WO2002007646A3 - Artificial vascular grafts, and methods of producing and using same - Google Patents

Artificial vascular grafts, and methods of producing and using same Download PDF

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Publication number
WO2002007646A3
WO2002007646A3 PCT/IL2001/000670 IL0100670W WO0207646A3 WO 2002007646 A3 WO2002007646 A3 WO 2002007646A3 IL 0100670 W IL0100670 W IL 0100670W WO 0207646 A3 WO0207646 A3 WO 0207646A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
artificial vascular
same
producing
vascular grafts
Prior art date
Application number
PCT/IL2001/000670
Other languages
French (fr)
Other versions
WO2002007646A2 (en
Inventor
Moshe Y Flugelman
Meir Preis
Zoya Gluzman
Belly Koren
Anat Weisz
Tzafra Cohen
Original Assignee
Mgvs Ltd
Moshe Y Flugelman
Meir Preis
Zoya Gluzman
Belly Koren
Anat Weisz
Tzafra Cohen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to HU0300810A priority Critical patent/HUP0300810A2/en
Application filed by Mgvs Ltd, Moshe Y Flugelman, Meir Preis, Zoya Gluzman, Belly Koren, Anat Weisz, Tzafra Cohen filed Critical Mgvs Ltd
Priority to AU2001278664A priority patent/AU2001278664A1/en
Priority to DE60142290T priority patent/DE60142290D1/en
Priority to JP2002513384A priority patent/JP5067822B2/en
Priority to IL15394601A priority patent/IL153946A0/en
Priority to CA002416548A priority patent/CA2416548A1/en
Priority to PL01362561A priority patent/PL362561A1/en
Priority to AT01956749T priority patent/ATE469615T1/en
Priority to EP01956749A priority patent/EP1301146B1/en
Publication of WO2002007646A2 publication Critical patent/WO2002007646A2/en
Publication of WO2002007646A3 publication Critical patent/WO2002007646A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/383—Nerve cells, e.g. dendritic cells, Schwann cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3808—Endothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3826—Muscle cells, e.g. smooth muscle cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Abstract

The present invention provides an artificial vascular graft (10) and methods of generating same. The artificial vascular graft (10) includes a synthetic tubular element (12) having a luminal surface being coated with a plurality of endothelial cells and/or smooth muscle cells (16) being genetically transformed to express at least one cell proliferating growth factor and at least one cellular adherence factor.
PCT/IL2001/000670 2000-07-20 2001-07-20 Artificial vascular grafts, and methods of producing and using same WO2002007646A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
HU0300810A HUP0300810A2 (en) 2000-07-20 2000-07-20 Artifical vascular grafts, and methods of producing and using same
AU2001278664A AU2001278664A1 (en) 2000-07-20 2001-07-20 Artificial vascular grafts, and methods of producing and using same
DE60142290T DE60142290D1 (en) 2000-07-20 2001-07-20 ARTIFICIAL, VASCULAR TRANSPLANT AND PROCESS FOR ITS MANUFACTURE AND ITS USE
JP2002513384A JP5067822B2 (en) 2000-07-20 2001-07-20 Artificial vascular graft and its production method and use
IL15394601A IL153946A0 (en) 2000-07-20 2001-07-20 Artificial vascular grafts, and methods of producing and using same
CA002416548A CA2416548A1 (en) 2000-07-20 2001-07-20 Artificial vascular grafts, and methods of producing and using same
PL01362561A PL362561A1 (en) 2000-07-20 2001-07-20 Artificial vascular grafts, and methods of producing and using same
AT01956749T ATE469615T1 (en) 2000-07-20 2001-07-20 ARTIFICIAL VASCULAR TRANSPLANT AND METHOD FOR THE PRODUCTION AND USE THEREOF
EP01956749A EP1301146B1 (en) 2000-07-20 2001-07-20 Artificial vascular grafts and methods of producing and using same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62022700A 2000-07-20 2000-07-20
US09/620,227 2000-07-20

Publications (2)

Publication Number Publication Date
WO2002007646A2 WO2002007646A2 (en) 2002-01-31
WO2002007646A3 true WO2002007646A3 (en) 2002-06-13

Family

ID=24485086

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2001/000670 WO2002007646A2 (en) 2000-07-20 2001-07-20 Artificial vascular grafts, and methods of producing and using same

Country Status (13)

Country Link
US (4) US7364725B1 (en)
EP (1) EP1301146B1 (en)
JP (1) JP5067822B2 (en)
AT (1) ATE469615T1 (en)
AU (1) AU2001278664A1 (en)
CA (1) CA2416548A1 (en)
CZ (1) CZ2003253A3 (en)
DE (1) DE60142290D1 (en)
HU (1) HUP0300810A2 (en)
IL (1) IL153946A0 (en)
PL (1) PL362561A1 (en)
WO (1) WO2002007646A2 (en)
ZA (1) ZA200300635B (en)

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NZ536564A (en) 2002-05-02 2008-05-30 Purdue Research Foundation Vascularization enhanced graft constructs which comprise a matrix composition consisting of liver basement membrane
CN1713861A (en) 2002-05-02 2005-12-28 普渡研究基金会 Vascularization enhanced graft constructs
CN1684589A (en) 2002-05-02 2005-10-19 普渡研究基金会 Vascularization enhanced graft constructs
EP1585426A4 (en) * 2002-05-02 2006-09-20 Cook Biotech Inc Cell-seeded extracellular matrix grafts
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Also Published As

Publication number Publication date
DE60142290D1 (en) 2010-07-15
JP5067822B2 (en) 2012-11-07
US20090263452A1 (en) 2009-10-22
PL362561A1 (en) 2004-11-02
US8022195B2 (en) 2011-09-20
HUP0300810A2 (en) 2003-08-28
US7563278B2 (en) 2009-07-21
WO2002007646A2 (en) 2002-01-31
CA2416548A1 (en) 2002-01-31
EP1301146B1 (en) 2010-06-02
ATE469615T1 (en) 2010-06-15
IL153946A0 (en) 2003-07-31
EP1301146A4 (en) 2008-11-19
US20080269472A1 (en) 2008-10-30
EP1301146A2 (en) 2003-04-16
US20060275338A1 (en) 2006-12-07
AU2001278664A1 (en) 2002-02-05
US8088160B2 (en) 2012-01-03
JP2004506418A (en) 2004-03-04
CZ2003253A3 (en) 2003-05-14
US7364725B1 (en) 2008-04-29
ZA200300635B (en) 2004-04-22

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