WO2002043701A2 - Method of making particles for use in a pharmaceutical composition - Google Patents
Method of making particles for use in a pharmaceutical composition Download PDFInfo
- Publication number
- WO2002043701A2 WO2002043701A2 PCT/GB2001/005315 GB0105315W WO0243701A2 WO 2002043701 A2 WO2002043701 A2 WO 2002043701A2 GB 0105315 W GB0105315 W GB 0105315W WO 0243701 A2 WO0243701 A2 WO 0243701A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- particles
- milling
- composite active
- active particles
- additive
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
Abstract
Description
Claims
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002545674A JP4380988B2 (en) | 2000-11-30 | 2001-11-30 | Method for producing particles used in a pharmaceutical composition |
ES01998328.7T ES2370236T5 (en) | 2000-11-30 | 2001-11-30 | Particle manufacturing process for use in a pharmaceutical composition |
NZ526059A NZ526059A (en) | 2000-11-30 | 2001-11-30 | Method of making composite active particles in the presence of an additive material for use in a pharmaceutical composition |
EP01998328.7A EP1337240B2 (en) | 2000-11-30 | 2001-11-30 | Method of making particles for use in a pharmaceutical composition |
AT01998328T ATE517607T1 (en) | 2000-11-30 | 2001-11-30 | METHOD FOR PRODUCING PARTICLES FOR USE IN A PHARMACEUTICAL COMPOSITION |
CA2429665A CA2429665C (en) | 2000-11-30 | 2001-11-30 | Method of making particles for use in a pharmaceutical composition |
US10/433,072 US7736670B2 (en) | 2000-11-30 | 2001-11-30 | Method of making particles for use in a pharmaceutical composition |
AU2211502A AU2211502A (en) | 2000-11-30 | 2001-11-30 | Method of making particles for use in a pharmaceutical composition |
DK01998328.7T DK1337240T4 (en) | 2000-11-30 | 2001-11-30 | A process for the preparation of particles for use in a pharmaceutical composition |
AU2002222115A AU2002222115B2 (en) | 2000-11-30 | 2001-11-30 | Method of making particles for use in a pharmaceutical composition |
HK04100843.5A HK1058145A1 (en) | 2000-11-30 | 2004-02-09 | Method of making particles for use in a pharmaceutical composition |
US12/767,530 US8303991B2 (en) | 2000-11-30 | 2010-04-26 | Method of making particles for use in a pharmaceutical composition |
US13/623,326 US8956661B2 (en) | 2000-11-30 | 2012-09-20 | Method of making composite particles for use in pharmaceutical compositions and composite particles and compositions thereof |
US14/553,187 US9931304B2 (en) | 2000-11-30 | 2014-11-25 | Method of making particles for use in a pharmaceutical composition |
US15/079,171 US9962338B2 (en) | 2000-11-30 | 2016-03-24 | Method of making particles for use in a pharmaceutical composition |
US15/457,420 US10973771B2 (en) | 2000-11-30 | 2017-03-13 | Method of making particles for use in a pharmaceutical composition |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0029261.5 | 2000-11-30 | ||
GB0029261A GB0029261D0 (en) | 2000-11-30 | 2000-11-30 | Method of making particles for use in a pharmaceutical composition |
GB0030946A GB0030946D0 (en) | 2000-12-19 | 2000-12-19 | Method of making particles for use in a pharmaceutical composition |
GB0030946.8 | 2000-12-19 | ||
PCT/GB2001/001606 WO2001076575A2 (en) | 2000-04-07 | 2001-04-09 | The treatment of respiratory diseases |
GBPCT/GB01/01606 | 2001-04-09 | ||
GB0124010A GB0124010D0 (en) | 2001-10-05 | 2001-10-05 | Pharmaceutical compositions for inhalation |
GB0124010.0 | 2001-10-05 |
Related Child Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10433072 A-371-Of-International | 2001-11-30 | ||
US10/433,072 A-371-Of-International US7736670B2 (en) | 2000-11-30 | 2001-11-30 | Method of making particles for use in a pharmaceutical composition |
US12/767,530 Continuation US8303991B2 (en) | 2000-11-30 | 2010-04-26 | Method of making particles for use in a pharmaceutical composition |
US12/767,530 Continuation-In-Part US8303991B2 (en) | 2000-11-30 | 2010-04-26 | Method of making particles for use in a pharmaceutical composition |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002043701A2 true WO2002043701A2 (en) | 2002-06-06 |
WO2002043701A3 WO2002043701A3 (en) | 2002-10-17 |
Family
ID=27447911
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2001/005315 WO2002043701A2 (en) | 2000-11-30 | 2001-11-30 | Method of making particles for use in a pharmaceutical composition |
PCT/GB2001/005334 WO2002043702A2 (en) | 2000-11-30 | 2001-11-30 | Pharmaceutical compositions for inhalation |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2001/005334 WO2002043702A2 (en) | 2000-11-30 | 2001-11-30 | Pharmaceutical compositions for inhalation |
Country Status (10)
Country | Link |
---|---|
EP (2) | EP1337240B2 (en) |
JP (1) | JP4380988B2 (en) |
AU (3) | AU2002222115B2 (en) |
CA (1) | CA2429665C (en) |
CY (2) | CY1117749T1 (en) |
DE (1) | DE60132239T2 (en) |
DK (1) | DK2283818T3 (en) |
ES (1) | ES2296831T3 (en) |
NZ (1) | NZ526059A (en) |
WO (2) | WO2002043701A2 (en) |
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2388541A (en) * | 2002-04-17 | 2003-11-19 | Nektar Therapeutics Uk Ltd | Aerosol formulations comprising a particulate active substance suspended in a hydrofluorocarbon |
WO2004060344A2 (en) * | 2002-12-19 | 2004-07-22 | Acusphere, Inc. | Methods for making pharmaceutical formulations comprising deagglomerated microparticles |
WO2005025540A2 (en) | 2003-09-15 | 2005-03-24 | Vectura Limited | Mucoactive agents for treating a pulmonary disease |
WO2005077339A1 (en) * | 2004-02-10 | 2005-08-25 | E.I. Dupont De Nemours And Company | Process for preparing stable sol of pharmaceutical ingredients and hydrofluorocarbon comprising milling the said sol, then transfert it into a canister |
WO2006021768A1 (en) * | 2004-08-23 | 2006-03-02 | Glaxo Group Limited | Process for milling poorly soluble drugs in presence of liquid propellants |
WO2006056812A1 (en) * | 2004-11-23 | 2006-06-01 | Vectura Limited | Dry powder inhaler formulations comprising surface-modified particles with anti- adherent additives |
JP2007505831A (en) * | 2003-09-15 | 2007-03-15 | ベクトゥラ・リミテッド | Pharmaceutical composition for treating premature ejaculation by pulmonary inhalation |
JP2007535522A (en) * | 2004-04-30 | 2007-12-06 | ベクトゥラ・リミテッド | Pharmaceutical composition |
JP2007536362A (en) * | 2004-05-10 | 2007-12-13 | ソセイ・アール・アンド・ディー・リミテッド | Treatment of childhood asthma |
JP2011019970A (en) * | 2003-04-14 | 2011-02-03 | Vectura Group Plc | Device and pharmaceutical composition enhancing administration efficiency |
EP2286797A2 (en) | 2003-09-15 | 2011-02-23 | Vectura Limited | Dry powder composition comprising co-jet milled particles for pulmonary inhalation |
WO2011070361A1 (en) | 2009-12-08 | 2011-06-16 | Vectura Limited | Process and product |
WO2011154418A1 (en) | 2010-06-09 | 2011-12-15 | Farma-Derma Srl | Preparation for vaginal and rectal use and relative production method |
WO2012066319A1 (en) | 2010-11-15 | 2012-05-24 | Vectura Limited | Apomorphine by pulmonary inhalation, oprionally in combination with l-dopa or a dopamine agonist for use in the treatment of parkinson |
WO2012073025A1 (en) | 2010-11-30 | 2012-06-07 | Vectura Limited | Glucosaminoglucans such as heparin for use in the treatment of pulmonary inflammation such as copd |
US20130142879A1 (en) * | 2008-02-01 | 2013-06-06 | Innovata Biomed Limited | Suspension formulations |
WO2014155134A1 (en) | 2013-03-28 | 2014-10-02 | Vectura Limited | Use of stearate in an inhalable formulation |
US9763965B2 (en) | 2012-04-13 | 2017-09-19 | Glaxosmithkline Intellectual Property Development Limited | Aggregate particles |
EP1617820B1 (en) | 2003-04-14 | 2018-03-21 | Vectura Limited | Dry power inhaler devices and dry power formulations for enhancing dosing efficiency |
US10314784B2 (en) | 2006-06-30 | 2019-06-11 | Novartis Ag | Compositions of glycopyrronium salt for inhalation |
US10532041B2 (en) | 2014-09-09 | 2020-01-14 | Vectura Limited | Formulation comprising glycopyrrolate, method and apparatus |
EP2957551B1 (en) | 2014-06-16 | 2020-01-15 | Arven Ilac Sanayi Ve Ticaret A.S. | Dry powder formulations comprising vilanterol |
EP2957552B1 (en) | 2014-06-16 | 2020-01-22 | Arven Ilac Sanayi Ve Ticaret A.S. | Vilanterol formulations |
EP1962797B1 (en) | 2005-12-12 | 2020-10-28 | Jagotec AG | Powder compositions for inhalation |
US11020338B2 (en) | 2014-12-17 | 2021-06-01 | L'oreal | Composite particle and preparation thereof |
WO2021236570A1 (en) * | 2020-05-18 | 2021-11-25 | Anovent Pharmaceutical (U.S.), Llc | Pharmaceutical formulation containing remdesivir and its active metabolites for dry powder inhalation |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
DE50211045D1 (en) * | 2001-03-30 | 2007-11-22 | Jagotec Ag | MEDICAL AEROSOL FORMULATIONS |
AU2002337692B2 (en) | 2001-09-26 | 2007-09-13 | Baxter International Inc. | Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal |
US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
EP1480691A4 (en) * | 2002-03-05 | 2007-11-28 | Univ State Cleveland | Agglomerated particles for aerosol drug delivery |
GB0426301D0 (en) * | 2004-11-30 | 2004-12-29 | Vectura Ltd | Pharmaceutical formulations |
WO2006076191A2 (en) * | 2005-01-10 | 2006-07-20 | Elc Management Llc | Discontinuous surface coating for particles |
WO2007019229A1 (en) * | 2005-08-05 | 2007-02-15 | 3M Innovative Properties Company | Compositions exhibiting improved flowability |
US9463161B2 (en) * | 2009-05-29 | 2016-10-11 | Pearl Therapeutics, Inc. | Compositions for pulmonary delivery of long-acting muscarinic antagonists and associated methods and systems |
DE102009049470A1 (en) * | 2009-10-15 | 2011-04-28 | Süd-Chemie AG | Process for the preparation of finely divided lithium titanium spinels and their use |
BR112012014405B1 (en) * | 2009-12-14 | 2019-05-14 | Chiesi Farmaceutici S.P.A. | DRY POWDER FORMULATION, MICROPARTY, CAPSULE FOR USE WITH A DRY POWDER INHALER, METHOD FOR PREPARING A MICROPARTYLE AND USING A MICROPARTYLE |
MY162391A (en) * | 2010-04-01 | 2017-06-15 | Chiesi Farm Spa | Process for preparing carrier particles for dry powders for inhalation |
KR102237799B1 (en) | 2012-11-14 | 2021-04-08 | 더블유.알. 그레이스 앤드 캄파니-콘. | Compositions containing a biologically active material and a non-ordered inorganic oxide |
AU2015338717B2 (en) | 2014-10-31 | 2018-12-20 | Glaxosmithkline Intellectual Property Development Limited | Powder formulation |
Family Cites Families (15)
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IT1204826B (en) † | 1986-03-04 | 1989-03-10 | Chiesi Farma Spa | INHALATION PHARMACEUTICAL COMPOSITIONS |
US5506203C1 (en) * | 1993-06-24 | 2001-02-06 | Astra Ab | Systemic administration of a therapeutic preparation |
DE4323636A1 (en) * | 1993-07-15 | 1995-01-19 | Hoechst Ag | Pharmaceutical preparations from coated, poorly water-soluble pharmaceutical substances for inhalation pharmaceutical forms and processes for their preparation |
US6524557B1 (en) * | 1994-12-22 | 2003-02-25 | Astrazeneca Ab | Aerosol formulations of peptides and proteins |
NZ298169A (en) * | 1994-12-22 | 1999-09-29 | Astra Ab | Aerosol drug formulation; comprises hydrofluoroalkane propellant, medicament for inhalation and a surfactant |
GB9501841D0 (en) † | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
GB9515182D0 (en) * | 1995-07-24 | 1995-09-20 | Co Ordinated Drug Dev | Improvements in and relating to powders for use in dry powder inhalers |
US6086376A (en) * | 1998-01-30 | 2000-07-11 | Rtp Pharma Inc. | Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant |
AP2000001961A0 (en) † | 1998-04-18 | 2000-12-31 | Glaxo Group Ltd | Pharmaceutical aerosol formulation. |
US7521068B2 (en) * | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
EP1862164A3 (en) † | 1998-11-13 | 2012-12-26 | Jagotec AG | Dry powder for inhalation |
GB9827145D0 (en) † | 1998-12-09 | 1999-02-03 | Co Ordinated Drug Dev | Improvements in or relating to powders |
DK1158958T3 (en) † | 1999-03-05 | 2007-10-08 | Chiesi Farma Spa | Improved powder formulation for inhalation |
PE20011227A1 (en) † | 2000-04-17 | 2002-01-07 | Chiesi Farma Spa | PHARMACEUTICAL FORMULATIONS FOR DRY POWDER INHALERS IN THE FORM OF HARD AGGLOMERATES |
ES2689704T3 (en) † | 2000-11-30 | 2018-11-15 | Vectura Limited | Particles for use in a pharmaceutical composition |
-
2001
- 2001-11-30 AU AU2002222115A patent/AU2002222115B2/en not_active Expired
- 2001-11-30 NZ NZ526059A patent/NZ526059A/en not_active IP Right Cessation
- 2001-11-30 ES ES01998329T patent/ES2296831T3/en not_active Expired - Lifetime
- 2001-11-30 CA CA2429665A patent/CA2429665C/en not_active Expired - Lifetime
- 2001-11-30 EP EP01998328.7A patent/EP1337240B2/en not_active Expired - Lifetime
- 2001-11-30 WO PCT/GB2001/005315 patent/WO2002043701A2/en active Search and Examination
- 2001-11-30 JP JP2002545674A patent/JP4380988B2/en not_active Expired - Fee Related
- 2001-11-30 WO PCT/GB2001/005334 patent/WO2002043702A2/en active Search and Examination
- 2001-11-30 AU AU2211502A patent/AU2211502A/en active Pending
- 2001-11-30 EP EP01998329A patent/EP1337241B1/en not_active Expired - Lifetime
- 2001-11-30 AU AU2002222118A patent/AU2002222118A1/en not_active Abandoned
- 2001-11-30 DE DE60132239T patent/DE60132239T2/en not_active Expired - Lifetime
- 2001-11-30 DK DK10185643.3T patent/DK2283818T3/en active
-
2016
- 2016-06-21 CY CY20161100553T patent/CY1117749T1/en unknown
-
2017
- 2017-09-26 CY CY20171101010T patent/CY1119400T1/en unknown
Non-Patent Citations (1)
Title |
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None |
Cited By (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2388541A (en) * | 2002-04-17 | 2003-11-19 | Nektar Therapeutics Uk Ltd | Aerosol formulations comprising a particulate active substance suspended in a hydrofluorocarbon |
GB2388541B (en) * | 2002-04-17 | 2005-02-02 | Nektar Therapeutics Uk Ltd | Aerosol formulations containing a particulate active substance |
WO2004060344A3 (en) * | 2002-12-19 | 2004-12-02 | Acusphere Inc | Methods for making pharmaceutical formulations comprising deagglomerated microparticles |
WO2004060344A2 (en) * | 2002-12-19 | 2004-07-22 | Acusphere, Inc. | Methods for making pharmaceutical formulations comprising deagglomerated microparticles |
JP2011019970A (en) * | 2003-04-14 | 2011-02-03 | Vectura Group Plc | Device and pharmaceutical composition enhancing administration efficiency |
EP1617820B1 (en) | 2003-04-14 | 2018-03-21 | Vectura Limited | Dry power inhaler devices and dry power formulations for enhancing dosing efficiency |
JP2014158978A (en) * | 2003-04-14 | 2014-09-04 | Vectura Ltd | Devices and pharmaceutical compositions for enhancing dosing efficiency |
WO2005025540A2 (en) | 2003-09-15 | 2005-03-24 | Vectura Limited | Mucoactive agents for treating a pulmonary disease |
EP2286797B2 (en) † | 2003-09-15 | 2022-01-26 | Vectura Limited | Dry powder composition comprising co-jet milled particles for pulmonary inhalation |
EP2286797B1 (en) | 2003-09-15 | 2018-03-14 | Vectura Limited | Dry powder composition comprising co-jet milled particles for pulmonary inhalation |
JP2007505831A (en) * | 2003-09-15 | 2007-03-15 | ベクトゥラ・リミテッド | Pharmaceutical composition for treating premature ejaculation by pulmonary inhalation |
EP2286797A2 (en) | 2003-09-15 | 2011-02-23 | Vectura Limited | Dry powder composition comprising co-jet milled particles for pulmonary inhalation |
US11103448B2 (en) | 2003-09-15 | 2021-08-31 | Vectura Limited | Manufacture of pharmaceutical compositions |
EP2277505A2 (en) | 2003-09-15 | 2011-01-26 | Vectura Limited | Mucoactive agents for treating a pulmonary disease |
WO2005077339A1 (en) * | 2004-02-10 | 2005-08-25 | E.I. Dupont De Nemours And Company | Process for preparing stable sol of pharmaceutical ingredients and hydrofluorocarbon comprising milling the said sol, then transfert it into a canister |
US20080063719A1 (en) * | 2004-04-30 | 2008-03-13 | Vectura Limited | Pharmaceutical Compositions |
JP2007535522A (en) * | 2004-04-30 | 2007-12-06 | ベクトゥラ・リミテッド | Pharmaceutical composition |
EP2422767A2 (en) | 2004-04-30 | 2012-02-29 | Vectura Limited | Methods for preparing dry powder compositions of glycopyrrolate |
EP2422766A2 (en) | 2004-04-30 | 2012-02-29 | Vectura Limited | Methods for preparing dry powder compositions of glycopyrrolate |
EP2422766B1 (en) | 2004-04-30 | 2015-06-24 | Vectura Limited | Dry powder compositions of glycopyrrolate and magnesium stearate |
JP2007536362A (en) * | 2004-05-10 | 2007-12-13 | ソセイ・アール・アンド・ディー・リミテッド | Treatment of childhood asthma |
WO2006021768A1 (en) * | 2004-08-23 | 2006-03-02 | Glaxo Group Limited | Process for milling poorly soluble drugs in presence of liquid propellants |
US8092785B2 (en) | 2004-08-23 | 2012-01-10 | Glaxo Group Limited | Process for milling poorly soluble drugs in presence of liquid propellants |
US9642800B2 (en) | 2004-11-23 | 2017-05-09 | Vectura Limited | Dry powder inhaler formulations comprising surface-modified particles with anti-adherent additives |
EP2311434A1 (en) | 2004-11-23 | 2011-04-20 | Vectura Limited | Dry powder inhaler formulations comprising surface-modified particles with anti-adherent additives |
EP2174653A1 (en) | 2004-11-23 | 2010-04-14 | Vectura Limited | Dry powder inhaler formulations comprising surface-modified particles with anti-adherent additives |
WO2006056812A1 (en) * | 2004-11-23 | 2006-06-01 | Vectura Limited | Dry powder inhaler formulations comprising surface-modified particles with anti- adherent additives |
EP2311434B1 (en) | 2004-11-23 | 2015-07-08 | Vectura Limited | Dry powder inhaler formulations comprising surface-modified particles with anti-adherent additives |
EP2949317A1 (en) | 2004-11-23 | 2015-12-02 | Vectura Limited | Dry powder inhaler formulations comprising surface-modified particles with anti-adherent additives |
EP2949317B1 (en) | 2004-11-23 | 2017-01-04 | Vectura Limited | Dry powder inhaler formulations comprising surface-modified particles with anti-adherent additives |
US9585834B2 (en) | 2004-11-23 | 2017-03-07 | Vectura Limited | Dry powder inhaler formulations comprising surface-modified particles with anti-adherent additives |
EP1962797B1 (en) | 2005-12-12 | 2020-10-28 | Jagotec AG | Powder compositions for inhalation |
US10314784B2 (en) | 2006-06-30 | 2019-06-11 | Novartis Ag | Compositions of glycopyrronium salt for inhalation |
US20130142879A1 (en) * | 2008-02-01 | 2013-06-06 | Innovata Biomed Limited | Suspension formulations |
US9381189B2 (en) | 2009-12-08 | 2016-07-05 | Vectura Limited | Ingredients for inhalation and methods for making the same |
WO2011070361A1 (en) | 2009-12-08 | 2011-06-16 | Vectura Limited | Process and product |
WO2011154418A1 (en) | 2010-06-09 | 2011-12-15 | Farma-Derma Srl | Preparation for vaginal and rectal use and relative production method |
WO2012066319A1 (en) | 2010-11-15 | 2012-05-24 | Vectura Limited | Apomorphine by pulmonary inhalation, oprionally in combination with l-dopa or a dopamine agonist for use in the treatment of parkinson |
WO2012073025A1 (en) | 2010-11-30 | 2012-06-07 | Vectura Limited | Glucosaminoglucans such as heparin for use in the treatment of pulmonary inflammation such as copd |
US9763965B2 (en) | 2012-04-13 | 2017-09-19 | Glaxosmithkline Intellectual Property Development Limited | Aggregate particles |
WO2014155134A1 (en) | 2013-03-28 | 2014-10-02 | Vectura Limited | Use of stearate in an inhalable formulation |
EP2957552B1 (en) | 2014-06-16 | 2020-01-22 | Arven Ilac Sanayi Ve Ticaret A.S. | Vilanterol formulations |
EP2957551B1 (en) | 2014-06-16 | 2020-01-15 | Arven Ilac Sanayi Ve Ticaret A.S. | Dry powder formulations comprising vilanterol |
US10532041B2 (en) | 2014-09-09 | 2020-01-14 | Vectura Limited | Formulation comprising glycopyrrolate, method and apparatus |
US11020338B2 (en) | 2014-12-17 | 2021-06-01 | L'oreal | Composite particle and preparation thereof |
WO2021236570A1 (en) * | 2020-05-18 | 2021-11-25 | Anovent Pharmaceutical (U.S.), Llc | Pharmaceutical formulation containing remdesivir and its active metabolites for dry powder inhalation |
Also Published As
Publication number | Publication date |
---|---|
WO2002043702A3 (en) | 2002-10-17 |
EP1337240B1 (en) | 2011-07-27 |
CY1119400T1 (en) | 2018-02-14 |
ES2296831T3 (en) | 2008-05-01 |
AU2002222115B2 (en) | 2006-09-28 |
EP1337240A2 (en) | 2003-08-27 |
WO2002043701A3 (en) | 2002-10-17 |
CA2429665C (en) | 2013-10-22 |
DK2283818T3 (en) | 2017-10-16 |
EP1337240B2 (en) | 2014-09-24 |
JP4380988B2 (en) | 2009-12-09 |
DE60132239D1 (en) | 2008-02-14 |
CA2429665A1 (en) | 2002-06-06 |
EP1337241B1 (en) | 2008-01-02 |
NZ526059A (en) | 2005-05-27 |
EP1337241A2 (en) | 2003-08-27 |
AU2002222118A1 (en) | 2002-06-11 |
DE60132239T2 (en) | 2008-05-08 |
JP2004514504A (en) | 2004-05-20 |
CY1117749T1 (en) | 2017-05-17 |
AU2211502A (en) | 2002-06-11 |
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