WO2002057791A3 - Diagnostic and therapeutic compositions and methods related to grp 38 - Google Patents

Diagnostic and therapeutic compositions and methods related to grp 38 Download PDF

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Publication number
WO2002057791A3
WO2002057791A3 PCT/US2001/045219 US0145219W WO02057791A3 WO 2002057791 A3 WO2002057791 A3 WO 2002057791A3 US 0145219 W US0145219 W US 0145219W WO 02057791 A3 WO02057791 A3 WO 02057791A3
Authority
WO
WIPO (PCT)
Prior art keywords
disease
compositions
grp
diagnostic
adenocarcinoma
Prior art date
Application number
PCT/US2001/045219
Other languages
French (fr)
Other versions
WO2002057791A2 (en
Inventor
Joseph P Brown
Glenna C Burmer
Christine L Roush
Bruce G Kulander
Original Assignee
Lifespan Biosciences Inc
Joseph P Brown
Glenna C Burmer
Christine L Roush
Bruce G Kulander
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lifespan Biosciences Inc, Joseph P Brown, Glenna C Burmer, Christine L Roush, Bruce G Kulander filed Critical Lifespan Biosciences Inc
Priority to AU2002245051A priority Critical patent/AU2002245051A1/en
Publication of WO2002057791A2 publication Critical patent/WO2002057791A2/en
Priority to US10/206,677 priority patent/US20030186336A1/en
Publication of WO2002057791A3 publication Critical patent/WO2002057791A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57426—Specifically defined cancers leukemia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette

Abstract

The present invention comprises systems, methods, compositions and the like, such as diagnostics, medicaments and therapeutics, relating to GPR 38 and Alzheimer's disease and Parkinson's disease, inflammatory bowel diseases including ulcerative colitis and Crohn's disease, Hodgkin's disease, glioblastoma and carcinomas including breast, colon, lung (small cell and adenocarcinoma) pancreatic (small cell and adenocarcinoma), ovarian, and prostate. Such diagnostics and therapeutics include peptide, protein, antibody and nucleic acid based compositions, including agonists, antagonists, probes, antisense and gene therapy compositions.
PCT/US2001/045219 2000-11-29 2001-11-29 Diagnostic and therapeutic compositions and methods related to grp 38 WO2002057791A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002245051A AU2002245051A1 (en) 2000-11-29 2001-11-29 Diagnostic and therapeutic compositions and methods related to grp 38
US10/206,677 US20030186336A1 (en) 2001-11-29 2002-07-26 Diagnostic and therapeutic compositions and methods related to GPCR 38, a G protein-coupled receptor (GPCR)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25025100P 2000-11-29 2000-11-29
US60/250,251 2000-11-29
US25045200P 2000-11-30 2000-11-30
US60/250,452 2000-11-30

Publications (2)

Publication Number Publication Date
WO2002057791A2 WO2002057791A2 (en) 2002-07-25
WO2002057791A3 true WO2002057791A3 (en) 2003-03-27

Family

ID=26940725

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/045219 WO2002057791A2 (en) 2000-11-29 2001-11-29 Diagnostic and therapeutic compositions and methods related to grp 38

Country Status (2)

Country Link
AU (1) AU2002245051A1 (en)
WO (1) WO2002057791A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004057328A2 (en) * 2002-12-23 2004-07-08 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein-coupled receptor 38 (gpr38)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712253A (en) * 1996-06-18 1998-01-27 Abbott Laboratories Macrocyclic 13-membered ring derivatives of erythromycins A and B
US5972939A (en) * 1997-10-28 1999-10-26 Ortho-Mcneil Pharmaceutical, Inc. Cyclopentene derivatives useful as antagonists of the motilin receptor
EP1006122A1 (en) * 1997-08-15 2000-06-07 Chugai Seiyaku Kabushiki Kaisha Phenethylamine derivatives
WO2001064836A2 (en) * 2000-03-01 2001-09-07 Smithkline Beecham Corporation Cloning of a gpr38 variant

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712253A (en) * 1996-06-18 1998-01-27 Abbott Laboratories Macrocyclic 13-membered ring derivatives of erythromycins A and B
EP1006122A1 (en) * 1997-08-15 2000-06-07 Chugai Seiyaku Kabushiki Kaisha Phenethylamine derivatives
US5972939A (en) * 1997-10-28 1999-10-26 Ortho-Mcneil Pharmaceutical, Inc. Cyclopentene derivatives useful as antagonists of the motilin receptor
WO2001064836A2 (en) * 2000-03-01 2001-09-07 Smithkline Beecham Corporation Cloning of a gpr38 variant

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FEIGHNER S D ET AL: "RECEPTOR FOR MOTILIN IDENTIFIED IN THE HUMAN GASTROINTESTINAL SYSTEM", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 284, no. 5423, 25 June 1999 (1999-06-25), pages 2184 - 2188, XP001088406, ISSN: 0036-8075 *

Also Published As

Publication number Publication date
WO2002057791A2 (en) 2002-07-25
AU2002245051A1 (en) 2002-07-30

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