WO2002015922A3 - New uses for amino acid anticonvulsants for treatment of pain - Google Patents

New uses for amino acid anticonvulsants for treatment of pain Download PDF

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Publication number
WO2002015922A3
WO2002015922A3 PCT/US2001/026568 US0126568W WO0215922A3 WO 2002015922 A3 WO2002015922 A3 WO 2002015922A3 US 0126568 W US0126568 W US 0126568W WO 0215922 A3 WO0215922 A3 WO 0215922A3
Authority
WO
WIPO (PCT)
Prior art keywords
pain
treatment
amino acid
new uses
anticonvulsants
Prior art date
Application number
PCT/US2001/026568
Other languages
French (fr)
Other versions
WO2002015922A2 (en
Inventor
Robert H Harris
Original Assignee
Res Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA2419285A priority Critical patent/CA2419285C/en
Priority to JP2002520843A priority patent/JP4307068B2/en
Priority to DK04021727T priority patent/DK1486205T3/en
Priority to EP01966230A priority patent/EP1365787B1/en
Priority to DK01966230T priority patent/DK1365787T3/en
Priority to AU8676301A priority patent/AU8676301A/en
Priority to DE60127459T priority patent/DE60127459T2/en
Priority to AU2001286763A priority patent/AU2001286763C1/en
Application filed by Res Corp Technologies Inc filed Critical Res Corp Technologies Inc
Publication of WO2002015922A2 publication Critical patent/WO2002015922A2/en
Publication of WO2002015922A3 publication Critical patent/WO2002015922A3/en
Priority to AU2007202336A priority patent/AU2007202336B9/en
Priority to CY20071100768T priority patent/CY1107668T1/en
Priority to LU91512C priority patent/LU91512I2/en
Priority to CY200900002C priority patent/CY2009002I2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention is directed to the use of compounds of the formula (I) for treating pain, in particular neuropathic pain, bipolar disease and migraine headaches.
PCT/US2001/026568 2000-08-25 2001-08-24 New uses for amino acid anticonvulsants for treatment of pain WO2002015922A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
DE60127459T DE60127459T2 (en) 2000-08-25 2001-08-24 Use of amino acid-containing anticonvulsants for the treatment of pain
DK04021727T DK1486205T3 (en) 2000-08-25 2001-08-24 Use of anticonvulsant amino acids for the treatment of migraine
EP01966230A EP1365787B1 (en) 2000-08-25 2001-08-24 Use of amino acid anticonvulsants for treatment of pain
DK01966230T DK1365787T3 (en) 2000-08-25 2001-08-24 Use of amino acid-containing anticonvulsants to treat pain
AU8676301A AU8676301A (en) 2000-08-25 2001-08-24 New uses for amino acid anticonvulsants
CA2419285A CA2419285C (en) 2000-08-25 2001-08-24 New uses for amino acid anticonvulsants
AU2001286763A AU2001286763C1 (en) 2000-08-25 2001-08-24 New uses for amino acid anticonvulsants for treatment of pain
JP2002520843A JP4307068B2 (en) 2000-08-25 2001-08-24 New uses of amino acid antispasmodic drugs
AU2007202336A AU2007202336B9 (en) 2000-08-25 2007-05-23 New uses for amino acid anticonvulsants
CY20071100768T CY1107668T1 (en) 2000-08-25 2007-06-11 USE OF AMINO ACID ANTISPLASMICS FOR THE THERAPEUTIC TREATMENT OF PAIN
LU91512C LU91512I2 (en) 2000-08-25 2009-01-14 "Lacosamide and its pharmaceutically acceptable derivatives (VIMPATr)"
CY200900002C CY2009002I2 (en) 2000-08-25 2009-02-18 USE OF AMINO ACID ANTISPLASMICS FOR THE THERAPEUTIC TREATMENT OF PAIN

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22823000P 2000-08-25 2000-08-25
US60/228,230 2000-08-25

Publications (2)

Publication Number Publication Date
WO2002015922A2 WO2002015922A2 (en) 2002-02-28
WO2002015922A3 true WO2002015922A3 (en) 2003-09-25

Family

ID=22856332

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/026568 WO2002015922A2 (en) 2000-08-25 2001-08-24 New uses for amino acid anticonvulsants for treatment of pain

Country Status (13)

Country Link
US (6) US6884910B2 (en)
EP (5) EP1486206B1 (en)
JP (2) JP4307068B2 (en)
AT (4) ATE357227T1 (en)
AU (6) AU2001286763C1 (en)
CA (2) CA2419285C (en)
CY (5) CY1107668T1 (en)
DE (4) DE60131032T2 (en)
DK (4) DK1486205T3 (en)
ES (5) ES2294414T3 (en)
LU (1) LU91512I2 (en)
PT (4) PT1365787E (en)
WO (1) WO2002015922A2 (en)

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EP1537862A1 (en) * 2003-12-02 2005-06-08 Schwarz Pharma Ag Novel use of peptide compounds for treating central neuropathic pain
EP1579858A1 (en) * 2004-03-26 2005-09-28 Schwarz Pharma Ag Novel use of peptide compounds for treating pain in painful diabetic neuropathy
EP1734980A1 (en) 2004-04-16 2006-12-27 Schwarz Pharma Ag Use of peptidic compounds for the prophylaxis and treatment of chronic headache
EP1604654A1 (en) * 2004-05-18 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating dyskinesia
EP1604655A1 (en) 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating pain in trigeminal neuralgia
US7427601B2 (en) * 2004-06-24 2008-09-23 Schwarz Pharma Ag Method for treating tremor
EP1629839A1 (en) * 2004-08-27 2006-03-01 Schwarz Pharma Ag Use of peptide compounds for treating bone cancer pain, chemotherapy- and nucleoside-induced pain
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PT1486206E (en) 2008-01-25
US20070142297A1 (en) 2007-06-21
EP1486205A1 (en) 2004-12-15
AU2009202362A1 (en) 2009-07-02
PT1695703E (en) 2010-11-16
JP4307068B2 (en) 2009-08-05
ATE476971T1 (en) 2010-08-15
DE60131033D1 (en) 2007-11-29
EP2210598B1 (en) 2013-09-18
CY2009002I1 (en) 2009-11-04
ATE375792T1 (en) 2007-11-15
ATE375793T1 (en) 2007-11-15
DE60127459T2 (en) 2007-07-12
JP2009108090A (en) 2009-05-21
US7186859B2 (en) 2007-03-06
CY2009002I2 (en) 2009-11-04
DK1695703T3 (en) 2010-10-25
WO2002015922A2 (en) 2002-02-28
AU2007202336B2 (en) 2009-09-24
EP1365787B1 (en) 2007-03-21
CA2740815C (en) 2014-03-18
AU2009202363A1 (en) 2009-07-02
DE60131032T2 (en) 2008-08-14
DE60142806D1 (en) 2010-09-23
US8519183B2 (en) 2013-08-27
ATE357227T1 (en) 2007-04-15
DE60131033T2 (en) 2008-07-17
US20040087508A1 (en) 2004-05-06
EP2210598A3 (en) 2011-07-20
PT1365787E (en) 2007-06-29
EP1695703B1 (en) 2010-08-11
ES2348646T3 (en) 2010-12-10
ES2294415T3 (en) 2008-04-01
DK1365787T3 (en) 2007-07-23
US6884910B2 (en) 2005-04-26
DK1486205T3 (en) 2008-02-18
EP1486206B1 (en) 2007-10-17
LU91512I2 (en) 2009-03-16
JP2004506692A (en) 2004-03-04
AU2001286763B2 (en) 2005-11-24
EP2210598A2 (en) 2010-07-28
ES2294414T3 (en) 2008-04-01
CY1112349T1 (en) 2015-12-09
ES2281439T3 (en) 2007-10-01
AU2011202293B2 (en) 2013-01-10
EP1486205B1 (en) 2007-10-17
AU2011202293A1 (en) 2011-06-09
AU2001286763C1 (en) 2006-03-02
US7148378B2 (en) 2006-12-12
EP1486206A1 (en) 2004-12-15
US20130316953A1 (en) 2013-11-28
ES2435000T3 (en) 2013-12-18
EP1365787A2 (en) 2003-12-03
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