WO2003043553A1 - A wound dressing - Google Patents
A wound dressing Download PDFInfo
- Publication number
- WO2003043553A1 WO2003043553A1 PCT/DK2002/000772 DK0200772W WO03043553A1 WO 2003043553 A1 WO2003043553 A1 WO 2003043553A1 DK 0200772 W DK0200772 W DK 0200772W WO 03043553 A1 WO03043553 A1 WO 03043553A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- layer
- adhesive
- dressing
- skin
- absorbent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0203—Adhesive plasters or dressings having a fluid handling member
Definitions
- the invention relates to a wound dressing, especially a non-adherent wound dressing being suitable for handling exuding wounds.
- Wound dressings with layers for absorbing body fluids are known in the art.
- Ab- sorbent layers are provided for the uptake of body fluids, especially wound exu- date, so as to enable the wound dressing to keep a constant moist environment over the wound site, and at the same time avoiding maceration of the skin surrounding the wound.
- Absorbent layers in wound dressings have comprised hydrocolloid, super absorbents, foams and synthetic materials which have extensive capacity to absorb body fluids, especially wound exudate.
- Hydrocolloid dressings are some of the most efficient and mostly used dressings, being skin-friendly, absorbent and capable of creating moist wound healing conditions. However, when used on some exuding wounds, the absorption rate tends to be too low.
- the advantages of the hydrocolloid dressing are the ability of creating a moist wound healing environment and acting as a barrier against bac- teria.
- a frequent problem when treating exuding wounds is maceration.
- the absorbent part of the dressing is optimised to substantially vertical absorption, so that the skin surrounding the wound is not exposed to the exudate in order to avoid maceration of this healthy, but fragile skin.
- Barrier cream/skin conditioning paste such as zinc paste, may be used on the surrounding skin in order to avoid the maceration, but the paste will often inhibit both the adhesive tack of the dressing as well as the ability of absorbing exudate.
- a way of overcoming the problems with limited absorption capacity is to create a dressing with high permeability. This is usually done by using a backing layer being more permeable to vapour, but still liquid and bacteria impermeable. Using such a film the absorption capacity will rise when the permeability rises, enhanc- ing the absorption capacity of the dressing. The capacity rises due to evaporation of moisture through the backing layer.
- Wound dressings comprising a direct contact between pressure sensitive adhe- sives, such as hydrocolloid adhesives or medical acrylate based adhesives, which are often used on commercially available film products, and the skin are not suitable for treatment of such wounds. Traumatic removal of the adhesive dressings with damage to the skin is common, and suggest the use of non- adhesive products.
- pressure sensitive adhe- sives such as hydrocolloid adhesives or medical acrylate based adhesives
- the skin may be so damaged that exudate trickles from the skin surrounding the wound, being a challenge to most of the well-known dressings.
- the area of the lower limb may comprise special demands to the flexibility properties of the dressing due to the anatomical complexity of the area combined with the movability of the joints of the ankle and malleolus.
- a non-adhesive dressing is usually combined with compression therapy.
- a dressing being flat, soft and without sharp edges is preferred.
- Leg ulcers are known to be highly exuding, and may give rise to increased risk of leakage and maceration, if the used wound dressing does not have a sufficient capacity of exudate handling with respect to time and amount. Hydrocolloid products as the above mentioned will often be unsuitable for use in wound healing stages with medium to high exudate level, especially if the skin is covered with a lipid containing products.
- WO A 98/31402 discloses a wound dressing comprising a perforated wound contacting layer such as a film or a net, a backing layer, and between these two layers is a fibrous absorbent layer. The absorbent layer and the backing layer are combined by heat-lamination. This bandage is absorbent and highly permeable, but may give rise to maceration as the absorbent part may be in contact with the surrounding skin. Leakage may also be a problem.
- WO 99/06077 is disclosed a non-adhesive wound dressing which is in the form of an island dressing.
- the dressing comprises a top film, coated with an adhesive, an absorbent pad of a size smaller than the top layer mounted on the adhesive layer, in order to create an adhesive- covered flange around the absorbent pad, and a non woven layer covering all of the skin contacting surface of the dressing.
- the permeability of the dressing may however be limited due to the overall adhesive coating as well as maceration may occur along the edges of the absorbent pad, extending further than the wound.
- the different layers of the dressing are often combined by the use of adhesive, usually by coating the backing layer, fully or partly, with adhesive, in order to hold the components of the dressing together.
- the adhesive coating will however, de- crease the permeability of the film significantly.
- the dressing may be produced by combining the layers of the dressing by lamination.
- the heat and pressure of the lamination process may change the permeability properties of the backing layer, as well as the structure of the absorbent layer may be crushed.
- the edge zone of the dressing may have very little if any absorbent properties, increasing the risk of maceration and leakage of the surrounding skin.
- the flexibility of a dressing wherein the layers are tied together by adhesive or lamination may also be reduced. This may give rise to handling problems and leakage when used on curved body parts.
- the present invention relates to a wound dressing comprising a backing layer, an adhesive layer and an absorbent layer between the backing layer and the adhe- sive layer.
- Figure 1 shows a cross-section of an embodiment of the invention.
- Figure 2 shows a top view of another embodiment of the invention.
- the present invention relates to a wound dressing comprising a backing layer, an adhesive layer and an absorbent layer between the backing layer and the adhe- sive layer, wherein the adhesive layer secures the absorbent layer to the backing layer and that the adhesive layer is interrupted in at least one zone enabling a direct contact between the absorbent layer and the backing layer and exposing at least a part of the skin contacting surface of the absorbent layer, characterised in that at least the skin-facing surface of the adhesive layer is provided with a non- detachable, non-adhesive cover layer.
- a dressing according to the invention is thus in the form of a single unit, not an assembly.
- the dressing will provide a high initial absorption due to the direct contact between the wound and the absorbent layer, and a high absorption capacity due to the lack of adhesive or lamination between the backing layer and the absorbent layer combined with a high permeability of the backing layer.
- a dressing in a single unit decrease the risk of leakage compared to an assembled or re- openable dressing.
- the adhesive will serve as a sealant of the parts of the dressing, but more important, the adhesive decrease the risk of maceration, as any moisture, e.g. in the form of exudate or sweat will be absorbed by the adhesive and thus protecting 043553
- the cover layer will not interfere with this function of the adhesive as the cover layer will be permeable to exudate and moisture.
- the dressing according to the invention is especially suitable for use on body parts having special demands to the flexibility of the dressing such as the lower limb, where the anatomical complexity of the area around the joints and malleo- lus often is difficult to apply a dressing to.
- a non-adhesive dressing according to the invention is usually combined with compression therapy.
- the dressing may also be secured to the patient by use of tape or wraps.
- the cover layer preferably comprising a soft and pliable material, combined with the other layers of the dressing provides a soft and flexible dressing, which feels pleasant against the skin.
- the backing layer and the cover layer may be combined along the edge portion by the adhesive layer, providing a thin, flexible and non-adhesive flange around the absorbent layer of the dressing. This flange may be capable of adapting to the contours of the treated body part as well as follow- ing the movements of the body part.
- the fragile skin is protected by the non- adhesive cover layer, and the adhesive layer between the cover layer and the backing layer may absorb any exudate or perspiration and thus protect the skin against maceration.
- the backing layer and the absorbent layer are mutually displaceable.
- the permeability of the backing layer will decrease.
- the influence of heat and/or pressure may disrupt the permeability qualities of the backing layer, as well as the absorber, which often is a fragile matrix structure, may be damaged.
- all of the non-skin-facing surface of the absorbent layer is adjacent to the backing layer.
- the adhesive layer may extend over a part of the surface between the absorbent layer and the backing layer.
- the backing layer and the absorbent layer may have connection points or lines.
- the points or lines may be achieved by dots or lines of adhesive or they may be created by welding. It is preferred that the points or lines are arranged in such a way that at least a part of the backing layer and the absorbent layer are still mu- tually displaceable.
- the adhesive layer may cover at least a fraction of the skin-facing surface of the absorbent layer.
- the adhesive layer may fully cover the skin-facing surface of the absorbent layer or the layer may be coated in a pattern or with one or more aper- tures or slits. 43553
- the adhesive layer may preferably comprise an aperture in the area covering the absorbent layer.
- the aperture may especially be located centrally over the wound and will render it possible to have a fast absorption as the absorbent layer will be in direct contact with the exudate, as the exudate will not have to pass through the adhesive layer first.
- the apertures may be in the form of a pattern of smaller or larger apertures.
- the apertures are in the area of the adhesive layer under the absorbent layer.
- the aperture has about the same dimensions as of the wound. This will enhance the absorption rate over the wound, while the fragile skin next to the wound will be protected by the adhesive layer.
- the aperture in the adhesive layer may be enlarged to adapt to the size of the wound.
- the enlargement may be done by scissors or by the use of pre-cuts lines in the cover layer and the adhesive layer, enabling easy removal of excess layer before application.
- the pre-cuts lines may e.g. be in the form of concentric circles, squares, or a helix.
- the adhesive layer may comprise a reinforcing layer.
- the reinforcing layer may be in the form of a web or a net, or a non woven, fibres, etc.
- the reinforcing layer may ease the handling during application and removal as well as the strength of the dressing is enhanced.
- the absorbent layer absorbs exudate the adhe- sive layer will be wetted not only from the skin-facing side but also from the top side, by absorbed exudate from the absorbent layer. This may alter the strength properties of the adhesive layer, and demand for a strengthening layer.
- the skin-facing adhesive surface of the dressing may be provided with a non- detachable, non-adhesive cover layer.
- the cover layer may be permeable to aqueous fluids. 43553
- the cover layer may be in the form of a woven or non-woven, knits, a perforated film or laminate or a foam.
- the woven may be in the form of a polymer net or a cotton or gauze.
- the perforated polymer film may be a polyurethane film.
- the foam may be any suitable foam, such as a polyurethane foam.
- the cover layer is in the form of a non-woven.
- the cover layer is a non-woven, more preferred a non-woven based upon PET fibres, and most preferred PET fibres with PTFE on the skin-contacting surface.
- the cover layer may be in the form of a coating of the adhesive skin-facing surface with a powder or a paste, such as zinc oxide or talc or zinc paste.
- the cover layer may be in the form of a cohesive layer, such as an adhesive without adhesive tack, an elastomer or a hydrogel.
- the cover layer is capable of absorbing aqueous liquids such as perspiration and wound exudate.
- a way of achieving a third hand may be to provide the skin-contacting surface of the dressing with adherent or high friction properties.
- Such a dressing may be slightly adhesive or adherent, enough for holding the dressing in place until properly secured by a bandage or the like, but not adhesive enough to give rise to the well-known problems of adhesive dressings.
- the dressing will still need a secondary dressing or bandage to secure it properly to the treated body part.
- the cover layer is provided with one or more perforations. Through these perforations the adhesive surface is exposed, providing discrete adhesive locations on the skin-facing surface of the dressing. These locations render it possible to adhere the dressing to the wound site while securing the dressing properly by applying the fixation means.
- the adhesive locations may be of any suitable number and size, and arranged in patterns or arrays or randomly spread over the skin-facing surface. It is preferred that the adhesive locations are situated at the portion of the cover layer being furthest away from the wound, thus minimizing any undesired effect the adhesive to the fragile skin surrounding the wound.
- the third hand may also be achieved by using a cover layer having an open structure exposing the adhesive through the pores of this open structure. Only a negligible amount of adhesive will be exposed through the pores of the cover layer, but enough to provide the dressing with low adherent properties. 43553
- dots or lines of adhesive or adherent material may be placed on the skin-facing surface of the cover layer.
- the adhesive may be printed on the cover layer or be in the form of a layer of a random- ised or systematic pattern.
- the adhesive markings may preferably comprise a pattern or a framing along the edge of the dressing.
- adheresive may cover any substance having adherent properties, such as adhesives, silicone or rubbery substances, petrolatum or the like, as the adhesive of the third hand only serves to immobilise the dressing until it is properly fastened by a secondary bandage. This function may also be achieved by using a material with high friction properties. Any substance, being skin-friendly and able to adhere or have the required friction for the purpose, may be suitable for use in this inven- tion.
- the skin-contacting surface may preferably be covered by a release-liner, which may be removed before use.
- the cohesive layer may have absorbent properties, e.g. comprise hydrocolloid particles.
- the cover layer may in one embodiment of the invention cover all of the skin- facing surface of the dressing.
- the cover layer may cover the adhesive part of the skin-facing surface of the dressing.
- the cover layer thus comprises any aperture in the adhesive layer.
- the surface of the cover layer may be slightly smaller than the adhesive surface, leaving an adhesive flange along the outer rim of the dressing.
- the cover layer is substantially non-absorbent.
- the cover layer is capable of transporting liquid. This renders it possible for the moisture to diffuse from the skin surface through the cover layer to the adhesive, leaving the skin-contacting surface substantially dry.
- the absorbent layer may comprise an exudate distributing material.
- a liquid distributing layer acting as a wick, may be incorporated in the dressing.
- the wicking layer renders it possible to utilise the areas of absorbent layer not being located right above the wound as well as the wetted surface of the absorbent layer will be enlarged and thus the evaporation through the backing layer will be enhanced.
- the absorbent layer may be in the form of one or more layers, e.g. a multilayer, comprising layers of different absorption properties in order to optimise the ab- sorption capacity of the absorbent layer.
- the absorbent layer may be in the form of a matrix structure, e.g. with incorporated particles.
- the absorbent layer comprises a material capable of distributing the absorbed exudate
- full utilisation of the absorption capacity in the dressing may be obtained.
- the absorbent layer may comprise any absorbent material known per se being suitable for use in wound care devices, e.g. polyacrylate, CMC, cellulose or derivatives thereof, gums, foam or alginate. 43553
- a material being capable of retaining and/or distributing the liquid is preferred.
- the absorbent layer may comprise super absorbent particles (SAP) and/or super absorbent fibres (SAF).
- SAP super absorbent particles
- SAF super absorbent fibres
- the absorbent layer may comprise a horizontally spreading/absorbent layer.
- the absorbent layer may comprise spheres or inclusions of absorbent material, in a structure like pearls on a string. Between the pearls a material capable of distributing the wound exudate is located.
- the absorbent layer may comprise a stop layer on the skin-facing surface for preventing any speck or fluff from the absorbent layer to enter the wound.
- the stop layer may be of any suitable material known in the art being capable of retaining absorbent material, such as a cellulose tissue, non-woven or a perforated polymeric film, knits, PP, PE, polyester or lycra.
- the absorbent layer may further comprise a wound contacting layer at the wound-facing surface.
- This wound contacting layer may prevent adherence to the wound as well as in growth of the dressing.
- the layer may preferably be highly permeable to wound exudate.
- the wound contacting layer is in the form of a polymer net.
- the absorbent layer may be embossed or pre-cut in order to enhance flexibility of the dressing.
- the backing layer may be liquid impervious but vapour permeable or it may be of a type having a higher water permeability when in contact with liquid water than when not in contact.
- the backing layer may be of any suitable material known per se for use in the preparation of wound dressings e.g. a foam, a nonwoven or a polyurethane, polyethylene, polyester or polyamide film.
- a suitable material for use as a backing layer is a polyurethane.
- a preferred low friction film material is disclosed in US patent No. 5,643,187.
- the adhesive has absorbent properties.
- the adhesive may absorb exudate leaking from the central part of the dressing, as well as it may absorb perspiration and exudate excreted from the surrounding skin. The moisture diffuses through the cover layer and into the adhesive layer, leaving the skin con- tacting cover layer dry against the skin, decreasing the risk of maceration.
- the adhesive layer of the invention may be any skin-friendly adhesive known per se, e.g. an adhesive comprising hydrocolloids or other moisture absorbing constituents for prolonging the time of use.
- the adhesive may suitably be of the type disclosed in GB patent specification No. 1 280 631 , in DK patent specifications Nos. 127,578, 148,408, 154,806, 147,226 and 154,747, in EP published application Nos. 0 097 846 and 0 415 183, in SE published application No. 365,410, in WO publication No. 88/06894, in US patent specification No. 4,867,748, and in NO published application No. 157,686.
- the adhesive comprises a hydrocolloid adhesive.
- a hydrocolloid adhesive may provide an excellent pro- tection of the surrounding skin of the wound by inducing the moist wound healing environment, and yet avoiding maceration.
- sorbing moisture renders it possible to absorb any leaking exudate from the dressing or from the surrounding skin.
- the adhesive layer may also comprise any other adhesives, chosen from a wide range of different types of adhesives for instance the acrylic types, and types derived from PIB, polyurethanes, EVA-compounds, APAO's, silicones, polyvinyl ether etc.
- the adhesive surface of the dressing may be provided with a detachable cover layer in the form of a permeable, non-adhesive layer.
- the cover layer may be removed like a release-liner if an adhesive dressing is desired, and stay on the dressing in the case of a non-adhesive dressing is desired.
- the detachable cover layer may be pre-cut into multiple parts, such as concentric circles or squares, rendering it possible to remove the desired part of the cover layer in order to expose a part of the adhesive.
- the dressing according to the invention may comprise one or more active ingredients.
- the wound dressing according to the invention may comprise one or more active ingredients, e.g. a pharmaceutical medicament.
- active ingredients e.g. a pharmaceutical medicament.
- Such pharmaceutical medicaments includes a cytochine such as a growth hormone or a polypeptide growth factor such as TGF, FGF, PDGF, EGF, IGF-1 , IGF-2, colony stimulating factor, transforming growth factor, nerve stimulating growth factor and the like giving rise to the incorporation of such active substances in a form being apt to local application in a wound in which the medicament may exercise its effect on the wound, other medicaments such as bac- teriostatic or bactericidal compounds, e.g.
- a cytochine such as a growth hormone or a polypeptide growth factor such as TGF, FGF, PDGF, EGF, IGF-1 , IGF-2, colony stimulating factor, transforming growth factor, nerve stimulating growth factor and the like giving rise to the incorporation of such active substances in a form being apt to local application in a wound in which the medicament may exercise its effect on the wound
- other medicaments such as bac- teriostatic or bactericidal compounds, e.g.
- iodine, iodopovidone complexes chloramine, chlorohexidine, silver salts such as sulphadiazine, silver nitrate, silver acetate, silver lactate, silver sulphate, silver sodium thiosulphate or silver chloride, zinc or salts thereof, metronidazol, sulpha drugs, and penicillin's, tissue- healing enhancing agents, e.g. RGD tripeptides and the like, proteins, amino acids such as taurine, vitamins such ascorbic acid, enzymes for cleansing of wounds, e.g.
- pepsin trypsin and the like
- proteinase inhibitors or metallopro- teinase inhibitors such as lllostat or ethylene diamine tetraacetic acid
- cytotoxic agents and proliferation inhibitors for use in for example surgical insertion of the product in cancer tissue and/or other therapeutic agents which optionally may be used for topical application
- pain relieving agents such as lidocaine or chincho- caine, emollients, retinoids or agents having a cooling effect which is also considered an aspect of the invention.
- the active ingredient may also comprise odour controlling or odour reducing material such as charcoal.
- the active ingredient may be present in the dressing, but not in direct contact with the wound, or it may migrate to the wound when exposed to wound exudate.
- the cover layer may be impregnated with zinc-paste or other skin-conditioning or healing enhancing materials.
- the adhesive layer may together with the cover layer be capable of adsorption or absorption and retention of high molecular parts of the wound exudate, e.g. proteins.
- the handling may be in the form of a mechanical collection of wound exu- date in e.g. a three-dimensional non-woven, a loosely knitted or woven material, a fleece material, a material with a wavy surface, or a filament material like a rya, or it may be chemically, by binding the high molecular parts of the wound exudate, or it may be enzymatically by degrading the high molecular parts of the wound exudate.
- the absorbent layer may be softened by incorporation of glycerine.
- the dressing comprises a backing layer (1 ) adjacent to an absorbent layer (2) and an adhesive layer (3) covering at least a part of the skin-facing surface of the dressing. A part of the skin-facing surface of the absorbent layer is left without the adhesive layer in order to facilitate rapid uptake of exudate from the wound.
- the skin-facing surface of the adhesive layer is provided with a cover layer (4) of the same proportions as the adhesive layer, leaving the skin-contacting surface of the dressing non- adhesive.
- Figure 2 shows another embodiment of the invention shown from above, with the skin-facing surface up.
- the cover layer (4) is located at the skin-facing surface of the adhesive layer and extends over the edge portion of the absorbent layer (2), having substantially the same dimensions as the backing layer of the dressing.
- the centre of the adhesive layer defines an aperture under the absorbent layer.
- the size of the aperture may be enlarged, e.g. by cutting with a pair of scissors, in order to costumize the size of the aperture to the size of the wound.
- An intermediate layer of approximately the same size of the absorbent layer may be located between the adhesive layer and the absorbent layer.
- the intermediate layer prevents the adhesive from adhering to the absorbent layer rendering removal of excess adhesive layer without damaging the absorbent layer possible.
- This intermediate layer may be any suitable material such as a non-woven, a permeable film or a foam.
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0401992A HUP0401992A2 (en) | 2001-11-23 | 2002-11-18 | A wound dressing |
DK02803336T DK1450740T3 (en) | 2001-11-23 | 2002-11-18 | Wound dressing |
AU2002366208A AU2002366208B2 (en) | 2001-11-23 | 2002-11-18 | A wound dressing |
EP02803336A EP1450740B1 (en) | 2001-11-23 | 2002-11-18 | A wound dressing |
US10/495,433 US7507870B2 (en) | 2001-11-23 | 2002-11-18 | Wound dressing |
DE60210144T DE60210144T2 (en) | 2001-11-23 | 2002-11-18 | WOUND DRESSING |
JP2003545235A JP4213591B2 (en) | 2001-11-23 | 2002-11-18 | Pharmaceutical material for wound |
CA002468003A CA2468003A1 (en) | 2001-11-23 | 2002-11-18 | A wound dressing |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200101752 | 2001-11-23 | ||
DKPA200101752 | 2001-11-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003043553A1 true WO2003043553A1 (en) | 2003-05-30 |
Family
ID=8160855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DK2002/000772 WO2003043553A1 (en) | 2001-11-23 | 2002-11-18 | A wound dressing |
Country Status (13)
Country | Link |
---|---|
US (1) | US7507870B2 (en) |
EP (1) | EP1450740B1 (en) |
JP (1) | JP4213591B2 (en) |
CN (2) | CN101380258B (en) |
AT (1) | ATE320781T1 (en) |
AU (1) | AU2002366208B2 (en) |
CA (1) | CA2468003A1 (en) |
DE (1) | DE60210144T2 (en) |
DK (1) | DK1450740T3 (en) |
ES (1) | ES2258669T3 (en) |
HU (1) | HUP0401992A2 (en) |
PL (1) | PL368683A1 (en) |
WO (1) | WO2003043553A1 (en) |
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US8410332B2 (en) | 2002-12-19 | 2013-04-02 | 3M Innovative Properties Company | Absorbent medical articles |
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US7910793B2 (en) | 2002-12-31 | 2011-03-22 | Ossur Hf | Wound dressing |
US8247635B2 (en) | 2002-12-31 | 2012-08-21 | Ossur Hf | Wound dressing |
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US8563447B2 (en) | 2003-08-14 | 2013-10-22 | Milliken & Company | Silver-containing wound care device |
US8394403B2 (en) | 2003-08-14 | 2013-03-12 | Milliken & Company | Wound care device having fluid transfer properties |
US7118761B2 (en) | 2003-08-14 | 2006-10-10 | Canada T Andrew | Method for producing a silver-containing wound care device |
US7842306B2 (en) | 2003-08-14 | 2010-11-30 | Milliken & Company | Wound care device having fluid transfer properties |
US7745682B2 (en) | 2003-09-17 | 2010-06-29 | Ossur Hf | Wound dressing and method for manufacturing the same |
US8093445B2 (en) | 2003-09-17 | 2012-01-10 | Ossur Hf | Wound dressing and method for manufacturing the same |
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EP2877191A4 (en) * | 2012-07-25 | 2016-04-27 | Kimovi Aps | A dressing product and a cosmetic or medical composition with kigelia africana |
US10271995B2 (en) | 2012-12-18 | 2019-04-30 | Kci Usa, Inc. | Wound dressing with adhesive margin |
US11141318B2 (en) | 2012-12-18 | 2021-10-12 | KCl USA, INC. | Wound dressing with adhesive margin |
EP3461466B1 (en) | 2017-09-29 | 2022-01-12 | Johnson & Johnson Consumer Inc. | Extensible dressings |
Also Published As
Publication number | Publication date |
---|---|
EP1450740A1 (en) | 2004-09-01 |
JP4213591B2 (en) | 2009-01-21 |
DE60210144T2 (en) | 2006-12-14 |
AU2002366208B2 (en) | 2007-05-31 |
DK1450740T3 (en) | 2006-07-31 |
CA2468003A1 (en) | 2003-05-30 |
HUP0401992A2 (en) | 2005-05-30 |
CN101380258B (en) | 2013-09-18 |
US20050080372A1 (en) | 2005-04-14 |
AU2002366208A1 (en) | 2003-06-10 |
PL368683A1 (en) | 2005-04-04 |
CN101380258A (en) | 2009-03-11 |
DE60210144D1 (en) | 2006-05-11 |
US7507870B2 (en) | 2009-03-24 |
ES2258669T3 (en) | 2006-09-01 |
CN1589128A (en) | 2005-03-02 |
ATE320781T1 (en) | 2006-04-15 |
EP1450740B1 (en) | 2006-03-22 |
JP2005509492A (en) | 2005-04-14 |
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