WO2003036300A3 - Diagnosis of cervical cancer - Google Patents

Diagnosis of cervical cancer Download PDF

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Publication number
WO2003036300A3
WO2003036300A3 PCT/GB2002/004887 GB0204887W WO03036300A3 WO 2003036300 A3 WO2003036300 A3 WO 2003036300A3 GB 0204887 W GB0204887 W GB 0204887W WO 03036300 A3 WO03036300 A3 WO 03036300A3
Authority
WO
WIPO (PCT)
Prior art keywords
cervical cancer
brn
female
diagnosis
mrna
Prior art date
Application number
PCT/GB2002/004887
Other languages
French (fr)
Other versions
WO2003036300A2 (en
Inventor
David Latchman
Michael Syndos
Daniel Ndisang
Original Assignee
Univ London
David Latchman
Michael Syndos
Daniel Ndisang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ London, David Latchman, Michael Syndos, Daniel Ndisang filed Critical Univ London
Publication of WO2003036300A2 publication Critical patent/WO2003036300A2/en
Publication of WO2003036300A3 publication Critical patent/WO2003036300A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57411—Specifically defined cancers of cervix
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/708—Specific hybridization probes for papilloma
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

A method of diagnosing cervical cancer in a female or identifying a female which is susceptible to cervical cancer, comprises determining whether cells of a cervical smear taken from the female contain detectable Brn-3a mRNA or detectable Brn-3a protein, wherein detection of Brn-3a mRNA or Brn-3a protein in the cells indicates that the female has cervical cancer or is susceptible to cervical cancer.
PCT/GB2002/004887 2001-10-26 2002-10-28 Diagnosis of cervical cancer WO2003036300A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0125764.1 2001-10-26
GB0125764A GB0125764D0 (en) 2001-10-26 2001-10-26 Diagnosis of cervicasl cancer

Publications (2)

Publication Number Publication Date
WO2003036300A2 WO2003036300A2 (en) 2003-05-01
WO2003036300A3 true WO2003036300A3 (en) 2003-10-30

Family

ID=9924611

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/004887 WO2003036300A2 (en) 2001-10-26 2002-10-28 Diagnosis of cervical cancer

Country Status (2)

Country Link
GB (1) GB0125764D0 (en)
WO (1) WO2003036300A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9513298B2 (en) 2004-07-30 2016-12-06 Hologic, Inc. Methods for detecting oncofetal fibronectin

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000034466A1 (en) * 1998-12-07 2000-06-15 University College London Cervical cancer treatment

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000034466A1 (en) * 1998-12-07 2000-06-15 University College London Cervical cancer treatment

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NDISANG D ET AL: "The Brn-3a transcription factor plays a key role in regulating the growth of cervical cancer cells in vivo.", ONCOGENE. ENGLAND 9 AUG 2001, vol. 20, no. 35, 9 August 2001 (2001-08-09), pages 4899 - 4903, XP002249290, ISSN: 0950-9232 *
NDISANG DANIEL ET AL: "The Brn-3a transcription factor plays a critical role in regulating human papilloma virus gene expression and determining the growth characteristics of cervical cancer cells", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 40, 1 October 1999 (1999-10-01), pages 28521 - 28527, XP002135723, ISSN: 0021-9258 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9513298B2 (en) 2004-07-30 2016-12-06 Hologic, Inc. Methods for detecting oncofetal fibronectin

Also Published As

Publication number Publication date
WO2003036300A2 (en) 2003-05-01
GB0125764D0 (en) 2001-12-19

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