communication network 1.
  • the pattern J is transmitted to the shared computer 2.
  • step D3 by transmitting “Gno.”, “Polymorphism address” and “polymorphism pattern” to the shared computer 2, the “Gno. Requests authentication of the requester having the genome-related information recording medium 24 of “.” (Authentication confirmation request).
  • step D4 shared computer 2 receives "Gno.”, “Polymorphism address”, and “polymorphism pattern” (authentication confirmation request) from personal computer 3.
  • the received “Gno.”, “Polymorphism address” and “polymorphism pattern” are stored in the memory unit A10.
  • the processing program 13 is started.
  • step D5 the processing program 13 of the shared computer 2 is executed.
  • step D6 according to the processing program 13, from the polymorphism pattern database 17 for authentication, a plurality of multiples enclosed by "Gno.”
  • the polymorphism pattern associated with the polymorphism address that matches the “polymorphism address” received in step D4 is read.
  • the read polymorphism pattern is recorded in the memory part A10 in association with the polymorphism address.
  • step D7 it is determined whether or not the “polymorphism pattern J” read in step D6 and the “polymorphism pattern” received in step D4 all match. If the result of the determination in step D7 is that the “polymorphism pattern” read out in step D6 and the “polymorphism pattern” received in step D4 all match, proceed to step D8 (SD8), If any one does not match, proceed to step D9 (SD9).
  • Step D8 the personal computer 3 is notified that the authentication for the usage qualification has been confirmed. Specifically, screen data to the effect that authentication has been confirmed is transmitted to the personal computer 3.
  • step D10 SD10
  • the personal computer 3 receives the image data, and causes the display device 22 to display the screen data.
  • the shared computer 2 can confirm the eligibility of the requester when using the present system, thereby preventing unauthorized use of the present system.
  • step D8 instead of transmitting the screen data to the personal computer 3, the authentication confirmation data may be transmitted. In this case, the personal computer 3 displays an authentication confirmation completion screen on the display device 22 from the received authentication confirmation data.
  • step D9 the personal computer 3 is notified that the authentication regarding the usage qualification could not be confirmed, and the processing is stopped. Specifically, screen data for rejecting the authentication confirmation processing is transmitted to the personal computer 3, and the display device 22 displays the screen data.
  • step D9 instead of transmitting the screen data to the personal computer 3, the authentication unconfirmed data may be transmitted. In this case, the personal computer 3 displays an authentication confirmation incomplete screen on the display device 22 from the received authentication unconfirmed data.
  • step D2 all “polymorphism addresses” and “polymorphism patterns” recorded in the genome-related information recording medium 24 are read, and in step D3, all of these “polymorphism addresses” are read.
  • step D6 a plurality of “polymorphism addresses” and “polymorphism patterns” that match the polymorphism addresses recorded in the authentication polymorphism pattern database 17 are selected. Select "Polymorphism address”.
  • step D7 the “polymorphism pattern” associated with the “polymorphism address” selected in step D6 is compared with the “polymorphism pattern” included in the authentication polymorphism pattern database 17. It is determined whether they match. Even in this case, the use qualification of the requester can be confirmed.
  • the requester may be an individual who possesses the genome-related information recording medium 24 or a person different from the individual to which the genome-related information 28 of the genome-related information recording medium 24 belongs. ,.
  • the doctor becomes the requester and makes the above-described authentication confirmation request using the patient's genome-related information recording medium 24.
  • FIG. 13 After performing the authentication confirmation step according to the flowchart shown in FIG. 13, the flow chart as shown in FIG. 9, FIG. 10, FIG. 11 or FIG.
  • the information processing operation can be performed according to the data.
  • the authentication confirmation step is performed according to the flowchart shown in FIG. 13 the number of times of transmitting and receiving information between the personal computer 3 and the shared computer 2 can be reduced in the authentication confirmation step. Therefore, according to the flowchart shown in FIG. 13, the authentication confirmation step can be performed relatively easily.
  • unauthorized use can be reliably prevented.
  • an authentication confirmation step for confirming a user's use qualification is performed, and thereafter, an information processing for providing the user with a possibility of suffering a predetermined disease.
  • a system can be provided.
  • the genome-related information recording medium 24 and the personal computer 3 used for the service are used for the authentication as they are. be able to. Therefore, according to the present invention, it is possible to easily perform authentication in a service using personal base sequence-related information.
  • the present invention is not limited to this information processing system, but can be applied to any system that requires authentication confirmation.
  • the present invention can be applied to a system that performs authentication confirmation when opening and closing a car door, authentication confirmation when entering and exiting a building, and membership authentication confirmation.
  • the authentication can be performed using the genome-related information recording medium 24 by applying the present invention.
  • an authorized user of the automobile has the genome-related information recording medium 24 and the authentication polymorphism pattern database 17 is built in the automobile.
  • the genome-related information recording medium 24 is built in a portable device such as a mobile phone or a dedicated device, or is detachable from the device.
  • the authentication polymorphism pattern database 17 may be provided in a computer of a management organization that manages a plurality of vehicles.
  • the notification or confirmation of the authentication is confirmed in the authentication confirmation process as shown in Fig. 7, Fig. 8 or Fig. 13. Since there is no need to transmit a notification to the effect that the vehicle could not be transmitted, a receiving device having only a receiving function may be incorporated in the vehicle instead of the transmitting / receiving device 18.
  • the authorized user can open and close the car by performing the authentication confirmation process as shown in FIG. 7 and the phoenix 8 or FIG. Specifically, in the flowcharts shown in FIGS. 7 and 8, the vehicle is unlocked when it is determined in step 15 that they match, and unlocked when it is determined in step 15 that they do not match. Not performed.
  • an authentication confirmation system at the time of opening and closing an automobile door. It is also possible to construct an authentication confirmation system that opens and closes the entrance door of the building when entering and exiting the building.
  • the present invention may be applied to a system using a so-called immobilizer.
  • the genome-related information recording medium 24 is built in the engine key
  • the authentication polymorphism pattern database 17 is built in the car.
  • the key is duplicated by performing an authentication confirmation process as shown in Fig. 7 and Phoenix 8 or Fig. 13 between the car and the engine key incorporating the genome-related information recording medium 24. This can prevent unauthorized use of vehicles.
  • the engine is started when it is determined in step 15 that they match, and the engine is started when it is determined in step 15 that they do not match. Not performed.
  • an authentication confirmation system using an immobilizer using the genome-related information recording medium 24.
  • the service uses the individual's nucleotide sequence-related information or the service that does not use the individual's nucleotide sequence-related information itself, it is necessary to separately examine the nucleotide sequence-related information for the individual who has the genome-related information recording medium 24. This makes it possible to strictly check whether the genome-related information recording medium 24 is properly owned by the person.

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Abstract

Selon la présente invention, l'utilisation efficace de différences dans des données de séquence de base parmi des individus permet d'utiliser des données sémantiques bénéfiques pour chaque individu et d'attester facilement, dès l'utilisation, la qualification, etc. d'utilisateurs. Cette invention concerne un système comportant une étape (a) consistant à obtenir une demande d'attestation de qualification d'un demandeur et à obtenir des données d'emplacement indiquant un emplacement dans une séquence de base et des données relatives à la séquence de base reposant sur les données d'emplacement, et une étape (b) consistant à déterminer si les données relatives à la séquence de base obtenues dans l'étape (a) s'accordent avec les données relatives à la séquence de base obtenues à partir d'un dispositif de mémoire contenant des données d'emplacement et les données relatives à la séquence de base reposant sur les données d'emplacement.
PCT/JP2002/012010 2001-11-22 2002-11-18 Systeme de traitement de donnees utilisant des donnees relatives a une sequence de base WO2003044678A1 (fr)

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JP2010204838A (ja) * 2009-03-02 2010-09-16 Toppan Printing Co Ltd 解析デバイス装置、解析システム、解析方法
US7981604B2 (en) 2004-02-19 2011-07-19 California Institute Of Technology Methods and kits for analyzing polynucleotide sequences
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