WO2002040060A3 - Conjugates of an antioxidants with metal chelating ligands - Google Patents

Conjugates of an antioxidants with metal chelating ligands Download PDF

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Publication number
WO2002040060A3
WO2002040060A3 PCT/US2001/046002 US0146002W WO0240060A3 WO 2002040060 A3 WO2002040060 A3 WO 2002040060A3 US 0146002 W US0146002 W US 0146002W WO 0240060 A3 WO0240060 A3 WO 0240060A3
Authority
WO
WIPO (PCT)
Prior art keywords
conjugates
antioxidants
metal chelating
chelating ligands
ligands
Prior art date
Application number
PCT/US2001/046002
Other languages
French (fr)
Other versions
WO2002040060A2 (en
Inventor
Ramachandra S Ranganathan
Helen Fan
Michael F Tweedle
Original Assignee
Bracco Int Bv
Ramachandra S Ranganathan
Helen Fan
Michael F Tweedle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Int Bv, Ramachandra S Ranganathan, Helen Fan, Michael F Tweedle filed Critical Bracco Int Bv
Priority to US10/399,265 priority Critical patent/US7160535B2/en
Priority to EP01987230A priority patent/EP1406669A2/en
Priority to JP2002542432A priority patent/JP2004526671A/en
Priority to AU2002239468A priority patent/AU2002239468A1/en
Priority to CA002421182A priority patent/CA2421182A1/en
Publication of WO2002040060A2 publication Critical patent/WO2002040060A2/en
Publication of WO2002040060A3 publication Critical patent/WO2002040060A3/en
Priority to US11/561,638 priority patent/US7407644B2/en
Priority to US12/169,105 priority patent/US7582280B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/0412—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K51/0419—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention provides radiopharmaceuticals for diagnostic and therapeutic applications, conjugates of antioxidants with metal chelating ligands, intermediate compounds, methods of making such radiopharmaceuticals, ligands, and intermediate compounds, and kits for preparing the radiopharmaceutical complexes.
PCT/US2001/046002 2000-10-31 2001-10-31 Conjugates of an antioxidants with metal chelating ligands WO2002040060A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US10/399,265 US7160535B2 (en) 2001-10-31 2001-10-31 Conjugates of antioxidants with metal chelating ligands for use in diagnostic and therapeutic applications
EP01987230A EP1406669A2 (en) 2000-10-31 2001-10-31 Conjugates of an antioxidants with metal chelating ligands
JP2002542432A JP2004526671A (en) 2000-10-31 2001-10-31 Conjugates of antioxidants with metal chelating ligands for use in diagnostic and therapeutic applications
AU2002239468A AU2002239468A1 (en) 2000-10-31 2001-10-31 Conjugates of an antioxidants with metal chelating ligands
CA002421182A CA2421182A1 (en) 2000-10-31 2001-10-31 Conjugates of antioxidants with metal chelating ligands for use in diagnostic and therapeutic applications
US11/561,638 US7407644B2 (en) 2000-10-31 2006-11-20 Conjugates of antioxidants with metal chelating ligands for use in diagnostic and therapeutic applications
US12/169,105 US7582280B2 (en) 2000-10-31 2008-07-08 Conjugates of antioxidants with metal chelating ligands for use in diagnostic and therapeutic applications

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24454700P 2000-10-31 2000-10-31
US60/244,547 2000-10-31

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10399265 A-371-Of-International 2001-10-31
US11/561,638 Division US7407644B2 (en) 2000-10-31 2006-11-20 Conjugates of antioxidants with metal chelating ligands for use in diagnostic and therapeutic applications

Publications (2)

Publication Number Publication Date
WO2002040060A2 WO2002040060A2 (en) 2002-05-23
WO2002040060A3 true WO2002040060A3 (en) 2003-12-31

Family

ID=22923208

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/046002 WO2002040060A2 (en) 2000-10-31 2001-10-31 Conjugates of an antioxidants with metal chelating ligands

Country Status (5)

Country Link
EP (1) EP1406669A2 (en)
JP (1) JP2004526671A (en)
AU (1) AU2002239468A1 (en)
CA (1) CA2421182A1 (en)
WO (1) WO2002040060A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0305422D0 (en) * 2003-03-10 2003-04-16 Univ Open Detection, monitoring and treatment of cancer
EP1466629A1 (en) 2003-04-11 2004-10-13 BRACCO IMAGING S.p.A. Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
EP1940841B9 (en) * 2005-10-07 2017-04-19 Guerbet Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium
FR2942227B1 (en) 2009-02-13 2011-04-15 Guerbet Sa USE OF BUFFERS FOR RADIONUCLEID COMPLEXATION
FR2968999B1 (en) 2010-12-20 2013-01-04 Guerbet Sa CHELATE NANOEMULSION FOR MRI
FR2980364B1 (en) 2011-09-26 2018-08-31 Guerbet NANOEMULSIONS AND THEIR USE AS CONTRAST AGENTS
DE102012208375B4 (en) * 2012-05-18 2015-07-23 Zentralklinik Bad Berka Gmbh Set and method of making a radiopharmaceutical
FR3001154B1 (en) 2013-01-23 2015-06-26 Guerbet Sa MAGNETO-EMULSION VECTORIZED
KR101603699B1 (en) * 2014-01-10 2016-03-15 경북대학교 산학협력단 Gadolinium Complex of DO3A-Aminomethyl Cyclohexan Derivatives
WO2020007822A1 (en) 2018-07-02 2020-01-09 Conservatoire National Des Arts Et Metiers (Cnam) Bismuth metallic (0) nanoparticles, process of manufacturing and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BEAUPERE D ET AL: "SELECTIVE AZIDATION OF L SORBOSE APPLICATION TO THE RAPID SYNTHESIS OF 1 DEOXYNOJIRIMYCIN", CARBOHYDRATE RESEARCH, vol. 191, no. 1, 1989, pages 163 - 166, XP002242556, ISSN: 0008-6215 *
LEWIS M R ET AL: "Maleimidocysteineamido-DOTA derivatives: new reagents for radiometal chelate conjugation to antibody sulfhydryl groups undergo pH-dependent cleavage reactions.", BIOCONJUGATE CHEMISTRY. UNITED STATES 1998 JAN-FEB, vol. 9, no. 1, January 1998 (1998-01-01), pages 72 - 86, XP002242557, ISSN: 1043-1802 *
RANGANATHAN R S ET AL: "Synthesis of conjugates of ascorbic acid with metal chelates.", ABSTRACTS OF PAPERS AMERICAN CHEMICAL SOCIETY, vol. 221, no. 1-2, 2001, 221st National Meeting of the American Chemical Society;San Diego, California, USA; April 01-05, 2001, pages CARB 59, XP008017651, ISSN: 0065-7727 *

Also Published As

Publication number Publication date
AU2002239468A1 (en) 2002-05-27
EP1406669A2 (en) 2004-04-14
WO2002040060A2 (en) 2002-05-23
JP2004526671A (en) 2004-09-02
CA2421182A1 (en) 2002-05-23

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