WO2003039459A3 - Viral vector production methods and compositions - Google Patents
Viral vector production methods and compositions Download PDFInfo
- Publication number
- WO2003039459A3 WO2003039459A3 PCT/US2002/035049 US0235049W WO03039459A3 WO 2003039459 A3 WO2003039459 A3 WO 2003039459A3 US 0235049 W US0235049 W US 0235049W WO 03039459 A3 WO03039459 A3 WO 03039459A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- viral vector
- compositions
- production methods
- vector production
- provides methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10351—Methods of production or purification of viral material
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002348151A AU2002348151A1 (en) | 2001-11-05 | 2002-10-31 | Viral vector production methods and compositions |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33287301P | 2001-11-05 | 2001-11-05 | |
US60/332,873 | 2001-11-05 | ||
US33212001P | 2001-11-13 | 2001-11-13 | |
US60/332,120 | 2001-11-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003039459A2 WO2003039459A2 (en) | 2003-05-15 |
WO2003039459A3 true WO2003039459A3 (en) | 2003-11-20 |
Family
ID=26988068
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/035049 WO2003039459A2 (en) | 2001-11-05 | 2002-10-31 | Viral vector production methods and compositions |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2002348151A1 (en) |
WO (1) | WO2003039459A2 (en) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007016250A1 (en) * | 2005-07-28 | 2007-02-08 | Genvec, Inc. | Method of purifying protein |
DK2424991T3 (en) | 2009-05-02 | 2018-09-17 | Genzyme Corp | Gene therapy for neurodegenerative diseases |
SG182490A1 (en) * | 2010-01-12 | 2012-08-30 | Vascular Biogenics Ltd | Methods of producing adenovirus vectors and viral preparations generated thereby |
AU2012342355B2 (en) | 2011-11-24 | 2017-10-12 | Genethon | Scalable lentiviral vector production system compatible with industrial pharmaceutical applications |
KR102015933B1 (en) * | 2012-04-08 | 2019-08-29 | 인벤트프라이즈 엘엘씨 | Systems and methods of virus propagation in cell culture for vaccine manufacture |
CN105143443A (en) * | 2013-02-22 | 2015-12-09 | 建新公司 | Microcarrier perfusion culturing methods and uses thereof |
MX367025B (en) | 2013-02-22 | 2019-08-02 | Genzyme Corp | Microcarrier perfusion culturing methods and uses thereof. |
DK2970920T3 (en) * | 2013-03-15 | 2018-08-06 | Childrens Hospital Philadelphia | SCALABLE MANUFACTURING PROCESS FOR MANUFACTURING RECOMBINANT LENTIVIRAL VECTORS IN SERUM-FREE SUSPENSION CELL CULTURE SYSTEM |
CA2920191C (en) * | 2013-07-18 | 2022-03-01 | Children's Hospital Medical Center | Methods of improving titer in transfection-based production systems using eukaryotic cells |
EP3122866B1 (en) | 2014-03-25 | 2019-11-20 | Terumo BCT, Inc. | Passive replacement of media |
TWI743024B (en) | 2014-06-06 | 2021-10-21 | 美商健臻公司 | Perfusion culturing methods and uses thereof |
TW202246486A (en) | 2014-06-09 | 2022-12-01 | 美商健臻公司 | Seed train processes and uses thereof |
SG11201705103WA (en) | 2014-12-22 | 2017-07-28 | Genzyme Corp | Methods of culturing a mammalian cell |
EP3054007A1 (en) | 2015-02-09 | 2016-08-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Recombinant adeno-associated virus particle purification comprising an immuno-affinity purification step |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
WO2018128688A1 (en) * | 2016-11-04 | 2018-07-12 | Baxalta Incorporated | Adeno-associated virus purification methods |
US11702634B2 (en) | 2017-03-31 | 2023-07-18 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
AU2018253088A1 (en) * | 2017-04-10 | 2019-11-28 | Epicentrx, Inc. | Method for producing recombinant virus |
US11603527B2 (en) * | 2017-12-27 | 2023-03-14 | Global Life Sciences Solutions Usa Llc | Method and kit for viral vector isolation |
CN110317832B (en) * | 2018-03-28 | 2022-07-05 | 西比曼生物科技(香港)有限公司 | GMP (good manufacturing practice) scale preparation method of purified preparation of recombinant lentiviral vector |
CN110317791A (en) | 2018-03-29 | 2019-10-11 | 西比曼生物科技(香港)有限公司 | The method of GMP grades of serum free suspension cell large-scale production slow virus |
CN114181970B (en) * | 2020-09-15 | 2023-07-25 | 上海药明巨诺生物医药研发有限公司 | Lentiviral vector purification method |
WO2022087509A1 (en) * | 2020-10-23 | 2022-04-28 | Ology Bioservices, Inc. | Method for infecting cells with virus |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6143548A (en) * | 1995-08-30 | 2000-11-07 | Genzyme Corporation | Chromatographic purification of adeno-associated virus (AAV) |
US6168941B1 (en) * | 2000-04-07 | 2001-01-02 | Genvec, Inc. | Method of producing adenoviral vector stocks |
US6194191B1 (en) * | 1996-11-20 | 2001-02-27 | Introgen Therapeutics, Inc. | Method for the production and purification of adenoviral vectors |
US6303362B1 (en) * | 1998-11-19 | 2001-10-16 | The Board Of Trustees Of The Leland Stanford Junior University | Adenoviral vector and methods for making and using the same |
US20010036657A1 (en) * | 1996-12-13 | 2001-11-01 | Tang John Chu-Tay | Methods for purifying viruses |
-
2002
- 2002-10-31 WO PCT/US2002/035049 patent/WO2003039459A2/en not_active Application Discontinuation
- 2002-10-31 AU AU2002348151A patent/AU2002348151A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6143548A (en) * | 1995-08-30 | 2000-11-07 | Genzyme Corporation | Chromatographic purification of adeno-associated virus (AAV) |
US6194191B1 (en) * | 1996-11-20 | 2001-02-27 | Introgen Therapeutics, Inc. | Method for the production and purification of adenoviral vectors |
US20010036657A1 (en) * | 1996-12-13 | 2001-11-01 | Tang John Chu-Tay | Methods for purifying viruses |
US6303362B1 (en) * | 1998-11-19 | 2001-10-16 | The Board Of Trustees Of The Leland Stanford Junior University | Adenoviral vector and methods for making and using the same |
US6168941B1 (en) * | 2000-04-07 | 2001-01-02 | Genvec, Inc. | Method of producing adenoviral vector stocks |
Also Published As
Publication number | Publication date |
---|---|
AU2002348151A1 (en) | 2003-05-19 |
WO2003039459A2 (en) | 2003-05-15 |
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