WO2002092024A3 - Compounds and methods for inhibiting axillary malodour - Google Patents

Compounds and methods for inhibiting axillary malodour Download PDF

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Publication number
WO2002092024A3
WO2002092024A3 PCT/CH2002/000262 CH0200262W WO02092024A3 WO 2002092024 A3 WO2002092024 A3 WO 2002092024A3 CH 0200262 W CH0200262 W CH 0200262W WO 02092024 A3 WO02092024 A3 WO 02092024A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
methods
malodour
axillary malodour
inhibiting
Prior art date
Application number
PCT/CH2002/000262
Other languages
French (fr)
Other versions
WO2002092024A2 (en
Inventor
Andreas Natsch
Gonzalo Acuna
Marie-Claude Fournie-Zaluski
Hans Gfeller
Original Assignee
Givaudan Sa
Pharmaleads
Andreas Natsch
Gonzalo Acuna
Marie-Claude Fournie-Zaluski
Hans Gfeller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Givaudan Sa, Pharmaleads, Andreas Natsch, Gonzalo Acuna, Marie-Claude Fournie-Zaluski, Hans Gfeller filed Critical Givaudan Sa
Priority to BR0209628-5A priority Critical patent/BR0209628A/en
Priority to EP02769446A priority patent/EP1387891B1/en
Priority to DE60218837T priority patent/DE60218837T2/en
Priority to AU2002308337A priority patent/AU2002308337A1/en
Priority to US10/477,858 priority patent/US7264956B2/en
Priority to MXPA03010323A priority patent/MXPA03010323A/en
Publication of WO2002092024A2 publication Critical patent/WO2002092024A2/en
Publication of WO2002092024A3 publication Critical patent/WO2002092024A3/en
Priority to US11/746,401 priority patent/US20100278768A1/en
Priority to US13/169,090 priority patent/US20110318290A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Enzymes mediating in the release of compounds characteristic of human malodour and in particular axillary malodour, and compounds that inhibit said enzymes having general formula (I).
PCT/CH2002/000262 2001-05-14 2002-05-14 Compounds and methods for inhibiting axillary malodour WO2002092024A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
BR0209628-5A BR0209628A (en) 2001-05-14 2002-05-14 Compounds and methods to inhibit axillary stench
EP02769446A EP1387891B1 (en) 2001-05-14 2002-05-14 Compounds and methods for inhibiting axillary malodour
DE60218837T DE60218837T2 (en) 2001-05-14 2002-05-14 COMPOUNDS AND METHOD FOR INHIBITING AXLE ODORING
AU2002308337A AU2002308337A1 (en) 2001-05-14 2002-05-14 Compounds and methods for inhibiting axillary malodour
US10/477,858 US7264956B2 (en) 2001-05-14 2002-05-14 Compounds and methods for inhibiting axillary malodour
MXPA03010323A MXPA03010323A (en) 2001-05-14 2002-05-14 Compounds and methods for inhibiting axillary malodour.
US11/746,401 US20100278768A1 (en) 2001-05-14 2007-05-09 Compounds and Methods for Inhibiting Axillary Malodour
US13/169,090 US20110318290A1 (en) 2001-05-14 2011-06-27 Compounds and Methods for Inhibiting Axillary Malodour

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01111637A EP1258531A1 (en) 2001-05-14 2001-05-14 Compounds and methods for inhibiting axillary malodour
EP01111637.3 2001-05-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/746,401 Division US20100278768A1 (en) 2001-05-14 2007-05-09 Compounds and Methods for Inhibiting Axillary Malodour

Publications (2)

Publication Number Publication Date
WO2002092024A2 WO2002092024A2 (en) 2002-11-21
WO2002092024A3 true WO2002092024A3 (en) 2003-10-16

Family

ID=8177410

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CH2002/000262 WO2002092024A2 (en) 2001-05-14 2002-05-14 Compounds and methods for inhibiting axillary malodour

Country Status (8)

Country Link
US (2) US7264956B2 (en)
EP (3) EP1258531A1 (en)
AT (1) ATE356876T1 (en)
AU (1) AU2002308337A1 (en)
BR (1) BR0209628A (en)
DE (1) DE60218837T2 (en)
MX (1) MXPA03010323A (en)
WO (1) WO2002092024A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1258531A1 (en) 2001-05-14 2002-11-20 Givaudan SA Compounds and methods for inhibiting axillary malodour
WO2004031766A1 (en) * 2002-10-04 2004-04-15 Kao Corporation Indicator for assessing body odor, process for producing the same, body odor assessment method, method of assessing efficaciousness of deodorant and kit for conveniently assesing body odor
GB0226550D0 (en) 2002-11-14 2002-12-18 Givaudan Sa Organic compounds
GB0227363D0 (en) * 2002-11-25 2002-12-31 Givaudan Sa Organic compounds
EP2368602A1 (en) 2003-03-03 2011-09-28 Takasago International Corporation Deodorant perfume composition comprising essential oils for masking an acid odour
WO2006079934A2 (en) * 2005-01-31 2006-08-03 Firmenich Sa Inhibition of sweat malodour
US9109246B2 (en) 2007-10-10 2015-08-18 Givaudan Sa Enzymatic methods and enzymes
DE102008001811A1 (en) 2008-05-15 2009-11-19 Beiersdorf Ag Cosmetic preparations for reducing sweat odor with ABCC modulators
GB201018171D0 (en) 2010-10-28 2010-12-08 Givaudan Sa Organic compounds
BR112013015067A2 (en) * 2010-12-17 2018-08-28 Basf Se bad odor standards and inhibitors
WO2012084426A1 (en) * 2010-12-22 2012-06-28 Unilever Nv Enzymatic laundry detergent composition for the promotion of hygiene and the prevention of malodour
CN103328014A (en) * 2011-01-27 2013-09-25 奇华顿股份有限公司 Compositions
DE102011089012A1 (en) * 2011-12-19 2013-06-20 Henkel Ag & Co. Kgaa Textile-friendly antiperspirants
CN107501024B (en) * 2017-09-15 2021-06-29 安徽省科学技术研究院 Synthesis method of 1, 2-diiodo olefin compound
WO2020201182A1 (en) 2019-04-04 2020-10-08 Universiteit Gent Microbial enzymes to reduce malodour of skin and textiles
GB202104969D0 (en) 2021-04-08 2021-05-26 Givaudan Sa Fragrance composition

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4745067A (en) * 1985-05-02 1988-05-17 Microbial Chemistry Research Foundation L-aminoacylases
EP0815833A2 (en) * 1996-06-24 1998-01-07 Givaudan-Roure (International) S.A. Malodour preventing agents
WO1998027201A2 (en) * 1996-12-16 1998-06-25 Hoechst Schering Agrevo Gmbh Genes coding for amino acid deacetylases with specificity for n-acetyl-l-phosphinothricin, their isolation and their use
WO2000001355A1 (en) * 1998-07-07 2000-01-13 Unilever Plc Method of reducing or preventing malodour

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3934004A (en) * 1973-03-09 1976-01-20 Orren Leonard J Stain resistant anti-perspirant composition
US5643559A (en) * 1991-10-30 1997-07-01 Colgate-Palmolive Company Deodorant compositions comprising inhibitors of odor-producing axillary bacterial exoenzymes
US5861145A (en) * 1997-06-09 1999-01-19 The Procter & Gamble Company Method of reducing body odor using perfumed, odor absorbing, two phase compositions
GB9814653D0 (en) 1998-07-07 1998-09-02 Quest Int Method of reducing or preventing malodour
DE19855956C2 (en) 1998-12-04 2000-11-02 Cognis Deutschland Gmbh Sterol phosphates
DE19858811A1 (en) 1998-12-21 2000-06-29 Cognis Deutschland Gmbh Cosmetic deodorant preparations contain glucosamine hydrochloride as esterase inhibitor and other active agent, have strong, possibly synergistic effect in preventing odor formation
JP2000288076A (en) * 1999-04-07 2000-10-17 Lion Corp Aromatic deodorant composition
EP1258531A1 (en) 2001-05-14 2002-11-20 Givaudan SA Compounds and methods for inhibiting axillary malodour

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4745067A (en) * 1985-05-02 1988-05-17 Microbial Chemistry Research Foundation L-aminoacylases
EP0815833A2 (en) * 1996-06-24 1998-01-07 Givaudan-Roure (International) S.A. Malodour preventing agents
WO1998027201A2 (en) * 1996-12-16 1998-06-25 Hoechst Schering Agrevo Gmbh Genes coding for amino acid deacetylases with specificity for n-acetyl-l-phosphinothricin, their isolation and their use
WO2000001355A1 (en) * 1998-07-07 2000-01-13 Unilever Plc Method of reducing or preventing malodour

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
A. NATSCH, ET AL.: "A specific bacterial aminoacylase cleaves odorant precursors secreted in the human axilla.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 8, 21 February 2003 (2003-02-21), American Society of Biological Chemists, Baltimore, MD, US, pages 5718 - 5727, XP002233274, ISSN: 0021-9258 *
C. FROEBE, ET AL.: "Axillary malodour production: a new mechanism", JOURNAL OF THE SOCIETY COSMETIC CHEMISTS, vol. 41, no. 3, 1990, Society of Cosmetic Chemists, New York, NY, US, pages 173 - 186, XP000993276, ISSN: 0037-9832 *
D.B. GOWER, ET AL.: "Comparison of 16-androstene steroid concentrations in sterile apocrine sweat and axillary secretions: interconversions of 16-androstenes by the axillary microflora - a mechanism for axillary odour production in man?", JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 48, no. 4, 1994, Elsevier Science Publishers, Oxford, GB, pages 409 - 418, XP000882081, ISSN: 0960-0760 *
DATABASE EMBL [online] 1 May 2000 (2000-05-01), XP002233278, retrieved from EBI Database accession no. Q9RKM4 *
S. PITTELKOW, ET AL: "Human and porcine aminoacylase I overproduced in a baculovirus expression vector system: Evidence for structural and functional identity with enzymes isolated from kidney.", PROTEIN EXPRESSION AND PURIFICATION, vol. 12, no. 2, March 1998 (1998-03-01), Academic Press, San Diego, CA, US, pages 269 - 276, XP002233275, ISSN: 1046-5928 *
X.-N. ZENG, ET AL.: "Analysis of characteristic odours from human male axillae", JOURNAL OF CHEMICAL ECOLOGY, vol. 17, no. 7, 1991, Kluwer Academic/Plenum Publishing, New York, NY, US, pages 1469 - 1492, XP008008746, ISSN: 0098-0331 *

Also Published As

Publication number Publication date
DE60218837T2 (en) 2007-11-15
EP1811034B1 (en) 2014-04-09
EP1387891B1 (en) 2007-03-14
EP1811034A2 (en) 2007-07-25
US20100278768A1 (en) 2010-11-04
DE60218837D1 (en) 2007-04-26
MXPA03010323A (en) 2004-02-17
AU2002308337A1 (en) 2002-11-25
EP1387891A2 (en) 2004-02-11
EP1811034A3 (en) 2011-03-16
ATE356876T1 (en) 2007-04-15
US20040241795A1 (en) 2004-12-02
US7264956B2 (en) 2007-09-04
EP1258531A1 (en) 2002-11-20
BR0209628A (en) 2004-06-22
WO2002092024A2 (en) 2002-11-21

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