WO2002016333A2 - Thioflavin derivatives and their use in diagnosis and theraphy of alzheimer's disease - Google Patents
Thioflavin derivatives and their use in diagnosis and theraphy of alzheimer's disease Download PDFInfo
- Publication number
- WO2002016333A2 WO2002016333A2 PCT/US2001/026427 US0126427W WO0216333A2 WO 2002016333 A2 WO2002016333 A2 WO 2002016333A2 US 0126427 W US0126427 W US 0126427W WO 0216333 A2 WO0216333 A2 WO 0216333A2
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- WO
- WIPO (PCT)
- Prior art keywords
- group
- compound
- amyloid
- lower alkyl
- ch2x
- Prior art date
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- 0 CN1CCN(*)CCN(*)CC1 Chemical compound CN1CCN(*)CCN(*)CC1 0.000 description 12
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Abstract
Description
Claims
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL360550A PL215711B1 (en) | 2000-08-24 | 2001-08-24 | Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
DK01966165.1T DK1334091T3 (en) | 2000-08-24 | 2001-08-24 | Thioflavin derivatives and their use in the diagnosis and therapy of Alzheimer's disease |
SI200131017T SI1334091T1 (en) | 2000-08-24 | 2001-08-24 | Thioflavin derivatives and their use in diagnosis and therapy of alzheimer's disease |
BR0113470-1 BRPI0113470B8 (en) | 2000-08-24 | 2001-08-24 | amyloid binding compound, pharmaceutical composition and methods of compound synthesis, of in vivo detection of amyloid deposits in an individual and in human or animal tissue, of quantification of amyloid deposit in biopsy or postmortem tissue, and of distinguishing a brain from disease alzheimer of a normal brain |
HU0302956A HU230375B1 (en) | 2000-08-24 | 2001-08-24 | Thioflavin derivatives and their use in diagnosis and treatment of alzheimer's disease |
AU2001286702A AU2001286702B2 (en) | 2000-08-24 | 2001-08-24 | Thioflavin derivatives and their use in diagnosis and theraphy of alzheimer's disease |
HU1500560A HU230581B1 (en) | 2000-08-24 | 2001-08-24 | Thioflavin derivatives and their use in diagnosis and treatment of alzheimer's disease |
ES01966165T ES2395721T3 (en) | 2000-08-24 | 2001-08-24 | Thioflavin derivatives and their use in diagnosis and therapy of Alzheimer's disease |
AU8670201A AU8670201A (en) | 2000-08-24 | 2001-08-24 | Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
JP2002521434A JP5022554B2 (en) | 2000-08-24 | 2001-08-24 | Thioflavin derivatives for prenatal diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposits |
CA2419420A CA2419420C (en) | 2000-08-24 | 2001-08-24 | Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
EP01966165A EP1334091B1 (en) | 2000-08-24 | 2001-08-24 | Thioflavin derivatives and their use in diagnosis and therapy of alzheimer's disease |
NO20030860A NO330176B1 (en) | 2000-08-24 | 2003-02-24 | Amyloid Binding Compounds, Methods of Preparation and Use, Pharmaceutical Composition for In Vivo Imaging and Use thereof |
HK04100858.7A HK1058041A1 (en) | 2000-08-24 | 2004-02-09 | Thioflavin derivatives and their use in diagnosis and therapy of alzheimer's disease |
AU2008202626A AU2008202626B9 (en) | 2000-08-24 | 2008-06-13 | Thioflavin derivatives and their use in diagnosis and therapy of Alzheimer's disease |
LTPA2015001C LTC1334091I2 (en) | 2000-08-24 | 2015-01-19 | Thioflavin derivatives and their use for diagnosis and therapy of Alzheimer's disease |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22760100P | 2000-08-24 | 2000-08-24 | |
US60/227,601 | 2000-08-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002016333A2 true WO2002016333A2 (en) | 2002-02-28 |
WO2002016333A3 WO2002016333A3 (en) | 2002-05-30 |
Family
ID=22853739
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/026427 WO2002016333A2 (en) | 2000-08-24 | 2001-08-24 | Thioflavin derivatives and their use in diagnosis and theraphy of alzheimer's disease |
Country Status (19)
Country | Link |
---|---|
US (5) | US20020133019A1 (en) |
EP (2) | EP2264018B1 (en) |
JP (2) | JP5022554B2 (en) |
CN (1) | CN1285582C (en) |
AU (3) | AU2001286702B2 (en) |
BR (1) | BRPI0113470B8 (en) |
CA (1) | CA2419420C (en) |
CY (1) | CY1113311T1 (en) |
DK (2) | DK1334091T3 (en) |
ES (2) | ES2536449T3 (en) |
HK (2) | HK1058041A1 (en) |
HU (2) | HU230375B1 (en) |
LT (1) | LTC1334091I2 (en) |
NO (1) | NO330176B1 (en) |
PL (1) | PL215711B1 (en) |
PT (2) | PT1334091E (en) |
RU (1) | RU2324686C2 (en) |
SI (1) | SI1334091T1 (en) |
WO (1) | WO2002016333A2 (en) |
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EP1266884A1 (en) * | 2000-03-22 | 2002-12-18 | BF Research Institute, Inc. | Image diagnosis probe based on substituted azobenzene or analogue thereof for disease attributable to amyloid accumulation and composition for image diagnosis containing the same |
WO2003106439A1 (en) * | 2002-06-12 | 2003-12-24 | 株式会社ビーエフ研究所 | Probe compound for image diagnosis of disease with amyloid accumulation, compound for staining age spots/diffuse age spots, and remedy for disease with amyloid accumulation |
WO2004004698A2 (en) * | 2002-07-09 | 2004-01-15 | Universitair Medisch Centrum Utrecht | Proteins binding to cross-beta structure comprising amyloid and methods for detection and modulation of the cross-beta structure, its formation and its associated toxicity |
WO2004056399A2 (en) | 2002-12-20 | 2004-07-08 | Ge Healthcare Limited | Solid-phase fluorination of benzothiazoles |
US6774248B2 (en) | 2001-12-18 | 2004-08-10 | Wyeth | Substituted 2-phenyl benzofurans as estrogenic agents |
WO2004083195A1 (en) * | 2003-03-14 | 2004-09-30 | University Of Pittsburgh | Benzothiazole derivative compounds, compositions and uses |
WO2004100998A2 (en) | 2003-05-07 | 2004-11-25 | General Electric Company | Compositions and methods for non-invasive imaging of soluble beta-amyloid |
WO2005016888A1 (en) * | 2003-08-13 | 2005-02-24 | Bf Research Institute, Inc. | Probe for diseases wth amyloid accumulation, amyloid-staining agent, remedy and preventive for diseases with amyloid accumulation and diagnostic probe and staining agent for neurofibrillary change |
WO2005016384A1 (en) * | 2003-08-13 | 2005-02-24 | Bf Research Institute, Inc. | Probe for disease with amyloid deposit, amyloid-staining agent, remedy and preventive for disease with amyloid deposit and diagnostic probe and staining agent for neurofibril change |
WO2005042461A1 (en) * | 2003-10-30 | 2005-05-12 | Dojindo Laboratories | Compound with amyloid affinity |
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US7008958B2 (en) | 2002-05-21 | 2006-03-07 | Bristol-Myers Squibb Company | 2-substituted 5-oxazolyl indole compounds useful as IMPDH inhibitors and pharmaceutical compositions comprising same |
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WO2006014381A3 (en) * | 2004-07-02 | 2007-01-18 | Univ Pittsburgh | Use of thioflavin radiolabeled derivatives in amyloid imaging gor assessing anti-amyloid therapies |
WO2007035405A2 (en) * | 2005-09-16 | 2007-03-29 | University Of Pittsburgh | In-vivo and in-vitro method for detecting amyloid deposits having at least one amyloidogenic protein |
US7214695B2 (en) | 2002-12-19 | 2007-05-08 | The Scripps Research Institute | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding |
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US7270800B2 (en) | 2000-08-24 | 2007-09-18 | University Of Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
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