WO2003000277A3 - Antimicrobial peptides - Google Patents

Antimicrobial peptides Download PDF

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Publication number
WO2003000277A3
WO2003000277A3 PCT/CA2002/000936 CA0200936W WO03000277A3 WO 2003000277 A3 WO2003000277 A3 WO 2003000277A3 CA 0200936 W CA0200936 W CA 0200936W WO 03000277 A3 WO03000277 A3 WO 03000277A3
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
sequence
gram
antimicrobial peptides
treating
Prior art date
Application number
PCT/CA2002/000936
Other languages
French (fr)
Other versions
WO2003000277A2 (en
Inventor
Charles M Deber
Liu Li-Ping
Original Assignee
Hospital For Sick Children
Charles M Deber
Liu Li-Ping
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hospital For Sick Children, Charles M Deber, Liu Li-Ping filed Critical Hospital For Sick Children
Priority to US10/481,286 priority Critical patent/US20040235745A1/en
Priority to JP2003506921A priority patent/JP2004534084A/en
Priority to CA2451310A priority patent/CA2451310C/en
Priority to EP02744972A priority patent/EP1401478A2/en
Priority to AU2002317071A priority patent/AU2002317071B2/en
Priority to IL15927402A priority patent/IL159274A0/en
Publication of WO2003000277A2 publication Critical patent/WO2003000277A2/en
Publication of WO2003000277A3 publication Critical patent/WO2003000277A3/en
Priority to US11/761,117 priority patent/US20080234188A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A method is described for treating a microbial infection with a peptide whose amino acid sequence has a formula selected from the group consisting of: (a) Bn1-Z; (b) Bn1-Z-Bn2; and (c) Z-Bn1 wherein B is a basic amino acid residue; n1 and n2 are 1 to 6; and Z is a sequence of about 11 to about 24 amino acid residues, the sequence having an average hydrophobicity value of at least 0.3, and preferably at least 0.4. These peptides show antimicrobial activity against microorganisms including both Gram-positive and Gram-negative bacteria.
PCT/CA2002/000936 2001-06-22 2002-06-21 Antimicrobial peptides WO2003000277A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US10/481,286 US20040235745A1 (en) 2001-06-22 2002-06-21 Antimicrobial Peptides
JP2003506921A JP2004534084A (en) 2001-06-22 2002-06-21 Antimicrobial peptide
CA2451310A CA2451310C (en) 2001-06-22 2002-06-21 Antimicrobial peptides
EP02744972A EP1401478A2 (en) 2001-06-22 2002-06-21 Antimicrobial peptides
AU2002317071A AU2002317071B2 (en) 2001-06-22 2002-06-21 Antimicrobial peptides
IL15927402A IL159274A0 (en) 2001-06-22 2002-06-21 Antimicrobial peptides
US11/761,117 US20080234188A1 (en) 2001-06-22 2007-06-11 Antimicrobial Peptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29972601P 2001-06-22 2001-06-22
US60/299,726 2001-06-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/761,117 Continuation US20080234188A1 (en) 2001-06-22 2007-06-11 Antimicrobial Peptides

Publications (2)

Publication Number Publication Date
WO2003000277A2 WO2003000277A2 (en) 2003-01-03
WO2003000277A3 true WO2003000277A3 (en) 2003-05-01

Family

ID=23156022

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2002/000936 WO2003000277A2 (en) 2001-06-22 2002-06-21 Antimicrobial peptides

Country Status (9)

Country Link
US (2) US20040235745A1 (en)
EP (1) EP1401478A2 (en)
JP (1) JP2004534084A (en)
CN (1) CN1516598A (en)
AU (1) AU2002317071B2 (en)
CA (1) CA2451310C (en)
IL (1) IL159274A0 (en)
WO (1) WO2003000277A2 (en)
ZA (1) ZA200309580B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5010798B2 (en) * 2001-10-03 2012-08-29 プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ Copolymers for inhibiting autoimmune diseases and methods of use thereof
EP1688486B1 (en) * 2003-10-29 2016-12-14 Toagosei Co., Ltd. Antibacterial peptide and utilization of the same
US7655221B2 (en) 2004-05-07 2010-02-02 Peptimmune, Inc. Methods of treating disease with random copolymers
GB0818074D0 (en) * 2008-10-02 2008-11-05 Lytix Biopharma As Treatment of biofilms
WO2010080819A1 (en) 2009-01-06 2010-07-15 C3 Jian, Inc. Targeted antimicrobial moieties
EP2444105A4 (en) * 2009-06-16 2013-08-21 Univ Tokai Anti-gram-negative bacteria agent
CN103221383B (en) * 2010-08-27 2016-04-20 株式会社新药 Promote the new compound of human antibiotic peptide secretion, its preparation method and contain its composition as activeconstituents
WO2013124436A1 (en) * 2012-02-23 2013-08-29 University Of East London Synthetic anti-microbial peptides with a minority of cationic and a majority hydrophobic side chains
CA2888068A1 (en) * 2014-04-15 2015-10-15 The Hospital For Sick Children Cationic antimicrobial peptides
IT202000006481A1 (en) * 2020-03-27 2021-09-27 Sanidrink S R L Antimicrobial tubular ducts

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997018826A1 (en) * 1995-11-22 1997-05-29 Intrabiotics Pharmaceuticals, Inc. Fine tuned protegrins
WO1998007745A2 (en) * 1996-08-21 1998-02-26 Micrologix Biotech, Inc. Compositions and methods for treating infections using analogues of indolicidin
WO1999065506A2 (en) * 1998-06-12 1999-12-23 Micrologix Biotech Inc. Cancer therapy with indolicidin or cationic peptides and their polymer conjugates
US6043220A (en) * 1997-12-03 2000-03-28 Intrabiotics Pharmaceuticals, Inc. Threonine-containing protegrins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714577A (en) * 1996-01-26 1998-02-03 University Of Pittsburgh Antimicrobial peptides
AU720405B2 (en) * 1996-02-16 2000-06-01 Regents Of The University Of California, The Antimicrobial peptides and methods of use
US6503881B2 (en) * 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997018826A1 (en) * 1995-11-22 1997-05-29 Intrabiotics Pharmaceuticals, Inc. Fine tuned protegrins
WO1998007745A2 (en) * 1996-08-21 1998-02-26 Micrologix Biotech, Inc. Compositions and methods for treating infections using analogues of indolicidin
US6043220A (en) * 1997-12-03 2000-03-28 Intrabiotics Pharmaceuticals, Inc. Threonine-containing protegrins
WO1999065506A2 (en) * 1998-06-12 1999-12-23 Micrologix Biotech Inc. Cancer therapy with indolicidin or cationic peptides and their polymer conjugates

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HANCOCK R E W ET AL: "Cationic peptides: a new source of antibiotics", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 16, no. 2, 1 February 1998 (1998-02-01), pages 82 - 88, XP004107047, ISSN: 0167-7799 *
LIU LI-PING ET AL: "Threshold hydrophobicity dictates helical conformations of peptides in membrane environments.", BIOPOLYMERS, vol. 39, no. 3, 1996, pages 465 - 470, XP009004885, ISSN: 0006-3525 *
STARK MARGARETA ET AL: "Cationic hydrophobic peptides with antimicrobial activity.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 46, no. 11, November 2002 (2002-11-01), November, 2002, pages 3585 - 3590, XP009004888, ISSN: 0066-4804 *

Also Published As

Publication number Publication date
WO2003000277A2 (en) 2003-01-03
ZA200309580B (en) 2004-07-28
AU2002317071B2 (en) 2008-01-31
CN1516598A (en) 2004-07-28
CA2451310C (en) 2014-02-25
JP2004534084A (en) 2004-11-11
US20040235745A1 (en) 2004-11-25
EP1401478A2 (en) 2004-03-31
IL159274A0 (en) 2004-06-01
CA2451310A1 (en) 2003-01-03
US20080234188A1 (en) 2008-09-25

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