WO2002068006A3 - Cross-linked ultra-high molecular weight polyethylene for use as medical implant - Google Patents

Cross-linked ultra-high molecular weight polyethylene for use as medical implant Download PDF

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Publication number
WO2002068006A3
WO2002068006A3 PCT/US2002/005511 US0205511W WO02068006A3 WO 2002068006 A3 WO2002068006 A3 WO 2002068006A3 US 0205511 W US0205511 W US 0205511W WO 02068006 A3 WO02068006 A3 WO 02068006A3
Authority
WO
WIPO (PCT)
Prior art keywords
molecular weight
weight polyethylene
cross
high molecular
medical implant
Prior art date
Application number
PCT/US2002/005511
Other languages
French (fr)
Other versions
WO2002068006A2 (en
Inventor
Marcus Lee Scott
Shilesh Chandrakant Jani
Original Assignee
Smith & Nephew Inc
Marcus Lee Scott
Shilesh Chandrakant Jani
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith & Nephew Inc, Marcus Lee Scott, Shilesh Chandrakant Jani filed Critical Smith & Nephew Inc
Priority to CA2439270A priority Critical patent/CA2439270C/en
Priority to AU2002245513A priority patent/AU2002245513B2/en
Priority to EP02713675A priority patent/EP1379288A2/en
Priority to KR1020037011069A priority patent/KR100913029B1/en
Priority to JP2002567369A priority patent/JP2004524900A/en
Priority to CN02808733.XA priority patent/CN1503682B/en
Publication of WO2002068006A2 publication Critical patent/WO2002068006A2/en
Publication of WO2002068006A3 publication Critical patent/WO2002068006A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/04—Homopolymers or copolymers of ethene
    • C08L23/06—Polyethene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2312/00—Crosslinking
    • C08L2312/06—Crosslinking by radiation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

The present invention relates to the prevention and decrease of osteolysis produced by wear of the ultrahigh molecular weight polyethylene (UHMWPE). Methods are disclosed for the isolation of wear particles, preparation of implants exhibiting decreased wear in comparison to conventional UHMWPE and preparation of implants that cause decreased biological response in comparison to conventional UHMWPE. The implants created by these methods are also included in the present invention.
PCT/US2002/005511 2001-02-23 2002-02-25 Cross-linked ultra-high molecular weight polyethylene for use as medical implant WO2002068006A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA2439270A CA2439270C (en) 2001-02-23 2002-02-25 Cross-linked ultra-high molecular weight polyethylene for use as medical implant
AU2002245513A AU2002245513B2 (en) 2001-02-23 2002-02-25 Cross-linked ultra-high molecular weight polyethylene for use as medical implant
EP02713675A EP1379288A2 (en) 2001-02-23 2002-02-25 Cross-linked ultra-high molecular weight polyethylene for use as medical implant
KR1020037011069A KR100913029B1 (en) 2001-02-23 2002-02-25 Cross?linked Ultra?high Molecular Weight Polyethylene for Medical Implant Use
JP2002567369A JP2004524900A (en) 2001-02-23 2002-02-25 Crosslinked ultra high molecular weight polyethylene used in medical implants
CN02808733.XA CN1503682B (en) 2001-02-23 2002-02-25 Cross-linked ultra-high molecular weight polyethylene for use as medical implant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/792,690 US6547828B2 (en) 2001-02-23 2001-02-23 Cross-linked ultra-high molecular weight polyethylene for medical implant use
US09/792,690 2001-02-23

Publications (2)

Publication Number Publication Date
WO2002068006A2 WO2002068006A2 (en) 2002-09-06
WO2002068006A3 true WO2002068006A3 (en) 2003-01-03

Family

ID=25157745

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/005511 WO2002068006A2 (en) 2001-02-23 2002-02-25 Cross-linked ultra-high molecular weight polyethylene for use as medical implant

Country Status (8)

Country Link
US (3) US6547828B2 (en)
EP (2) EP2272542A3 (en)
JP (2) JP2004524900A (en)
KR (2) KR101079923B1 (en)
CN (1) CN1503682B (en)
AU (1) AU2002245513B2 (en)
CA (1) CA2439270C (en)
WO (1) WO2002068006A2 (en)

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Also Published As

Publication number Publication date
CA2439270A1 (en) 2002-09-06
KR20090074832A (en) 2009-07-07
EP2272542A2 (en) 2011-01-12
CN1503682B (en) 2010-04-28
EP2272542A3 (en) 2016-07-27
JP5301417B2 (en) 2013-09-25
US6709464B2 (en) 2004-03-23
US6726727B2 (en) 2004-04-27
WO2002068006A2 (en) 2002-09-06
JP2004524900A (en) 2004-08-19
US6547828B2 (en) 2003-04-15
US20020161438A1 (en) 2002-10-31
EP1379288A2 (en) 2004-01-14
CN1503682A (en) 2004-06-09
AU2002245513B2 (en) 2007-05-31
KR101079923B1 (en) 2011-11-04
US20030130743A1 (en) 2003-07-10
KR20030080025A (en) 2003-10-10
US20030127778A1 (en) 2003-07-10
CA2439270C (en) 2015-02-03
KR100913029B1 (en) 2009-08-20
JP2010088908A (en) 2010-04-22

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