WO2002051436A2 - Stable enzymatic wound debrider - Google Patents
Stable enzymatic wound debrider Download PDFInfo
- Publication number
- WO2002051436A2 WO2002051436A2 PCT/US2001/041558 US0141558W WO02051436A2 WO 2002051436 A2 WO2002051436 A2 WO 2002051436A2 US 0141558 W US0141558 W US 0141558W WO 02051436 A2 WO02051436 A2 WO 02051436A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- enzymatic
- usp units
- papain
- wound
- debrider
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MXPA03005851A MXPA03005851A (en) | 2000-12-27 | 2001-08-06 | Stable enzymatic wound debrider. |
JP2002552578A JP4071628B2 (en) | 2000-12-27 | 2001-08-06 | Stable enzyme debridement |
DE60132113T DE60132113T2 (en) | 2000-12-27 | 2001-08-06 | STABILIZED COMPOSITION FOR ENZYMATIC REMOVAL OF WOUND BASIN |
DK01962345T DK1345620T3 (en) | 2000-12-27 | 2001-08-06 | Stabilized composition for wound debridement |
CA002433080A CA2433080C (en) | 2000-12-27 | 2001-08-06 | Stable enzymatic wound debrider |
EP01962345A EP1345620B1 (en) | 2000-12-27 | 2001-08-06 | Stable enzymatic wound debrider |
AU2001283537A AU2001283537B2 (en) | 2000-12-27 | 2001-08-06 | Stable enzymatic wound debrider |
HK03108779A HK1056834A1 (en) | 2000-12-27 | 2003-12-02 | Stable enzymatic wound debrider |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/749,217 | 2000-12-27 | ||
US09/749,217 US6548556B2 (en) | 2000-12-27 | 2000-12-27 | Stable enzymatic wound debrider |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002051436A2 true WO2002051436A2 (en) | 2002-07-04 |
WO2002051436A3 WO2002051436A3 (en) | 2002-10-03 |
Family
ID=25012779
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/041558 WO2002051436A2 (en) | 2000-12-27 | 2001-08-06 | Stable enzymatic wound debrider |
Country Status (14)
Country | Link |
---|---|
US (1) | US6548556B2 (en) |
EP (1) | EP1345620B1 (en) |
JP (1) | JP4071628B2 (en) |
CN (1) | CN1230200C (en) |
AT (1) | ATE381941T1 (en) |
AU (1) | AU2001283537B2 (en) |
CA (1) | CA2433080C (en) |
DE (1) | DE60132113T2 (en) |
DK (1) | DK1345620T3 (en) |
ES (1) | ES2296788T3 (en) |
HK (1) | HK1056834A1 (en) |
MX (1) | MXPA03005851A (en) |
PT (1) | PT1345620E (en) |
WO (1) | WO2002051436A2 (en) |
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7785584B2 (en) | 2003-08-13 | 2010-08-31 | Healthpoint, Ltd. | Ointment wound spray |
WO2012155027A1 (en) * | 2011-05-12 | 2012-11-15 | Healthpoint, Ltd. | Wound debridement compositions containing seaprose and methods of wound treatment using same |
WO2013116732A1 (en) * | 2012-02-02 | 2013-08-08 | Curelon Llc | Enzyme compositions and use thereof for wound healing |
US9320780B2 (en) | 2008-06-26 | 2016-04-26 | Curemark Llc | Methods and compositions for the treatment of symptoms of Williams Syndrome |
US9377459B2 (en) | 2000-11-16 | 2016-06-28 | Curemark Llc | Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions |
US9408895B2 (en) | 2008-03-13 | 2016-08-09 | Curemark, Llc | Method of treating pregnancy-induced hypertension |
US9492515B2 (en) | 2011-04-21 | 2016-11-15 | Curemark, Llc | Method of treatment of schizophreniform disorder |
US9511125B2 (en) | 2009-10-21 | 2016-12-06 | Curemark Llc | Methods and compositions for the treatment of influenza |
US9624525B2 (en) | 1999-12-17 | 2017-04-18 | Curemark, Llc | Method for treating pervasive development disorders |
US9687452B2 (en) | 2009-04-13 | 2017-06-27 | Curemark, Llc | Enzyme delivery systems and methods of preparation and use |
US9687535B2 (en) | 2008-10-03 | 2017-06-27 | Curemark, Llc | Methods and compositions for the treatment of symptoms of prion diseases |
US9687534B2 (en) | 2008-04-18 | 2017-06-27 | Curemark, Llc | Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same |
US9694100B2 (en) | 2009-12-08 | 2017-07-04 | Smith & Nephew, Inc. | Enzymatic wound debriding compositions with enhanced enzymatic activity |
US9895427B2 (en) | 2009-01-06 | 2018-02-20 | Galenagen, Llc | Compositions and methods for the treatment or the prevention of E. coli infections and for the eradication or reduction of E. coli surfaces |
US10350278B2 (en) | 2012-05-30 | 2019-07-16 | Curemark, Llc | Methods of treating Celiac disease |
US10350229B2 (en) | 2005-08-30 | 2019-07-16 | Curemark, Llc | Use of lactulose in the treatment of autism |
US10736946B2 (en) | 2009-01-06 | 2020-08-11 | Galenagen, Llc | Compositions and methods for treatment or prevention of Staphylococcus aureus infections and for the eradication or reduction of Staphylococcus aureus on surfaces |
US10776453B2 (en) | 2008-08-04 | 2020-09-15 | Galenagen, Llc | Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain |
US11016104B2 (en) | 2008-07-01 | 2021-05-25 | Curemark, Llc | Methods and compositions for the treatment of symptoms of neurological and mental health disorders |
US11096992B2 (en) | 2012-05-11 | 2021-08-24 | Smith & Nephew, Inc. | Use of seaprose to remove bacterial biofilm |
US11413300B2 (en) | 2017-01-30 | 2022-08-16 | Smith & Nephew, Inc. | Synergistic combination of thermolysin and an antibacterial agent to reduce or eliminate bacterial biofilms from surfaces |
US11541009B2 (en) | 2020-09-10 | 2023-01-03 | Curemark, Llc | Methods of prophylaxis of coronavirus infection and treatment of coronaviruses |
US11628207B2 (en) | 2016-07-27 | 2023-04-18 | Smith & Nephew, Inc. | Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030099693A1 (en) * | 2001-11-02 | 2003-05-29 | Auffret Anthony David | Wafer |
US20030198631A1 (en) * | 2002-04-18 | 2003-10-23 | Healthpoint, Ltd. | Thermolysin enzymatic wound debrider |
US7368128B2 (en) | 2003-10-10 | 2008-05-06 | Coloplast A/S | Controlled release dressing for enzymatic debridement of necrotic and non-viable tissue in a wound |
US20050079147A1 (en) * | 2003-10-14 | 2005-04-14 | Bernard Delaey | Wound healing compositions and uses |
US20060182705A1 (en) * | 2005-02-11 | 2006-08-17 | Cruse Maria K | Composition for reduction and prevention of wrinkles on the skin |
FR2892949B1 (en) * | 2005-11-08 | 2008-05-16 | Maco Pharma Sa | LEUCOCYTES FILTRATION UNIT WITH REDUCED PLATELET ADHESION |
CA2634045C (en) * | 2005-12-20 | 2019-05-07 | Swiss-American Products, Inc. | Protease compositions for the treatment of damaged tissue |
GB0606921D0 (en) * | 2006-04-06 | 2006-05-17 | Insense Ltd | Skin dressing |
WO2008063229A2 (en) * | 2006-05-12 | 2008-05-29 | Livingston James A | Enzymatic debridement therapy for abnormal cell proliferation |
EP2226382A1 (en) | 2009-03-03 | 2010-09-08 | B.R.A.I.N. Biotechnology Research and Information Network AG | Protease for wound conditioning and skin care |
CA2801548C (en) | 2010-06-08 | 2018-10-09 | Buckman Laboratories International, Inc. | Methods to degrade sludge from pulp and paper manufacturing |
CA2890757C (en) | 2012-11-14 | 2021-10-26 | Smith & Nephew, Inc. | Stable thermolysin hydrogel |
AU2014235578B2 (en) | 2013-03-15 | 2017-08-17 | Smith & Nephew, Inc. | Dissolvable gel-forming film for delivery of active agents |
WO2015074159A1 (en) | 2013-11-25 | 2015-05-28 | Dermal Devices Inc. | Composition, system and method for treating skin |
US10238719B2 (en) | 2014-10-10 | 2019-03-26 | Rochal Industries, Llc | Compositions and kits for enzymatic debridement and methods of using the same |
US20160101166A1 (en) | 2014-10-10 | 2016-04-14 | Rochal Industries, Llp | Compositions and kits for treating pruritus and methods of using the same |
US9592280B2 (en) | 2014-10-10 | 2017-03-14 | Rochal Industries Llc | Compositions and kits for enzymatic debridement and methods of using the same |
WO2016094675A1 (en) | 2014-12-12 | 2016-06-16 | Smith & Nephew, Inc. | Use of clostridium histolyticum protease mixture in promoting wound healing |
CN105255825B (en) * | 2015-11-16 | 2019-07-19 | 广州赛莱拉干细胞科技股份有限公司 | Primary isolated digestive juice of tendon stem cells from achilles tendon and isolation method |
WO2017130204A1 (en) | 2016-01-31 | 2017-08-03 | Mediwound Ltd. | Debriding composition for treating wounds |
US20190142910A1 (en) | 2016-04-18 | 2019-05-16 | Mediwound Ltd | Methods of debridement of chronic wounds |
CN106902075A (en) * | 2017-02-23 | 2017-06-30 | 任君刚 | A kind of water sensitive adhesiveness ointment based on non-aqueous techniques and preparation method thereof |
CN110180019A (en) * | 2019-07-11 | 2019-08-30 | 周玉芳 | A kind of complex enzyme and preparation method thereof improving skin repair function |
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US3983209A (en) * | 1975-01-28 | 1976-09-28 | Alza Corporation | Method for treating burns |
EP0194647A2 (en) * | 1985-03-12 | 1986-09-17 | Johnson & Johnson Products Inc. | Debriding tape |
EP0498532A1 (en) * | 1991-01-10 | 1992-08-12 | E.R. SQUIBB & SONS, INC. | Necrotic tissue debridement powder composition containing a proteolytic enzyme |
EP0576279A1 (en) * | 1992-06-26 | 1993-12-29 | Genzyme Corporation | Hydrophilic cream for the delivery of therapeutic agents |
WO1995023614A1 (en) * | 1994-03-01 | 1995-09-08 | E.R. Squibb & Sons, Inc. | Enzymatic debridement compositions and methods |
EP0674001A2 (en) * | 1994-03-23 | 1995-09-27 | Ethicon, Inc. | Novel protease for treating devitalized tissue |
WO1998055604A1 (en) * | 1997-06-02 | 1998-12-10 | W.R. Grace & Co.-Conn. | Hydrophilic composition containing protease produced by vibrio |
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US2917433A (en) | 1956-04-02 | 1959-12-15 | Rystan Company | Stable aqueous papain topical compositions |
US2995493A (en) | 1957-04-17 | 1961-08-08 | Johnson & Johnson | Ficus enzyme and hydrophilic carrier composition |
US3019171A (en) | 1957-11-25 | 1962-01-30 | Ethicon Inc | Activated enzyme compositions |
US3003917A (en) | 1959-01-14 | 1961-10-10 | Nat Drug Co | Wound healing composition |
US3409719A (en) | 1967-05-23 | 1968-11-05 | Baxter Laboratories Inc | Debridement agent |
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-
2000
- 2000-12-27 US US09/749,217 patent/US6548556B2/en not_active Expired - Fee Related
-
2001
- 2001-08-06 PT PT01962345T patent/PT1345620E/en unknown
- 2001-08-06 MX MXPA03005851A patent/MXPA03005851A/en active IP Right Grant
- 2001-08-06 DE DE60132113T patent/DE60132113T2/en not_active Expired - Lifetime
- 2001-08-06 CA CA002433080A patent/CA2433080C/en not_active Expired - Fee Related
- 2001-08-06 EP EP01962345A patent/EP1345620B1/en not_active Expired - Lifetime
- 2001-08-06 ES ES01962345T patent/ES2296788T3/en not_active Expired - Lifetime
- 2001-08-06 WO PCT/US2001/041558 patent/WO2002051436A2/en active IP Right Grant
- 2001-08-06 AU AU2001283537A patent/AU2001283537B2/en not_active Ceased
- 2001-08-06 AT AT01962345T patent/ATE381941T1/en active
- 2001-08-06 CN CNB018214770A patent/CN1230200C/en not_active Expired - Fee Related
- 2001-08-06 JP JP2002552578A patent/JP4071628B2/en not_active Expired - Fee Related
- 2001-08-06 DK DK01962345T patent/DK1345620T3/en active
-
2003
- 2003-12-02 HK HK03108779A patent/HK1056834A1/en not_active IP Right Cessation
Patent Citations (7)
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US3983209A (en) * | 1975-01-28 | 1976-09-28 | Alza Corporation | Method for treating burns |
EP0194647A2 (en) * | 1985-03-12 | 1986-09-17 | Johnson & Johnson Products Inc. | Debriding tape |
EP0498532A1 (en) * | 1991-01-10 | 1992-08-12 | E.R. SQUIBB & SONS, INC. | Necrotic tissue debridement powder composition containing a proteolytic enzyme |
EP0576279A1 (en) * | 1992-06-26 | 1993-12-29 | Genzyme Corporation | Hydrophilic cream for the delivery of therapeutic agents |
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EP0674001A2 (en) * | 1994-03-23 | 1995-09-27 | Ethicon, Inc. | Novel protease for treating devitalized tissue |
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Cited By (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9624526B2 (en) | 1999-12-17 | 2017-04-18 | Curemark Llc | Method for treating pervasive development disorders |
US9624525B2 (en) | 1999-12-17 | 2017-04-18 | Curemark, Llc | Method for treating pervasive development disorders |
US9377459B2 (en) | 2000-11-16 | 2016-06-28 | Curemark Llc | Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions |
US10209253B2 (en) | 2000-11-16 | 2019-02-19 | Curemark, Llc | Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions |
US7785584B2 (en) | 2003-08-13 | 2010-08-31 | Healthpoint, Ltd. | Ointment wound spray |
US11033563B2 (en) | 2005-08-30 | 2021-06-15 | Curemark, Llc | Use of lactulose in the treatment of autism |
US10350229B2 (en) | 2005-08-30 | 2019-07-16 | Curemark, Llc | Use of lactulose in the treatment of autism |
US9408895B2 (en) | 2008-03-13 | 2016-08-09 | Curemark, Llc | Method of treating pregnancy-induced hypertension |
US9925250B2 (en) | 2008-03-13 | 2018-03-27 | Curemark, Llc | Method of treating proteinuria in pregnancy |
US11045527B2 (en) | 2008-03-13 | 2021-06-29 | Curemark, Llc | Method of diagnosing preeclampsia or pregnancy-induced hypertension |
US10272141B2 (en) | 2008-04-18 | 2019-04-30 | Curemark, Llc | Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same |
US9687534B2 (en) | 2008-04-18 | 2017-06-27 | Curemark, Llc | Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same |
US11235038B2 (en) | 2008-04-18 | 2022-02-01 | Curemark, Llc | Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same |
US9320780B2 (en) | 2008-06-26 | 2016-04-26 | Curemark Llc | Methods and compositions for the treatment of symptoms of Williams Syndrome |
US10588948B2 (en) | 2008-06-26 | 2020-03-17 | Curemark, Llc | Methods and compositions for the treatment of symptoms of Williams Syndrome |
US11016104B2 (en) | 2008-07-01 | 2021-05-25 | Curemark, Llc | Methods and compositions for the treatment of symptoms of neurological and mental health disorders |
US10776453B2 (en) | 2008-08-04 | 2020-09-15 | Galenagen, Llc | Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain |
US9687535B2 (en) | 2008-10-03 | 2017-06-27 | Curemark, Llc | Methods and compositions for the treatment of symptoms of prion diseases |
US10413601B2 (en) | 2008-10-03 | 2019-09-17 | Curemark, Llc | Methods and compositions for the treatment of symptoms of prion diseases |
US10736946B2 (en) | 2009-01-06 | 2020-08-11 | Galenagen, Llc | Compositions and methods for treatment or prevention of Staphylococcus aureus infections and for the eradication or reduction of Staphylococcus aureus on surfaces |
US11357835B2 (en) | 2009-01-06 | 2022-06-14 | Galenagen, Llc | Compositions and methods for the treatment or the prevention of E. coli infections and for the eradication or reduction of E. coli surfaces |
US9895427B2 (en) | 2009-01-06 | 2018-02-20 | Galenagen, Llc | Compositions and methods for the treatment or the prevention of E. coli infections and for the eradication or reduction of E. coli surfaces |
US9687452B2 (en) | 2009-04-13 | 2017-06-27 | Curemark, Llc | Enzyme delivery systems and methods of preparation and use |
US11419821B2 (en) | 2009-04-13 | 2022-08-23 | Curemark, Llc | Enzyme delivery systems and methods of preparation and use |
US10098844B2 (en) | 2009-04-13 | 2018-10-16 | Curemark, Llc | Enzyme delivery systems and methods of preparation and use |
US9931302B2 (en) | 2009-04-13 | 2018-04-03 | Curemark , LLC | Enzyme delivery systems and methods of preparation and use |
US9511125B2 (en) | 2009-10-21 | 2016-12-06 | Curemark Llc | Methods and compositions for the treatment of influenza |
US10716835B2 (en) | 2009-10-21 | 2020-07-21 | Curemark, Llc | Methods and compositions for the prevention and treatment of influenza |
US9694100B2 (en) | 2009-12-08 | 2017-07-04 | Smith & Nephew, Inc. | Enzymatic wound debriding compositions with enhanced enzymatic activity |
US10155061B2 (en) | 2009-12-08 | 2018-12-18 | Smith & Nephew, Inc. | Enzymatic wound debriding compositions with enhanced enzymatic activity |
US10556037B2 (en) | 2009-12-08 | 2020-02-11 | Smith & Nephew, Inc. | Enzymatic wound debriding compositions with enhanced enzymatic activity |
US10279016B2 (en) | 2011-04-21 | 2019-05-07 | Curemark, Llc | Method of treatment of schizophreniform disorder |
US9492515B2 (en) | 2011-04-21 | 2016-11-15 | Curemark, Llc | Method of treatment of schizophreniform disorder |
US10940187B2 (en) | 2011-04-21 | 2021-03-09 | Curemark, Llc | Method of treatment of schizophreniform disorder |
WO2012155027A1 (en) * | 2011-05-12 | 2012-11-15 | Healthpoint, Ltd. | Wound debridement compositions containing seaprose and methods of wound treatment using same |
CN103687610A (en) * | 2011-05-12 | 2014-03-26 | 史密夫和内修整形外科股份公司 | Wound debridement compositions containing seaprose and methods of wound treatment using same |
US10206982B2 (en) | 2011-05-12 | 2019-02-19 | Smith & Nephew Orthopaedics Ag | Wound debridement compositions containing seaprose and methods of wound treatment using same |
WO2013116732A1 (en) * | 2012-02-02 | 2013-08-08 | Curelon Llc | Enzyme compositions and use thereof for wound healing |
US11096992B2 (en) | 2012-05-11 | 2021-08-24 | Smith & Nephew, Inc. | Use of seaprose to remove bacterial biofilm |
US10350278B2 (en) | 2012-05-30 | 2019-07-16 | Curemark, Llc | Methods of treating Celiac disease |
US11364287B2 (en) | 2012-05-30 | 2022-06-21 | Curemark, Llc | Methods of treating celiac disease |
US11628207B2 (en) | 2016-07-27 | 2023-04-18 | Smith & Nephew, Inc. | Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces |
US11413300B2 (en) | 2017-01-30 | 2022-08-16 | Smith & Nephew, Inc. | Synergistic combination of thermolysin and an antibacterial agent to reduce or eliminate bacterial biofilms from surfaces |
US11957698B2 (en) | 2017-01-30 | 2024-04-16 | Smith & Nephew, Inc. | Synergistic combination of thermolysin and an antibacterial agent to reduce or eliminate bacterial biofilms from surfaces |
US11541009B2 (en) | 2020-09-10 | 2023-01-03 | Curemark, Llc | Methods of prophylaxis of coronavirus infection and treatment of coronaviruses |
Also Published As
Publication number | Publication date |
---|---|
US20020114798A1 (en) | 2002-08-22 |
DK1345620T3 (en) | 2008-05-13 |
CN1494431A (en) | 2004-05-05 |
PT1345620E (en) | 2008-01-10 |
DE60132113D1 (en) | 2008-02-07 |
CA2433080A1 (en) | 2002-07-04 |
EP1345620B1 (en) | 2007-12-26 |
ES2296788T3 (en) | 2008-05-01 |
AU2001283537B2 (en) | 2005-04-14 |
WO2002051436A3 (en) | 2002-10-03 |
CN1230200C (en) | 2005-12-07 |
CA2433080C (en) | 2004-07-06 |
EP1345620A2 (en) | 2003-09-24 |
HK1056834A1 (en) | 2004-03-05 |
DE60132113T2 (en) | 2008-12-18 |
JP2004520321A (en) | 2004-07-08 |
JP4071628B2 (en) | 2008-04-02 |
ATE381941T1 (en) | 2008-01-15 |
US6548556B2 (en) | 2003-04-15 |
MXPA03005851A (en) | 2004-05-04 |
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