WO2002038597A3 - Genomic fragment of streptococcus suis and clinical uses thereof - Google Patents

Genomic fragment of streptococcus suis and clinical uses thereof Download PDF

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Publication number
WO2002038597A3
WO2002038597A3 PCT/NL2001/000805 NL0100805W WO0238597A3 WO 2002038597 A3 WO2002038597 A3 WO 2002038597A3 NL 0100805 W NL0100805 W NL 0100805W WO 0238597 A3 WO0238597 A3 WO 0238597A3
Authority
WO
WIPO (PCT)
Prior art keywords
genomic fragment
streptococcus suis
streptococcus
fragment
clinical uses
Prior art date
Application number
PCT/NL2001/000805
Other languages
French (fr)
Other versions
WO2002038597A2 (en
Inventor
Hilda Elizabeth Smith
Original Assignee
Id Lelystad Inst Dierhouderij
Hilda Elizabeth Smith
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Id Lelystad Inst Dierhouderij, Hilda Elizabeth Smith filed Critical Id Lelystad Inst Dierhouderij
Priority to CA2428278A priority Critical patent/CA2428278C/en
Priority to AT01993615T priority patent/ATE428787T1/en
Priority to DK01993615T priority patent/DK1334196T3/en
Priority to AU2002224207A priority patent/AU2002224207A1/en
Priority to EP01993615A priority patent/EP1334196B8/en
Priority to DE60138408T priority patent/DE60138408D1/en
Publication of WO2002038597A2 publication Critical patent/WO2002038597A2/en
Publication of WO2002038597A3 publication Critical patent/WO2002038597A3/en
Priority to US10/435,654 priority patent/US7109006B2/en
Priority to US11/499,884 priority patent/US7670835B2/en
Priority to US12/592,923 priority patent/US8071111B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention relates to the field of diagnosis of and vaccination against Streptococcal infections and to the detection of virulence markers of Streptococci. The invention provides a method for modulating virulence of a Streptococcus comprising modifying a genomic fragment of said Streptococcus wherein said genomic fragment comprises at least a functional part of a fragment identifiable by hybridisation in Streptococcus suis to a nucleic acid or fragment thereof as shown in figure 5.
PCT/NL2001/000805 2000-11-09 2001-11-06 Genomic fragment of streptococcus suis and clinical uses thereof WO2002038597A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CA2428278A CA2428278C (en) 2000-11-09 2001-11-06 Virulence of streptococci
AT01993615T ATE428787T1 (en) 2000-11-09 2001-11-06 FRAGMENT FROM THE GENOME OF STREPTOCOCCUS SUIS AND ITS CLINICAL USES
DK01993615T DK1334196T3 (en) 2000-11-09 2001-11-06 Genomic fragment of Streptococcus suis and its clinical applications
AU2002224207A AU2002224207A1 (en) 2000-11-09 2001-11-06 Genomic fragment of streptococcus suis and clinical uses thereof
EP01993615A EP1334196B8 (en) 2000-11-09 2001-11-06 Genomic fragment of streptococcus suis and clinical uses thereof
DE60138408T DE60138408D1 (en) 2000-11-09 2001-11-06 FRAGMENT FROM THE GENREOM OF STREPTOCOCCUS SUIS AND ITS CLINICAL USES
US10/435,654 US7109006B2 (en) 2000-11-09 2003-05-09 Virulence of Streptococci
US11/499,884 US7670835B2 (en) 2000-11-09 2006-08-03 Virulence of streptococci
US12/592,923 US8071111B2 (en) 2000-11-09 2009-12-03 Virulence of Streptococci

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00203947A EP1205552A1 (en) 2000-11-09 2000-11-09 Virulence of streptococci, involving ORFs from Streptococcus suis
EP00203947.7 2000-11-09

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/435,654 Continuation US7109006B2 (en) 2000-11-09 2003-05-09 Virulence of Streptococci

Publications (2)

Publication Number Publication Date
WO2002038597A2 WO2002038597A2 (en) 2002-05-16
WO2002038597A3 true WO2002038597A3 (en) 2002-08-08

Family

ID=8172250

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL2001/000805 WO2002038597A2 (en) 2000-11-09 2001-11-06 Genomic fragment of streptococcus suis and clinical uses thereof

Country Status (9)

Country Link
US (3) US7109006B2 (en)
EP (2) EP1205552A1 (en)
AT (1) ATE428787T1 (en)
AU (1) AU2002224207A1 (en)
CA (1) CA2428278C (en)
DE (1) DE60138408D1 (en)
DK (1) DK1334196T3 (en)
ES (1) ES2325911T3 (en)
WO (1) WO2002038597A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1098980T3 (en) 1998-07-22 2014-09-29 Stichting Dienst Landbouwkundi STREPTOCOCCUS SUIS VACCINES AND DIAGNOSTIC TESTS
EP1205552A1 (en) 2000-11-09 2002-05-15 ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid B.V. Virulence of streptococci, involving ORFs from Streptococcus suis
WO2002061070A2 (en) 2001-02-02 2002-08-08 Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. Environmentally regulated genes, involved in the virulence of streptococcus suis
US6962485B2 (en) * 2003-04-14 2005-11-08 Goodrich Pump And Engine Control Systems, Inc. Constant bypass flow controller for a variable displacement pump
EP2023143A1 (en) * 2007-08-06 2009-02-11 Boehringer Ingelheim Vetmedica Gmbh Immunogenic streptococcus proteins
CN103409546B (en) * 2013-08-20 2015-05-20 长沙市疾病预防控制中心 Kit for detecting streptococcus suis type 2 and application of kit
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
MX2019005499A (en) * 2016-11-11 2019-07-04 Boehringer Ingelheim Vetmedica Gmbh Attenuating bacterial virulence by attenuating bacterial folate transport.
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
CN110938636B (en) * 2019-12-05 2023-05-26 中国水产科学研究院黑龙江水产研究所 Main pathogenic fragment of yersinia ruckeri hemolysin gene, screening method and application

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610011A (en) * 1991-03-21 1997-03-11 Centraal Diergeneeskundig Instituut Virulence-encoding DNA sequences of Strepococcus suis and related products and methods
WO2000005378A2 (en) * 1998-07-22 2000-02-03 Id-Lelystad Instituut Voor Dierhouderij En Diergezondheid B.V. Streptococcus suis vaccines and diagnostic tests

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5928900A (en) * 1993-09-01 1999-07-27 The Rockefeller University Bacterial exported proteins and acellular vaccines based thereon
WO1995031548A1 (en) 1994-05-16 1995-11-23 The Uab Research Foundation Streptococcus pneumoniae capsular polysaccharide genes and flanking regions
US5681570A (en) * 1995-01-12 1997-10-28 Connaught Laboratories Limited Immunogenic conjugate molecules
EP0750042A1 (en) * 1995-06-20 1996-12-27 Societe Des Produits Nestle S.A. Exopolysaccarides-producing lactic acid bacteria
EP0750043B1 (en) 1995-06-20 2001-05-23 Societe Des Produits Nestle S.A. Exopolysaccharides-producing lactic acid bacteria
JP2001510989A (en) 1996-11-01 2001-08-07 スミスクライン・ビーチャム・コーポレイション New coding sequence
US6800744B1 (en) * 1997-07-02 2004-10-05 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
EP1144640A3 (en) * 1998-07-27 2001-11-28 Microbial Technics Limited Nucleic acids and proteins from streptococcus pneumoniae
EP1205552A1 (en) 2000-11-09 2002-05-15 ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid B.V. Virulence of streptococci, involving ORFs from Streptococcus suis
WO2002061070A2 (en) 2001-02-02 2002-08-08 Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. Environmentally regulated genes, involved in the virulence of streptococcus suis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610011A (en) * 1991-03-21 1997-03-11 Centraal Diergeneeskundig Instituut Virulence-encoding DNA sequences of Strepococcus suis and related products and methods
WO2000005378A2 (en) * 1998-07-22 2000-02-03 Id-Lelystad Instituut Voor Dierhouderij En Diergezondheid B.V. Streptococcus suis vaccines and diagnostic tests

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ALLGAIER A. ET AL: "Relatedness of Streptococcus suis isolates of various serotypes and clinical backgrounds as evaluated by macrorestriction analysis and expression of potential virulence traits.", JOURNAL OF CLINICAL MICROBIOLOGY, (2001) 39/2 (445-453)., XP000992120 *
BUSQUE P. ET AL: "Immunization of pigs against Streptococcus suis serotype 2 infection using a live avirulent strain.", CANADIAN JOURNAL OF VETERINARY RESEARCH, (1997) 61/4 (275-279)., XP000991156 *
SMITH H.E. ET AL: "Cloning and nucleotide sequence of the gene encoding the 136-kilodalton surface protein (muramidase-released protein) of Streptococcus suis type 2.", INFECTION AND IMMUNITY, (1992) 60/6 (2361-2367)., XP000990323 *
SMITH H.E. ET AL: "Identification and characterization of the cps locus of Streptococcus suis serotype 2: The capsule protects against phagocytosis and is an important virulence factor.", INFECTION AND IMMUNITY, (1999) 67/4 (1750-1756)., XP002126886 *
SMITH H.E. ET AL: "Repeats in an extracellular protein of weakly pathogenic strains of Streptococcus suis type 2 are absent in pathogenic strains.", INFECTION AND IMMUNITY, (1993) 61/8 (3318-3326)., XP000990324 *
SMITH HILDE E ET AL: "Selection of virulence-associated determinants of Streptococcus suis serotype 2 by in vivo complementation.", INFECTION AND IMMUNITY, vol. 69, no. 3, March 2001 (2001-03-01), pages 1961 - 1966, XP002199921, ISSN: 0019-9567 *
SMITH, H. E. DE ET AL: "The cps locus of Streptococcus suis serotype 2: genetic determinant for the synthesis of sialic acid", MICROBIAL PATHOGENESIS, (2000) VOL. 29, NO. 2, PP. 127-134. 28 REF. ISSN: 0882-4010, Department of Bacteriology, Institute for Animal Science and Health, P.O. Box 65, 8200 AB Lelystad, Netherlands., XP000991174 *

Also Published As

Publication number Publication date
US20040009192A1 (en) 2004-01-15
ATE428787T1 (en) 2009-05-15
EP1334196B8 (en) 2009-09-02
US20070053938A1 (en) 2007-03-08
WO2002038597A2 (en) 2002-05-16
US8071111B2 (en) 2011-12-06
DK1334196T3 (en) 2009-07-06
ES2325911T3 (en) 2009-09-24
US7670835B2 (en) 2010-03-02
CA2428278A1 (en) 2002-05-16
AU2002224207A1 (en) 2002-05-21
CA2428278C (en) 2011-08-23
EP1334196B1 (en) 2009-04-15
EP1205552A1 (en) 2002-05-15
US7109006B2 (en) 2006-09-19
EP1334196A2 (en) 2003-08-13
US20100136057A1 (en) 2010-06-03
DE60138408D1 (en) 2009-05-28

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