WO2002022210A1 - Method and device for verifying a therapeutic irradiation - Google Patents

Method and device for verifying a therapeutic irradiation Download PDF

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Publication number
WO2002022210A1
WO2002022210A1 PCT/EP2001/009483 EP0109483W WO0222210A1 WO 2002022210 A1 WO2002022210 A1 WO 2002022210A1 EP 0109483 W EP0109483 W EP 0109483W WO 0222210 A1 WO0222210 A1 WO 0222210A1
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WO
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Prior art keywords
beam
characterized
verification
modulation
target volume
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PCT/EP2001/009483
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German (de)
French (fr)
Inventor
Bernd-Michael Hesse
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Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048Monitoring, verifying, controlling systems and methods
    • A61N5/1049Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048Monitoring, verifying, controlling systems and methods
    • A61N5/1049Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A61N2005/1061Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using an x-ray imaging system having a separate imaging source

Abstract

The invention relates to a method and device for verifying a therapeutic irradiation using a high-energy modulated beam (1). To this end, the shape of the beam (1) is detected between a unit for carrying out beam modulation (2) and the target volume (3) to be irradiated. According to the inventive device, a medium (8, 13) for detecting the high-energy modulated beam (1) is arranged between a unit for carrying out beam modulation (2) and the target volume (3) to be irradiated. The verification of the radiation to be applied is improved by virtue of the fact that an X-ray beam (4), which is directed towards the target volume (3) in the opposite direction (5) to that (6) of the high-energy beam (1), is provided for detecting the target volume (3), and that the X-ray beam (4), with regard to its direction (5), is detected behind the target volume (3). The detection of the target volume (3) using the X-ray beam (4) serves to verify and correct the modulation of the high-energy beam (1).

Description

Method and device for verification of therapeutic irradiation

description

The invention relates to a method for the verification of therapeutic irradiation of a high energy modulated beam, wherein for verifying the shape of the beam between a device for beam modulation and the bestrahlen- to the target volume is detected.

The invention further relates to an apparatus for verification of therapeutic irradiation of a high energy modulated beam, this is detected for verification by means of a medium which is disposed between a device for beam modulation and the target volume to be irradiated,

The most commonly suggested method for the verification of therapeutic irradiation is based on the detection of the energy beam by means of the transit dosimetry. The medium for detecting the modulated energy beam is arranged underneath the patient table, so that the beam is only detected when it is passed through the patient's body. The following proposals of the prior art are based on the Transitdosimetrie: US 4, 726, 046 A; US 5, 825, 845 A; US 5, 471, 516 A; US 5, 278, 886 A and TR Mackie et al ( "TomoTherapy: A new concept for the delivery of dynamic conformal radiotherapy", Med.Phy.20 (1993) 1709-1719). And David A. Jaffray et al ( "A radiographic and tomographic imaging system integrated into a medical linear accelerator for localization of bone and soft-tissue targets" in Int.J.Radiat. Oncol.Biol.Phys., Volume 45, No. 3 (1999) 773- 789) , However, with this method depends on passage of the beam through the patient and the patient table to scattering of the beam as well as weaknesses by different absorption. Thus, it can be detected accurately neither the image of the contour of the target volume nor a distribution of radiation dose within the irradiated area. This is insufficiently checked whether the applied radiation is consistent with the treatment plan and it is also not possible already to undergo minor deviations an immediate correction.

A direct, made during radiation imaging with respect to the anatomy of the patient with the help of the therapy beam is difficult because such a method would either lead to an increased radiation dose, which is unacceptable, or imaging would be unsatisfactory. It must be added that the beam is limited by the collimator, which can be imaged only a limited image section, not the environment of the target volume, and that no soft tissue can be imaged. For this reason, (Mackie and Jaffray), the target volume by means of a, was proposed by the latter two writings of the above-mentioned prior art to detect disposed at an angle of 90 ° to the therapy beam X-ray. In such an arrangement, however, only an axis perpendicular to the treatment beam area of ​​the target volume can be detected. Thus, if the proposed Thomotherapie- the target volume of the patient by means Orbiting when the Thomographie is detected, then the therapy beam passes only after a further rotation of 90 ° in this position. Here, however, the location and shape of the target volume, eg. have changed by respiration, heart rate, muscle tension, etc. B.. This leads to uncertainty and thus, so that an optimal error-free radiation is not guaranteed to inadequate correction also using this method.

From other writings (US 4, 726, 046 A, US 5, 825, 845 A, US 5, 471, 516 A, US 5, 278, 886 A, US 5, 471, 516 A) is proposed that the therapy beam and to integrate the X-ray beam to the target volume acquisition in one source with the same beam direction. The problem with this solution is that two radiation sources can not be simultaneously at identical locations. Either a certain spatial displacement must be provided which leads or through different places and perspectives errors sources are introduced successively to the same place, then there is a time lag, which in turn leads to errors, since the position and shape of the target volume during the can change time offset. The aforementioned problem of the time offset is 197 81 999 Tl also the subject matter of DE. In this field, a light is arranged at the radiation source and a reference structure to the patient placed and fixed to the latter. Then the prepared collimator for radiation is imaged on the reference structure by means of the field light. This figure is compared for verification with the treatment plan and made the irradiation at a match. In this proposal, however, the energy modulated beam is not detected, but the field light, which is sent through the same Kollimatoröffhung. The consequent large temporal offset includes the consideration of short-term changes such as z. For example, by heartbeat, breathing, or sudden muscle tension are beding, completely out.

Although the WO 99 32 189 AI treated verification, but in a magnetic resonance imaging device, which differs essentially from the above verification process, since the patient is magnetic resonance imaging device. Timely verification by a magnetic resonance imaging device is already questionable because irradiation with accelerated particles - and this is at a high-energy therapy beam the rule - by the magnetic fields of magnetic resonance imaging device is deflected and the latter can be turned on and off even in the short term.

Finally, a method and a device of the type mentioned in the US 5, 538, 494 A. While it is intended to detect the shape of the beam between a means for radiation modulation and to be irradiated target volume, however, the verification is not timely. Instead of a timely determination of the shape and location of the target volume, the path is chosen there, adapt to these changes a not promptly determined shape and location of the target volume by sensor detection of breathing and heartbeat by means of a computing process. This method does not have the disadvantage that only the processes detected by sensors are included in a correction and other movements such as muscle tension. In addition, the inclusion of computational dressed in mathematical functions effects of the heartbeat or respiration goes out, which can detect evaluate the current state only from Experience - but of these the respective real situation may be different.

The invention is therefore based on the object to improve the verification of the to be applied radiation, especially an exact checking the conformity of the applied radiation with the predetermined by the treatment plan radiation allow to correct the therapy beam better and even at minor deviations ,

An additional object is to make the verification of the effect that a timely scan possible is possible to optimally adjust the treatment beam to the actual state.

With respect to the method, the object is achieved in that an X-ray beam is formed for detection of the target volume, which is directed in the opposite direction as that of the energy beam to the target volume and that the X-ray beam is detected with respect to its direction behind the target volume, wherein the detection of the is the target volume by the X-ray verification and correction of the modulation of the energy beam.

With regard to the apparatus the object is achieved in that a radiation source for an X-ray beam relative to the target volume of the radiation source for the energy beam is arranged opposite to the verification of conformity to the shape of energy modulated beam to the shape and location of the target volume so that the directions the beams are opposite and that a medium for detecting the X-ray beam with respect to the direction thereof is arranged behind the target volume. By the invention, the treatment beam before passing through the patient and thus detected without distortion by variations is thereby a precise detection of the contour of the generally successively from different directions ornamental to appli- rays is possible.

The verification is used a the treatment beam exactly opposite direction of X-ray, so that there is no angular difference between the treatment beam and the verification serving ray occurs. In addition, the therapy beam and X-ray can be almost instantly transmitted and detected.

If the invention is further developed in that the intensity of the beam is detected by the beam sensing medium is also formed for detecting the intensity of the beam, so also this is exactly verifiable as may occur no absorption of portions of the beams before detection ,

, The additional object is achieved in that the verification and correction of the modulation of the energy beam is carried out on the basis of an almost simultaneously detected X-ray. This is preferably achieved by the method and the device are designed such that is detected in a pulsed energy beam of X-ray in the emission pauses of the energy beam. Characterized accurate detection of X-rays without anti-scatter of the energy beam is possible. In order to keep the radiation exposure as low as possible, it is also expedient if the X-ray beam is emitted only in the transmission pauses of the energy beam. '

As already mentioned, the detection of the target volume by the X-ray is used appropriately verification and correction of the modulation of the energy beam. This can be done, for example, characterized in that said data of detection by the X-rays are immediately to correct the setting of a collimator, for example a MultileafkoUimators used. The corrections thus are each time closer they are implemented accurately. Since the pulses of the energy beam in the microsecond range and the pauses in the millisecond range, is - upon detection in the emission pauses of the energy beam - this order, the lower limit for the time equality. so it can achieve such timeliness that during these periods there are no relevant changes more with high computing speed of the computer used. This can be achieved optimum accuracy.

The invention limits the verification not only to check whether the appli- ed beam corresponds to the proposed methods and apparatus are expediently designed such that the anatomy and position of the patient by the X-ray can be detected and further that is verifiable, whether the patient's anatomy and the position corresponding to the time of irradiation of the anatomy and location which were the subject of the development of the treatment plan. There is an almost identical time verification of the anatomy and position and thus compliance with the treatment plan, for example, its timely adaptation to the anatomy and position of the patient allows, so that changes can be considered without delay. It is possible to include or the changes in the correction of the therapy beam off the treatment beam. Thereby, it is possible that the target volume - even if it changes its position and / or its shape - with high accuracy the predetermined radiation dose is obtained and the dose exactly at the edge of the target volume - so steep falls off that surrounding tissue - typically the tumor margin is not damaged as possible. Thereby, the invention increases the success of therapy, while reducing the side effects. In particular, tumors which are directly adjacent organs at risk can be treated in this way better and with much reduced risk.

In addition to this increase in the accuracy of the irradiation dose distribution with respect to contour and the invention enables also, that can be dispensed on a strict fixation of the patient, since positional changes of the patient can be detected and incorporable in the correction. It is no longer necessary to store a patient in tight-fitting rigid shells, although they take him any motion possibility, but ultimately can not give a complete guarantee of an unchanged anatomy as respiratory movements, muscle tension and the transfer of organs are always present , By using the above-mentioned improvement of the verification according to the invention all this can be detected and taken into account. Both changes in position of the target volume and organs at risk of or changes in position of the patient, the treatment can be continued with appropriate variations with corrections or interrupted, the latter if a sufficiently rapid correction is not possible.

Since complicated shapes can often only be detected by an all-round view, it is proposed that the method and device are formed such that the shape of the target volume is detected prior to the irradiation with the energy beam by a detection of the target volume by means of an X-ray beam from different directions, and that this information is included in the verification and correction of the modulation of the energy beam.

Since it provide treatment plans usually that different areas are treated with a different dose of irradiation, these areas are appropriately involved in the verification and correction of the modulation of the energy beam.

To spare organs at risk optimally, it is further proposed this also to be recorded in one of the aforementioned ways and be considered in the verification and correction of the modulation of the energy beam. It is appropriate in this case if the position and shape of organs at risk almost simultaneously determined and with the verification and modulating the energy beam through the X-ray to be considered for a correction of the modulation.

With respect to the apparatus is suggested as advantageous development that both media, to detect the high-energy beam and for detecting the X-ray beam, as a medium to be formed. In this way, a detection medium is eliminated, which reduces the equipment complexity. The assignment of the two acquisitions is simplified. Here, the individual sensing elements for the detection of both beams can be used by the X-rays is detected, for example, directly at the surface and the therapeutic beam in the radiation throughput of the medium. The medium must be made of a material which is not damaged by the harsh treatment beam. For example, the medium may be an array of photodiodes, the latter being made of amorphous silicon. These may be no destruction of a lattice structure. If these photodiodes arranged in a plastic housing, so there is also no significant attenuation or scattering of the radiation to be detected.

Preferably, the device according to the invention is designed such that the radiation sources, the means for beam modulation and the medium or the media for detecting the beams are arranged on a gantry, whereby they can take together different directions to the target volume. is most conveniently the arrangement of a medium for the detection of both beams, which leads to the above advantages. If the radiation source for the X-ray beam and a medium for detecting two beams attached to a conventional exposure apparatus, then the apparatus of the invention are prepared in a simple manner and it is possible nachzurösten existing devices.

The apparatus may comprise a computer further is for verification and correction of the modulation of the energy beam formed due to the power absorbed by the medium or the media data and set up. In the APPEND supply to an existing irradiation apparatus is sufficient to set up the computer by means of appropriate software, if this has sufficient computing capacity. Preferably, the computer is adapted for almost simultaneous verification and correction or decorated. Likewise, the inclusion of previously determined anatomical data in the almost simultaneous verification and correction.

The invention is explained below with reference to the drawing. In the drawings Fig. 1 is a schematic diagram of an exemplary embodiment of the present invention

Device,

Fig. 2 shows a device according to the invention in use, and

Fig. 3 is an explanation of the principle of an optimum irradiation which is to be verified according to the invention.

Fig. 1 shows the principle of the invention shows one embodiment of the inventive device. An energy beam 1 is generated by a radiation source 11 and modulated by a device for radiation modulation 2, for example a multi-leaf collimator according to the treatment plan and directed to a target volume. 3 In general, this is a tumor of a patient 21 being treated lying on a patient table 19th Between the device 2 for beam modulation and the patient 21, a medium 8 for detecting the energy modulated beam 1 is arranged according to the invention in the beam path 9, so that the shape and intensity of modifications may be detected by the device 2 for beam modulation and monitored. Giving way to the modulation of the beam 1 from its target value, a shutdown or a correction can be made.

Opposite the radiation source 11 for the energy beam 1 a radiation source 10 for an X-ray beam 4 is arranged. The arrangement is such that a beam path is created 9, wherein the direction 5 of the X-ray beam 4, the direction is opposite exactly 6 of the high-energy beam. 1 The X-ray beam 4 is used to detect the target volume 3 and of the anatomy and position of the patient 21 in the manner already described above way. For detecting the X-ray beam 4 after passing thereof through the patient 21, a medium 12 is arranged. Expediently, however, the media are formed as a medium 13 for detecting the energy beam 1 and the X-ray beam 4 8 and 12. FIG. With regard to a practical embodiment referred to above. The arrangement of the radiation sources 11 and 10 is performed so that the target volume 3 is detected by the therapeutic beam 1 and by the X-ray beam 4 the target volume 3 and its environment that should be taken into account in the modulation of the therapy beam. 1 For this reason, the X-ray beam 4 is further drawn divergent than the therapeutic beam 1, wherein it may be of course also formed narrower than drawn, ie does not have to cover the entire patient 21st

A detection medium 13 is provided, its surface must be dimensioned such that it detects the position of arrangement of the sensing medium 13, the conically diverging beams 1 and 4. FIG.

The implementation of a treatment expediently in the following steps:

In a first step of the verification procedure that is, the X-ray beam 4 and a medium 12 or 13, a current computed tomography data set from the patient 21 is obtained in therapy situation immediately before the start of radiation therapy with the aid of the computer tomography system. Changes in the target region 3 and overlay error of the patient 21 can be hereby acknowledge directly, so that the subsequent therapy on this new data can be matched.

In a second step during application of the therapeutic radiation fields 24 (see Fig. 3), the field shape and the intensity distribution of the therapy beam 1 is measured and recorded. Thus, and based on the current computer tomography data set to the patient 21 applied radiation dose distribution 16, 16 ', 16 "(see FIG. 3) be reconstructed and verified online. Optionally, the radiation application can be interrupted at any deviations or with corresponding immediate corrections to be continued. the nature of the arrangement of the X-ray genstrahlquelle 10 and the medium 13 for detecting the beams 1 and 4, it is also possible for the relative position of structures (target volume 3, with a different dose to be irradiated regions 16, 16 ' , 16 "of the target volume 3 and risk organs 17) (low contrast soft tissue contrast) in the therapeutic radiation field 24 and its vicinity (see FIG. 3) using the X-ray beam 4 during the application of the individual therapeutic radiation fields 24 to monitor and, if possible, an immediate, possible make almost simultaneous correction.

Fig. 2 shows an apparatus according to the invention in use. This is a conventional structure of an irradiation apparatus 18 with a radiation source 11 for the treatment beam 1, a patient table 19 and a device 2 for radiation modulation to the medically indicated radiation to a target volume 3, for example on the head 20 of a patient 21, so as to judge that a tumor damaged maximum and the surrounding tissue becomes maximum spared. To this end, a frame (gantry) 14 is provided, which can revolve around the patient 21 on all sides. The gantry 14 contains the radiation source 11 for the treatment beam 1, wherein the high-energy radiation is generated, for example, by a linear accelerator 22. 1 The radiation source 11 is arranged on the gantry 14, the radiation source 10 for the X-ray beam 4 in the manner already described to Fig. 1 manner opposite. In this regard, reference is made to the above description, wherein like reference numerals denote functionally identical parts.

The gantry 14 is rotatable about a horizontal axis of rotation 23, wherein the beams 1 and 4 to the target volume 3 and its environment are directed. The target volume 3 is located at the isocenter of the beams 1 and 4, wherein the radiation sources 11 and 10 and a device 2 for beam modulation by the rotation of gantry 14 about the axis 23 orbiting the patient 21st At the same time a displacement or rotation of the treatment table 19 can take place to make a precise adjustment of the irradiation of the treatment beam to the target volume 1 3 of the patient 21st

The purpose of such a gantry is that by the different irradiation directions 7 (see Fig. 3), the target volume 3 undergoes a maximum irradiation, however, the surrounding tissue becomes maximum spared, as it is always exposed only for short periods to high-energy beams 1. In addition, it is often required that certain areas of the body such as the spinal cord or other risk organs are completely spared 17 of the high-energy radiation 1 as possible, that is by the design of therapeutic radiation fields 24 from the various devices 7 (see Fig. 3) as far as possible are recessed.

The location and the profile of the target volume 3, and the position of organs at risk 17 or areas 16, 16 ', 16 "which are provided to different doses of irradiation is detected from the medium 13 by means of the X-ray beam 4 the same time also the actual state. detects the modeled therapy beam. 1 These data are converted such that the collimator 2 forms a corresponding collimator, wherein the inventive detection and verification, the exact shape of the target volume 3 with the desired radiation dose distribution 16, 16 ', 16 "(see Fig. 3 ) can be irradiated. At a collimator 2, the radiation dose distribution 16, 16 ', 16 "is achieved by one or more therapeutic radiation fields 24 of different time duration, also be applied from multiple directions. 7

To use all the settings, a computer 15 is provided which is directed einge- such on the basis of a treatment planning and the current verification that it controls the gantry 14, the device 2 for beam modulation and possibly also the patient table 21st When setting up 2 can be either a collimator and a scanner. The therapeutic radiation fields to be treated 24 are limited by the collimator or generated by scanning a beam therapy. 1

Fig. 3 shows an explanation of the principle of a tumor irradiation, the administration of a medically indicated energy radiation 1 from different directions 7 is made. In order to be irradiated target volume 3, for example, to irradiate in the already explained way in an optimum manner and to protect the adjacent tissue as possible a tumor, it is necessary that various therapeutic radiation fields 24 are formed for each of the different directions of irradiation. 7 Serves the means 2 for radiation modulation, which can be designed as a collimator or as a scanner. In order to achieve that DAS receives the necessary dose to be irradiated target volume 3, but risk members 17 are preserved, it is provided that the therapeutic radiation fields 24 are formed as matrices 25 of individual fields 26 of varying radiation dose. Such matrices 25 can be reproduced in almost any conceivable shape through the Leafverstellungen a MultileafkoUimators, wherein the finest possible replica of the to be irradiated therapeutic radiation fields 24 is achieved by thin Leafs. In addition, several different therapeutic radiation fields for display may be applied 24 with different time period from a direction 7, to areas 16, 16 '16 to achieve in an optimal manner, "with a different dose of radiation. In this process, the verification and correction according to the invention, almost at the identical place in above described manner instead.

The presentation of the figures is only an exemplary illustration of the invention. It is also conceivable that the therapeutic radiation fields 24 are generated instead by a collimator by a scanner. Then, this serves as the means 2 for beam modulation and the medium 8 or 13 must detect the scanned therapeutic radiation fields 24, so can be carried out the verification according to the invention as well as a correction, and optionally also a discontinuation of treatment in a corresponding manner. Of course, further embodiments are conceivable that make the principles of the invention use.

Method and device for verification of therapeutic irradiation

LIST OF REFERENCE NUMBERS

energy modulated beam (treatment beam) device for beam modulation target volume x-ray beam toward the X-ray beam direction of the energy beam different directions of the recording and irradiation of the target volume medium for detecting the energy modulated beam ray path 0-ray source for X-ray 1 Radiation source of energy beam 2 medium for detecting the X-ray beam 3 medium for detecting the high energy beam and the X-ray beam 4 gantry 5 computer 6, 16 ', 16 "regions of different irradiation dose (irradiation dose distribution) 7 organs at risk (z. B. spinal cord) 8 irradiation apparatus 9 patient table 0 head 1 patient Linearbeschleumger

Axis of rotation of the gantry

Therapeutic radiation fields

matrices

individual fields

brain

Claims

Method and device for verification of therapeutic irradiation Patent claims
1. A method for verification of therapeutic irradiation of a high energy modulated beam (1), wherein the shape of the beam for the verification (1) is detected between a means for radiation modulation (2) and to be irradiated target volume (3), characterized in that an X-ray beam (4) for detecting the target volume (3) is formed, which is directed in the reverse direction (5) as the (6) of the energy beam (1) to the target volume (3) and that the X-ray beam (4) with respect its direction (5) is detected behind the target volume (3), wherein the detection of the target volume (3) through the X-ray beam (4) of the verification and correction of the modulation of the energy beam (1).
2. The method according to claim 1, characterized in that the intensity of the beam (1) is detected.
3. The method of claim 1 or 2, characterized in that the verification and correction of the modulation of the energy beam (1) on the basis of an almost simultaneously detected X-ray beam (4).
4. The method according to claim 3, characterized in that when a pulsed energy beam (1) of the X-ray beam (4) in the emission pauses of the energy beam (1) is detected.
5. The method according to claim 4, characterized in that the X-ray beam (4) only in the emission pauses of the energy beam (1) is emitted.
6. A method according to any one of claims 1 to 5, characterized in that the anatomy and position of the patient (21) through the X-ray beam (4) is detected.
7. The method according to claim 6, characterized in that it is verified whether this anatomy and position of the patient (21) corresponding to that which were the subject of the preparation of the treatment plan.
8. The method according to claim 6 and 7, characterized in that the treatment plan in a timely manner the anatomy and position of the patient (21) is adjusted.
9. The method according to any one of claims 1 to 8, characterized in that prior to the irradiation with the energy beam (1) by a detection of the target volume (3) by means of the X-ray beam (4) from different directions (7) (the shape of the target volume 3) is detected and that this information (in the verification and correction of the modulation of the energy beam 1) is included.
10. A method according to any one of claims 2 to 9, characterized in that the verification and correction of the modulation of the energy beam (1) regions (16) of different radiation dose to be included.
11. A method according to any one of claims 1 to 10, characterized in that in the verification and correction of the modulation of the energy beam (1) the shape and position of organs at risk (17) is taken into account.
12. The method according to claim 11, characterized in that also the position of organs at risk almost simultaneously with the verification and modulation of the energy beam (1) by the X-ray beam (4) is determined and is taken into account for a correction of the modulation.
13. An apparatus for the verification of therapeutic irradiation of a high energy modulated beam (1), this for verification by means of a medium (8, 13) is detected, between a means for radiation modulation (2) and to be irradiated target volume (3) is arranged, characterized in that for verifying the conformity of the shape of the energy modulated beam (1) a radiation source with the shape and location of the target volume (3) (10) for an X-ray beam (4) in relation to the target volume
(3) the radiation source (11) for the energy beam (1) is arranged oppositely, that the directions (5, 6) of the beams (1, 4) are opposite and that a medium (12) for detecting the X-ray beam
(4) relative to the direction (5) of the same behind the target volume (3) is arranged.
14. The apparatus according to claim 13, characterized in that formed the medium (8, 13) also for detecting the intensity of the beam (1).
15. The apparatus of claim 13 or 14, characterized in that it is constructed such that the detection of the target volume (3) through the X-ray beam (4) of the correction of the modulation of the energy beam (1).
16. The apparatus according to claim 15, characterized in that it is designed such that the verification and correction of the modulation of the energy beam (1) on the basis of an almost simultaneously detected X-ray beam (4).
17. The apparatus according to claim 16, characterized in that it is designed such that when a pulsed energy beam (1) of the X-ray beam (4) in the emission pauses of the energy beam (1) is detected.
18. The apparatus according to claim 17, characterized in that it is designed such that the X-ray beam (4) is emitted only in the emission pauses of the energy beam (1).
19. Device according to one of claims 13 to 18, characterized in that it is designed such that by the X-ray beam (4), the anatomy and position of the patient (21) is detectable.
20. The apparatus according to claim 19, characterized in that it is designed in such a way that is verifiable whether the anatomy and position of the patient (21) corresponding to that which were the subject of the preparation of the treatment plan.
21. The apparatus according to claim 20, characterized in that it is designed such that it can adjust the treatment plan in a timely manner the anatomy and position of the patient (21).
22. The device according to one of claims 13 to 21, characterized in that it is designed in such a way that prior to the irradiation with the energy beam (1) by a detection of the target volume (3) by means of the X-ray beam (4) (from different directions 7 ) has the shape of the target volume (3) is detected and that this information (in the verification and correction of the modulation of the energy beam 1) is included.
23. Device according to one of claims 14 to 22, characterized in that it is designed such that in the verification and correction of the modulation of the energy beam (1) regions (16) of different radiation dose to be included.
24. Device according to one of claims 13 to 23, characterized in that it is designed such that during verification and correction of the modulation of the energy beam (1) the shape and position of organs at risk (17) is taken into account.
25. Device according to one of claims 13 to 24, characterized in that it is designed such that also the position of organs at risk determined virtually simultaneously with the verification and modulation of the energy beam (1) by the X-ray (4) and for a correction the modulation is considered.
26. The device according to any one of claims 13 to 25, characterized in that the media (8, 12) are designed as a medium (13) for detecting the energy beam (1) and the X-ray beam (4).
27. The device according to claim 26, characterized in that the medium (13) is an array of existing amorphous silicon photodiodes.
28. Device according to claim 27, characterized in that the photodiodes are arranged in a plastic housing.
29. The device according to any one of claims 13 to 28, characterized in that the radiation sources (10, 11), the means for beam modulation (2) and the medium (13 or 8 and 12) are arranged on a gantry (14), whereby they can take different directions together (7) to the target volume (3).
30. The device having any one of claims 13 to 29, characterized in that it comprises a computer (15), the captured for verification and correction of the modulation of the energy beam (1) due to the through the medium (13 or 8 and 12) is data formed and arranged.
31. The device according to claim 30, characterized in that the computer (15) is designed for an almost simultaneous verification and correction and furnished.
32. Apparatus according to claim 31, characterized in that the computer (15) previously determined for the incorporation of anatomical data is formed in the almost simultaneous verification and correction and furnished.
PCT/EP2001/009483 2000-09-15 2001-08-17 Method and device for verifying a therapeutic irradiation WO2002022210A1 (en)

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DE10045797 2000-09-15
DE10045797.5 2000-09-15
DE2001100958 DE10100958C2 (en) 2000-09-15 2001-01-11 An apparatus for verification of therapeutic irradiation
DE10100958.5 2001-01-11

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Cited By (2)

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