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Closed loop neuromodulation for supperssion of epileptic activity

Info

Publication number
WO2002087438A3
WO2002087438A3 PCT/US2002/010995 US0210995W WO2002087438A3 WO 2002087438 A3 WO2002087438 A3 WO 2002087438A3 US 0210995 W US0210995 W US 0210995W WO 2002087438 A3 WO2002087438 A3 WO 2002087438A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
neurological
occurrence
potentials
level
field
Prior art date
Application number
PCT/US2002/010995
Other languages
French (fr)
Other versions
WO2002087438A2 (en )
Inventor
Wytse Wadman
Frans L H Gielen
Original Assignee
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/04Detecting, measuring or recording bioelectric signals of the body or parts thereof
    • A61B5/0476Electroencephalography
    • A61B5/0484Electroencephalography using evoked response
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/40Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4094Diagnosing or monitoring seizure diseases, e.g. epilepsy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Abstract

A system and method for predicting the likelihood of occurrence of an impending neurological episode. Electrical stimuli are delivered to a structure of the brain. Response field potentials evoked by the stimuli are sensed. Analysis of these field potentials allows for predictions as to the occurrence of an impending, but not yet occurring, neurological disorder. In one example, a measurement of change in response pulses is used to determine a level of interconnectivity in the structures of the brain. The level of functional interconnectivity is used in predicting the occurrence of the neurological event. An example of such a neurological event includes an epileptic seizure.
PCT/US2002/010995 2001-04-27 2002-04-05 Closed loop neuromodulation for supperssion of epileptic activity WO2002087438A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US09842813 US6671555B2 (en) 2001-04-27 2001-04-27 Closed loop neuromodulation for suppression of epileptic activity
US09/842,813 2001-04-27

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE2002604451 DE60204451D1 (en) 2001-04-27 2002-04-05 Detecting neurological conditions by means of potentials reizevozierten
DE2002604451 DE60204451T2 (en) 2001-04-27 2002-04-05 Detecting neurological conditions by means of potentials reizevozierten
EP20020747811 EP1385426B1 (en) 2001-04-27 2002-04-05 Detection of neurological disorders using evoked response potentials

Publications (2)

Publication Number Publication Date
WO2002087438A2 true WO2002087438A2 (en) 2002-11-07
WO2002087438A3 true true WO2002087438A3 (en) 2003-11-27

Family

ID=25288290

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/010995 WO2002087438A3 (en) 2001-04-27 2002-04-05 Closed loop neuromodulation for supperssion of epileptic activity

Country Status (4)

Country Link
US (2) US6671555B2 (en)
DE (2) DE60204451D1 (en)
EP (1) EP1385426B1 (en)
WO (1) WO2002087438A3 (en)

Families Citing this family (167)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6597954B1 (en) * 1997-10-27 2003-07-22 Neuropace, Inc. System and method for controlling epileptic seizures with spatially separated detection and stimulation electrodes
US9375573B2 (en) 1998-08-05 2016-06-28 Cyberonics, Inc. Systems and methods for monitoring a patient's neurological disease state
US7853329B2 (en) 1998-08-05 2010-12-14 Neurovista Corporation Monitoring efficacy of neural modulation therapy
US9415222B2 (en) 1998-08-05 2016-08-16 Cyberonics, Inc. Monitoring an epilepsy disease state with a supervisory module
US9042988B2 (en) 1998-08-05 2015-05-26 Cyberonics, Inc. Closed-loop vagus nerve stimulation
US7209787B2 (en) 1998-08-05 2007-04-24 Bioneuronics Corporation Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US7747325B2 (en) 1998-08-05 2010-06-29 Neurovista Corporation Systems and methods for monitoring a patient's neurological disease state
US8762065B2 (en) 1998-08-05 2014-06-24 Cyberonics, Inc. Closed-loop feedback-driven neuromodulation
US6485938B1 (en) * 1999-11-16 2002-11-26 Zymogenetics, Inc. Nucleic acid molecules that encodes human Zven1
US7561919B2 (en) 2002-11-14 2009-07-14 Brainsgate Ltd. SPG stimulation via the greater palatine canal
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation
US8010189B2 (en) 2004-02-20 2011-08-30 Brainsgate Ltd. SPG stimulation for treating complications of subarachnoid hemorrhage
US7136696B2 (en) * 2002-04-05 2006-11-14 The Cleveland Clinic Foundation Neuron signal analysis system and method
CA2500772A1 (en) * 2002-10-07 2004-04-22 Zymogenetics, Inc. Uses of human zven antagonists
US20050010261A1 (en) * 2002-10-21 2005-01-13 The Cleveland Clinic Foundation Application of stimulus to white matter to induce a desired physiological response
US20050049649A1 (en) * 2002-10-21 2005-03-03 The Cleveland Clinic Foundation Electrical stimulation of the brain
JP3732476B2 (en) * 2002-10-22 2006-01-05 株式会社日立メディコ Living body measuring device
WO2004041069A3 (en) 2002-11-01 2004-07-15 George Mason Intellectual Prop Methods and devices for determining brain state
US9854985B2 (en) * 2002-12-09 2018-01-02 Bio-Signal Group Corp. Brain signal telemetry and seizure prediction
US7153256B2 (en) 2003-03-07 2006-12-26 Neuronetics, Inc. Reducing discomfort caused by electrical stimulation
US8118722B2 (en) 2003-03-07 2012-02-21 Neuronetics, Inc. Reducing discomfort caused by electrical stimulation
US7155279B2 (en) * 2003-03-28 2006-12-26 Advanced Bionics Corporation Treatment of movement disorders with drug therapy
US9278208B1 (en) 2003-10-20 2016-03-08 University Of Central Florida Research Foundation, Inc. Spatial-temporal deep brain stimulation methods and systems
US8024049B1 (en) 2003-10-20 2011-09-20 University Of Central Florida Research Foundation, Inc. Spatial-temporal deep brain stimulation methods and systems
US9050469B1 (en) 2003-11-26 2015-06-09 Flint Hills Scientific, Llc Method and system for logging quantitative seizure information and assessing efficacy of therapy using cardiac signals
US8197395B2 (en) * 2004-07-14 2012-06-12 Arizona Board Of Regents For And On Behalf Of Arizona State University Pacemaker for treating physiological system dysfunction
US20060058854A1 (en) * 2004-09-14 2006-03-16 Scimed Life Systems, Inc. Method for stimulating neural tissue in response to a sensed physiological event
US20060161216A1 (en) * 2004-10-18 2006-07-20 John Constance M Device for neuromuscular peripheral body stimulation and electrical stimulation (ES) for wound healing using RF energy harvesting
WO2006047264A1 (en) * 2004-10-21 2006-05-04 Advanced Neuromodulation Systems, Inc. Peripheral nerve stimulation to treat auditory dysfunction
US7734340B2 (en) * 2004-10-21 2010-06-08 Advanced Neuromodulation Systems, Inc. Stimulation design for neuromodulation
US7366571B2 (en) * 2004-12-10 2008-04-29 Cyberonics, Inc. Neurostimulator with activation based on changes in body temperature
US8209019B2 (en) 2004-12-17 2012-06-26 Medtronic, Inc. System and method for utilizing brain state information to modulate cardiac therapy
US8485979B2 (en) * 2004-12-17 2013-07-16 Medtronic, Inc. System and method for monitoring or treating nervous system disorders
US8112153B2 (en) * 2004-12-17 2012-02-07 Medtronic, Inc. System and method for monitoring or treating nervous system disorders
US8214035B2 (en) * 2004-12-17 2012-07-03 Medtronic, Inc. System and method for utilizing brain state information to modulate cardiac therapy
DE602005026054D1 (en) * 2004-12-17 2011-03-03 Medtronic Inc System for monitoring or treatment of disorders of the nervous system
US8108038B2 (en) 2004-12-17 2012-01-31 Medtronic, Inc. System and method for segmenting a cardiac signal based on brain activity
US8112148B2 (en) * 2004-12-17 2012-02-07 Medtronic, Inc. System and method for monitoring cardiac signal activity in patients with nervous system disorders
US8209009B2 (en) * 2004-12-17 2012-06-26 Medtronic, Inc. System and method for segmenting a cardiac signal based on brain stimulation
US8108046B2 (en) 2004-12-17 2012-01-31 Medtronic, Inc. System and method for using cardiac events to trigger therapy for treating nervous system disorders
US20070239060A1 (en) * 2004-12-17 2007-10-11 Medtronic, Inc. System and method for regulating cardiac triggered therapy to the brain
US9352145B2 (en) * 2004-12-22 2016-05-31 Boston Scientific Neuromodulation Corporation Methods and systems for treating a psychotic disorder
US8600521B2 (en) 2005-01-27 2013-12-03 Cyberonics, Inc. Implantable medical device having multiple electrode/sensor capability and stimulation based on sensed intrinsic activity
US7454245B2 (en) * 2005-01-28 2008-11-18 Cyberonics, Inc. Trained and adaptive response in a neurostimulator
US9314633B2 (en) 2008-01-25 2016-04-19 Cyberonics, Inc. Contingent cardio-protection for epilepsy patients
US7561918B2 (en) * 2005-01-28 2009-07-14 Cyberonics, Inc. Autocapture in a neurostimulator
US8565867B2 (en) 2005-01-28 2013-10-22 Cyberonics, Inc. Changeable electrode polarity stimulation by an implantable medical device
US20060173493A1 (en) * 2005-01-28 2006-08-03 Cyberonics, Inc. Multi-phasic signal for stimulation by an implantable device
US7751884B2 (en) * 2005-04-28 2010-07-06 Cardiac Pacemakers, Inc. Flexible neural stimulation engine
US7769447B2 (en) * 2005-04-28 2010-08-03 Cardiac Pacemakers, Inc. Cardiac pacemaker with table-based pacing mode implementation
US7396326B2 (en) 2005-05-17 2008-07-08 Neuronetics, Inc. Ferrofluidic cooling and acoustical noise reduction in magnetic stimulators
EP1723983B1 (en) * 2005-05-20 2013-07-10 Imec Probe device for electrical stimulation and recording of the activity of excitable cells
US20070027486A1 (en) * 2005-07-29 2007-02-01 Cyberonics, Inc. Medical devices for enhancing intrinsic neural activity
US7499752B2 (en) 2005-07-29 2009-03-03 Cyberonics, Inc. Selective nerve stimulation for the treatment of eating disorders
US20070027499A1 (en) * 2005-07-29 2007-02-01 Cyberonics, Inc. Neurostimulation device for treating mood disorders
US7532935B2 (en) * 2005-07-29 2009-05-12 Cyberonics, Inc. Selective neurostimulation for treating mood disorders
US8055347B2 (en) 2005-08-19 2011-11-08 Brainsgate Ltd. Stimulation for treating brain events and other conditions
EP1924603A2 (en) * 2005-09-13 2008-05-28 Zymogenetics, Inc. Prok2 antagonists and methods of use
US8428731B2 (en) * 2005-10-27 2013-04-23 Cyberonics, Inc. Sequenced therapy protocols for an implantable medical device
US7957796B2 (en) 2005-10-28 2011-06-07 Cyberonics, Inc. Using physiological sensor data with an implantable medical device
US7555344B2 (en) * 2005-10-28 2009-06-30 Cyberonics, Inc. Selective neurostimulation for treating epilepsy
US8694118B2 (en) 2005-10-28 2014-04-08 Cyberonics, Inc. Variable output ramping for an implantable medical device
US20070100377A1 (en) * 2005-10-28 2007-05-03 Cyberonics, Inc. Providing multiple signal modes for a medical device
WO2007075477A3 (en) * 2005-12-19 2008-12-04 Univ Florida Closed-loop state-dependent seizure prevention systems
US8725243B2 (en) 2005-12-28 2014-05-13 Cyberonics, Inc. Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders
US8868172B2 (en) 2005-12-28 2014-10-21 Cyberonics, Inc. Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders
US7996079B2 (en) 2006-01-24 2011-08-09 Cyberonics, Inc. Input response override for an implantable medical device
US7657310B2 (en) 2006-01-26 2010-02-02 Cyberonics, Inc. Treatment of reproductive endocrine disorders by vagus nerve stimulation
US7974697B2 (en) 2006-01-26 2011-07-05 Cyberonics, Inc. Medical imaging feedback for an implantable medical device
US7801601B2 (en) 2006-01-27 2010-09-21 Cyberonics, Inc. Controlling neuromodulation using stimulus modalities
US8190251B2 (en) * 2006-03-24 2012-05-29 Medtronic, Inc. Method and apparatus for the treatment of movement disorders
US8615309B2 (en) 2006-03-29 2013-12-24 Catholic Healthcare West Microburst electrical stimulation of cranial nerves for the treatment of medical conditions
US7869885B2 (en) 2006-04-28 2011-01-11 Cyberonics, Inc Threshold optimization for tissue stimulation therapy
US7962220B2 (en) 2006-04-28 2011-06-14 Cyberonics, Inc. Compensation reduction in tissue stimulation therapy
WO2007150003A3 (en) 2006-06-23 2008-11-06 Neurovista Corp Minimally invasive monitoring systems and methods
US7583999B2 (en) * 2006-07-31 2009-09-01 Cranial Medical Systems, Inc. Multi-channel connector for brain stimulation system
US8321025B2 (en) 2006-07-31 2012-11-27 Cranial Medical Systems, Inc. Lead and methods for brain monitoring and modulation
US7869867B2 (en) 2006-10-27 2011-01-11 Cyberonics, Inc. Implantable neurostimulator with refractory stimulation
US8295934B2 (en) 2006-11-14 2012-10-23 Neurovista Corporation Systems and methods of reducing artifact in neurological stimulation systems
US20080154331A1 (en) * 2006-12-21 2008-06-26 Varghese John Device for multicentric brain modulation, repair and interface
US7706875B2 (en) * 2007-01-25 2010-04-27 Cyberonics, Inc. Modulation of drug effects by vagus nerve stimulation
WO2008092133A3 (en) 2007-01-25 2008-09-12 Neurovista Corp Methods and systems for measuring a subject's susceptibility to a seizure
US7391257B1 (en) 2007-01-31 2008-06-24 Medtronic, Inc. Chopper-stabilized instrumentation amplifier for impedance measurement
US7385443B1 (en) * 2007-01-31 2008-06-10 Medtronic, Inc. Chopper-stabilized instrumentation amplifier
US9615744B2 (en) 2007-01-31 2017-04-11 Medtronic, Inc. Chopper-stabilized instrumentation amplifier for impedance measurement
US8265769B2 (en) * 2007-01-31 2012-09-11 Medtronic, Inc. Chopper-stabilized instrumentation amplifier for wireless telemetry
US8036736B2 (en) 2007-03-21 2011-10-11 Neuro Vista Corporation Implantable systems and methods for identifying a contra-ictal condition in a subject
US8364273B2 (en) * 2007-04-24 2013-01-29 Dirk De Ridder Combination of tonic and burst stimulations to treat neurological disorders
US7869884B2 (en) * 2007-04-26 2011-01-11 Cyberonics, Inc. Non-surgical device and methods for trans-esophageal vagus nerve stimulation
US7962214B2 (en) 2007-04-26 2011-06-14 Cyberonics, Inc. Non-surgical device and methods for trans-esophageal vagus nerve stimulation
US7904175B2 (en) 2007-04-26 2011-03-08 Cyberonics, Inc. Trans-esophageal vagus nerve stimulation
US7974701B2 (en) 2007-04-27 2011-07-05 Cyberonics, Inc. Dosing limitation for an implantable medical device
US8000788B2 (en) * 2007-04-27 2011-08-16 Medtronic, Inc. Implantable medical device for treating neurological conditions including ECG sensing
US9788750B2 (en) * 2007-04-30 2017-10-17 Medtronic, Inc. Seizure prediction
US8594779B2 (en) * 2007-04-30 2013-11-26 Medtronic, Inc. Seizure prediction
US8781595B2 (en) * 2007-04-30 2014-07-15 Medtronic, Inc. Chopper mixer telemetry circuit
US9592377B2 (en) * 2007-07-27 2017-03-14 Second Sight Medical Products, Inc. Implantable device for the brain
US9788744B2 (en) 2007-07-27 2017-10-17 Cyberonics, Inc. Systems for monitoring brain activity and patient advisory device
US20090083070A1 (en) * 2007-09-24 2009-03-26 Medtronic, Inc. Therapy adjustment based on patient event indication
US9529972B2 (en) * 2007-09-24 2016-12-27 Medtronic, Inc. Patient event indication
US8376943B2 (en) * 2007-09-24 2013-02-19 Medtronic, Inc. Patient event information
US7714757B2 (en) * 2007-09-26 2010-05-11 Medtronic, Inc. Chopper-stabilized analog-to-digital converter
US7623053B2 (en) * 2007-09-26 2009-11-24 Medtronic, Inc. Implantable medical device with low power delta-sigma analog-to-digital converter
US8380314B2 (en) 2007-09-26 2013-02-19 Medtronic, Inc. Patient directed therapy control
CN101848677B (en) * 2007-09-26 2014-09-17 麦德托尼克公司 Frequency selective monitoring of physiological signals
WO2009051638A1 (en) 2007-10-16 2009-04-23 Medtronic, Inc. Therapy control based on a patient movement state
WO2009055000A1 (en) 2007-10-23 2009-04-30 Optima Neuroscience, Inc. System for seizure monitoring and detection
US20090259095A1 (en) * 2007-11-12 2009-10-15 Nicholas Sieveking System and method for treatment of hypo-orgasmia and anorgasmia
US9259591B2 (en) 2007-12-28 2016-02-16 Cyberonics, Inc. Housing for an implantable medical device
US8260426B2 (en) 2008-01-25 2012-09-04 Cyberonics, Inc. Method, apparatus and system for bipolar charge utilization during stimulation by an implantable medical device
WO2009094050A1 (en) 2008-01-25 2009-07-30 Medtronic, Inc. Sleep stage detection
US8204603B2 (en) 2008-04-25 2012-06-19 Cyberonics, Inc. Blocking exogenous action potentials by an implantable medical device
WO2009140283A1 (en) * 2008-05-13 2009-11-19 The Board Of Trustees Of The University Of Illinois Apparatus for managing a neurological disorder
US8280516B2 (en) * 2008-10-09 2012-10-02 Daniel Graupe Method and apparatus for closed-loop deep brain stimulation in treating neurological diseases
US8457747B2 (en) 2008-10-20 2013-06-04 Cyberonics, Inc. Neurostimulation with signal duration determined by a cardiac cycle
US8417344B2 (en) 2008-10-24 2013-04-09 Cyberonics, Inc. Dynamic cranial nerve stimulation based on brain state determination from cardiac data
WO2010049931A1 (en) * 2008-10-29 2010-05-06 Ai Medical Semiconductor Ltd. Optimal cardiac pacing with q learning
US8478402B2 (en) * 2008-10-31 2013-07-02 Medtronic, Inc. Determining intercardiac impedance
US20100113964A1 (en) * 2008-10-31 2010-05-06 Wahlstrand John D Determining intercardiac impedance
US20100121214A1 (en) * 2008-11-11 2010-05-13 Medtronic, Inc. Seizure disorder evaluation based on intracranial pressure and patient motion
GB0821325D0 (en) * 2008-11-21 2008-12-31 Ucl Business Plc Method and apparatus for performing deep brain stimulation with an electric field
US8849390B2 (en) 2008-12-29 2014-09-30 Cyberonics, Inc. Processing for multi-channel signals
US8588933B2 (en) 2009-01-09 2013-11-19 Cyberonics, Inc. Medical lead termination sleeve for implantable medical devices
US20100191304A1 (en) * 2009-01-23 2010-07-29 Scott Timothy L Implantable Medical Device for Providing Chronic Condition Therapy and Acute Condition Therapy Using Vagus Nerve Stimulation
US8774923B2 (en) 2009-03-22 2014-07-08 Sorin Crm Sas Optimal deep brain stimulation therapy with Q learning
US8827912B2 (en) 2009-04-24 2014-09-09 Cyberonics, Inc. Methods and systems for detecting epileptic events using NNXX, optionally with nonlinear analysis parameters
US8239028B2 (en) 2009-04-24 2012-08-07 Cyberonics, Inc. Use of cardiac parameters in methods and systems for treating a chronic medical condition
US20100280336A1 (en) * 2009-04-30 2010-11-04 Medtronic, Inc. Anxiety disorder monitoring
US8786624B2 (en) 2009-06-02 2014-07-22 Cyberonics, Inc. Processing for multi-channel signals
US9770204B2 (en) 2009-11-11 2017-09-26 Medtronic, Inc. Deep brain stimulation for sleep and movement disorders
US8914115B2 (en) * 2009-12-03 2014-12-16 Medtronic, Inc. Selecting therapy cycle parameters based on monitored brain signal
US9643019B2 (en) 2010-02-12 2017-05-09 Cyberonics, Inc. Neurological monitoring and alerts
US9717439B2 (en) 2010-03-31 2017-08-01 Medtronic, Inc. Patient data display
US8562536B2 (en) 2010-04-29 2013-10-22 Flint Hills Scientific, Llc Algorithm for detecting a seizure from cardiac data
US8831732B2 (en) 2010-04-29 2014-09-09 Cyberonics, Inc. Method, apparatus and system for validating and quantifying cardiac beat data quality
US8649871B2 (en) 2010-04-29 2014-02-11 Cyberonics, Inc. Validity test adaptive constraint modification for cardiac data used for detection of state changes
US8679009B2 (en) 2010-06-15 2014-03-25 Flint Hills Scientific, Llc Systems approach to comorbidity assessment
US8641646B2 (en) 2010-07-30 2014-02-04 Cyberonics, Inc. Seizure detection using coordinate data
WO2012030831A1 (en) 2010-08-30 2012-03-08 Advanced Neuromodulation Systems, Inc. Use of a new stimulation design to treat neurological disorder
US8583237B2 (en) 2010-09-13 2013-11-12 Cranial Medical Systems, Inc. Devices and methods for tissue modulation and monitoring
US8571643B2 (en) 2010-09-16 2013-10-29 Flint Hills Scientific, Llc Detecting or validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex
WO2012050847A3 (en) 2010-09-28 2012-06-21 Masimo Corporation Depth of consciousness monitor including oximeter
US8382667B2 (en) 2010-10-01 2013-02-26 Flint Hills Scientific, Llc Detecting, quantifying, and/or classifying seizures using multimodal data
US8337404B2 (en) 2010-10-01 2012-12-25 Flint Hills Scientific, Llc Detecting, quantifying, and/or classifying seizures using multimodal data
US8684921B2 (en) 2010-10-01 2014-04-01 Flint Hills Scientific Llc Detecting, assessing and managing epilepsy using a multi-variate, metric-based classification analysis
US8565886B2 (en) 2010-11-10 2013-10-22 Medtronic, Inc. Arousal state modulation with electrical stimulation
US8706181B2 (en) 2011-01-25 2014-04-22 Medtronic, Inc. Target therapy delivery site selection
US8562523B2 (en) 2011-03-04 2013-10-22 Flint Hills Scientific, Llc Detecting, assessing and managing extreme epileptic events
US9504390B2 (en) 2011-03-04 2016-11-29 Globalfoundries Inc. Detecting, assessing and managing a risk of death in epilepsy
US8562524B2 (en) 2011-03-04 2013-10-22 Flint Hills Scientific, Llc Detecting, assessing and managing a risk of death in epilepsy
US8892207B2 (en) 2011-04-20 2014-11-18 Medtronic, Inc. Electrical therapy for facilitating inter-area brain synchronization
US9173609B2 (en) 2011-04-20 2015-11-03 Medtronic, Inc. Brain condition monitoring based on co-activation of neural networks
US8868173B2 (en) 2011-04-20 2014-10-21 Medtronic, Inc. Method and apparatus for assessing neural activation
US8914119B2 (en) 2011-04-20 2014-12-16 Medtronic, Inc. Electrical brain therapy parameter determination based on a bioelectrical resonance response
US8725239B2 (en) 2011-04-25 2014-05-13 Cyberonics, Inc. Identifying seizures using heart rate decrease
US8812098B2 (en) 2011-04-28 2014-08-19 Medtronic, Inc. Seizure probability metrics
US9402550B2 (en) 2011-04-29 2016-08-02 Cybertronics, Inc. Dynamic heart rate threshold for neurological event detection
FR2989240B1 (en) * 2012-04-10 2017-08-11 Commissariat Energie Atomique data synchronization method and data transmission system implementing such a process a.
US8918176B2 (en) 2012-04-23 2014-12-23 Medtronic, Inc. Assessing cognitive disorders based on non-motor epileptiform bioelectrical brain activity
US8849408B1 (en) 2013-01-04 2014-09-30 University Of Central Florida Research Foundation, Inc. Methods for electronic directionality of deep-brain stimulation
US9439150B2 (en) 2013-03-15 2016-09-06 Medtronic, Inc. Control of spectral agressors in a physiological signal montoring device
US9521979B2 (en) 2013-03-15 2016-12-20 Medtronic, Inc. Control of spectral agressors in a physiological signal monitoring device
US9056195B2 (en) 2013-03-15 2015-06-16 Cyberonics, Inc. Optimization of cranial nerve stimulation to treat seizure disorderse during sleep
US9675796B2 (en) 2013-11-10 2017-06-13 Brainsgate Ltd. Implant and delivery system for neural stimulator
US9302109B2 (en) 2014-04-25 2016-04-05 Cyberonics, Inc. Cranial nerve stimulation to treat depression during sleep
US9585611B2 (en) 2014-04-25 2017-03-07 Cyberonics, Inc. Detecting seizures based on heartbeat data
US20170332934A1 (en) * 2014-07-29 2017-11-23 Nibs Neuroscience Technologies Ltd. Neurocerebral assessment using stimulated eeg response

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6018682A (en) * 1998-04-30 2000-01-25 Medtronic, Inc. Implantable seizure warning system
US6128538A (en) * 1997-10-27 2000-10-03 Neuropace, Inc. Means and method for the treatment of neurological disorders

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001122A (en) * 1973-08-22 1977-01-04 Telan Corporation Method and device for separating blood components
US4867164A (en) 1983-09-14 1989-09-19 Jacob Zabara Neurocybernetic prosthesis
US5025807A (en) 1983-09-14 1991-06-25 Jacob Zabara Neurocybernetic prosthesis
US5263488A (en) * 1992-10-05 1993-11-23 Nicolet Instrument Corporation Method and apparatus for localization of intracerebral sources of electrical activity
US5392788A (en) * 1993-02-03 1995-02-28 Hudspeth; William J. Method and device for interpreting concepts and conceptual thought from brainwave data and for assisting for diagnosis of brainwave disfunction
US5840502A (en) * 1994-08-31 1998-11-24 Activated Cell Therapy, Inc. Methods for enriching specific cell-types by density gradient centrifugation
US6463328B1 (en) * 1996-02-02 2002-10-08 Michael Sasha John Adaptive brain stimulation method and system
US5713923A (en) 1996-05-13 1998-02-03 Medtronic, Inc. Techniques for treating epilepsy by brain stimulation and drug infusion
US5941906A (en) * 1997-10-15 1999-08-24 Medtronic, Inc. Implantable, modular tissue stimulator
US5938688A (en) * 1997-10-22 1999-08-17 Cornell Research Foundation, Inc. Deep brain stimulation method
US6459936B2 (en) 1997-10-27 2002-10-01 Neuropace, Inc. Methods for responsively treating neurological disorders
US6224549B1 (en) * 1999-04-20 2001-05-01 Nicolet Biomedical, Inc. Medical signal monitoring and display
US6539263B1 (en) * 1999-06-11 2003-03-25 Cornell Research Foundation, Inc. Feedback mechanism for deep brain stimulation
US6310880B1 (en) * 2000-03-17 2001-10-30 Silicon Aquarius, Inc. Content addressable memory cells and systems and devices using the same
US6466822B1 (en) 2000-04-05 2002-10-15 Neuropace, Inc. Multimodal neurostimulator and process of using it
US6401552B1 (en) * 2000-04-17 2002-06-11 Carlos D. Elkins Centrifuge tube and method for collecting and dispensing mixed concentrated fluid samples
US6591138B1 (en) * 2000-08-31 2003-07-08 Neuropace, Inc. Low frequency neurostimulator for the treatment of neurological disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6128538A (en) * 1997-10-27 2000-10-03 Neuropace, Inc. Means and method for the treatment of neurological disorders
US6018682A (en) * 1998-04-30 2000-01-25 Medtronic, Inc. Implantable seizure warning system

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HAO QU ET AL.: "A Patient-Specific Algorithm for the Detection of Seizure Onset in Long-Term EEG Monitoring: Possible USe as a Warning Device", IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, IEEE INC., vol. 44, no. 2, - 1 February 1997 (1997-02-01), New York, US, pages 115 - 122, XP000658735 *
LOPES DA SILVA F. H. ET AL.: "Dynamics of local neuronal networks: control parameters and state bifurcations in epileptogenesis", PROGRESS IN BRAIN RESEARCH, vol. 102, - 1994, Amsterdam, NL, pages 359 - 370, XP001090895 *
MARCOS VELASCO ET AL.: "Acute and Chronic Electrical Stimulation of the Centromedian Thalamic Nucleus: Modulation of Reticulo-Cortical Systems and Predictor Factors for Generalized Seizure Control", ELSEVIER, ARCHIVES OF MEDICAL RESEARCH, no. 31, 2000, USA, pages 304 - 315, XP002228561 *
OSORIO ET AL.: "Real-Time Automated Detection and Quantitative Analysis of Seizure and Short-Term Prediction of Clinical Onset", EPILEPSIA, vol. 39, no. 6, June 1998 (1998-06-01), USA, pages 615 - 627, XP001090899 *
WILSON C. L. ET AL: "Paired pulse suppression and facilitation in human epileptogenic hippocampal formation", EPILEPSY RESEARCH, vol. 31, no. 3, - August 1998 (1998-08-01), pages 211 - 230, XP002228562 *

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