WO2002058681A3 - Utilisation d'une rhéine pour la préparation d'un médicament pour le traitement d'un taux élevé d'il-1. - Google Patents

Utilisation d'une rhéine pour la préparation d'un médicament pour le traitement d'un taux élevé d'il-1. Download PDF

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Publication number
WO2002058681A3
WO2002058681A3 PCT/FR2002/000271 FR0200271W WO02058681A3 WO 2002058681 A3 WO2002058681 A3 WO 2002058681A3 FR 0200271 W FR0200271 W FR 0200271W WO 02058681 A3 WO02058681 A3 WO 02058681A3
Authority
WO
WIPO (PCT)
Prior art keywords
rhein
treating
medicine
preparing
high level
Prior art date
Application number
PCT/FR2002/000271
Other languages
English (en)
Other versions
WO2002058681A2 (fr
WO2002058681A8 (fr
Inventor
Suzy Charbit
Francois Schutze
Alain Taccoen
Jean-Pierre Pelletier
Diego Provvedini
Original Assignee
Negma Lerads
Suzy Charbit
Francois Schutze
Alain Taccoen
Jean-Pierre Pelletier
Diego Provvedini
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Negma Lerads, Suzy Charbit, Francois Schutze, Alain Taccoen, Jean-Pierre Pelletier, Diego Provvedini filed Critical Negma Lerads
Priority to EP02712018A priority Critical patent/EP1363613A2/fr
Priority to MXPA03006596A priority patent/MXPA03006596A/es
Priority to IL15695702A priority patent/IL156957A0/xx
Priority to CA002434052A priority patent/CA2434052A1/fr
Priority to AU2002231927A priority patent/AU2002231927A1/en
Publication of WO2002058681A2 publication Critical patent/WO2002058681A2/fr
Publication of WO2002058681A3 publication Critical patent/WO2002058681A3/fr
Publication of WO2002058681A8 publication Critical patent/WO2002058681A8/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne l'utilisation de la rhéine et de dérivés de rhéine en thérapeutique.La rhéine et des dérivés de rhéine sont utilisés en thérapeutique humaine ou vétérinaire pour le traitement de patients souffrant de maladies inflammatoires et auto-immunes dans lesquelles les cytokines inflammatoires (IL-1 et TNF) sont présentes ô des teneurs anormalement élevées.
PCT/FR2002/000271 2001-01-23 2002-01-23 Utilisation d'une rhéine pour la préparation d'un médicament pour le traitement d'un taux élevé d'il-1. WO2002058681A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP02712018A EP1363613A2 (fr) 2001-01-23 2002-01-23 Utilisation d'une rheine pour la preparation d'un medicament pour le traitement d'un taux eleve d'il-1.
MXPA03006596A MXPA03006596A (es) 2001-01-23 2002-01-23 Uso de una reina para preparacion de un medicamento para el tratamiento de un nivel elevado de il-1.
IL15695702A IL156957A0 (en) 2001-01-23 2002-01-23 Use of rhein for preparing a medicine for treating a high level of il-1
CA002434052A CA2434052A1 (fr) 2001-01-23 2002-01-23 Utilisation d'une rheine pour la preparation d'un medicament pour le traitement d'un taux eleve d'il-1
AU2002231927A AU2002231927A1 (en) 2001-01-23 2002-01-23 Use of rhein for preparing a medicine for treating a high level of il-1

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/768,816 US20020128317A1 (en) 2001-01-23 2001-01-23 Treatment of pathological conditions characterized by an increased IL-1 level
US09/768,816 2001-01-23

Publications (3)

Publication Number Publication Date
WO2002058681A2 WO2002058681A2 (fr) 2002-08-01
WO2002058681A3 true WO2002058681A3 (fr) 2002-12-19
WO2002058681A8 WO2002058681A8 (fr) 2003-03-06

Family

ID=25083563

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2002/000271 WO2002058681A2 (fr) 2001-01-23 2002-01-23 Utilisation d'une rhéine pour la préparation d'un médicament pour le traitement d'un taux élevé d'il-1.

Country Status (7)

Country Link
US (1) US20020128317A1 (fr)
EP (1) EP1363613A2 (fr)
AU (1) AU2002231927A1 (fr)
CA (1) CA2434052A1 (fr)
IL (1) IL156957A0 (fr)
MX (1) MXPA03006596A (fr)
WO (1) WO2002058681A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6797727B2 (en) 2001-07-16 2004-09-28 Transition Therapeutics Inc. Use of rhein or diacerhein compounds for the treatment or prevention of vascular diseases
FR2842738B1 (fr) * 2002-07-23 2006-02-10 Negma Lerads Utilisation d'une rheine pour la preparation d'un medicament pour le traitement de l'inflammation chronique, la prevention et le traitement du rejet des transplantations d'organes et de tissus
CN1314361C (zh) * 2003-04-02 2007-05-09 李安虎 一种关节保健饮品或食品及其制备方法
MXPA04009698A (es) * 2004-10-04 2006-04-05 Maria Elena Garcia Armenta Formulaciones farmaceuticas solidas conteniendo diacereina y meloxicam.
WO2009034409A2 (fr) * 2007-09-14 2009-03-19 Wockhardt Research Centre Compositions pharmaceutiques de rheine ou de diacereine
FR2920991A1 (fr) * 2007-09-14 2009-03-20 Wockhardt Ltd Composition a base de diacerheine pour le traitement de l'arthrose
EP2060562A1 (fr) * 2007-11-16 2009-05-20 Laboratoire Medidom S.A. Dérivés de sulfonate de dioxoanthracène
US9119819B2 (en) * 2008-04-30 2015-09-01 Wockhardt Ltd. Oral liquid compositions of rhein or diacerein
EP3337782A4 (fr) * 2015-08-17 2019-04-03 TWI Biotechnology, Inc. Diacéréine ou ses analogues pour inhibition de l'expression des protéines asc et nlrp3, et/ou de la formation du complexe de l'inflammasome nlrp3
TW201739448A (zh) * 2016-05-06 2017-11-16 安成生物科技股份有限公司 用於治療及/或預防血液相關疾病之方法及配方
BR112019014761A2 (pt) * 2017-01-18 2020-03-03 Tairx, Inc. Composições para uso no tratamento de doenças inflamatórias do intestino e da colite intestinal

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0698594A1 (fr) * 1994-08-24 1996-02-28 Lilly Industries Limited Dérivés pharmaceutiques d'anthraquinone
EP0822178A1 (fr) * 1996-07-31 1998-02-04 Laboratoire Medidom S.A. Dérivés de la rhéine et procédés pour produire des dérivés de la rhéine
JPH10114650A (ja) * 1996-10-15 1998-05-06 Dokutaazu Kosumeteikusu:Kk 津液改善剤及びそれを含有する経口投与用組成物
JPH10120556A (ja) * 1996-10-18 1998-05-12 Dokutaazu Kosumeteikusu:Kk 津液改善用皮膚外用剤
US5952383A (en) * 1996-07-04 1999-09-14 Negma-Steba International Development N.V. Pharmaceutical composition for oral delivery
US6124358A (en) * 1996-12-23 2000-09-26 Mazal Pharmaceutique (Sarl) Pharmaceutical composition containing rhein or diacerhein with improved bioavailability
WO2001051044A2 (fr) * 2000-01-12 2001-07-19 Laboratoire Medidom S.A. Substances utilisees dans le traitement du psoriasis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA761627B (en) * 1976-03-16 1978-01-25 C Friedmann Improvements in or relating to the treatment of arthritis
IT1283772B1 (it) * 1996-07-31 1998-04-30 Medidom Lab Procedimento per la preparazione di reina e diacereina

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0698594A1 (fr) * 1994-08-24 1996-02-28 Lilly Industries Limited Dérivés pharmaceutiques d'anthraquinone
US5952383A (en) * 1996-07-04 1999-09-14 Negma-Steba International Development N.V. Pharmaceutical composition for oral delivery
EP0822178A1 (fr) * 1996-07-31 1998-02-04 Laboratoire Medidom S.A. Dérivés de la rhéine et procédés pour produire des dérivés de la rhéine
JPH10114650A (ja) * 1996-10-15 1998-05-06 Dokutaazu Kosumeteikusu:Kk 津液改善剤及びそれを含有する経口投与用組成物
JPH10120556A (ja) * 1996-10-18 1998-05-12 Dokutaazu Kosumeteikusu:Kk 津液改善用皮膚外用剤
US6124358A (en) * 1996-12-23 2000-09-26 Mazal Pharmaceutique (Sarl) Pharmaceutical composition containing rhein or diacerhein with improved bioavailability
WO2001051044A2 (fr) * 2000-01-12 2001-07-19 Laboratoire Medidom S.A. Substances utilisees dans le traitement du psoriasis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 1998, no. 10 31 August 1998 (1998-08-31) *

Also Published As

Publication number Publication date
WO2002058681A2 (fr) 2002-08-01
EP1363613A2 (fr) 2003-11-26
IL156957A0 (en) 2004-02-08
MXPA03006596A (es) 2004-05-05
CA2434052A1 (fr) 2002-08-01
AU2002231927A1 (en) 2002-08-06
US20020128317A1 (en) 2002-09-12
WO2002058681A8 (fr) 2003-03-06

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