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Isoform-selective inhibitors and activators of pde3 cyclic

Info

Publication number
WO2003012030A3
WO2003012030A3 PCT/US2002/019319 US0219319W WO2003012030A3 WO 2003012030 A3 WO2003012030 A3 WO 2003012030A3 US 0219319 W US0219319 W US 0219319W WO 2003012030 A3 WO2003012030 A3 WO 2003012030A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
methods
inhibitors
activators
selective
along
Prior art date
Application number
PCT/US2002/019319
Other languages
French (fr)
Other versions
WO2003012030A2 (en )
Inventor
Matthew Movsesian
Original Assignee
Univ Utah Technology Transfer
Matthew Movsesian
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay
    • G01N33/573Immunoassay; Biospecific binding assay for enzymes or isoenzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18Carboxylic ester hydrolases (3.1.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/916Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Abstract

The present invention concerns methods and compositions related to type 3 phosphodiesterases (PDE3). Certain embodiments concern isolated peptides corresponding to various PDE3A isiforms and/or site-specific mutants of PDE3A isoforms, along with expression vectors encoding such isoforms or mutants. In specific embodiments, methods for identifying isoform selective inhibitors or activators of PDE3 are provided, along with methods of use of such inhibitors or activators in the treatment of dilated cardiomyopathy, pulmonary hypertension and/or other medical conditions related to PDE3 effects on cAMP levels in different intracellular compartments.
PCT/US2002/019319 2001-08-01 2002-06-19 Isoform-selective inhibitors and activators of pde3 cyclic WO2003012030A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US30927101 true 2001-08-01 2001-08-01
US60/309,271 2001-08-01

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE2002637696 DE60237696D1 (en) 2001-08-01 2002-06-19 On the n-terminus truncated isoform of cyclic phosphodiesterases PDE3A
JP2003517208A JP2004536614A (en) 2001-08-01 2002-06-19 Pde3 cyclic nucleotide phosphodiesterase isoform selective inhibitors and activators
EP20020739923 EP1430140B1 (en) 2001-08-01 2002-06-19 N-terminally truncated isoforms of pde3a cyclic phosphodiesterases

Publications (2)

Publication Number Publication Date
WO2003012030A2 true WO2003012030A2 (en) 2003-02-13
WO2003012030A3 true true WO2003012030A3 (en) 2004-04-08

Family

ID=23197473

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/019319 WO2003012030A3 (en) 2001-08-01 2002-06-19 Isoform-selective inhibitors and activators of pde3 cyclic

Country Status (5)

Country Link
US (3) US20030158133A1 (en)
JP (1) JP2004536614A (en)
DE (1) DE60237696D1 (en)
EP (1) EP1430140B1 (en)
WO (1) WO2003012030A3 (en)

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US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
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ES2631879T3 (en) 2005-11-14 2017-09-05 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the treatment of heart failure asymptomatic (occult)
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Also Published As

Publication number Publication date Type
US8722866B2 (en) 2014-05-13 grant
JP2004536614A (en) 2004-12-09 application
EP1430140A4 (en) 2005-01-26 application
US20140350047A1 (en) 2014-11-27 application
WO2003012030A2 (en) 2003-02-13 application
DE60237696D1 (en) 2010-10-28 grant
US20030158133A1 (en) 2003-08-21 application
US9513289B2 (en) 2016-12-06 grant
EP1430140A2 (en) 2004-06-23 application
EP1430140B1 (en) 2010-09-15 grant
US20100267046A1 (en) 2010-10-21 application

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