WO2002062400A1 - Prion disinfection - Google Patents
Prion disinfection Download PDFInfo
- Publication number
- WO2002062400A1 WO2002062400A1 PCT/AU2002/000092 AU0200092W WO02062400A1 WO 2002062400 A1 WO2002062400 A1 WO 2002062400A1 AU 0200092 W AU0200092 W AU 0200092W WO 02062400 A1 WO02062400 A1 WO 02062400A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ofthe
- agents
- molecular weight
- cleavage
- protein
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/12—Microwaves
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/50—Isolated enzymes; Isolated proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/025—Ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/085—Infrared radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/24—Medical instruments, e.g. endoscopes, catheters, sharps
Definitions
- This invention relates to compositions and methods for inactivating prions and to means
- infectious agents such as bacteria, fungi, parasites, and viroids have well
- Prions are infectious particles that differ from bacteria and other previously known
- human diseases attributed to prions include Kuru,
- CJD Creutzfeldt- Jakob disease
- GSS Gerstmarm-Straussler-Scheinker disease
- Fatal
- disorders of animals are included in the group of
- BSE bovine spongiform encephalopathy
- Groups possibly at risk of infection include patients who may come into contact with infected medical instruments during surgery, medical staff dissecting infected material, and
- a protein which can be the soluble, non-disease, cellular form PrP c or can be an
- PrP c form is
- PrP Sc useful in diagnosing the infective altered conformational form are a protease resistant core of 27 -
- US5633349 describes a procedure for treating a biological material involving
- PCT/USOO/14353 describes a method of rendering prions non-infectious by use of a
- the protein can exist in an intermediate form which has a ⁇ -sheet content
- insoluble proteins is thought to be causative of, or implicated in, a variety of other diseases.
- An object ofthe invention is to provide improved, or at least alternative, means of
- prion protein as herein used includes variants, fragments, fusions, and
- PrP Sc prion protein is intended to have a similarly broad meaning but is limited to prion proteins which by virtue
- the invention provides a method comprising the steps of treating
- the invention provides a method according to the first aspect
- agent is herein used to include both chemical reagents for example anionic
- the invention provides a method according to the first or second
- said one or more agents selected to favour conformational unfolding includes one or more agents selected from the group consisting of irradiation, electric field,
- agents is employed, for example the agents of step (2) include an anionic surfactant in
- the prion is subjected to sound waves in the ultrasonic range during the
- energetic input may include from
- the invention extends to include compositions for use in
- a contaminated surface for example a surgical instrument contaminated with a PrP Sc protein
- the invention involves the conception that it is possible to select one or more
- PrP Sc protein sufficiently for an enzyme to gain access and cleave PrP Sc protein.
- the denaturation includes
- PrP Sc protein on the other hand is highly resistant to unfolding. It has hitherto been considered impossible to formulate a system in
- the unfolding agent selectively and sufficiently unfolds the prion to provide access to the enzyme for prion scission.
- the surface may be first treated with the one or more agents and the one or more enzymes
- the enzyme is preferably a proteolytic enzyme. Suitable enzymes are:
- non-specific proteinases e.g. serine-, aspartic-, metalloproteinases
- the one or more agents selected to favour conformational unfolding ofthe prion protein are chosen to be effective to provider access by the enzyme to the prion protein.
- the folding-unfolding of a polypeptide chain may be a thermodynamically
- agents which promote unfolding include: -
- DMSO dimethylsulphoxide
- Anionic detergents are very strong denaturants. E.g. Sodium dodecyl
- SDS sulfate
- Dodecyl benzene sulfonate is also a denaturant.
- Cationic surfactants are usually less effective
- albumin decreases with increasing ethoxy groups and disappears for ethoxy greater
- Inorganic salts can induce conformational transitions in proteins.
- LiBr LiBr
- the residual ordered structure may be
- agents which cause scission ofthe S - S bond such as thioglycols
- protons to the action of electric and /or magnetic fields may be able to promote unfolding
- a combination of agents is used for example a surfactant
- vibration may be induced by other forms of electromechanical radiation or energetic
- energetic input may include from electron beam irradiation, laser, or electrolysis.
- the unfolding agent must be combined with a folding agent.
- Suitable folding agents include (1) Nucleophillic solvents and highly hydrogen bonded organic solvents. There is competition between the energy of the peptide hydrogen bonds and the strength of
- Solvents such as dioxan, acetonitrile, dimethylformamide, pyridine, and, at low
- DMSO dimethylsulphoxide
- Stabilizing solvents such as polyhydric alcohols (e.g. glycerol, ethylene glycol, and
- Non-ionic surfactants such as alkyl, phenyl or alkyl ethoxylates, propoxylates or
- sarcosinate do not alter the tertiary structure of protein and any unfolding occurs in the
- buffers e.g. phosphates, acetates, citrates, borates
- Bovine albumin with high globulin content (Sigma product A7906), beta-galactosidase
- the "Prionics-Check” is an immunological test for the detection of prions in animal tissues
- reaction mixture is bound by the antibody and detected using an enzyme coupled to the
- microgram of recombinant prion protein and the Prionics Check was performed as per the
- 1-1 differs from 1-2 by inclusion of an unfolding agent (3% DOBS ) shown to be effective
- 2-2 and 3-2 differ from 2-1 and 3-1 respectively by inclusion of sonication.
- 4-2 differs from 4-1 by the combination of borax with SDS at a more elevated temperature.
- 5-2 differs from 5-1 by combining DOBS with Triton X-100 in the absence of boron
- 6-2 differs from 6-1 by increasing the concentration of DMSO from reversibly unfolding
- DOBS dodecyl benzene sulfonic acid (Sigma Product No. D2525)
- DMSO dimethylsulfoxide (Sigma Product No. D5879)
- the small proteins migrate faster than the large proteins. After a period of time the smallest
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Detergent Compositions (AREA)
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020037010430A KR100927494B1 (en) | 2001-02-07 | 2002-01-31 | Prion disinfection method |
AT02709900T ATE520424T1 (en) | 2001-02-07 | 2002-01-31 | PRION DISINFECTION |
AU2002227785A AU2002227785B2 (en) | 2001-02-07 | 2002-01-31 | Prion disinfection |
CN02805928XA CN1494438B (en) | 2001-02-07 | 2002-01-31 | Prion disinfection |
EP02709900A EP1370303B1 (en) | 2001-02-07 | 2002-01-31 | Prion disinfection |
US10/467,591 US9480761B2 (en) | 2001-02-07 | 2002-01-31 | Prion disinfection |
JP2002562405A JP4638655B2 (en) | 2001-02-07 | 2002-01-31 | Method for inactivating prions and compositions used therefor |
NZ527860A NZ527860A (en) | 2001-02-07 | 2002-01-31 | Prion disinfection |
BRPI0207305A BRPI0207305B8 (en) | 2001-02-07 | 2002-01-31 | non-therapeutic disinfection method and composition for treating a surface contaminated with a prion prpsc protein or a substitute thereof. |
CA2437566A CA2437566C (en) | 2001-02-07 | 2002-01-31 | Prion disinfection |
US12/965,697 US20110086414A1 (en) | 2001-02-07 | 2010-12-10 | Prion Disinfection |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPR2938 | 2001-02-07 | ||
AUPR2938A AUPR293801A0 (en) | 2001-02-07 | 2001-02-07 | Prion disinfection |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/965,697 Division US20110086414A1 (en) | 2001-02-07 | 2010-12-10 | Prion Disinfection |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002062400A1 true WO2002062400A1 (en) | 2002-08-15 |
Family
ID=3826963
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/AU2002/000092 WO2002062400A1 (en) | 2001-02-07 | 2002-01-31 | Prion disinfection |
Country Status (15)
Country | Link |
---|---|
US (2) | US9480761B2 (en) |
EP (2) | EP1370303B1 (en) |
JP (2) | JP4638655B2 (en) |
KR (1) | KR100927494B1 (en) |
CN (1) | CN1494438B (en) |
AR (1) | AR032548A1 (en) |
AT (1) | ATE520424T1 (en) |
AU (2) | AUPR293801A0 (en) |
BR (1) | BRPI0207305B8 (en) |
CA (1) | CA2437566C (en) |
ES (1) | ES2370164T3 (en) |
MY (1) | MY128229A (en) |
NZ (1) | NZ527860A (en) |
TW (2) | TWI337620B (en) |
WO (1) | WO2002062400A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2394663A (en) * | 2002-11-01 | 2004-05-05 | Medical Res Council | Prion decontamination |
WO2008120140A1 (en) * | 2007-04-03 | 2008-10-09 | Kimberly-Clark Worldwide, Inc. | Use of sonication to eliminate prions |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPR293801A0 (en) * | 2001-02-07 | 2001-03-01 | Novapharm Research (Australia) Pty Ltd | Prion disinfection |
US20050032913A1 (en) * | 2003-08-08 | 2005-02-10 | Steris Inc. | Decontamination of prion-contaminated surfaces with phenols |
US8034766B2 (en) * | 2006-10-27 | 2011-10-11 | E I Du Pont De Nemours And Company | Compositions and methods for prion decontamination |
US20080131500A1 (en) * | 2006-12-04 | 2008-06-05 | The Board Of Regents Of The University Of Texas System | Methods and compositions for rapid inactivation of proteins |
US8293174B2 (en) | 2007-10-17 | 2012-10-23 | American Sterilizer Company | Prion deactivating composition and methods of using same |
CN106488976A (en) | 2014-05-02 | 2017-03-08 | 凯斯医疗有限公司 | For processing compositionss and the method for potential prion pollutant |
US10246731B2 (en) | 2016-03-29 | 2019-04-02 | Oneighty°C Technologies Corporation | Method for rapidly determining effective sterilization , deimmunization, and/or disinfection |
KR101907155B1 (en) * | 2016-12-29 | 2018-10-11 | 호남대학교 산학협력단 | robot for tree climbing |
CN111420813B (en) * | 2020-04-06 | 2022-01-28 | 四川大学华西医院 | PRP centrifugal sleeve, PRP centrifugal machine and PRP preparation method |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0358500A1 (en) * | 1988-09-08 | 1990-03-14 | The Public Health Laboratory Service Board | Method and composition for the treatment and prevention of viral infections |
EP0742018A2 (en) * | 1995-05-01 | 1996-11-13 | Collagen Corporation | Prion inactivation in connective tissue materials |
WO1999042829A1 (en) * | 1998-02-20 | 1999-08-26 | The Regents Of The University Of California | Assay for specific strains of multiple disease related conformations of a protein |
WO1999051279A1 (en) * | 1998-04-01 | 1999-10-14 | Nokuta Pty. Ltd. | A method for treating contaminated products and articles |
Family Cites Families (13)
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US3573170A (en) * | 1968-09-19 | 1971-03-30 | Monsanto Co | Enzyme products |
US4481190A (en) * | 1982-12-21 | 1984-11-06 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists |
US4456544A (en) * | 1983-08-05 | 1984-06-26 | Vsesojuzny Nauchno-Issledovatelsky Biotecknichesky Institut | Enzyme-containing detergent composition for presterilization treatment of medical instruments and equipment |
GB8726999D0 (en) * | 1987-11-18 | 1987-12-23 | Unilever Plc | Enzymatic liquid detergent composition |
AT408191B (en) | 1991-08-19 | 2001-09-25 | Haemosan Erzeugung Pharmazeuti | METHOD FOR INACTIVATING PRIONS |
US5527487A (en) * | 1991-11-27 | 1996-06-18 | Novo Nordisk A/S | Enzymatic detergent composition and method for enzyme stabilization |
CN1170035A (en) * | 1996-06-21 | 1998-01-14 | 董巨川 | Bactericidal whitening detergent and preparation method |
US6322802B1 (en) * | 1999-06-01 | 2001-11-27 | The Regents Of The University Of California | Method of sterilizing |
US6210639B1 (en) * | 1998-10-26 | 2001-04-03 | Novartis Ag | Apparatus, method and composition for cleaning and disinfecting |
CN1279954A (en) | 2000-07-03 | 2001-01-17 | 丛繁滋 | Arsenic composite preparation suitable for cancer arterial insertion administration and its preparing method |
US7303907B2 (en) | 2001-01-08 | 2007-12-04 | Health Protection Agency | Degradation and detection of TSE infectivity |
PT1360282E (en) * | 2001-01-08 | 2005-06-30 | Health Prot Agency | METHOD OF INACTIVATION OF TSE |
AUPR293801A0 (en) * | 2001-02-07 | 2001-03-01 | Novapharm Research (Australia) Pty Ltd | Prion disinfection |
-
2001
- 2001-02-07 AU AUPR2938A patent/AUPR293801A0/en not_active Abandoned
-
2002
- 2002-01-31 JP JP2002562405A patent/JP4638655B2/en not_active Expired - Lifetime
- 2002-01-31 CA CA2437566A patent/CA2437566C/en not_active Expired - Lifetime
- 2002-01-31 BR BRPI0207305A patent/BRPI0207305B8/en not_active IP Right Cessation
- 2002-01-31 ES ES02709900T patent/ES2370164T3/en not_active Expired - Lifetime
- 2002-01-31 AU AU2002227785A patent/AU2002227785B2/en not_active Expired
- 2002-01-31 US US10/467,591 patent/US9480761B2/en active Active
- 2002-01-31 AT AT02709900T patent/ATE520424T1/en active
- 2002-01-31 CN CN02805928XA patent/CN1494438B/en not_active Expired - Lifetime
- 2002-01-31 KR KR1020037010430A patent/KR100927494B1/en active IP Right Grant
- 2002-01-31 EP EP02709900A patent/EP1370303B1/en not_active Expired - Lifetime
- 2002-01-31 NZ NZ527860A patent/NZ527860A/en unknown
- 2002-01-31 WO PCT/AU2002/000092 patent/WO2002062400A1/en active IP Right Grant
- 2002-01-31 EP EP10152838A patent/EP2206522A1/en not_active Withdrawn
- 2002-02-06 TW TW091102113A patent/TWI337620B/en not_active IP Right Cessation
- 2002-02-06 TW TW099134731A patent/TW201105792A/en unknown
- 2002-02-06 AR ARP020100390A patent/AR032548A1/en active IP Right Grant
- 2002-02-06 MY MYPI20020405A patent/MY128229A/en unknown
-
2010
- 2010-06-02 JP JP2010126859A patent/JP2011000432A/en active Pending
- 2010-12-10 US US12/965,697 patent/US20110086414A1/en not_active Abandoned
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EP0358500A1 (en) * | 1988-09-08 | 1990-03-14 | The Public Health Laboratory Service Board | Method and composition for the treatment and prevention of viral infections |
EP0742018A2 (en) * | 1995-05-01 | 1996-11-13 | Collagen Corporation | Prion inactivation in connective tissue materials |
WO1999042829A1 (en) * | 1998-02-20 | 1999-08-26 | The Regents Of The University Of California | Assay for specific strains of multiple disease related conformations of a protein |
WO1999051279A1 (en) * | 1998-04-01 | 1999-10-14 | Nokuta Pty. Ltd. | A method for treating contaminated products and articles |
Non-Patent Citations (4)
Title |
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BOLTON D.C. ET AL: "Molecular characteristics of the major srapie prion protein", BIOCHEMISTRY, vol. 23, 1984, pages 5898 - 5906, XP002961644 * |
DIENER T.O. ET AL: "Viroids and prions", PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 5220 - 5224, XP002971773 * |
KOCISKO D.A. ET AL: "Partial unfolding and refolding of scrapie-associated prion protein: evidence for a critical 16-kDa C-terminal domain", BIOCHEMISTRY, vol. 35, 1996, pages 13434 - 13442, XP002150538 * |
RIESNER D. ET AL: "Disruption of prion rods generates 10-nm spherical particles having high alpha-helical content and lacking scrapie infectivity", JOURNAL OF VIROLOGY, vol. 70, no. 3, 1996, pages 1714 - 1722, XP002971239 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2394663A (en) * | 2002-11-01 | 2004-05-05 | Medical Res Council | Prion decontamination |
GB2394663B (en) * | 2002-11-01 | 2006-07-12 | Medical Res Council | Prion decontamination |
WO2008120140A1 (en) * | 2007-04-03 | 2008-10-09 | Kimberly-Clark Worldwide, Inc. | Use of sonication to eliminate prions |
US7922970B2 (en) | 2007-04-03 | 2011-04-12 | Kimberly-Clark Worldwide, Inc. | Use of sonication to eliminate prions |
Also Published As
Publication number | Publication date |
---|---|
CA2437566A1 (en) | 2002-08-15 |
CN1494438B (en) | 2010-05-05 |
BR0207305B1 (en) | 2014-09-16 |
JP2004533994A (en) | 2004-11-11 |
BRPI0207305B8 (en) | 2021-06-22 |
AUPR293801A0 (en) | 2001-03-01 |
EP1370303B1 (en) | 2011-08-17 |
CN1494438A (en) | 2004-05-05 |
ATE520424T1 (en) | 2011-09-15 |
US20110086414A1 (en) | 2011-04-14 |
EP2206522A1 (en) | 2010-07-14 |
AU2002227785B2 (en) | 2006-12-21 |
JP4638655B2 (en) | 2011-02-23 |
AR032548A1 (en) | 2003-11-12 |
JP2011000432A (en) | 2011-01-06 |
TW201105792A (en) | 2011-02-16 |
TWI337620B (en) | 2011-02-21 |
CA2437566C (en) | 2013-10-22 |
EP1370303A1 (en) | 2003-12-17 |
NZ527860A (en) | 2005-01-28 |
KR20030077610A (en) | 2003-10-01 |
MY128229A (en) | 2007-01-31 |
BR0207305A (en) | 2004-02-10 |
ES2370164T3 (en) | 2011-12-13 |
KR100927494B1 (en) | 2009-11-17 |
EP1370303A4 (en) | 2004-03-31 |
US20040106188A1 (en) | 2004-06-03 |
US9480761B2 (en) | 2016-11-01 |
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