WO2002058667A3 - Improved process for the production of sustained release drug delivery devices - Google Patents

Improved process for the production of sustained release drug delivery devices Download PDF

Info

Publication number
WO2002058667A3
WO2002058667A3 PCT/US2002/002119 US0202119W WO02058667A3 WO 2002058667 A3 WO2002058667 A3 WO 2002058667A3 US 0202119 W US0202119 W US 0202119W WO 02058667 A3 WO02058667 A3 WO 02058667A3
Authority
WO
WIPO (PCT)
Prior art keywords
coating layer
sustained release
suture tab
release drug
production
Prior art date
Application number
PCT/US2002/002119
Other languages
French (fr)
Other versions
WO2002058667A2 (en
Inventor
Michael J Brubaker
Pavlos Papadopoulos
Ramesh Krishnamoorthy
Original Assignee
Bausch & Lomb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bausch & Lomb filed Critical Bausch & Lomb
Priority to EP02703234A priority Critical patent/EP1365738A2/en
Priority to JP2002559001A priority patent/JP2004520900A/en
Priority to CA002433528A priority patent/CA2433528A1/en
Publication of WO2002058667A2 publication Critical patent/WO2002058667A2/en
Publication of WO2002058667A3 publication Critical patent/WO2002058667A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

Disclosed is an improved sustained release drug delivers device and method of producing such device. The device comprises a drug core in an impermeable cup or impermeable coating layer that is adhered to an uncured suture tab and covered with a permeable polmer coating layer that is similar to the makeup of the suture tab. The permeable polmer coating layer that covers the device, covering the impermeable coating layer and at least a portion of the drug core, is cured (after drying) along witht he uncured suture tab. The 'cocuring' or one step curing process forms a very strong bond between the outer coating layer to the suture tab preventing leaks.
PCT/US2002/002119 2001-01-26 2002-01-23 Improved process for the production of sustained release drug delivery devices WO2002058667A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP02703234A EP1365738A2 (en) 2001-01-26 2002-01-23 Improved process for the production of sustained release drug delivery devices
JP2002559001A JP2004520900A (en) 2001-01-26 2002-01-23 Improved manufacturing method of sustained release drug delivery device
CA002433528A CA2433528A1 (en) 2001-01-26 2002-01-23 Improved process for the production of sustained release drug delivery devices

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26444101P 2001-01-26 2001-01-26
US60/264,441 2001-01-26

Publications (2)

Publication Number Publication Date
WO2002058667A2 WO2002058667A2 (en) 2002-08-01
WO2002058667A3 true WO2002058667A3 (en) 2003-03-13

Family

ID=23006089

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/002119 WO2002058667A2 (en) 2001-01-26 2002-01-23 Improved process for the production of sustained release drug delivery devices

Country Status (5)

Country Link
US (2) US6991808B2 (en)
EP (1) EP1365738A2 (en)
JP (1) JP2004520900A (en)
CA (1) CA2433528A1 (en)
WO (1) WO2002058667A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9463114B2 (en) 2004-04-15 2016-10-11 Mati Therapeutics Inc. Punctal plug with active agent

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7943162B2 (en) 1999-10-21 2011-05-17 Alcon, Inc. Drug delivery device
JP2004520900A (en) * 2001-01-26 2004-07-15 ボシュ・アンド・ロム・インコーポレイテッド Improved manufacturing method of sustained release drug delivery device
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
WO2002100318A2 (en) 2001-06-12 2002-12-19 Johns Hopkins University School Of Medicine Reservoir device for intraocular drug delivery
US7838026B2 (en) 2001-09-28 2010-11-23 Mcneil-Ppc, Inc. Burst-release polymer composition and dosage forms comprising the same
US7122143B2 (en) * 2001-09-28 2006-10-17 Mcneil-Ppc, Inc. Methods for manufacturing dosage forms
US20060034929A1 (en) * 2001-12-27 2006-02-16 Brubaker Michael J Sustained release drug delivery devices with prefabricated permeable plugs
US20050143363A1 (en) * 2002-09-29 2005-06-30 Innorx, Inc. Method for subretinal administration of therapeutics including steroids; method for localizing pharmacodynamic action at the choroid of the retina; and related methods for treatment and/or prevention of retinal diseases
US20050261668A1 (en) * 2003-03-28 2005-11-24 Bausch & Lomb Incorporated Drug delivery device
US7037521B2 (en) * 2003-03-28 2006-05-02 Bausch & Lomb Incorporated Using a laser for cutting a hole in a capsule for controlled drug delivery
US20040265356A1 (en) * 2003-06-30 2004-12-30 Bausch & Lomb Incorporated Drug delivery device
US20050054586A1 (en) * 2003-06-30 2005-03-10 Bartels Stephen P. Treatment of ophthalmic disorders
US20050136095A1 (en) * 2003-12-22 2005-06-23 Brian Levy Drug delivery device with suture ring
US20050137538A1 (en) 2003-12-22 2005-06-23 Bausch & Lomb Incorporated Drug delivery device
US20050158365A1 (en) * 2003-12-22 2005-07-21 David Watson Drug delivery device with mechanical locking mechanism
US7211272B2 (en) * 2003-12-22 2007-05-01 Bausch & Lomb Incorporated Drug delivery device
US20060018949A1 (en) * 2004-04-07 2006-01-26 Bausch & Lomb Incorporated Injectable biodegradable drug delivery system
EP1761283A2 (en) * 2004-06-07 2007-03-14 California Institute Of Technology Biodegradable drug-polymer delivery system
WO2006004795A2 (en) 2004-06-25 2006-01-12 The Johns Hopkins University Angiogenesis inhibitors
EP1765454B1 (en) 2004-07-02 2016-04-13 Mati Therapeutics Inc. Treatment medium delivery device for the eye
US20060067978A1 (en) * 2004-09-29 2006-03-30 Bausch & Lomb Incorporated Process for preparing poly(vinyl alcohol) drug delivery devices
US20060068012A1 (en) * 2004-09-29 2006-03-30 Bausch & Lomb Incorporated Process for preparing poly (vinyl alcohol) drug delivery devices with humidity control
WO2006039459A1 (en) * 2004-09-30 2006-04-13 Bausch & Lomb Incorporated Capsule for encasing tablets for surgical insertion into the human body
WO2006039333A1 (en) * 2004-09-30 2006-04-13 Bausch & Lomb Incorporated Ophthalmic drug release device for multiple drug release
US20060078592A1 (en) * 2004-10-12 2006-04-13 Bausch & Lomb Incorporated Drug delivery systems
US20070276481A1 (en) * 2004-12-08 2007-11-29 Renner Steven B Drug delivery device
US20060134162A1 (en) * 2004-12-16 2006-06-22 Larson Christopher W Methods for fabricating a drug delivery device
US20060134175A1 (en) * 2004-12-22 2006-06-22 Stephen Bartels Drug eluting pharmaceutical delivery system for treatment of ocular disease and method of use
WO2006068898A1 (en) * 2004-12-22 2006-06-29 Bausch & Lomb Incorporated Reusable drug delivery device
US20060134174A1 (en) * 2004-12-22 2006-06-22 Bausch & Lomb Incorporated Pharmaceutical delivery system and method of use
US20060292202A1 (en) * 2005-06-27 2006-12-28 Bausch & Lomb Incorporated Drug delivery device
ATE543914T1 (en) * 2005-09-01 2012-02-15 Bristol Myers Squibb Co BIOMARRKERS AND METHODS FOR DETERMINING SENSITIVITY TO VEGFR2 MODULATOR.
KR101062796B1 (en) 2006-03-31 2011-09-06 큐엘티 인코포레이티드 Nasal Tube Drain System Implants for Drug Therapy
CN101861135A (en) 2007-09-07 2010-10-13 Qlt栓塞输送公司 Lacrimal implant detection
ES2533359T3 (en) * 2007-09-07 2015-04-09 Mati Therapeutics Inc. Drug cores for sustained release of therapeutic agents
CN102670352A (en) * 2007-09-07 2012-09-19 Qlt股份有限公司 Insertion and extraction tools for lacrimal implants
DK2865361T3 (en) * 2007-09-07 2019-07-08 Mati Therapeutics Inc TEA REPLACEMENTS AND RELATED PROCEDURES
US9775882B2 (en) * 2007-09-20 2017-10-03 Medtronic, Inc. Medical devices and methods including polymers having biologically active agents therein
RU2010136822A (en) * 2008-02-18 2012-03-10 Клт Плаг Диливери, Инк. (Us) LACRIMAL IMPLANTS AND RELATED WAYS
JP5552482B2 (en) 2008-04-30 2014-07-16 キュー エル ティー インク． Composite lacrimal insert and related methods
AU2009244804A1 (en) 2008-05-09 2009-11-12 Qlt Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
CN102365109B (en) 2009-01-29 2015-06-03 弗赛特影像4股份有限公司 Posterior segment drug delivery
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
CA2977078C (en) 2009-02-23 2021-07-20 Mati Therapeutics, Inc. Lacrimal implants and related methods
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
WO2010141729A1 (en) 2009-06-03 2010-12-09 Forsight Labs, Llc Anterior segment drug delivery
WO2013022801A1 (en) 2011-08-05 2013-02-14 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
HUE057267T2 (en) 2010-08-05 2022-05-28 Forsight Vision4 Inc Apparatus to treat an eye
JP6063382B2 (en) 2010-08-05 2017-01-18 フォーサイト・ビジョン フォー・インコーポレーテッド System for injecting therapeutic agents into the implant of the eye
WO2012019139A1 (en) 2010-08-05 2012-02-09 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
AU2011329656B2 (en) 2010-11-19 2017-01-05 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
WO2013003620A2 (en) 2011-06-28 2013-01-03 Forsight Vision4, Inc. Diagnostic methods and apparatus
CA2846384C (en) 2011-08-29 2020-12-15 Qlt Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
US9974685B2 (en) 2011-08-29 2018-05-22 Mati Therapeutics Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
WO2013040238A2 (en) * 2011-09-13 2013-03-21 Vista Scientific Llc Sustained release ocular drug delivery devices and methods of manufacture
KR102071083B1 (en) 2011-09-14 2020-01-29 포사이트 비젼5, 인크. Ocular insert apparatus and methods
PT2755600T (en) 2011-09-16 2021-04-19 Forsight Vision4 Inc Fluid exchange apparatus and methods
WO2013116061A1 (en) 2012-02-03 2013-08-08 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
US9750636B2 (en) 2012-10-26 2017-09-05 Forsight Vision5, Inc. Ophthalmic system for sustained release of drug to eye
AU2014236455B2 (en) 2013-03-14 2018-07-12 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
JP6385423B2 (en) 2013-03-28 2018-09-05 フォーサイト・ビジョン フォー・インコーポレーテッド Ocular graft for therapeutic substance delivery
WO2015184173A1 (en) 2014-05-29 2015-12-03 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
MY182497A (en) 2014-07-15 2021-01-25 Forsight Vision4 Inc Ocular implant delivery device and method
WO2016020901A1 (en) 2014-08-07 2016-02-11 Acerta Pharma B.V. Methods of treating cancers, immune and autoimmune diseases, and inflammatory diseases based on btk occupancy and btk resynthesis rate
AU2015301054B2 (en) 2014-08-08 2020-05-14 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
US10507101B2 (en) 2014-10-13 2019-12-17 W. L. Gore & Associates, Inc. Valved conduit
US10500091B2 (en) 2014-11-10 2019-12-10 Forsight Vision4, Inc. Expandable drug delivery devices and methods of use
US20160296532A1 (en) 2015-04-13 2016-10-13 Forsight Vision5, Inc. Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
WO2017053885A1 (en) 2015-09-25 2017-03-30 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
KR20180084104A (en) 2015-11-20 2018-07-24 포사이트 비젼4, 인크. Porous structures for extended release drug delivery devices
MX2018012021A (en) 2016-04-05 2019-01-24 Forsight Vision4 Inc Implantable ocular drug delivery devices.
CN109937025B (en) 2016-04-20 2022-07-29 多斯医学公司 Delivery device for bioabsorbable ocular drugs
US11406533B2 (en) 2017-03-17 2022-08-09 W. L. Gore & Associates, Inc. Integrated aqueous shunt for glaucoma treatment
CA3082891A1 (en) 2017-11-21 2019-05-31 Forsight Vision4, Inc. Fluid exchange apparatus for expandable port delivery system and methods of use
EP3801462A4 (en) 2018-05-24 2022-03-16 Celanese EVA Performance Polymers LLC Implantable device for sustained release of a macromolecular drug compound
CN111989068A (en) 2018-05-24 2020-11-24 塞拉尼斯伊娃高性能聚合物公司 Implantable devices for sustained release of macromolecular drug compounds
US11678983B2 (en) 2018-12-12 2023-06-20 W. L. Gore & Associates, Inc. Implantable component with socket

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378475A (en) * 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US5773019A (en) * 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US5902598A (en) * 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3416530A (en) 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US3618604A (en) 1969-06-09 1971-11-09 Alza Corp Ocular insert
US4014335A (en) 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4378475A (en) * 1982-03-02 1983-03-29 Mcniel Frederick A Velocity sensitive impact switch
ES2231257T3 (en) * 1999-10-21 2005-05-16 Alcon Inc. DEVICE FOR THE ADMINISTRATION OF PHARMACOS.
US6331313B1 (en) * 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
EP1345588A2 (en) * 2000-12-29 2003-09-24 Bausch & Lomb Incorporated Sustained release drug delivery devices
CA2432225C (en) * 2001-01-03 2008-01-15 Michael J. Brubaker Sustained release drug delivery devices with prefabricated permeable plugs
JP2004520900A (en) * 2001-01-26 2004-07-15 ボシュ・アンド・ロム・インコーポレイテッド Improved manufacturing method of sustained release drug delivery device
US6713081B2 (en) * 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378475A (en) * 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US5773019A (en) * 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US5902598A (en) * 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9463114B2 (en) 2004-04-15 2016-10-11 Mati Therapeutics Inc. Punctal plug with active agent

Also Published As

Publication number Publication date
US20060062826A1 (en) 2006-03-23
US6991808B2 (en) 2006-01-31
JP2004520900A (en) 2004-07-15
EP1365738A2 (en) 2003-12-03
WO2002058667A2 (en) 2002-08-01
CA2433528A1 (en) 2002-08-01
US20020110635A1 (en) 2002-08-15

Similar Documents

Publication Publication Date Title
WO2002058667A3 (en) Improved process for the production of sustained release drug delivery devices
AU2002327718A1 (en) Catheter having an improved balloon-to-catheter bond
EP2155831B1 (en) A method for manufacturing two different patterned adhesive layers simultaneously
WO2005113225A3 (en) Partially adhered tube and method and apparatus for manufacturing same
EP1400342A3 (en) Composite pressure container or tubular body and composite intermediate
HK1045263B (en) Multilayered film containing an active substance and made of cross-linked hydrophilic polymers
GB2330553A (en) In-mold coating for golf balls
WO2000059450A3 (en) Aloe vera glove and manufacturing method
WO2008072050A3 (en) Part manufacturing method, part, and tank
WO2005105038A3 (en) A system and a method for producing layered oral dosage forms
EP1069447A3 (en) Coated fiber strands having one or more heterogeneous regions and methods of making the same
WO2002062566A3 (en) System and method of forming composite structures
EP1277883A3 (en) Paving material for footways and method of producing the same
EP1398183A4 (en) Reinforced air bladder for safety tire,method of manufacturing the air bladder, and method of manufacturing reinforced layer formed body
EP1367146A3 (en) Method of preparing a metal material for bonding
ATE302111T1 (en) HOLLOW MOLDED BODY MADE OF COMPOSITE MATERIAL AND METHOD FOR THE PRODUCTION THEREOF
MY117807A (en) Soft, strong hydraulically entangled nonwoven composite material and method for making the same
WO2008093757A1 (en) Process for producing prepreg sheet, apparatus therefor and prepreg sheet
WO2003053596A3 (en) Method for producing layers
DE60025973D1 (en) Molded part and method for its production
JP2002538626A5 (en)
WO2005108671A3 (en) Coated airbag fabric
AU2001247391A1 (en) A splint with a moisture-impervious layer
WO2001045644A3 (en) Dental adhesive device and method for producing same
EP1260279A3 (en) Method and apparatus for manufacturing sheet flooring by simultaneous multi-layer die coating

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2002703234

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2433528

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2002559001

Country of ref document: JP

WWP Wipo information: published in national office

Ref document number: 2002703234

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 2002703234

Country of ref document: EP