WO2003039702A3 - Methods and compositions for chromatography - Google Patents

Methods and compositions for chromatography Download PDF

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Publication number
WO2003039702A3
WO2003039702A3 PCT/US2002/036497 US0236497W WO03039702A3 WO 2003039702 A3 WO2003039702 A3 WO 2003039702A3 US 0236497 W US0236497 W US 0236497W WO 03039702 A3 WO03039702 A3 WO 03039702A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compositions
chromatography
present
preparative
Prior art date
Application number
PCT/US2002/036497
Other languages
French (fr)
Other versions
WO2003039702A2 (en
Inventor
Heath H Herman
Original Assignee
Kinetic Biosystems Inc
Heath H Herman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kinetic Biosystems Inc, Heath H Herman filed Critical Kinetic Biosystems Inc
Priority to JP2003541590A priority Critical patent/JP4139333B2/en
Priority to EP02797103.5A priority patent/EP1441823B1/en
Priority to AU2002361623A priority patent/AU2002361623A1/en
Priority to CA002466664A priority patent/CA2466664A1/en
Publication of WO2003039702A2 publication Critical patent/WO2003039702A2/en
Publication of WO2003039702A3 publication Critical patent/WO2003039702A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N2030/381—Flow patterns centrifugal chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N2030/386—Radial chromatography, i.e. with mobile phase traversing radially the stationary phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6052—Construction of the column body
    • G01N30/6065—Construction of the column body with varying cross section

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

The present invention is directed to methods and compositions for separating and isolating target molecules. In particular, the present invention comprises devices, such as CCDs, that contain particles without the need of support structures. Chromatography separation techniques, including but not limited to, ion exchange, reversed phase and normal phase partitioning, are used in the CCD. Methods also include low, medium and high pressure liquid chromatography. such methods can be used for analytical, semi-preparative processes, initial clarification, preparative filtration and process scale applications.
PCT/US2002/036497 2001-11-09 2002-11-12 Methods and compositions for chromatography WO2003039702A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2003541590A JP4139333B2 (en) 2001-11-09 2002-11-12 Method and composition for chromatography
EP02797103.5A EP1441823B1 (en) 2001-11-09 2002-11-12 Methods and compositions for chromatography
AU2002361623A AU2002361623A1 (en) 2001-11-09 2002-11-12 Methods and compositions for chromatography
CA002466664A CA2466664A1 (en) 2001-11-09 2002-11-12 Methods and compositions for chromatography

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34474501P 2001-11-09 2001-11-09
US60/344,745 2001-11-09

Publications (2)

Publication Number Publication Date
WO2003039702A2 WO2003039702A2 (en) 2003-05-15
WO2003039702A3 true WO2003039702A3 (en) 2003-11-13

Family

ID=23351835

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/036497 WO2003039702A2 (en) 2001-11-09 2002-11-12 Methods and compositions for chromatography

Country Status (6)

Country Link
US (4) US6942804B2 (en)
EP (1) EP1441823B1 (en)
JP (1) JP4139333B2 (en)
AU (1) AU2002361623A1 (en)
CA (1) CA2466664A1 (en)
WO (1) WO2003039702A2 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050266548A1 (en) * 1995-03-28 2005-12-01 Kbi Biopharma, Inc. Biocatalyst chamber encapsulation system for bioremediation and fermentation with improved rotor
EP1441823B1 (en) * 2001-11-09 2013-08-21 KBI Biopharma, Inc. Methods and compositions for chromatography
US20050037331A1 (en) * 2003-08-13 2005-02-17 William Galbraith Apparatuses and methods for reducing albumin in samples
US8052669B2 (en) 2004-02-25 2011-11-08 Femasys Inc. Methods and devices for delivery of compositions to conduits
US8048101B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US9238127B2 (en) 2004-02-25 2016-01-19 Femasys Inc. Methods and devices for delivering to conduit
US8048086B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US7964380B2 (en) * 2005-01-21 2011-06-21 Argylia Technologies Nanoparticles for manipulation of biopolymers and methods of thereof
US20100234577A1 (en) * 2006-06-14 2010-09-16 Smithkline Beecham Corporation Methods for purifying antibodies using ceramic hydroxyapatite
FR2908054A1 (en) * 2006-11-07 2008-05-09 Partus Technologies Sa Non-miscible liquid-liquid separating method for disk/monoblock type cylindrical rotor, involves adjusting rotor rotation direction and driving direction to oppositely set driving direction and circuit's content driving direction
US8883012B2 (en) * 2007-01-19 2014-11-11 Purolite Corporation Reduced fouling of reverse osmosis membranes
WO2009045897A1 (en) * 2007-10-03 2009-04-09 Dyax Corp. Systems and methods for purifying proteins
US8735846B1 (en) 2008-03-14 2014-05-27 Advanced Technology Applications, Llc Electromagnetic biosensor
US7812318B1 (en) 2008-03-14 2010-10-12 Advanced Technology Applications, Llc Electromagnetic biosensor
CA2730528C (en) 2008-07-16 2018-06-12 Kbi Biopharma, Inc. Methods and systems for manipulating particles using a fluidized bed
US10070888B2 (en) 2008-10-03 2018-09-11 Femasys, Inc. Methods and devices for sonographic imaging
US9554826B2 (en) 2008-10-03 2017-01-31 Femasys, Inc. Contrast agent injection system for sonographic imaging
US8293100B2 (en) * 2009-03-13 2012-10-23 Terrasep, Llc Methods and apparatus for centrifugal liquid chromatography
EP2309266A1 (en) * 2009-09-21 2011-04-13 F. Hoffmann-La Roche AG Method for carrying out reactions in an analytical device
JP5774012B2 (en) 2009-10-06 2015-09-02 ケーセップ・システムズ，リミテッド・ライアビリティ・カンパニー Method, system, and apparatus for processing particles
US10589239B2 (en) * 2010-07-07 2020-03-17 Ge Healthcare Bio-Sciences Ab Fluid mixing in a disposable fluid processing system
CA2821711C (en) 2010-12-15 2017-10-10 Baxter International Inc. Eluate collection using conductivity gradient
JP6334569B2 (en) 2013-01-31 2018-05-30 イー・エム・デイー・ミリポア・コーポレイシヨン Disposable direct capture device
WO2019138338A1 (en) 2018-01-09 2019-07-18 Universidade Do Porto Process of separation and purification of glycerol derivatives
JP6600123B1 (en) * 2018-04-18 2019-10-30 積水メディカル株式会社 Hemoglobin analysis method
US20210163868A1 (en) 2018-05-22 2021-06-03 Nantkwest, Inc. Methods and systems for cell bed formation during bioprocessing
US11237138B2 (en) 2019-06-19 2022-02-01 The Wrangler Group Selection and design of columns for liquid chromatography

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005572A1 (en) * 1988-11-16 1990-05-31 Alfa-Laval Ab Method of separating a substance from a liquid by means of a particulate material
US6214617B1 (en) * 1995-03-28 2001-04-10 Kinetic Biosystems, Inc. Centrifugal fermentation process

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4279753A (en) 1979-03-19 1981-07-21 Arco Environmental Company Wastewater treatment system including multiple stages of alternate aerobic-anerobic bioreactors in series
US4422941A (en) * 1980-09-08 1983-12-27 University Of Pittsburgh Apparatus for liquid-solid column centrifugation chromatography and method
WO1986004519A1 (en) 1985-02-09 1986-08-14 Era Gmbh Purification plant and process for removing pollution from hot gases
US4632762A (en) * 1985-05-28 1986-12-30 Arnold Ramsland Centrifugal chromatography
US4900446A (en) * 1987-06-23 1990-02-13 Large Scale Biology Centrifugal fast chromatograph
US4857187A (en) * 1987-09-28 1989-08-15 The Government Of The U.S. As Represented By The Secretary Of The Department Of Health And Human Services Multistage mixer-settler centrifuge
US5273656A (en) * 1991-09-04 1993-12-28 Large Scale Biology Corporation System for solid phase reactions
US5186824A (en) * 1991-09-04 1993-02-16 Large Scale Biology Corporation System for solid phase reactions
US5328673A (en) 1992-11-23 1994-07-12 Olin Corporation Process for removal of NOx and SOx oxides from waste gases with chloric acid
US20030064428A1 (en) 1998-12-31 2003-04-03 Herman Heath H. Methods and devices for remediation and fermentation
US6916652B2 (en) 1995-03-28 2005-07-12 Kinetic Biosystems, Inc. Biocatalyst chamber encapsulation system for bioremediation and fermentation
US5622819A (en) 1995-03-28 1997-04-22 Kinetic Biosystems, Inc. Centrifugal fermentation process
US6133019A (en) * 1995-03-28 2000-10-17 Kinetic Biosystems, Inc. Centrifugal fermentation process
AU2001236601A1 (en) 2000-01-31 2001-08-07 Robert A. Cuneo Methods and devices for remediation and fermentation
US6280696B1 (en) 2000-04-05 2001-08-28 Taiwan Semiconductor Manufacturing Company, Ltd Method and apparatus for removing high boiling point volatile organic compounds from an exhaust
US20020061270A1 (en) 2000-05-30 2002-05-23 Osborne Gerard W. Method and apparatus for wet gas scrubbing
EP1441823B1 (en) * 2001-11-09 2013-08-21 KBI Biopharma, Inc. Methods and compositions for chromatography

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005572A1 (en) * 1988-11-16 1990-05-31 Alfa-Laval Ab Method of separating a substance from a liquid by means of a particulate material
US6214617B1 (en) * 1995-03-28 2001-04-10 Kinetic Biosystems, Inc. Centrifugal fermentation process

Also Published As

Publication number Publication date
JP2005508497A (en) 2005-03-31
AU2002361623A1 (en) 2003-05-19
CA2466664A1 (en) 2003-05-15
US6942804B2 (en) 2005-09-13
EP1441823A2 (en) 2004-08-04
US8425770B2 (en) 2013-04-23
US20130264263A1 (en) 2013-10-10
US20030146161A1 (en) 2003-08-07
WO2003039702A2 (en) 2003-05-15
US20060000779A1 (en) 2006-01-05
US7347943B2 (en) 2008-03-25
JP4139333B2 (en) 2008-08-27
US20080264865A1 (en) 2008-10-30
EP1441823B1 (en) 2013-08-21

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