WO2002041882A3 - Combination comprising an agent decreasing vegf activity and an agent decreasing egf activity - Google Patents

Combination comprising an agent decreasing vegf activity and an agent decreasing egf activity Download PDF

Info

Publication number
WO2002041882A3
WO2002041882A3 PCT/EP2001/013441 EP0113441W WO0241882A3 WO 2002041882 A3 WO2002041882 A3 WO 2002041882A3 EP 0113441 W EP0113441 W EP 0113441W WO 0241882 A3 WO0241882 A3 WO 0241882A3
Authority
WO
WIPO (PCT)
Prior art keywords
activity
combination
agent decreasing
egf
agent
Prior art date
Application number
PCT/EP2001/013441
Other languages
French (fr)
Other versions
WO2002041882A2 (en
Inventor
Jeanette Marjorie Wood
Ralf Brandt
Guido Bold
Peter Traxler
Original Assignee
Novartis Ag
Novartis Pharma Gmbh
Jeanette Marjorie Wood
Ralf Brandt
Guido Bold
Peter Traxler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0028467A external-priority patent/GB0028467D0/en
Priority claimed from GB0121813A external-priority patent/GB0121813D0/en
Application filed by Novartis Ag, Novartis Pharma Gmbh, Jeanette Marjorie Wood, Ralf Brandt, Guido Bold, Peter Traxler filed Critical Novartis Ag
Priority to CA002427184A priority Critical patent/CA2427184A1/en
Priority to US10/432,303 priority patent/US20040034026A1/en
Priority to JP2002544061A priority patent/JP2004513964A/en
Priority to EP01997301A priority patent/EP1339458B1/en
Priority to DE60130017T priority patent/DE60130017T2/en
Priority to AU2002223684A priority patent/AU2002223684A1/en
Publication of WO2002041882A2 publication Critical patent/WO2002041882A2/en
Publication of WO2002041882A3 publication Critical patent/WO2002041882A3/en
Priority to US11/498,027 priority patent/US20060270665A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to a combination which comprises a first active ingredient which is a vasculostatic compound and a second active ingredient which decreases the activity of the epidermal growth factor (EGF), in particular, for the delay of progression or treatment of a disease associated with deregulated angiogenesis, especially a proliferative disease; a pharmaceutical composition comprising such a combination; a commercial package comprising such a combination as a combined preparation; and to a method of treatment of a warm-blooded animal, especially a human.
PCT/EP2001/013441 2000-11-22 2001-11-20 Combination comprising an agent decreasing vegf activity and an agent decreasing egf activity WO2002041882A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002427184A CA2427184A1 (en) 2000-11-22 2001-11-20 Combination comprising an agent decreasing vegf activity and an agent decreasing egf activity
US10/432,303 US20040034026A1 (en) 2000-11-22 2001-11-20 Combination comprising an agent decreasing vegf activity and an agent decreasing egf activity
JP2002544061A JP2004513964A (en) 2000-11-22 2001-11-20 Combination comprising VEGF activity reducer and EGF activity reducer
EP01997301A EP1339458B1 (en) 2000-11-22 2001-11-20 Combination comprising an agent decreasing vegf activity and an agent decreasing egf activity
DE60130017T DE60130017T2 (en) 2000-11-22 2001-11-20 COMBINATION CONTAINING A MEANS TO REDUCE VEGF ACTIVITY AND A MEANS TO REDUCE EGF ACTIVITY
AU2002223684A AU2002223684A1 (en) 2000-11-22 2001-11-20 Combination comprising an agent decreasing vegf activity and an agent decreasing egf activity
US11/498,027 US20060270665A1 (en) 2000-11-22 2006-08-02 Combination comprising an agent decreasing VEGF activity and an agent decreasing EGF activity

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0028467.9 2000-11-22
GB0028467A GB0028467D0 (en) 2000-11-22 2000-11-22 Use of organic compounds
GB0121813.0 2001-09-10
GB0121813A GB0121813D0 (en) 2001-09-10 2001-09-10 Organic compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/498,027 Continuation US20060270665A1 (en) 2000-11-22 2006-08-02 Combination comprising an agent decreasing VEGF activity and an agent decreasing EGF activity

Publications (2)

Publication Number Publication Date
WO2002041882A2 WO2002041882A2 (en) 2002-05-30
WO2002041882A3 true WO2002041882A3 (en) 2002-09-06

Family

ID=26245316

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/013441 WO2002041882A2 (en) 2000-11-22 2001-11-20 Combination comprising an agent decreasing vegf activity and an agent decreasing egf activity

Country Status (10)

Country Link
US (2) US20040034026A1 (en)
EP (2) EP1810715A3 (en)
JP (1) JP2004513964A (en)
AT (1) ATE369894T1 (en)
AU (1) AU2002223684A1 (en)
CA (1) CA2427184A1 (en)
DE (1) DE60130017T2 (en)
ES (1) ES2290199T3 (en)
PT (1) PT1339458E (en)
WO (1) WO2002041882A2 (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8865737B2 (en) 2006-08-28 2014-10-21 Eisai R&D Management Co., Ltd. Antitumor agent for undifferentiated gastric cancer
US8952035B2 (en) 2007-11-09 2015-02-10 Eisai R&D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
US8962650B2 (en) 2011-04-18 2015-02-24 Eisai R&D Management Co., Ltd. Therapeutic agent for tumor
US8962655B2 (en) 2007-01-29 2015-02-24 Eisai R&D Management Co., Ltd. Composition for treatment of undifferentiated gastric cancer
US8969344B2 (en) 2005-08-02 2015-03-03 Eisai R&D Management Co., Ltd. Method for assay on the effect of vascularization inhibitor
US9006256B2 (en) 2006-05-18 2015-04-14 Eisai R&D Management Co., Ltd. Antitumor agent for thyroid cancer
US9012458B2 (en) 2010-06-25 2015-04-21 Eisai R&D Management Co., Ltd. Antitumor agent using compounds having kinase inhibitory effect in combination
US9334239B2 (en) 2012-12-21 2016-05-10 Eisai R&D Management Co., Ltd. Amorphous form of quinoline derivative, and method for producing same
US9504746B2 (en) 2004-09-17 2016-11-29 Eisai R&D Management Co., Ltd. Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3686610B2 (en) 1999-06-21 2005-08-24 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト Bicyclic heterocyclic compounds, pharmaceutical compositions containing the compounds, methods of use and preparation
DE60137273D1 (en) 2000-10-20 2009-02-12 Eisai R&D Man Co Ltd Process for the preparation of 4-phenoxyquinoline derivatives
US7019012B2 (en) 2000-12-20 2006-03-28 Boehringer Ingelheim International Pharma Gmbh & Co. Kg Quinazoline derivatives and pharmaceutical compositions containing them
US20050038048A1 (en) * 2001-10-29 2005-02-17 Ball Howard Ashley Use of 7h-pyrrollo{2,3-d}pyrimidine derivatives in the treatment of solid tumor diseases
US20050019424A1 (en) * 2001-12-21 2005-01-27 Adams Paul E. Anti-angiogenesis combination therapies comprising pyridazine or pyridine derivatives
US6924285B2 (en) 2002-03-30 2005-08-02 Boehringer Ingelheim Pharma Gmbh & Co. Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
DE10221018A1 (en) 2002-05-11 2003-11-27 Boehringer Ingelheim Pharma Use of inhibitors of EGFR-mediated signal transduction for the treatment of benign prostatic hyperplasia (BPH) / prostatic hypertrophy
JP2005531622A (en) * 2002-06-28 2005-10-20 ノバルティス アクチエンゲゼルシャフト Combination for treating tumors comprising a vasostatic compound and an alkylating agent
US7642252B2 (en) * 2002-07-22 2010-01-05 Chemgenex Pharmaceuticals, Inc. Angiogenesis inhibition by cephalotaxine alkaloids, derivatives, compositions and uses thereof
GB0218526D0 (en) * 2002-08-09 2002-09-18 Astrazeneca Ab Combination therapy
GB0223341D0 (en) * 2002-10-08 2002-11-13 Groningen Acad Ziekenhuis Organic compounds
EP1604665B1 (en) 2003-03-10 2011-05-11 Eisai R&D Management Co., Ltd. C-kit kinase inhibitor
GB0316127D0 (en) * 2003-07-10 2003-08-13 Astrazeneca Ab Combination therapy
GB0317665D0 (en) 2003-07-29 2003-09-03 Astrazeneca Ab Qinazoline derivatives
JP2007504122A (en) 2003-08-29 2007-03-01 ファイザー・インク Thienopyridine-phenylacetamide and its derivatives useful as novel anti-angiogenic agents
CA2538752C (en) * 2003-09-19 2011-08-02 Astrazeneca Ab Quinazoline derivatives
GB0322409D0 (en) 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
US7683172B2 (en) * 2003-11-11 2010-03-23 Eisai R&D Management Co., Ltd. Urea derivative and process for preparing the same
JP4503022B2 (en) 2003-12-23 2010-07-14 ファイザー・インク New quinoline derivatives
JP5032851B2 (en) 2004-02-03 2012-09-26 アストラゼネカ アクチボラグ Quinazoline derivatives
FR2865733B1 (en) * 2004-02-04 2007-10-12 Merck Sante Sas THIAZOLYLIMIDAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND MEDICINE APPLICATIONS THEREOF
GB0406445D0 (en) * 2004-03-23 2004-04-28 Astrazeneca Ab Combination therapy
WO2006004703A2 (en) 2004-06-29 2006-01-12 Amgen Inc. PYRROLO[2,3-d]PYRIMIDINES THAT MODULATE ACK1 AND LCK ACTIVITY
CA2575808A1 (en) * 2004-08-02 2006-02-16 Osi Pharmaceuticals, Inc. Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds
JO2596B1 (en) * 2004-11-30 2011-02-27 نوفارتيس ايه جي Combinations comprising Epothilones and protein Tyrosine Kinase inhibitors and pharmaceutical uses thereof.
US20100105031A1 (en) * 2005-08-01 2010-04-29 Esai R & D Management Co., Ltd. Method for prediction of the efficacy of vascularization inhibitor
JP5209966B2 (en) * 2005-09-01 2013-06-12 エーザイ・アール・アンド・ディー・マネジメント株式会社 Method for producing pharmaceutical composition with improved disintegration
WO2007052849A1 (en) * 2005-11-07 2007-05-10 Eisai R & D Management Co., Ltd. USE OF COMBINATION OF ANTI-ANGIOGENIC SUBSTANCE AND c-kit KINASE INHIBITOR
CA2629244C (en) 2005-11-11 2014-08-05 Boehringer Ingelheim International Gmbh Quinazoline derivatives for the treatment of cancer diseases
WO2007061130A1 (en) * 2005-11-22 2007-05-31 Eisai R & D Management Co., Ltd. Anti-tumor agent for multiple myeloma
JP2009120486A (en) * 2005-12-05 2009-06-04 Mitsubishi Pharma Corp New activator of orphan receptor in nucleus and application of the same
WO2008001956A1 (en) * 2006-06-29 2008-01-03 Eisai R & D Management Co., Ltd. Therapeutic agent for liver fibrosis
SI2068880T1 (en) 2006-09-18 2012-08-31 Boehringer Ingelheim Int Method for treating cancer harboring egfr mutations
EP1921070A1 (en) 2006-11-10 2008-05-14 Boehringer Ingelheim Pharma GmbH & Co. KG Bicyclic heterocycles, medicaments comprising them, their use and process for their preparation
KR20090116782A (en) 2007-02-06 2009-11-11 베링거 인겔하임 인터내셔날 게엠베하 Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof
JP4827986B2 (en) 2007-06-08 2011-11-30 マンカインド コーポレ−ション IRE-1α inhibitor
JP5399926B2 (en) * 2008-01-29 2014-01-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 Combination of vascular inhibitor and taxane
ME01461B (en) 2008-02-07 2014-04-20 Boehringer Ingelheim Int Spirocyclic heterocycles, medicaments containing said compounds, use thereof and method for their production
DE102008021699A1 (en) 2008-04-25 2009-10-29 Schebo Biotech Ag New pyrrolopyrimidine compounds are epidermal growth factor receptor tyrosine kinase inhibitors useful for preventing or treating proliferative or inflammatory disease, where the disease is e.g. cancer, asthma, allergy and psoriasis
CA2733153C (en) 2008-08-08 2016-11-08 Boehringer Ingelheim International Gmbh Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them
ES2731901T3 (en) 2009-07-06 2019-11-19 Boehringer Ingelheim Int Process for drying BIBW2992, its salts and solid pharmaceutical formulations comprising this active ingredient
EP2474311B1 (en) 2009-08-31 2014-09-03 Postech Academy-industry Foundation Method for treating th17 inflammatory disease through inhibition of vascular endothelial growth factor receptors and pharmaceutical composition therefor
US8916574B2 (en) 2009-09-28 2014-12-23 Qilu Pharmaceutical Co., Ltd. 4-(substituted anilino)-quinazoline derivatives useful as tyrosine kinase inhibitors
EP3444363B1 (en) 2011-06-03 2020-11-25 Eisai R&D Management Co., Ltd. Biomarkers for prediciting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
WO2013143057A1 (en) 2012-03-26 2013-10-03 中国科学院福建物质结构研究所 Quinazoline derivative and application thereof
JP6411379B2 (en) 2013-05-14 2018-10-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
US9242965B2 (en) 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
LT3524595T (en) 2014-08-28 2022-09-26 Eisai R&D Management Co., Ltd. High-purity quinoline derivative and method for manufacturing same
RS65049B1 (en) 2015-02-25 2024-02-29 Eisai R&D Man Co Ltd Method for suppressing bitterness of quinoline derivative
WO2016140717A1 (en) 2015-03-04 2016-09-09 Merck Sharp & Dohme Corp. Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer
WO2016204193A1 (en) 2015-06-16 2016-12-22 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ Anticancer agent

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997002266A1 (en) * 1995-07-06 1997-01-23 Novartis Ag Pyrrolopyrimidines and processes for the preparation thereof
WO1998035958A1 (en) * 1997-02-13 1998-08-20 Novartis Ag Phthalazines with angiogenesis inhibiting activity
WO1999002532A2 (en) * 1997-07-07 1999-01-21 Novartis Ag Partially hydrogenated polycyclic compounds
WO2000000206A1 (en) * 1998-06-26 2000-01-06 Georgetown University Inhibitors of phosphatidyl myo-inositol cycle
WO2000059509A1 (en) * 1999-03-30 2000-10-12 Novartis Ag Phthalazine derivatives for treating inflammatory diseases
WO2001047507A2 (en) * 1999-12-27 2001-07-05 Novartis Ag Combinations of receptor tyrosine kinase inhibitor with an a1-acidic glycoprotein binding compound

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0739203A4 (en) * 1994-01-14 2000-12-20 Cell Therapeutics Inc Method for treating diseases mediated by cellular proliferation in response to pdgf, egf, fgf and vegf
US5731325A (en) * 1995-06-06 1998-03-24 Andrulis Pharmaceuticals Corp. Treatment of melanomas with thalidomide alone or in combination with other anti-melanoma agents
US5747498A (en) * 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997002266A1 (en) * 1995-07-06 1997-01-23 Novartis Ag Pyrrolopyrimidines and processes for the preparation thereof
WO1998035958A1 (en) * 1997-02-13 1998-08-20 Novartis Ag Phthalazines with angiogenesis inhibiting activity
WO1999002532A2 (en) * 1997-07-07 1999-01-21 Novartis Ag Partially hydrogenated polycyclic compounds
WO2000000206A1 (en) * 1998-06-26 2000-01-06 Georgetown University Inhibitors of phosphatidyl myo-inositol cycle
WO2000059509A1 (en) * 1999-03-30 2000-10-12 Novartis Ag Phthalazine derivatives for treating inflammatory diseases
WO2001047507A2 (en) * 1999-12-27 2001-07-05 Novartis Ag Combinations of receptor tyrosine kinase inhibitor with an a1-acidic glycoprotein binding compound

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9504746B2 (en) 2004-09-17 2016-11-29 Eisai R&D Management Co., Ltd. Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide
US8969344B2 (en) 2005-08-02 2015-03-03 Eisai R&D Management Co., Ltd. Method for assay on the effect of vascularization inhibitor
US9006240B2 (en) 2005-08-02 2015-04-14 Eisai R&D Management Co., Ltd. Method for assay on the effect of vascularization inhibitor
US9006256B2 (en) 2006-05-18 2015-04-14 Eisai R&D Management Co., Ltd. Antitumor agent for thyroid cancer
US8865737B2 (en) 2006-08-28 2014-10-21 Eisai R&D Management Co., Ltd. Antitumor agent for undifferentiated gastric cancer
US8962655B2 (en) 2007-01-29 2015-02-24 Eisai R&D Management Co., Ltd. Composition for treatment of undifferentiated gastric cancer
US8952035B2 (en) 2007-11-09 2015-02-10 Eisai R&D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
US9012458B2 (en) 2010-06-25 2015-04-21 Eisai R&D Management Co., Ltd. Antitumor agent using compounds having kinase inhibitory effect in combination
US8962650B2 (en) 2011-04-18 2015-02-24 Eisai R&D Management Co., Ltd. Therapeutic agent for tumor
US9334239B2 (en) 2012-12-21 2016-05-10 Eisai R&D Management Co., Ltd. Amorphous form of quinoline derivative, and method for producing same

Also Published As

Publication number Publication date
DE60130017D1 (en) 2007-09-27
EP1339458A2 (en) 2003-09-03
DE60130017T2 (en) 2008-05-15
WO2002041882A2 (en) 2002-05-30
EP1810715A2 (en) 2007-07-25
US20040034026A1 (en) 2004-02-19
AU2002223684A1 (en) 2002-06-03
EP1810715A3 (en) 2009-12-16
PT1339458E (en) 2007-11-09
CA2427184A1 (en) 2002-05-30
JP2004513964A (en) 2004-05-13
EP1339458B1 (en) 2007-08-15
ATE369894T1 (en) 2007-09-15
US20060270665A1 (en) 2006-11-30
ES2290199T3 (en) 2008-02-16

Similar Documents

Publication Publication Date Title
WO2002041882A3 (en) Combination comprising an agent decreasing vegf activity and an agent decreasing egf activity
EP1247456A3 (en) Palatable pharmaceutical compositions for companion animals
WO2001078683A3 (en) Sustained release formulations comprising growth hormone
WO2003002136A3 (en) Stable formulation of modified glp-1
WO2001095856A3 (en) Urea derivative useful as an anti-cancer agent and process for preparing same
WO2002019969A3 (en) (5-(2-hydroxy-4-chlorobenzoyl) aminovaleric acid and salts thereof and compositions containing the same for delivering active agents
GB0100758D0 (en) Immunogenic complex method of preparation thereof and pharmaceutical compositions containing the same, useful for disease control
WO2001032596A8 (en) Phenoxy carboxylic acid compounds and compositions for delivering active agents
MXPA03001169A (en) Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them.
AU2000279625A1 (en) Blood mmp-3 level-lowering agent containing il-6 antgonist as the active ingredient
WO2006060515A3 (en) System for improved percutaneous absorption of skin benefiting agents
ATE452640T1 (en) REMEDIES FOR DISEASES ASSOCIATED WITH BONE LOSS
EP1053989A3 (en) Hydroxydiphenyl ether compounds
WO2002015959A3 (en) Compounds and compositions for delivering active agents
AU2108500A (en) Galenic formulation containing biotin
AU2002238855A1 (en) N-phenylarylsulfonamide compound, drug containing the compound as active ingredient, intermediate for the compound, and processes for producing the same
WO2002030467A3 (en) Pharmaceutical composition containing honey for the treatment of wounds
WO2002067941A8 (en) Combination comprising a signal transduction inhibitor and an epothilone derivative
WO2003028475A1 (en) Feeds and fertilizers containing pentacyclic triterpenes
DE60017361D1 (en) DIRECTPRESSABLE MATRIX FOR CONTROLLED DELIVERY OF ONE-ON-THE-BOTTLE CANS OF CLARITHROMYCIN
AU2001228825A1 (en) Remedies
WO2002024665A8 (en) Arylalkane-sulfonamides having endothelin-antagonist activity
WO2002049607A3 (en) Flavoured oral drug delivery system
EP1550667A4 (en) Tyrosinase activity controlling agents, process for producing the same and external preparations containing the same
WO2002000208A3 (en) Combination preparations of 3-n-formylhydroxylaminopropyl phosphonic acid derivatives or 3-n-acetylhydroxylaminopropyl phosphonic acid derivatives combined with specific pharmaceutical active agents

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LT LU LV MA MD MK MN MX NO NZ OM PH PL PT RO RU SE SG SI SK TJ TM TR TT UA US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2001997301

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2427184

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2002544061

Country of ref document: JP

Ref document number: 10432303

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 2001997301

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 2001997301

Country of ref document: EP