WO2002004434A1 - Colchinol derivatives as vascular damaging agents - Google Patents
Colchinol derivatives as vascular damaging agents Download PDFInfo
- Publication number
- WO2002004434A1 WO2002004434A1 PCT/GB2001/002966 GB0102966W WO0204434A1 WO 2002004434 A1 WO2002004434 A1 WO 2002004434A1 GB 0102966 W GB0102966 W GB 0102966W WO 0204434 A1 WO0204434 A1 WO 0204434A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- formula
- carbamoyl
- optionally substituted
- group
- Prior art date
Links
- 0 CC(C)*C(CCC1CC(OC)=C2OC)c3cc(OC(c4cccc(CCl)c4)=O)ccc3C1C2OC Chemical compound CC(C)*C(CCC1CC(OC)=C2OC)c3cc(OC(c4cccc(CCl)c4)=O)ccc3C1C2OC 0.000 description 3
- RINCXYDBBGOEEQ-UHFFFAOYSA-N O=C(CC1)OC1=O Chemical compound O=C(CC1)OC1=O RINCXYDBBGOEEQ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
- C07C2603/32—Dibenzocycloheptenes; Hydrogenated dibenzocycloheptenes
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR0112224-0A BR0112224A (en) | 2000-07-07 | 2001-07-04 | Compound, pharmaceutical composition, use of a compound or a pharmaceutically acceptable salt, solvate or prodrug thereof, and process for preparing a compound |
NZ522861A NZ522861A (en) | 2000-07-07 | 2001-07-04 | Colchinol derivatives as vascular damaging agents |
AU2001266233A AU2001266233B2 (en) | 2000-07-07 | 2001-07-04 | Colchinol derivatives as vascular damaging agents |
MXPA02012905A MXPA02012905A (en) | 2000-07-07 | 2001-07-04 | Colchinol derivatives as vascular damaging agents. |
CA002411160A CA2411160A1 (en) | 2000-07-07 | 2001-07-04 | Colchinol derivatives as vascular damaging agents |
JP2002509300A JP2004502766A (en) | 2000-07-07 | 2001-07-04 | Colhinol derivatives as vascular damaging agents |
IL15348401A IL153484A0 (en) | 2000-07-07 | 2001-07-04 | Colchinol derivatives as angiogenesis inhibitors |
KR10-2003-7000206A KR20030014425A (en) | 2000-07-07 | 2001-07-04 | Colchinol derivatives as vascular damaging agents |
AU6623301A AU6623301A (en) | 2000-07-07 | 2001-07-04 | Colchinol derivatives as vascular damaging agents |
EP01943702A EP1301497A1 (en) | 2000-07-07 | 2001-07-04 | Colchinol derivatives as vascular damaging agents |
US10/332,129 US20050277627A1 (en) | 2000-07-07 | 2001-07-04 | Colchinol derivatives as vascular damaging agents |
NO20030056A NO20030056L (en) | 2000-07-07 | 2003-01-06 | Colchinol derivatives as vascular damaging agents |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00401978 | 2000-07-07 | ||
EP00401978.2 | 2000-07-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002004434A1 true WO2002004434A1 (en) | 2002-01-17 |
Family
ID=8173763
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2001/002966 WO2002004434A1 (en) | 2000-07-07 | 2001-07-04 | Colchinol derivatives as vascular damaging agents |
Country Status (14)
Country | Link |
---|---|
US (1) | US20050277627A1 (en) |
EP (1) | EP1301497A1 (en) |
JP (1) | JP2004502766A (en) |
KR (1) | KR20030014425A (en) |
CN (1) | CN1255391C (en) |
AU (2) | AU2001266233B2 (en) |
BR (1) | BR0112224A (en) |
CA (1) | CA2411160A1 (en) |
IL (1) | IL153484A0 (en) |
MX (1) | MXPA02012905A (en) |
NO (1) | NO20030056L (en) |
NZ (1) | NZ522861A (en) |
WO (1) | WO2002004434A1 (en) |
ZA (1) | ZA200209776B (en) |
Cited By (292)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6720323B2 (en) | 2000-07-07 | 2004-04-13 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as angiogenesis inhibitors |
WO2004089885A1 (en) | 2003-04-07 | 2004-10-21 | Astrazeneca Ab | Novel compounds |
WO2005051300A2 (en) | 2003-11-19 | 2005-06-09 | Array Biopharma Inc. | Bicyclic inhibitors of mek and methods of use thereof |
WO2006001751A1 (en) | 2004-06-24 | 2006-01-05 | Astrazeneca Ab | Chemical compounds i |
WO2006005909A1 (en) | 2004-07-08 | 2006-01-19 | Astrazeneca Ab | Substituted acids for the treatment of respiratory diseases |
US7071193B2 (en) | 2000-10-20 | 2006-07-04 | Astrazeneca Ab | 7-amino-2-alkylthiopteridin-4-yl-amines for the treatment of chemokine-related diseases |
WO2006082392A1 (en) | 2005-02-04 | 2006-08-10 | Astrazeneca Ab | Pyrazolylaminopyridine derivatives useful as kinase inhibitors |
US7135502B1 (en) | 1999-01-07 | 2006-11-14 | Angiogene Pharmaceuticals Ltd. | Colchinol derivatives as vascular damaging agents |
FR2886151A1 (en) * | 2005-05-31 | 2006-12-01 | Mayoly Spindler Soc Par Action | Use of colchicine or derivative for preparation of a medicament to diagnose, prevent and/or treat endometriosis and its symptoms, particularly pains and sterility resulting from endometriosis |
WO2007011293A1 (en) | 2005-07-21 | 2007-01-25 | Astrazeneca Ab | Novel piperidine derivatives |
WO2007018461A1 (en) | 2005-08-09 | 2007-02-15 | Astrazeneca Ab | Novel benzothiazolone derivatives |
WO2007034916A1 (en) | 2005-09-22 | 2007-03-29 | Dainippon Sumitomo Pharma Co., Ltd. | Novel adenine compound |
WO2007034817A1 (en) | 2005-09-22 | 2007-03-29 | Dainippon Sumitomo Pharma Co., Ltd. | Novel adenine compound |
WO2007034881A1 (en) | 2005-09-22 | 2007-03-29 | Dainippon Sumitomo Pharma Co., Ltd. | Novel adenine compound |
WO2007034917A1 (en) | 2005-09-22 | 2007-03-29 | Dainippon Sumitomo Pharma Co., Ltd. | Novel adenine compound |
WO2007034882A1 (en) | 2005-09-22 | 2007-03-29 | Dainippon Sumitomo Pharma Co., Ltd. | Novel adenine compound |
WO2007039736A1 (en) | 2005-10-06 | 2007-04-12 | Astrazeneca Ab | Novel compounds |
WO2007069978A1 (en) | 2005-12-12 | 2007-06-21 | Astrazeneca Ab | Novel n-(fluoro-pyrazinyl)-phenylsulfonamid.es as moodulators of chemokine receptor ccr4. |
WO2007068894A2 (en) | 2005-12-15 | 2007-06-21 | Astrazeneca Ab | Substituted diphenylethers, -amines, -sulfides and -methanes for the treatment of respiratory disease |
EP1847539A1 (en) | 2002-12-24 | 2007-10-24 | AstraZeneca AB | Quinazoline derivatives |
WO2007138282A2 (en) | 2006-05-26 | 2007-12-06 | Astrazeneca Ab | Bi-aryl or aryl-heteroaryl substituted indoles |
WO2008017361A2 (en) | 2006-08-10 | 2008-02-14 | Merck Patent Gmbh | 2-(heterocyclylbenzyl)pyridazinone derivatives |
WO2008075005A1 (en) | 2006-12-19 | 2008-06-26 | Astrazeneca Ab | Quinuclidinol derivatives as muscarinic receptor antagonists |
WO2008114817A1 (en) | 2007-03-20 | 2008-09-25 | Dainippon Sumitomo Pharma Co., Ltd. | Novel adenine compound |
WO2008114819A1 (en) | 2007-03-20 | 2008-09-25 | Dainippon Sumitomo Pharma Co., Ltd. | Novel adenine compound |
DE102007025718A1 (en) | 2007-06-01 | 2008-12-04 | Merck Patent Gmbh | pyridazinone derivatives |
DE102007026341A1 (en) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
DE102007025717A1 (en) | 2007-06-01 | 2008-12-11 | Merck Patent Gmbh | Aryl ether pyridazinone derivatives |
WO2009004379A1 (en) | 2007-07-05 | 2009-01-08 | Astrazeneca Ab | Novel compounds 951: a biphenyloxypropanoic acid as crth2 modulator and intermediates |
WO2009006959A1 (en) | 2007-07-12 | 2009-01-15 | Merck Patent Gmbh | Pyridazinone derivates |
US7482355B2 (en) | 2002-08-24 | 2009-01-27 | Astrazeneca Ab | Pyrimidine derivatives as modulators of chemokine receptor activity |
EP2025670A1 (en) | 2003-05-27 | 2009-02-18 | AstraZeneca AB | 3-(Phenyl or quinolyl)thio-1H-indole-1-acetic acid derivatives as modulators of CRTh2 receptor activity |
DE102007038957A1 (en) | 2007-08-17 | 2009-02-19 | Merck Patent Gmbh | 6-thioxo-pyridazine derivatives |
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US7521473B2 (en) | 2004-02-25 | 2009-04-21 | Wyeth | Inhibitors of protein tyrosine phosphatase 1B |
US7528156B2 (en) | 2000-06-20 | 2009-05-05 | Astrazeneca Ab | Compounds |
DE102007061963A1 (en) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | pyridazinone derivatives |
WO2009098448A1 (en) | 2008-02-06 | 2009-08-13 | Astrazeneca Ab | Compounds |
EP2090575A1 (en) | 2005-11-15 | 2009-08-19 | Array Biopharma, Inc. | Processes and intermediates for the preparation of N4-phenyl-quinazoline-4-amine derivatives |
US7579342B2 (en) | 2000-02-23 | 2009-08-25 | Astrazeneca | Pteridine compounds for the treatment of psoriasis |
US7582644B2 (en) | 2002-07-27 | 2009-09-01 | Astrazeneca Ab | Pyrimidyl sulphone amide derivatives as chemokine receptor modulators |
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DE102008019907A1 (en) | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | pyridazinone derivatives |
WO2009143945A1 (en) | 2008-05-29 | 2009-12-03 | Merck Patent Gmbh, | Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors |
WO2009152920A1 (en) | 2008-06-18 | 2009-12-23 | Merck Patent Gmbh | 3-(3-pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazine derivatives as met kinase inhibitors |
DE102008029734A1 (en) | 2008-06-23 | 2009-12-24 | Merck Patent Gmbh | Thiazolyl-piperidine derivatives |
DE102008037790A1 (en) | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclic triazole derivatives |
DE102008038221A1 (en) | 2008-08-18 | 2010-02-25 | Merck Patent Gmbh | 7-azaindole derivatives |
DE102008052943A1 (en) | 2008-10-23 | 2010-04-29 | Merck Patent Gmbh | azaindole derivatives |
US7723337B2 (en) | 2007-01-25 | 2010-05-25 | Astrazeneca Ab | 3-cinnolinecarboxamide derivatives and their use for treating cancer |
WO2010067102A1 (en) | 2008-12-09 | 2010-06-17 | Astrazeneca Ab | Diazaspiro [5.5] undecane derivatives and related compounds as muscarinic-receptor antagonists and beta-adrenoreceptor agonists for the treatment of pulmonary disorders |
DE102008062825A1 (en) | 2008-12-23 | 2010-06-24 | Merck Patent Gmbh | 3- (3-pyrimidin-2-yl-benzyl) - [1,2,4] triazolo [4,3-b] pyridazine derivatives |
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DE102008063667A1 (en) | 2008-12-18 | 2010-07-01 | Merck Patent Gmbh | 3- (3-pyrimidin-2-yl-benzyl) - ° [1,2,4] triazolo [4,3-b] pyrimidine derivatives |
WO2010072296A1 (en) | 2008-12-23 | 2010-07-01 | Merck Patent Gmbh | Pyridazinone derivatives |
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WO2010109230A1 (en) | 2009-03-25 | 2010-09-30 | Pharminox Limited | Novel prodrugs |
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EP2256117A1 (en) | 2006-11-14 | 2010-12-01 | AstraZeneca AB | Quiniclidine derivatives of (hetero) arylcycloheptanecarboxylic acid as muscarinic receptor antagonists |
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US7863325B2 (en) | 2008-12-11 | 2011-01-04 | Axcentua Pharmaceuticals Ab | Crystalline genistein sodium salt dihydrate |
WO2011012896A2 (en) | 2009-07-31 | 2011-02-03 | Astrazeneca Ab | Compounds - 801 |
EP2284194A1 (en) | 2004-12-21 | 2011-02-16 | AstraZeneca AB | Antibodies directed to angiopoietin-2 and uses thereof |
US7902189B2 (en) | 2006-08-23 | 2011-03-08 | Astrazeneca Ab | Compounds |
EP2292615A1 (en) | 2002-02-01 | 2011-03-09 | AstraZeneca AB | Quinazoline compounds |
WO2011035855A1 (en) | 2009-09-28 | 2011-03-31 | Merck Patent Gmbh | Pyridinyl-imidazolone derivatives for inhibiting pi3 kinases |
EP2305671A1 (en) | 2004-01-05 | 2011-04-06 | AstraZeneca AB | Thiophene and thiazole derivatives as CHK1 inhibitors |
WO2011039528A1 (en) | 2009-10-02 | 2011-04-07 | Astrazeneca Ab | 2-pyridone compounds used as inhibitors of neutrophil elastase |
DE102009049679A1 (en) | 2009-10-19 | 2011-04-21 | Merck Patent Gmbh | Pyrazolopyrimidinderivate |
WO2011048409A1 (en) | 2009-10-20 | 2011-04-28 | Astrazeneca Ab | Cyclic amine derivatives having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
WO2011051704A1 (en) | 2009-10-27 | 2011-05-05 | Astrazeneca Ab | Chromenone derivatives with anti-tumour activity |
WO2011068233A1 (en) | 2009-12-03 | 2011-06-09 | Dainippon Sumitomo Pharma Co., Ltd. | Imidazoquinolines which act via toll - like receptors (tlr) |
DE102009058280A1 (en) | 2009-12-14 | 2011-06-16 | Merck Patent Gmbh | thiazole |
WO2011072791A1 (en) | 2009-12-14 | 2011-06-23 | Merck Patent Gmbh | Sphingosine kinase inhibitors |
WO2011082732A1 (en) | 2009-12-17 | 2011-07-14 | Merck Patent Gmbh | Sphingosine kinase inhibitors |
WO2011089416A1 (en) | 2010-01-19 | 2011-07-28 | Astrazeneca Ab | Pyrazine derivatives |
WO2011095807A1 (en) | 2010-02-07 | 2011-08-11 | Astrazeneca Ab | Combinations of mek and hh inhibitors |
EP2357202A1 (en) | 2006-04-10 | 2011-08-17 | AstraZeneca AB | Targeted binding agents directed to Upar and uses thereof |
EP2361905A1 (en) | 2005-05-18 | 2011-08-31 | Array Biopharma Inc. | Heterocyclic Inhibitors of MEK and methods of use thereof |
WO2011114148A1 (en) | 2010-03-17 | 2011-09-22 | Astrazeneca Ab | 4h- [1, 2, 4] triazolo [5, 1 -b] pyrimidin-7 -one derivatives as ccr2b receptor antagonists |
EP2388259A1 (en) | 2005-10-28 | 2011-11-23 | AstraZeneca AB | 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer |
WO2011147528A1 (en) | 2010-05-26 | 2011-12-01 | Merck Patent Gmbh | Biguanide compounds and its use for treating cancer |
WO2011154737A1 (en) | 2010-06-11 | 2011-12-15 | Astrazeneca Ab | Morpholino pyrimidines and their use in therapy |
WO2011154678A1 (en) | 2010-06-11 | 2011-12-15 | Astrazeneca Ab | Compounds |
WO2011154677A1 (en) | 2010-06-09 | 2011-12-15 | Astrazeneca Ab | Substituted n-[1-cyano-2-(phenyl)ethyl] 1-aminocycloalk-1-ylcarboxamide compounds - 760 |
EP2404616A2 (en) | 2005-12-13 | 2012-01-11 | AstraZeneca AB | Binding proteins specific for insulin-like growth factors and uses thereof |
WO2012017239A2 (en) | 2010-08-02 | 2012-02-09 | Astrazeneca Ab | Chemical compounds |
WO2012017251A1 (en) | 2010-08-06 | 2012-02-09 | Astrazeneca Ab | N-acylsulfonamide apoptosis promoters |
EP2420513A1 (en) | 2006-08-03 | 2012-02-22 | MedImmune Limited | Targeted binding agents directed to PDGFR-alpha and uses thereof |
WO2012022408A1 (en) | 2010-08-18 | 2012-02-23 | Merck Patent Gmbh | Pyrimidine derivatives as fak inhibitors |
US8143261B2 (en) | 1999-10-01 | 2012-03-27 | Astrazeneca Ab | Thiazolo (4,5-D) pyrimidine compounds |
US8148405B2 (en) | 2005-08-02 | 2012-04-03 | Astrazeneca Ab | Salt I |
WO2012042265A1 (en) | 2010-09-30 | 2012-04-05 | Pharminox Limited | Novel acridine derivatives |
US8163724B2 (en) | 2007-10-04 | 2012-04-24 | Astrazeneca Ab | Glucocorticosteroids, processes for their preparation, pharmaceutical compositions containing them and their use in therapy |
DE102010049595A1 (en) | 2010-10-26 | 2012-04-26 | Merck Patent Gmbh | quinazoline derivatives |
WO2012052102A1 (en) | 2010-10-20 | 2012-04-26 | Merck Patent Gmbh | Quinoxaline derivates |
WO2012066336A1 (en) | 2010-11-19 | 2012-05-24 | Astrazeneca Ab | Benzylamine compounds as toll -like receptor 7 agonists |
WO2012067269A1 (en) | 2010-11-19 | 2012-05-24 | Dainippon Sumitomo Pharma Co., Ltd. | Aminoalkoxyphenyl compounds and their use in the treatment of disease |
WO2012067268A1 (en) | 2010-11-19 | 2012-05-24 | Dainippon Sumitomo Pharma Co., Ltd. | Cyclic amide compounds and their use in the treatment of disease |
WO2012066335A1 (en) | 2010-11-19 | 2012-05-24 | Astrazeneca Ab | Phenol compounds als toll -like receptor 7 agonists |
US8198302B2 (en) | 2003-02-28 | 2012-06-12 | Oxigene, Inc. | Compositions and methods with enhanced therapeutic activity |
WO2012080730A1 (en) | 2010-12-17 | 2012-06-21 | Astrazeneca Ab | Purine derivatives |
WO2012080728A1 (en) | 2010-12-16 | 2012-06-21 | Astrazeneca Ab | Imidazo [4, 5 -c] quinolin- 1 -yl derivative useful in therapy |
WO2012085015A1 (en) | 2010-12-20 | 2012-06-28 | Medimmune Limited | Anti-il-18 antibodies and their uses |
WO2012110773A1 (en) | 2011-02-17 | 2012-08-23 | Cancer Therapeutics Crc Pty Limited | Fak inhibitors |
WO2012110774A1 (en) | 2011-02-17 | 2012-08-23 | Cancer Therapeutics Crc Pty Limited | Selective fak inhibitors |
WO2012123745A1 (en) | 2011-03-14 | 2012-09-20 | Cancer Research Technology Limited | Pyrrolopyridineamino derivatives as mps1 inhibitors |
WO2012140419A1 (en) | 2011-04-13 | 2012-10-18 | Astrazeneca Ab | Chromenone compounds as pi 3 -kinase inhibitors for the treatment of cancer |
WO2012175991A1 (en) | 2011-06-24 | 2012-12-27 | Pharminox Limited | Fused pentacyclic anti - proliferative compounds |
WO2013003697A1 (en) | 2011-06-30 | 2013-01-03 | Trustees Of Boston University | Method for controlling tumor growth, angiogenesis and metastasis using immunoglobulin containing and proline rich receptor-1 (igpr-1) |
WO2013008002A1 (en) | 2011-07-12 | 2013-01-17 | Astrazeneca Ab | N- (6- ( (2r,3s) -3,4-dihydroxybutan-2-yloxy) -2- (4 - fluorobenzylthio) pyrimidin- 4 - yl) -3- methylazetidine- 1 - sulfonamide as chemokine receptor modulator |
WO2013014448A1 (en) | 2011-07-27 | 2013-01-31 | Astrazeneca Ab | 2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer |
WO2013026516A1 (en) | 2011-08-23 | 2013-02-28 | Merck Patent Gmbh | Bicyclic heteroaromatic compounds |
US8389580B2 (en) | 2009-06-02 | 2013-03-05 | Duke University | Arylcyclopropylamines and methods of use |
WO2013032951A1 (en) | 2011-08-26 | 2013-03-07 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
WO2013040515A1 (en) | 2011-09-14 | 2013-03-21 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
WO2013045955A1 (en) | 2011-09-29 | 2013-04-04 | The University Of Liverpool | Prevention and/or treatment of cancer and/or cancer metastasis |
EP2604628A2 (en) | 2007-12-21 | 2013-06-19 | Medimmune Limited | Binding members for interleukin-4 receptor alpha (IL-4R) - 173 |
US8486966B2 (en) | 2007-05-04 | 2013-07-16 | Astrazeneca Ab | 9-(pyrazol-3-yl)-9H-purine-2-amine and 3-(pyrazol-3-yl) -3H-imidazo[4,5-B] pyridin-5-amine derivatives and their use for the treatment of cancer |
WO2013110309A1 (en) | 2012-01-28 | 2013-08-01 | Merck Patent Gmbh | Triazolo[4,5-d]pyrimidine derivatives |
WO2013117285A1 (en) | 2012-02-09 | 2013-08-15 | Merck Patent Gmbh | Furo [3, 2 - b] - and thieno [3, 2 - b] pyridine derivatives as tbk1 and ikk inhibitors |
WO2013117288A1 (en) | 2012-02-09 | 2013-08-15 | Merck Patent Gmbh | Tetrahydro-quinazolinone derivatives as tank and parp inhibitors |
EP2628751A2 (en) | 2006-11-30 | 2013-08-21 | AstraZeneca AB | Binding members for interleukin-6 and use thereof |
WO2013126132A1 (en) | 2012-02-21 | 2013-08-29 | Merck Patent Gmbh | Cyclic diaminopyrimidine derivatives |
WO2013124025A1 (en) | 2012-02-21 | 2013-08-29 | Merck Patent Gmbh | Furopyridine derivatives |
WO2013124026A1 (en) | 2012-02-21 | 2013-08-29 | Merck Patent Gmbh | 8 - substituted 2 -amino - [1,2,4] triazolo [1, 5 -a] pyrazines as syk tryrosine kinase inhibitors and gcn2 serin kinase inhibitors |
US8530467B2 (en) | 2009-11-18 | 2013-09-10 | Neomed Institute | Benzoimidazole compounds and uses thereof |
WO2013131609A1 (en) | 2012-03-07 | 2013-09-12 | Merck Patent Gmbh | Triazolopyrazine derivatives |
WO2013144532A1 (en) | 2012-03-30 | 2013-10-03 | Astrazeneca Ab | 3 -cyano- 5 -arylamino-7 -cycloalkylaminopyrrolo [1, 5 -a] pyrimidine derivatives and their use as antitumor agents |
WO2013143663A1 (en) | 2012-03-28 | 2013-10-03 | Merck Patent Gmbh | Bicyclic pyrazinone derivatives |
WO2013150043A1 (en) | 2012-04-05 | 2013-10-10 | F. Hoffmann-La Roche Ag | Bispecific antibodies against human tweak and human il17 and uses thereof |
WO2013164061A1 (en) | 2012-05-04 | 2013-11-07 | dedeMERCK PATENT GMBH | Pyrrolotriazinone derivatives |
WO2014015934A1 (en) | 2012-07-24 | 2014-01-30 | Merck Patent Gmbh | Hydroxystatin derivatives for treatment of arthrosis |
WO2014023385A1 (en) | 2012-08-07 | 2014-02-13 | Merck Patent Gmbh | Pyridopyrimidine derivatives as protein kinase inhibitors |
WO2014023390A2 (en) | 2012-08-08 | 2014-02-13 | Merck Patent Gmbh | (aza-)isoquinolinone derivatives |
WO2014026243A1 (en) | 2012-08-17 | 2014-02-20 | Cancer Therapeutics Crc Pty Limited | Vegfr3 inhibitors |
WO2014041349A1 (en) | 2012-09-12 | 2014-03-20 | Cancer Therapeutics Crc Pty Ltd | Tetrahydropyran-4-ylethylamino- or tetrahydropyranyl-4-ethyloxy-pyrimidines or -pyridazines as isoprenylcysteincarboxymethyl transferase inhibitors |
WO2014047648A1 (en) | 2012-09-24 | 2014-03-27 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
WO2014048532A1 (en) | 2012-09-26 | 2014-04-03 | Merck Patent Gmbh | Quinazolinone derivatives as parp inhibitors |
WO2014063205A1 (en) | 2012-10-26 | 2014-05-01 | The University Of Queensland | Use of endocytosis inhibitors and antibodies for cancer therapy |
EP2727913A1 (en) | 2008-12-15 | 2014-05-07 | Astrazeneca AB | (4-Tert-butylpiperazin-2-yl)(piperazin-1-yl)methanone-N-carboxamide derivatives |
WO2014075754A1 (en) | 2012-11-16 | 2014-05-22 | Merck Patent Gmbh | 3-aminocyclopentane carboxamide derivatives |
US8735584B2 (en) | 2008-02-28 | 2014-05-27 | Merck Patent Gmbh | Protein kinase inhibitors and use thereof |
WO2014127881A1 (en) | 2013-02-25 | 2014-08-28 | Merck Patent Gmbh | 2-amino -3,4-dihydro-quinazoline derivatives and the use thereof as cathepsin d inhibitors |
WO2014135245A1 (en) | 2013-03-05 | 2014-09-12 | Merck Patent Gmbh | 9-(aryl or heteroaryl)-2-(pyrazolyl, pyrrolidinyl or cyclopentyl)aminopurine derivatives as anticancer agents |
EP2778156A1 (en) | 2008-05-27 | 2014-09-17 | AstraZeneca AB (Publ) | Phenoxypyridinylamide derivatives and their use in the treatment of PDE4 mediated disease states |
WO2014140644A1 (en) | 2013-03-15 | 2014-09-18 | Fundación Centro Nacional De Investigaciones Oncológicas Carlos Iii | Chemical entities |
WO2014161570A1 (en) | 2013-04-03 | 2014-10-09 | Roche Glycart Ag | Antibodies against human il17 and uses thereof |
US8901307B2 (en) | 2008-07-02 | 2014-12-02 | Astrazeneca Ab | Chemical compounds 251 |
WO2014195507A1 (en) | 2013-06-07 | 2014-12-11 | Universite Catholique De Louvain | 3-carboxy substituted coumarin derivatives with a potential utility for the treatment of cancer diseases |
WO2014205511A1 (en) | 2013-06-25 | 2014-12-31 | University Of Canberra | Methods and compositions for modulating cancer stem cells |
US8980273B1 (en) | 2014-07-15 | 2015-03-17 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
US8986691B1 (en) | 2014-07-15 | 2015-03-24 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
WO2015039187A1 (en) | 2013-09-18 | 2015-03-26 | University Of Canberra | Stem cell modulation ii |
US8993550B2 (en) | 2010-01-15 | 2015-03-31 | Suzhou Neupharma Co., Ltd. | Certain chemical entities, compositions, and methods |
WO2015048852A1 (en) | 2013-10-01 | 2015-04-09 | The University Of Queensland | Kits and methods for diagnosis, screening, treatment and disease monitoring |
US9012495B2 (en) | 2008-12-11 | 2015-04-21 | Axcentua Pharmaceuticals Ab | Crystalline forms of genistein |
US9018197B2 (en) | 2010-08-28 | 2015-04-28 | Suzhou Neupharma Co. Ltd. | Tetradecahydro-1H-cyclopenta[a]phenanthrene compounds, compositions, and related methods of use |
EP2927244A1 (en) | 2008-09-19 | 2015-10-07 | MedImmune, LLC | Antibodies directed to DLL4 and uses thereof |
US9249111B2 (en) | 2011-09-30 | 2016-02-02 | Neupharma, Inc. | Substituted quinoxalines as B-RAF kinase inhibitors |
US9249110B2 (en) | 2011-09-21 | 2016-02-02 | Neupharma, Inc. | Substituted quinoxalines as B-raf kinase inhibitors |
WO2016029262A1 (en) | 2014-08-25 | 2016-03-03 | University Of Canberra | Compositions for modulating cancer stem cells and uses therefor |
US9328081B2 (en) | 2011-09-01 | 2016-05-03 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US9340570B2 (en) | 2012-04-29 | 2016-05-17 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
WO2016077881A1 (en) | 2014-11-17 | 2016-05-26 | The University Of Queensland | Glycoprotein biomarkers for esophageal adenocarcinoma and barrett's esophagus and uses thereof |
US9447092B2 (en) | 2012-06-21 | 2016-09-20 | Cancer Research Technology Limited | Pharmaceutically active compounds |
US9493503B2 (en) | 2011-02-02 | 2016-11-15 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
WO2016198507A1 (en) | 2015-06-09 | 2016-12-15 | Monash University | Aryl sulfonohydrazides |
US9550770B2 (en) | 2013-08-23 | 2017-01-24 | Neupharma, Inc. | Substituted quinazolines for inhibiting kinase activity |
US9585850B2 (en) | 2011-12-23 | 2017-03-07 | Duke University | Methods of treatment using arylcyclopropylamine compounds |
US9598409B2 (en) | 2013-01-31 | 2017-03-21 | Neomed Institute | Imidazopyridine compounds and uses thereof |
US9670180B2 (en) | 2012-01-25 | 2017-06-06 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US9725421B2 (en) | 2012-11-12 | 2017-08-08 | Neupharma, Inc. | Substituted quinoxalines as B-raf kinase inhibitors |
WO2017132728A1 (en) | 2016-02-01 | 2017-08-10 | University Of Canberra | Proteinaceous compounds and uses therefor |
WO2017142871A1 (en) | 2016-02-15 | 2017-08-24 | Astrazeneca Ab | Methods comprising fixed intermittent dosing of cediranib |
WO2017187156A1 (en) | 2016-04-26 | 2017-11-02 | Big Dna Ltd | Combination therapy |
WO2018022992A1 (en) | 2016-07-29 | 2018-02-01 | Flx Bio, Inc. | Chemokine receptor modulators and uses thereof |
EP3279215A1 (en) | 2009-11-24 | 2018-02-07 | MedImmune Limited | Targeted binding agents against b7-h1 |
WO2018035061A1 (en) | 2016-08-15 | 2018-02-22 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
WO2018055402A1 (en) | 2016-09-22 | 2018-03-29 | Cancer Research Technology Limited | Preparation and uses of pyrimidinone derivatives |
US9938268B2 (en) | 2008-12-17 | 2018-04-10 | Merck Patent Gmbh | C-ring modified tricyclic benzonaphthiridinone protein kinase inhibitors and use thereof |
US9937137B2 (en) | 2013-03-15 | 2018-04-10 | Neurocentria, Inc. | Magnesium compositions and uses thereof for cancers |
WO2018065787A1 (en) | 2016-10-07 | 2018-04-12 | Cancer Research Technology Limited | Deuterated n-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-fluorophenyl)-2-((4-ethylpiperazin-1 -yl)methyl)quinoline-6-carboxamide |
WO2018106606A1 (en) | 2016-12-05 | 2018-06-14 | Apros Therapeutics, Inc. | Pyrimidine compounds containing acidic groups |
EP3354752A1 (en) | 2012-11-05 | 2018-08-01 | GMDx Co Pty Ltd | Methods for determining the cause of somatic mutagenesis |
WO2018141002A2 (en) | 2017-02-01 | 2018-08-09 | University Of South Australia | DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO [1,2-a]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS |
WO2018162625A1 (en) | 2017-03-09 | 2018-09-13 | Truly Translational Sweden Ab | Prodrugs of sulfasalazine, pharmaceutical compositions thereof and their use in the treatment of autoimmune disease |
WO2018167276A1 (en) | 2017-03-17 | 2018-09-20 | Argonaut Therapeutics Limited | Tricyclic compounds for use in treatment of proliferative disorders |
WO2018189553A1 (en) | 2017-04-13 | 2018-10-18 | Cancer Research Technology Limited | Compounds useful as ret inhibitors |
WO2018210246A1 (en) | 2017-05-15 | 2018-11-22 | 朱程刚 | Triazine compound and pharmaceutically acceptable salt thereof |
WO2018215798A1 (en) | 2017-05-26 | 2018-11-29 | Cancer Research Technology Limited | 2-quinolone derived inhibitors of bcl6 |
WO2018220101A1 (en) | 2017-05-31 | 2018-12-06 | Truly Translational Sweden Ab | A pharmaceutical composition comprising a combination of methotrexate and novobiocin, and the use of said composition in therapy |
WO2019007447A1 (en) | 2017-07-05 | 2019-01-10 | E.P.O.S Iasis Research And Development Limited | Multifunctional conjugates |
WO2019025099A1 (en) | 2017-08-01 | 2019-02-07 | Merck Patent Gmbh | Thiazolopyridine derivatives as adenosine receptor antagonists |
US10201623B2 (en) | 2013-03-15 | 2019-02-12 | Memorial Sloan Kettering Cancer Center | HSP90-targeted cardiac imaging and therapy |
WO2019034890A1 (en) | 2017-08-18 | 2019-02-21 | Cancer Research Technology Limited | Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer |
WO2019038214A1 (en) | 2017-08-21 | 2019-02-28 | Merck Patent Gmbh | Quinoxaline derivatives as adenosine receptor antagonists |
WO2019038215A1 (en) | 2017-08-21 | 2019-02-28 | Merck Patent Gmbh | Bezimidazole derivatives as adenosine receptor antagonists |
WO2019070167A1 (en) | 2017-10-06 | 2019-04-11 | Закрытое Акционерное Общество "Биокад" | Epidermal growth factor receptor inhibitors |
WO2019083365A1 (en) | 2017-10-25 | 2019-05-02 | Universiteit Leiden | Delivery vectors |
WO2019090272A1 (en) | 2017-11-06 | 2019-05-09 | Flx Bio, Inc. | Chemokine receptor modulators for treatment of epstein barr virus positive cancer |
EP3489222A1 (en) | 2017-11-23 | 2019-05-29 | medac Gesellschaft für klinische Spezialpräparate mbH | Sulfasalazine salts, production processes and uses |
EP3488868A1 (en) | 2017-11-23 | 2019-05-29 | medac Gesellschaft für klinische Spezialpräparate mbH | Pharmaceutical composition for oral administration containing sulfasalazine and / or a sulfasalazine organic salt, production process and use |
WO2019136514A1 (en) | 2018-01-15 | 2019-07-18 | University Of South Australia | 5-(pyrimidin-4-yl)thiazol-2-yl urea derivatives as therapeutic agents |
WO2019145718A1 (en) | 2018-01-24 | 2019-08-01 | Oxford University Innovation Limited | Compounds |
WO2019147862A1 (en) | 2018-01-26 | 2019-08-01 | Flx Bio, Inc. | Chemokine receptor modulators and uses thereof |
WO2019157225A2 (en) | 2018-02-08 | 2019-08-15 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
WO2019175093A1 (en) | 2018-03-12 | 2019-09-19 | Astrazeneca Ab | Method for treating lung cancer |
EP3575299A1 (en) | 2014-02-28 | 2019-12-04 | Cancer Research Technology Limited | N2-phenyl-pyrido[3,4-d]pyrimidine-2,8-diamine derivatives and their use as mps1 inhibitors |
WO2019236496A1 (en) | 2018-06-04 | 2019-12-12 | Apros Therapeutics, Inc. | Pyrimidine compounds containing acidic groups useful to treat diseases connected to the modulation of tlr7 |
WO2019236631A1 (en) | 2018-06-05 | 2019-12-12 | Rapt Therapeutics, Inc. | Pyrazolo-pyrimidin-amino-cycloalkyl compounds and their therapeutic uses |
WO2019234405A1 (en) | 2018-06-04 | 2019-12-12 | Oxford University Innovation Limited | Compounds useful in the treatment of disorders associated with mutant ras |
WO2020002587A1 (en) | 2018-06-28 | 2020-01-02 | Ctxt Pty Limited | Compounds |
WO2020068600A1 (en) | 2018-09-24 | 2020-04-02 | Rapt Therapeutics, Inc. | Ubiquitin-specific-processing protease 7 (usp7) modulators and uses thereof |
WO2020083878A1 (en) | 2018-10-25 | 2020-04-30 | Merck Patent Gmbh | 5-azaindazole derivatives as adenosine receptor antagonists |
WO2020083856A1 (en) | 2018-10-25 | 2020-04-30 | Merck Patent Gmbh | 5-azaindazole derivatives as adenosine receptor antagonists |
US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
WO2020104820A1 (en) | 2018-11-23 | 2020-05-28 | Cancer Research Technology Limited | Substituted benzimidazolones as anti-cancer agents |
WO2020132844A1 (en) | 2018-12-25 | 2020-07-02 | 中国医学科学院基础医学研究所 | Small rna medicament for prevention and treatment of inflammation-related diseases and combination thereof |
WO2020152132A1 (en) | 2019-01-22 | 2020-07-30 | Merck Patent Gmbh | Thiazolopyridine derivatives as adenosine receptor antagonists |
WO2020181283A1 (en) | 2019-03-07 | 2020-09-10 | Merck Patent Gmbh | Carboxamide-pyrimidine derivatives as shp2 antagonists |
US10786502B2 (en) | 2016-12-05 | 2020-09-29 | Apros Therapeutics, Inc. | Substituted pyrimidines containing acidic groups as TLR7 modulators |
WO2020200158A1 (en) | 2019-03-29 | 2020-10-08 | 深圳福沃药业有限公司 | N-heteroaromatic amide derivatives for treatment of cancer |
WO2020201773A1 (en) | 2019-04-05 | 2020-10-08 | Storm Therapeutics Ltd | Mettl3 inhibitory compounds |
WO2020210384A1 (en) | 2019-04-08 | 2020-10-15 | Merck Patent Gmbh | Pyrimidinone derivatives as shp2 antagonists |
WO2020212697A1 (en) | 2019-04-15 | 2020-10-22 | Azeria Therapeutics Limited | Inhibitor compounds |
WO2020247054A1 (en) | 2019-06-05 | 2020-12-10 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
WO2020254831A1 (en) | 2019-06-20 | 2020-12-24 | Storm Therapeutics Ltd | Bicyclic heterocyclic compounds as inhibitors ofbcdin3d activity |
US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
US10918735B2 (en) | 2012-12-04 | 2021-02-16 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4-diones for cancer treatment |
WO2021037219A1 (en) | 2019-08-31 | 2021-03-04 | 上海奕拓医药科技有限责任公司 | Pyrazole derivative for fgfr inhibitor and preparation method therefor |
US10947201B2 (en) | 2015-02-17 | 2021-03-16 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
WO2021055744A1 (en) | 2019-09-20 | 2021-03-25 | Ideaya Biosciences, Inc. | 4-substituted indole and indazole sulfonamido derivatives as parg inhibitors |
WO2021058974A1 (en) | 2019-09-27 | 2021-04-01 | Celleron Therapeutics Limited | Novel treatment |
WO2021074620A1 (en) | 2019-10-14 | 2021-04-22 | Cancer Research Technology Limited | [1,4]oxazepino[2,3-c]qui noli none derivatives as blc6 inhibitors |
WO2021084265A1 (en) | 2019-10-31 | 2021-05-06 | Cancer Research Technology Limited | Isoquinoline derivatives as sik2 inhibitors |
WO2021084266A1 (en) | 2019-10-31 | 2021-05-06 | Cancer Research Technology Limited | Bicyclic nitrogen containing heterocycles as inhibitors of salt-inuced kinase sik2 |
WO2021084264A1 (en) | 2019-10-31 | 2021-05-06 | Cancer Research Technology Limited | Isoquinoline derivatives as sik2 inhibitors |
WO2021111124A1 (en) | 2019-12-02 | 2021-06-10 | Storm Therapeutics Limited | Polyheterocyclic compounds as mettl3 inhibitors |
WO2021198709A1 (en) | 2020-04-03 | 2021-10-07 | Kinsensus Limited | Naphthyridine compounds as inhibitors of mer tyrosine kinase and axl tyrosine kinase |
EP3907224A1 (en) | 2014-12-19 | 2021-11-10 | Cancer Research Technology Limited | Parg inhibitory compounds |
WO2021245405A1 (en) | 2020-06-01 | 2021-12-09 | Neophore Limited | Inhibitors of mlh1 and/or pms2 for cancer treatment |
US11225690B2 (en) | 2015-08-26 | 2022-01-18 | Gmdx Co Pty Ltd | Methods of detecting cancer recurrence |
WO2022034313A1 (en) | 2020-08-11 | 2022-02-17 | University Of Huddersfield | Novel compounds and therapeutic uses thereof |
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WO2022074391A1 (en) | 2020-10-08 | 2022-04-14 | Storm Therapeutics Limited | Compounds inhibitors of mettl3 |
WO2022074379A1 (en) | 2020-10-06 | 2022-04-14 | Storm Therapeutics Limited | Mettl3 inhibitory compounds |
US11304950B2 (en) | 2018-04-27 | 2022-04-19 | Spruce Biosciences, Inc. | Methods for treating testicular and ovarian adrenal rest tumors |
WO2022185041A1 (en) | 2021-03-01 | 2022-09-09 | Cambridge Enterprise Limited | Benzo[c][2,6]naphthyridine derivatives, compositions and therapeutic uses thereof |
WO2022197641A1 (en) | 2021-03-15 | 2022-09-22 | Rapt Therapeutics, Inc. | 1h-pyrazolo[3,4-d]pyrimidin-6-yl-amine derivatives as hematopoietic progenitor kinase 1 (hpk1) modulators and/or inhibitors for the treatment of cancer and other diseases |
WO2022233718A2 (en) | 2021-05-03 | 2022-11-10 | Merck Patent Gmbh | Her2 targeting fc antigen binding fragment-drug conjugates |
WO2022245061A1 (en) | 2021-05-17 | 2022-11-24 | 에이치케이이노엔 주식회사 | Benzamide derivative, method for preparing same, and pharmaceutical composition for prevention or treatment of cancer containing same as active ingredient |
WO2022248380A1 (en) | 2021-05-25 | 2022-12-01 | Merck Patent Gmbh | Egfr targeting fc antigen binding fragment-drug conjugates |
WO2022254216A1 (en) | 2021-06-02 | 2022-12-08 | Storm Therapeutics Ltd | Combination therapies comprising a mettl3 inhibitor and a further anticancer agent |
WO2022258986A1 (en) | 2021-06-11 | 2022-12-15 | Argonaut Therapeutics Limited | Compounds useful in the treatment or prevention of a prmt5-mediated disorder |
EP4104837A2 (en) | 2016-04-15 | 2022-12-21 | Cancer Research Technology Limited | Heterocyclic compounds as ret kinase inhibitors |
WO2023002165A1 (en) | 2021-07-19 | 2023-01-26 | Neophore Limited | Inhibitor compounds |
WO2023057389A1 (en) | 2021-10-04 | 2023-04-13 | Forx Therapeutics Ag | Parg inhibitory compounds |
WO2023057394A1 (en) | 2021-10-04 | 2023-04-13 | Forx Therapeutics Ag | N,n-dimethyl-4-(7-(n-(1-methylcyclopropyl)sulfamoyl)-imidazo[1,5-a]pyridin-5-yl)piperazine-1-carboxamide derivatives and the corresponding pyrazolo[1,5-a]pyridine derivatives as parg inhibitors for the treatment of cancer |
WO2023094834A1 (en) | 2021-11-29 | 2023-06-01 | Neophore Limited | Isoindolines as pms2 inhibitors |
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EP4201939A1 (en) | 2018-04-13 | 2023-06-28 | Cancer Research Technology Limited | Bcl6 inhibitors |
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WO2023156791A1 (en) | 2022-02-18 | 2023-08-24 | Cancer Research Technology Limited | Heterocyclic compounds useful for treating a erk5-mediated disease |
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WO2023218201A1 (en) | 2022-05-11 | 2023-11-16 | Cancer Research Technology Limited | Ikk inhibitors |
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EP4335439A2 (en) | 2018-06-20 | 2024-03-13 | Ctxt Pty Ltd | Compounds |
WO2024052692A1 (en) | 2022-09-08 | 2024-03-14 | Cambridge Enterprise Limited | Novel compounds as ck2 inhibitors |
WO2024052693A1 (en) | 2022-09-08 | 2024-03-14 | Cambridge Enterprise Limited | Prodrugs |
WO2024052701A1 (en) | 2022-09-08 | 2024-03-14 | Cambridge Enterprise Limited | Novel compounds, compositions and therapeutic uses thereof |
WO2024052702A1 (en) | 2022-09-08 | 2024-03-14 | Cambridge Enterprise Limited | Novel compounds as ck2 inhibitors |
WO2024052690A1 (en) | 2022-09-08 | 2024-03-14 | Cambridge Enterprise Limited | Novel compounds, compositions and therapeutic uses thereof |
US11932650B2 (en) | 2017-05-11 | 2024-03-19 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
WO2024074497A1 (en) | 2022-10-03 | 2024-04-11 | Forx Therapeutics Ag | Parg inhibitory compound |
EP4360713A2 (en) | 2018-09-18 | 2024-05-01 | F. Hoffmann-La Roche AG | Quinazoline derivatives as antitumor agents |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20060036058A (en) * | 2003-06-18 | 2006-04-27 | 앤지오젠 파마슈티칼스 리미티드 | Compositions comprising zd6126 together with 5-fu, cpt-11 or 5-fu and cpt-11 having vascular damaging activity for treating e.g. colorectal cancer |
GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999002166A1 (en) * | 1997-07-08 | 1999-01-21 | Angiogene Pharmaceuticals Ltd. | Use of colchinol derivatives as vascular damaging agents |
WO2000040529A1 (en) * | 1999-01-07 | 2000-07-13 | Angiogene Pharmaceuticals Ltd. | Colchinol derivatives as vascular damaging agents |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3442953A (en) * | 1963-06-19 | 1969-05-06 | Roussel Uclaf | Novel 7-oxo-7-desacetylaminocolchicine compounds |
IT1270124B (en) * | 1994-10-05 | 1997-04-28 | Indena Spa | COLCHICINE DERIVATIVES AND THEIR THERAPEUTIC USE |
US5561122A (en) * | 1994-12-22 | 1996-10-01 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Combretastatin A-4 prodrug |
IT1276996B1 (en) * | 1995-06-27 | 1997-11-04 | Indena Spa | COLCHICINE DERIVATIVES, THEIR USE AND FORMULATIONS CONTAINING THEM |
US5760092A (en) * | 1995-09-13 | 1998-06-02 | Brandeis University | Allocolchinones and uses thereof |
WO2004052918A2 (en) * | 2002-12-09 | 2004-06-24 | The Trustees Of Columbia University In The City Of New York | Peptides and methods for deactivation of organophosphorus-based nerve agents and insecticides |
-
2001
- 2001-07-04 CN CNB018124135A patent/CN1255391C/en not_active Expired - Fee Related
- 2001-07-04 MX MXPA02012905A patent/MXPA02012905A/en unknown
- 2001-07-04 US US10/332,129 patent/US20050277627A1/en not_active Abandoned
- 2001-07-04 NZ NZ522861A patent/NZ522861A/en unknown
- 2001-07-04 CA CA002411160A patent/CA2411160A1/en not_active Abandoned
- 2001-07-04 KR KR10-2003-7000206A patent/KR20030014425A/en not_active Application Discontinuation
- 2001-07-04 AU AU2001266233A patent/AU2001266233B2/en not_active Expired - Fee Related
- 2001-07-04 IL IL15348401A patent/IL153484A0/en unknown
- 2001-07-04 AU AU6623301A patent/AU6623301A/en active Pending
- 2001-07-04 BR BR0112224-0A patent/BR0112224A/en not_active IP Right Cessation
- 2001-07-04 EP EP01943702A patent/EP1301497A1/en not_active Withdrawn
- 2001-07-04 WO PCT/GB2001/002966 patent/WO2002004434A1/en not_active Application Discontinuation
- 2001-07-04 JP JP2002509300A patent/JP2004502766A/en active Pending
-
2002
- 2002-12-02 ZA ZA200209776A patent/ZA200209776B/en unknown
-
2003
- 2003-01-06 NO NO20030056A patent/NO20030056L/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999002166A1 (en) * | 1997-07-08 | 1999-01-21 | Angiogene Pharmaceuticals Ltd. | Use of colchinol derivatives as vascular damaging agents |
WO2000040529A1 (en) * | 1999-01-07 | 2000-07-13 | Angiogene Pharmaceuticals Ltd. | Colchinol derivatives as vascular damaging agents |
Non-Patent Citations (2)
Title |
---|
BOYE O ET AL: "Synthesis of carbon-14 labeled electrophilic ligands of the colchicine binding site of tubulin: chloroacetates of demethylthiocolchicines and of N-acetylcolchinol, isothiocyanates of 9-deoxy-N-acetylcolchinol", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, SUSSEX, GB, vol. 33, no. 4, 1993, pages 293 - 299, XP002081866, ISSN: 0362-4803 * |
GIL-JONG KANG ET AL: "n-acetylcolchinol O-methyl ether and thiocolchicine, potent nalogs of colchicine modified in the C-ring", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 265, no. 18, 25 June 1990 (1990-06-25), pages 10255 - 10259, XP002081868, ISSN: 0021-9258 * |
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US7579342B2 (en) | 2000-02-23 | 2009-08-25 | Astrazeneca | Pteridine compounds for the treatment of psoriasis |
US7528156B2 (en) | 2000-06-20 | 2009-05-05 | Astrazeneca Ab | Compounds |
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US7582644B2 (en) | 2002-07-27 | 2009-09-01 | Astrazeneca Ab | Pyrimidyl sulphone amide derivatives as chemokine receptor modulators |
US8106063B2 (en) | 2002-07-27 | 2012-01-31 | Astrazeneca Ab | Pyrimidyl sulphone amide derivatives as chemokine receptor modulators |
US7482355B2 (en) | 2002-08-24 | 2009-01-27 | Astrazeneca Ab | Pyrimidine derivatives as modulators of chemokine receptor activity |
US7585867B2 (en) | 2002-09-20 | 2009-09-08 | Astrazeneca Ab | Substituted thiazolo[4,5-d]pyrimidin-2(3H)-one |
EP1847539A1 (en) | 2002-12-24 | 2007-10-24 | AstraZeneca AB | Quinazoline derivatives |
US8198302B2 (en) | 2003-02-28 | 2012-06-12 | Oxigene, Inc. | Compositions and methods with enhanced therapeutic activity |
WO2004089885A1 (en) | 2003-04-07 | 2004-10-21 | Astrazeneca Ab | Novel compounds |
EP2281815A1 (en) | 2003-05-27 | 2011-02-09 | AstraZeneca AB | 4-(Acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl-1H-indole-1-acetic acid ethyl ester intermediate compound |
EP2025670A1 (en) | 2003-05-27 | 2009-02-18 | AstraZeneca AB | 3-(Phenyl or quinolyl)thio-1H-indole-1-acetic acid derivatives as modulators of CRTh2 receptor activity |
WO2005051300A2 (en) | 2003-11-19 | 2005-06-09 | Array Biopharma Inc. | Bicyclic inhibitors of mek and methods of use thereof |
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US7790883B2 (en) | 2003-12-05 | 2010-09-07 | Astrazeneca Ab | Process for the preparation of thiazolopyrimidines |
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US7521473B2 (en) | 2004-02-25 | 2009-04-21 | Wyeth | Inhibitors of protein tyrosine phosphatase 1B |
WO2006001751A1 (en) | 2004-06-24 | 2006-01-05 | Astrazeneca Ab | Chemical compounds i |
WO2006005909A1 (en) | 2004-07-08 | 2006-01-19 | Astrazeneca Ab | Substituted acids for the treatment of respiratory diseases |
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US8269002B2 (en) | 2004-08-28 | 2012-09-18 | Astrazeneca Ab | Pyrimidine sulphonamide derivatives as chemokine receptor modulators |
US7838675B2 (en) | 2004-08-28 | 2010-11-23 | Astrazeneca Ab | Pyrimidine sulphonamide derivatives as chemokine receptor modulators |
US8722883B2 (en) | 2004-08-28 | 2014-05-13 | Astrazeneca Ab | Pyrimidine sulphonamide derivatives as chemokine receptor modulators |
EP2301933A1 (en) | 2004-08-28 | 2011-03-30 | AstraZeneca AB | Thiopyrimidine derivative, useful as an intermediate for chemokine receptor modulators |
US8410123B2 (en) | 2004-08-28 | 2013-04-02 | Astrazeneca Ab | Pyrimidine sulphonamide derivatives as chemokine receptor modulators |
EP3699191A1 (en) | 2004-12-21 | 2020-08-26 | MedImmune Limited | Antibodies directed to angiopoietin-2 and uses thereof |
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WO2006082392A1 (en) | 2005-02-04 | 2006-08-10 | Astrazeneca Ab | Pyrazolylaminopyridine derivatives useful as kinase inhibitors |
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EP2361905A1 (en) | 2005-05-18 | 2011-08-31 | Array Biopharma Inc. | Heterocyclic Inhibitors of MEK and methods of use thereof |
EP2364973A1 (en) | 2005-05-18 | 2011-09-14 | Array Biopharma, Inc. | Heterocyclic inhibitors of MEK and Methods of use thereof |
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US8148405B2 (en) | 2005-08-02 | 2012-04-03 | Astrazeneca Ab | Salt I |
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WO2007034882A1 (en) | 2005-09-22 | 2007-03-29 | Dainippon Sumitomo Pharma Co., Ltd. | Novel adenine compound |
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WO2007039736A1 (en) | 2005-10-06 | 2007-04-12 | Astrazeneca Ab | Novel compounds |
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EP2090575A1 (en) | 2005-11-15 | 2009-08-19 | Array Biopharma, Inc. | Processes and intermediates for the preparation of N4-phenyl-quinazoline-4-amine derivatives |
WO2007069978A1 (en) | 2005-12-12 | 2007-06-21 | Astrazeneca Ab | Novel n-(fluoro-pyrazinyl)-phenylsulfonamid.es as moodulators of chemokine receptor ccr4. |
EP2404616A2 (en) | 2005-12-13 | 2012-01-11 | AstraZeneca AB | Binding proteins specific for insulin-like growth factors and uses thereof |
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WO2007068894A2 (en) | 2005-12-15 | 2007-06-21 | Astrazeneca Ab | Substituted diphenylethers, -amines, -sulfides and -methanes for the treatment of respiratory disease |
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WO2007138282A2 (en) | 2006-05-26 | 2007-12-06 | Astrazeneca Ab | Bi-aryl or aryl-heteroaryl substituted indoles |
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EP2420513A1 (en) | 2006-08-03 | 2012-02-22 | MedImmune Limited | Targeted binding agents directed to PDGFR-alpha and uses thereof |
WO2008017361A2 (en) | 2006-08-10 | 2008-02-14 | Merck Patent Gmbh | 2-(heterocyclylbenzyl)pyridazinone derivatives |
US9717736B2 (en) | 2006-08-23 | 2017-08-01 | Kudos Pharmaceuticals Limited | Pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors |
US7902189B2 (en) | 2006-08-23 | 2011-03-08 | Astrazeneca Ab | Compounds |
US8435985B2 (en) | 2006-08-23 | 2013-05-07 | Keith Menear | Pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors |
US10034884B2 (en) | 2006-08-23 | 2018-07-31 | Kudos Pharmaceuticals Limited | Pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors |
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US8101602B2 (en) | 2006-08-23 | 2012-01-24 | Kudos Pharmaceuticals, Ltd. | Pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors |
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US7723337B2 (en) | 2007-01-25 | 2010-05-25 | Astrazeneca Ab | 3-cinnolinecarboxamide derivatives and their use for treating cancer |
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WO2008148449A1 (en) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | 2-oxo-3-benzyl-benzoxazol-2-one derivatives and related compounds as met kinase inhibitors for the treatment of tumors |
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US8163724B2 (en) | 2007-10-04 | 2012-04-24 | Astrazeneca Ab | Glucocorticosteroids, processes for their preparation, pharmaceutical compositions containing them and their use in therapy |
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DE102007061963A1 (en) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | pyridazinone derivatives |
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US8735584B2 (en) | 2008-02-28 | 2014-05-27 | Merck Patent Gmbh | Protein kinase inhibitors and use thereof |
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DE102008019907A1 (en) | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | pyridazinone derivatives |
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WO2009143945A1 (en) | 2008-05-29 | 2009-12-03 | Merck Patent Gmbh, | Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors |
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DE102008028905A1 (en) | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3- (3-pyrimidin-2-yl-benzyl) - [1,2,4] triazolo [4,3-b] pyridazine derivatives |
WO2009152920A1 (en) | 2008-06-18 | 2009-12-23 | Merck Patent Gmbh | 3-(3-pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazine derivatives as met kinase inhibitors |
DE102008029734A1 (en) | 2008-06-23 | 2009-12-24 | Merck Patent Gmbh | Thiazolyl-piperidine derivatives |
US8901307B2 (en) | 2008-07-02 | 2014-12-02 | Astrazeneca Ab | Chemical compounds 251 |
DE102008037790A1 (en) | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclic triazole derivatives |
DE102008038221A1 (en) | 2008-08-18 | 2010-02-25 | Merck Patent Gmbh | 7-azaindole derivatives |
EP2927244A1 (en) | 2008-09-19 | 2015-10-07 | MedImmune, LLC | Antibodies directed to DLL4 and uses thereof |
DE102008052943A1 (en) | 2008-10-23 | 2010-04-29 | Merck Patent Gmbh | azaindole derivatives |
WO2010067102A1 (en) | 2008-12-09 | 2010-06-17 | Astrazeneca Ab | Diazaspiro [5.5] undecane derivatives and related compounds as muscarinic-receptor antagonists and beta-adrenoreceptor agonists for the treatment of pulmonary disorders |
US9492425B2 (en) | 2008-12-11 | 2016-11-15 | Axcentua Pharmaceuticals Ab | Crystalline forms of genistein |
US9012495B2 (en) | 2008-12-11 | 2015-04-21 | Axcentua Pharmaceuticals Ab | Crystalline forms of genistein |
US7863325B2 (en) | 2008-12-11 | 2011-01-04 | Axcentua Pharmaceuticals Ab | Crystalline genistein sodium salt dihydrate |
EP2727913A1 (en) | 2008-12-15 | 2014-05-07 | Astrazeneca AB | (4-Tert-butylpiperazin-2-yl)(piperazin-1-yl)methanone-N-carboxamide derivatives |
US9938268B2 (en) | 2008-12-17 | 2018-04-10 | Merck Patent Gmbh | C-ring modified tricyclic benzonaphthiridinone protein kinase inhibitors and use thereof |
DE102008063667A1 (en) | 2008-12-18 | 2010-07-01 | Merck Patent Gmbh | 3- (3-pyrimidin-2-yl-benzyl) - ° [1,2,4] triazolo [4,3-b] pyrimidine derivatives |
WO2010070346A2 (en) | 2008-12-18 | 2010-06-24 | Medimmune Limited | BINDING MEMBERS FOR INTERLEUKIN-4 RECEPTOR ALPHA (IL-4Ra) - 836 |
WO2010080253A1 (en) | 2008-12-18 | 2010-07-15 | Merck Patent Gmbh | Tricyclic azaindoles |
US8853391B2 (en) | 2008-12-18 | 2014-10-07 | Merck Patent Gmbh | Tricyclic azaindoles |
WO2010073034A1 (en) | 2008-12-22 | 2010-07-01 | Astrazeneca Ab | Pyrimidine indole derivatives for treating cancer |
WO2010072301A1 (en) | 2008-12-23 | 2010-07-01 | Merck Patent Gmbh | 3-(3-pyrimidine-2-yl-benzyl)-[1,2,4] triazolo [4,3-b] pyridazine derivatives |
WO2010072296A1 (en) | 2008-12-23 | 2010-07-01 | Merck Patent Gmbh | Pyridazinone derivatives |
WO2010072740A2 (en) | 2008-12-23 | 2010-07-01 | Astrazeneca Ab | TARGETED BINDING AGENTS DIRECTED TO α5β1 AND USES THEREOF |
DE102008062825A1 (en) | 2008-12-23 | 2010-06-24 | Merck Patent Gmbh | 3- (3-pyrimidin-2-yl-benzyl) - [1,2,4] triazolo [4,3-b] pyridazine derivatives |
DE102008062826A1 (en) | 2008-12-23 | 2010-07-01 | Merck Patent Gmbh | pyridazinone derivatives |
DE102009003975A1 (en) | 2009-01-07 | 2010-07-08 | Merck Patent Gmbh | Benzothiazolonderivate |
WO2010078905A1 (en) | 2009-01-07 | 2010-07-15 | Merck Patent Gmbh | Benzothiazolone derivative |
WO2010078910A1 (en) | 2009-01-07 | 2010-07-15 | Merck Patent Gmbh | Pyridazinone derivatives |
DE102009003954A1 (en) | 2009-01-07 | 2010-07-08 | Merck Patent Gmbh | pyridazinone derivatives |
DE102009004061A1 (en) | 2009-01-08 | 2010-07-15 | Merck Patent Gmbh | pyridazinone derivatives |
WO2010089580A1 (en) | 2009-02-06 | 2010-08-12 | Astrazeneca Ab | Use of a mct1 inhibitor in the treatment of cancers expressing mct1 over mct4 |
WO2010092371A1 (en) | 2009-02-10 | 2010-08-19 | Astrazeneca Ab | Triazolo [4,3-b] pyridazine derivatives and their uses for prostate cancer |
WO2010109230A1 (en) | 2009-03-25 | 2010-09-30 | Pharminox Limited | Novel prodrugs |
WO2010114476A1 (en) | 2009-04-03 | 2010-10-07 | Astrazeneca Ab | Novel derivatives of steroidal[3,2-c]pyrazole compounds with glucocorticoid activity |
US8338587B2 (en) | 2009-04-03 | 2012-12-25 | Astrazeneca Ab | Compounds |
US8389580B2 (en) | 2009-06-02 | 2013-03-05 | Duke University | Arylcyclopropylamines and methods of use |
WO2010142994A1 (en) | 2009-06-12 | 2010-12-16 | Astrazeneca Ab | 2, 3-dihydro-1h-indene compounds and their use to treat cancer |
WO2011012896A2 (en) | 2009-07-31 | 2011-02-03 | Astrazeneca Ab | Compounds - 801 |
DE102009043260A1 (en) | 2009-09-28 | 2011-04-28 | Merck Patent Gmbh | Pyridinyl-imidazolone derivatives |
WO2011035855A1 (en) | 2009-09-28 | 2011-03-31 | Merck Patent Gmbh | Pyridinyl-imidazolone derivatives for inhibiting pi3 kinases |
WO2011039528A1 (en) | 2009-10-02 | 2011-04-07 | Astrazeneca Ab | 2-pyridone compounds used as inhibitors of neutrophil elastase |
WO2011047770A2 (en) | 2009-10-19 | 2011-04-28 | Merck Patent Gmbh | Pyrazolopyrimidine derivatives |
DE102009049679A1 (en) | 2009-10-19 | 2011-04-21 | Merck Patent Gmbh | Pyrazolopyrimidinderivate |
WO2011048409A1 (en) | 2009-10-20 | 2011-04-28 | Astrazeneca Ab | Cyclic amine derivatives having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
WO2011051704A1 (en) | 2009-10-27 | 2011-05-05 | Astrazeneca Ab | Chromenone derivatives with anti-tumour activity |
US8530467B2 (en) | 2009-11-18 | 2013-09-10 | Neomed Institute | Benzoimidazole compounds and uses thereof |
EP3279215A1 (en) | 2009-11-24 | 2018-02-07 | MedImmune Limited | Targeted binding agents against b7-h1 |
WO2011068233A1 (en) | 2009-12-03 | 2011-06-09 | Dainippon Sumitomo Pharma Co., Ltd. | Imidazoquinolines which act via toll - like receptors (tlr) |
WO2011072779A1 (en) | 2009-12-14 | 2011-06-23 | Merck Patent Gmbh | Thiazole derivatives for treating diseases such as cancer |
WO2011072791A1 (en) | 2009-12-14 | 2011-06-23 | Merck Patent Gmbh | Sphingosine kinase inhibitors |
DE102009058280A1 (en) | 2009-12-14 | 2011-06-16 | Merck Patent Gmbh | thiazole |
WO2011082732A1 (en) | 2009-12-17 | 2011-07-14 | Merck Patent Gmbh | Sphingosine kinase inhibitors |
US10179141B2 (en) | 2010-01-15 | 2019-01-15 | Suzhou Neupharma Co., Ltd. | Certain chemical entities, compositions, and methods |
US10471078B2 (en) | 2010-01-15 | 2019-11-12 | Suzhou Neupharma Co., Ltd. | Certain chemical entities, compositions, and methods |
US10912784B2 (en) | 2010-01-15 | 2021-02-09 | Suzhou Neupharma Co., Ltd. | Certain chemical entities, compositions, and methods |
EP3296313A1 (en) | 2010-01-15 | 2018-03-21 | Suzhou Neupharma Co., Ltd | Certain chemical entities, compositions, and methods |
US9399659B2 (en) | 2010-01-15 | 2016-07-26 | Suzhou Neupharma Co., Ltd | Certain chemical entities, compositions, and methods |
US9814735B2 (en) | 2010-01-15 | 2017-11-14 | Suzhou Neupharma Co., Ltd | Certain chemical entities, compositions, and methods |
US8993550B2 (en) | 2010-01-15 | 2015-03-31 | Suzhou Neupharma Co., Ltd. | Certain chemical entities, compositions, and methods |
WO2011089416A1 (en) | 2010-01-19 | 2011-07-28 | Astrazeneca Ab | Pyrazine derivatives |
WO2011095807A1 (en) | 2010-02-07 | 2011-08-11 | Astrazeneca Ab | Combinations of mek and hh inhibitors |
WO2011114148A1 (en) | 2010-03-17 | 2011-09-22 | Astrazeneca Ab | 4h- [1, 2, 4] triazolo [5, 1 -b] pyrimidin-7 -one derivatives as ccr2b receptor antagonists |
WO2011147528A1 (en) | 2010-05-26 | 2011-12-01 | Merck Patent Gmbh | Biguanide compounds and its use for treating cancer |
WO2011154677A1 (en) | 2010-06-09 | 2011-12-15 | Astrazeneca Ab | Substituted n-[1-cyano-2-(phenyl)ethyl] 1-aminocycloalk-1-ylcarboxamide compounds - 760 |
WO2011154678A1 (en) | 2010-06-11 | 2011-12-15 | Astrazeneca Ab | Compounds |
WO2011154737A1 (en) | 2010-06-11 | 2011-12-15 | Astrazeneca Ab | Morpholino pyrimidines and their use in therapy |
WO2012017239A2 (en) | 2010-08-02 | 2012-02-09 | Astrazeneca Ab | Chemical compounds |
US9018381B2 (en) | 2010-08-06 | 2015-04-28 | Astrazeneca Ab | Chemical compounds |
US9248140B2 (en) | 2010-08-06 | 2016-02-02 | Astrazeneca Ab | Chemical compounds |
WO2012017251A1 (en) | 2010-08-06 | 2012-02-09 | Astrazeneca Ab | N-acylsulfonamide apoptosis promoters |
DE102010034699A1 (en) | 2010-08-18 | 2012-02-23 | Merck Patent Gmbh | pyrimidine derivatives |
WO2012022408A1 (en) | 2010-08-18 | 2012-02-23 | Merck Patent Gmbh | Pyrimidine derivatives as fak inhibitors |
US9018197B2 (en) | 2010-08-28 | 2015-04-28 | Suzhou Neupharma Co. Ltd. | Tetradecahydro-1H-cyclopenta[a]phenanthrene compounds, compositions, and related methods of use |
WO2012042265A1 (en) | 2010-09-30 | 2012-04-05 | Pharminox Limited | Novel acridine derivatives |
DE102010048800A1 (en) | 2010-10-20 | 2012-05-10 | Merck Patent Gmbh | quinoxaline |
WO2012052102A1 (en) | 2010-10-20 | 2012-04-26 | Merck Patent Gmbh | Quinoxaline derivates |
DE102010049595A1 (en) | 2010-10-26 | 2012-04-26 | Merck Patent Gmbh | quinazoline derivatives |
WO2012055466A1 (en) | 2010-10-26 | 2012-05-03 | Merck Patent Gmbh | Quinazoline derivatives |
WO2012066335A1 (en) | 2010-11-19 | 2012-05-24 | Astrazeneca Ab | Phenol compounds als toll -like receptor 7 agonists |
WO2012067268A1 (en) | 2010-11-19 | 2012-05-24 | Dainippon Sumitomo Pharma Co., Ltd. | Cyclic amide compounds and their use in the treatment of disease |
WO2012067269A1 (en) | 2010-11-19 | 2012-05-24 | Dainippon Sumitomo Pharma Co., Ltd. | Aminoalkoxyphenyl compounds and their use in the treatment of disease |
WO2012066336A1 (en) | 2010-11-19 | 2012-05-24 | Astrazeneca Ab | Benzylamine compounds as toll -like receptor 7 agonists |
WO2012080728A1 (en) | 2010-12-16 | 2012-06-21 | Astrazeneca Ab | Imidazo [4, 5 -c] quinolin- 1 -yl derivative useful in therapy |
WO2012080730A1 (en) | 2010-12-17 | 2012-06-21 | Astrazeneca Ab | Purine derivatives |
WO2012085015A1 (en) | 2010-12-20 | 2012-06-28 | Medimmune Limited | Anti-il-18 antibodies and their uses |
EP3453714A2 (en) | 2011-02-02 | 2019-03-13 | Suzhou Neupharma Co., Ltd | Cardenolide and bufadienolide 3-carbonate and 3-carbamate derivatives for the treatment of cancer and compositions thereof |
US10344048B2 (en) | 2011-02-02 | 2019-07-09 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US9493503B2 (en) | 2011-02-02 | 2016-11-15 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US10766920B2 (en) | 2011-02-02 | 2020-09-08 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US9174946B2 (en) | 2011-02-17 | 2015-11-03 | Cancer Therapeutics Crc Pty Ltd | Selective FAK inhibitors |
US9421205B2 (en) | 2011-02-17 | 2016-08-23 | Cancer Therapeutics CRC Pty Ltd. | FAK inhibitors |
US9012461B2 (en) | 2011-02-17 | 2015-04-21 | Cancer Therapeutics Crc Pty Ltd | FAK inhibitors |
WO2012110774A1 (en) | 2011-02-17 | 2012-08-23 | Cancer Therapeutics Crc Pty Limited | Selective fak inhibitors |
US9120761B2 (en) | 2011-02-17 | 2015-09-01 | Cancer Therapeutics Crc Pty Ltd | Selective FAK inhibitors |
WO2012110773A1 (en) | 2011-02-17 | 2012-08-23 | Cancer Therapeutics Crc Pty Limited | Fak inhibitors |
WO2012123745A1 (en) | 2011-03-14 | 2012-09-20 | Cancer Research Technology Limited | Pyrrolopyridineamino derivatives as mps1 inhibitors |
WO2012140419A1 (en) | 2011-04-13 | 2012-10-18 | Astrazeneca Ab | Chromenone compounds as pi 3 -kinase inhibitors for the treatment of cancer |
WO2012175991A1 (en) | 2011-06-24 | 2012-12-27 | Pharminox Limited | Fused pentacyclic anti - proliferative compounds |
WO2013003697A1 (en) | 2011-06-30 | 2013-01-03 | Trustees Of Boston University | Method for controlling tumor growth, angiogenesis and metastasis using immunoglobulin containing and proline rich receptor-1 (igpr-1) |
EP3255043A2 (en) | 2011-07-12 | 2017-12-13 | AstraZeneca AB | N-(6-((2r,3s)-3,4-dihydroxybutan-2-yloxy)-2-(4-fluorobenzylthio)pyrimidin-4-yl)-3- methylazetidine-1-sulfonamide as chemokine receptor modulator |
WO2013008002A1 (en) | 2011-07-12 | 2013-01-17 | Astrazeneca Ab | N- (6- ( (2r,3s) -3,4-dihydroxybutan-2-yloxy) -2- (4 - fluorobenzylthio) pyrimidin- 4 - yl) -3- methylazetidine- 1 - sulfonamide as chemokine receptor modulator |
EP3686194A1 (en) | 2011-07-27 | 2020-07-29 | Astrazeneca AB | 2-(2,4,5-substituted-anilino)pyrimidine compounds |
EP3686193A1 (en) | 2011-07-27 | 2020-07-29 | Astrazeneca AB | 2-(2,4,5-substituted-anilino)pyrimidine compounds |
EP4119551A1 (en) | 2011-07-27 | 2023-01-18 | Astrazeneca AB | 2-(2,4,5-substituted-anilino)pyrimidine compounds |
EP4086246A1 (en) | 2011-07-27 | 2022-11-09 | AstraZeneca AB | 2-(2,4,5-substituted-anilino)pyrimidine compounds as egfr modulators |
EP3009431A1 (en) | 2011-07-27 | 2016-04-20 | Astrazeneca AB | 2-(2,4,5-substituted-anilino)pyrimidine derivatives as egfr modulators useful for treating cancer |
WO2013014448A1 (en) | 2011-07-27 | 2013-01-31 | Astrazeneca Ab | 2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer |
WO2013026516A1 (en) | 2011-08-23 | 2013-02-28 | Merck Patent Gmbh | Bicyclic heteroaromatic compounds |
DE102011111400A1 (en) | 2011-08-23 | 2013-02-28 | Merck Patent Gmbh | Bicyclic heteroaromatic compounds |
US9295671B2 (en) | 2011-08-26 | 2016-03-29 | Neupharma, Inc. | Benzenesulfonamide derivatives of quinoxaline, pharmaceutical compositions thereof, and their use in methods for treating cancer |
WO2013032951A1 (en) | 2011-08-26 | 2013-03-07 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US9572808B2 (en) | 2011-08-26 | 2017-02-21 | Neupharma, Inc. | Benzenesulfonamide derivatives of quinoxaline, pharmaceutical compositions thereof, and their use in methods for treating cancer |
US10137125B2 (en) | 2011-08-26 | 2018-11-27 | Neupharma, Inc. | Benzenesulfonamide derivatives of quinoxaline, pharmaceutical compositions thereof, and their use in methods for treating cancer |
US10561652B2 (en) | 2011-08-26 | 2020-02-18 | Neupharma, Inc. | Benzenesulfonamide derivatives of quinoxaline, pharmaceutical compositions thereof, and their use in methods for treating cancer |
US9707202B2 (en) | 2011-09-01 | 2017-07-18 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US9328081B2 (en) | 2011-09-01 | 2016-05-03 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US9822081B2 (en) | 2011-09-14 | 2017-11-21 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
EP3332785A1 (en) | 2011-09-14 | 2018-06-13 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US10065932B2 (en) | 2011-09-14 | 2018-09-04 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
WO2013040515A1 (en) | 2011-09-14 | 2013-03-21 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US9518029B2 (en) | 2011-09-14 | 2016-12-13 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US10759766B2 (en) | 2011-09-14 | 2020-09-01 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US9249110B2 (en) | 2011-09-21 | 2016-02-02 | Neupharma, Inc. | Substituted quinoxalines as B-raf kinase inhibitors |
WO2013045955A1 (en) | 2011-09-29 | 2013-04-04 | The University Of Liverpool | Prevention and/or treatment of cancer and/or cancer metastasis |
US9249111B2 (en) | 2011-09-30 | 2016-02-02 | Neupharma, Inc. | Substituted quinoxalines as B-RAF kinase inhibitors |
US9585850B2 (en) | 2011-12-23 | 2017-03-07 | Duke University | Methods of treatment using arylcyclopropylamine compounds |
US9908866B2 (en) | 2012-01-25 | 2018-03-06 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US9670180B2 (en) | 2012-01-25 | 2017-06-06 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US10590106B2 (en) | 2012-01-25 | 2020-03-17 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
WO2013110309A1 (en) | 2012-01-28 | 2013-08-01 | Merck Patent Gmbh | Triazolo[4,5-d]pyrimidine derivatives |
WO2013117285A1 (en) | 2012-02-09 | 2013-08-15 | Merck Patent Gmbh | Furo [3, 2 - b] - and thieno [3, 2 - b] pyridine derivatives as tbk1 and ikk inhibitors |
WO2013117288A1 (en) | 2012-02-09 | 2013-08-15 | Merck Patent Gmbh | Tetrahydro-quinazolinone derivatives as tank and parp inhibitors |
WO2013124025A1 (en) | 2012-02-21 | 2013-08-29 | Merck Patent Gmbh | Furopyridine derivatives |
US9073944B2 (en) | 2012-02-21 | 2015-07-07 | Merck Patent Gmbh | Cyclic diaminopyrimidine derivatives |
WO2013126132A1 (en) | 2012-02-21 | 2013-08-29 | Merck Patent Gmbh | Cyclic diaminopyrimidine derivatives |
WO2013124026A1 (en) | 2012-02-21 | 2013-08-29 | Merck Patent Gmbh | 8 - substituted 2 -amino - [1,2,4] triazolo [1, 5 -a] pyrazines as syk tryrosine kinase inhibitors and gcn2 serin kinase inhibitors |
WO2013131609A1 (en) | 2012-03-07 | 2013-09-12 | Merck Patent Gmbh | Triazolopyrazine derivatives |
WO2013143663A1 (en) | 2012-03-28 | 2013-10-03 | Merck Patent Gmbh | Bicyclic pyrazinone derivatives |
WO2013144532A1 (en) | 2012-03-30 | 2013-10-03 | Astrazeneca Ab | 3 -cyano- 5 -arylamino-7 -cycloalkylaminopyrrolo [1, 5 -a] pyrimidine derivatives and their use as antitumor agents |
WO2013150043A1 (en) | 2012-04-05 | 2013-10-10 | F. Hoffmann-La Roche Ag | Bispecific antibodies against human tweak and human il17 and uses thereof |
US9714292B2 (en) | 2012-04-05 | 2017-07-25 | Hoffmann-La Roche Inc. | Bispecific antibodies against human TWEAK and human IL17 and uses thereof |
US10065986B2 (en) | 2012-04-29 | 2018-09-04 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US9676813B2 (en) | 2012-04-29 | 2017-06-13 | Neupharma, Inc. | Certain steroids and methods for using the same in the treatment of cancer |
US11325940B2 (en) | 2012-04-29 | 2022-05-10 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US9340570B2 (en) | 2012-04-29 | 2016-05-17 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
EP3453713A1 (en) | 2012-04-29 | 2019-03-13 | Neupharma, Inc. | Bufadienolide compounds substituted in position 3 by an amine group for use in the treatment of cancer |
US10487108B2 (en) | 2012-04-29 | 2019-11-26 | Neupharma, Inc. | Certain steroids and methods for using the same in the treatment of cancer |
WO2013164061A1 (en) | 2012-05-04 | 2013-11-07 | dedeMERCK PATENT GMBH | Pyrrolotriazinone derivatives |
US9447092B2 (en) | 2012-06-21 | 2016-09-20 | Cancer Research Technology Limited | Pharmaceutically active compounds |
WO2014015934A1 (en) | 2012-07-24 | 2014-01-30 | Merck Patent Gmbh | Hydroxystatin derivatives for treatment of arthrosis |
WO2014023385A1 (en) | 2012-08-07 | 2014-02-13 | Merck Patent Gmbh | Pyridopyrimidine derivatives as protein kinase inhibitors |
WO2014023390A2 (en) | 2012-08-08 | 2014-02-13 | Merck Patent Gmbh | (aza-)isoquinolinone derivatives |
WO2014026243A1 (en) | 2012-08-17 | 2014-02-20 | Cancer Therapeutics Crc Pty Limited | Vegfr3 inhibitors |
WO2014041349A1 (en) | 2012-09-12 | 2014-03-20 | Cancer Therapeutics Crc Pty Ltd | Tetrahydropyran-4-ylethylamino- or tetrahydropyranyl-4-ethyloxy-pyrimidines or -pyridazines as isoprenylcysteincarboxymethyl transferase inhibitors |
WO2014047648A1 (en) | 2012-09-24 | 2014-03-27 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US10457641B2 (en) | 2012-09-24 | 2019-10-29 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US9688635B2 (en) | 2012-09-24 | 2017-06-27 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
WO2014048532A1 (en) | 2012-09-26 | 2014-04-03 | Merck Patent Gmbh | Quinazolinone derivatives as parp inhibitors |
WO2014063205A1 (en) | 2012-10-26 | 2014-05-01 | The University Of Queensland | Use of endocytosis inhibitors and antibodies for cancer therapy |
EP3354752A1 (en) | 2012-11-05 | 2018-08-01 | GMDx Co Pty Ltd | Methods for determining the cause of somatic mutagenesis |
US9725421B2 (en) | 2012-11-12 | 2017-08-08 | Neupharma, Inc. | Substituted quinoxalines as B-raf kinase inhibitors |
US10047059B2 (en) | 2012-11-12 | 2018-08-14 | Neupharma, Inc. | Substituted quinoxalines for inhibiting kinase activity |
WO2014075754A1 (en) | 2012-11-16 | 2014-05-22 | Merck Patent Gmbh | 3-aminocyclopentane carboxamide derivatives |
US10918735B2 (en) | 2012-12-04 | 2021-02-16 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4-diones for cancer treatment |
EP3998267A1 (en) | 2013-01-31 | 2022-05-18 | Bellus Health Cough Inc. | Imidazopyridine compounds and uses thereof |
US9937185B2 (en) | 2013-01-31 | 2018-04-10 | Neomed Institute | Imidazopyridine compounds and uses thereof |
US9814725B2 (en) | 2013-01-31 | 2017-11-14 | Neomed Institute | Imidazopyridine compounds and uses thereof |
EP3381917A1 (en) | 2013-01-31 | 2018-10-03 | Neomed Institute | Imidazopyridine compounds and uses thereof |
US9598409B2 (en) | 2013-01-31 | 2017-03-21 | Neomed Institute | Imidazopyridine compounds and uses thereof |
WO2014127881A1 (en) | 2013-02-25 | 2014-08-28 | Merck Patent Gmbh | 2-amino -3,4-dihydro-quinazoline derivatives and the use thereof as cathepsin d inhibitors |
WO2014135245A1 (en) | 2013-03-05 | 2014-09-12 | Merck Patent Gmbh | 9-(aryl or heteroaryl)-2-(pyrazolyl, pyrrolidinyl or cyclopentyl)aminopurine derivatives as anticancer agents |
US9453031B2 (en) | 2013-03-15 | 2016-09-27 | Fundación Centro Nacional De Investigaciones Oncológicas Carlos Iii | Chemical entities |
US9937137B2 (en) | 2013-03-15 | 2018-04-10 | Neurocentria, Inc. | Magnesium compositions and uses thereof for cancers |
US10201623B2 (en) | 2013-03-15 | 2019-02-12 | Memorial Sloan Kettering Cancer Center | HSP90-targeted cardiac imaging and therapy |
WO2014140644A1 (en) | 2013-03-15 | 2014-09-18 | Fundación Centro Nacional De Investigaciones Oncológicas Carlos Iii | Chemical entities |
WO2014161570A1 (en) | 2013-04-03 | 2014-10-09 | Roche Glycart Ag | Antibodies against human il17 and uses thereof |
WO2014195507A1 (en) | 2013-06-07 | 2014-12-11 | Universite Catholique De Louvain | 3-carboxy substituted coumarin derivatives with a potential utility for the treatment of cancer diseases |
WO2014205511A1 (en) | 2013-06-25 | 2014-12-31 | University Of Canberra | Methods and compositions for modulating cancer stem cells |
US11304957B2 (en) | 2013-08-23 | 2022-04-19 | Neupharma, Inc. | Substituted quinazolines for inhibiting kinase activity |
US10653701B2 (en) | 2013-08-23 | 2020-05-19 | Neupharma, Inc. | Substituted quinazolines for inhibiting kinase activity |
US9849139B2 (en) | 2013-08-23 | 2017-12-26 | Neupharma, Inc. | Substituted quinazolines for inhibiting kinase activity |
US10172868B2 (en) | 2013-08-23 | 2019-01-08 | Neupharma, Inc. | Substituted quinazolines for inhibiting kinase activity |
US9550770B2 (en) | 2013-08-23 | 2017-01-24 | Neupharma, Inc. | Substituted quinazolines for inhibiting kinase activity |
EP3508204A1 (en) | 2013-08-23 | 2019-07-10 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US11865120B2 (en) | 2013-08-23 | 2024-01-09 | Neupharma, Inc. | Substituted quinazolines for inhibiting kinase activity |
WO2015039187A1 (en) | 2013-09-18 | 2015-03-26 | University Of Canberra | Stem cell modulation ii |
WO2015048852A1 (en) | 2013-10-01 | 2015-04-09 | The University Of Queensland | Kits and methods for diagnosis, screening, treatment and disease monitoring |
EP3575299A1 (en) | 2014-02-28 | 2019-12-04 | Cancer Research Technology Limited | N2-phenyl-pyrido[3,4-d]pyrimidine-2,8-diamine derivatives and their use as mps1 inhibitors |
US8980273B1 (en) | 2014-07-15 | 2015-03-17 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
US8986691B1 (en) | 2014-07-15 | 2015-03-24 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
WO2016029262A1 (en) | 2014-08-25 | 2016-03-03 | University Of Canberra | Compositions for modulating cancer stem cells and uses therefor |
WO2016077881A1 (en) | 2014-11-17 | 2016-05-26 | The University Of Queensland | Glycoprotein biomarkers for esophageal adenocarcinoma and barrett's esophagus and uses thereof |
EP3907224A1 (en) | 2014-12-19 | 2021-11-10 | Cancer Research Technology Limited | Parg inhibitory compounds |
US10947201B2 (en) | 2015-02-17 | 2021-03-16 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
WO2016198507A1 (en) | 2015-06-09 | 2016-12-15 | Monash University | Aryl sulfonohydrazides |
EP3957637A1 (en) | 2015-08-04 | 2022-02-23 | Aucentra Therapeutics Pty Ltd | N-(pyridin-2-yl)-4-(thiazol-5-yl)pyrimidin-2-amine derivatives as therapeutic compounds |
US11225690B2 (en) | 2015-08-26 | 2022-01-18 | Gmdx Co Pty Ltd | Methods of detecting cancer recurrence |
WO2017132728A1 (en) | 2016-02-01 | 2017-08-10 | University Of Canberra | Proteinaceous compounds and uses therefor |
EP4071174A1 (en) | 2016-02-15 | 2022-10-12 | AstraZeneca AB | Methods comprising fixed intermittent dosing of cediranib |
WO2017142871A1 (en) | 2016-02-15 | 2017-08-24 | Astrazeneca Ab | Methods comprising fixed intermittent dosing of cediranib |
EP4104837A2 (en) | 2016-04-15 | 2022-12-21 | Cancer Research Technology Limited | Heterocyclic compounds as ret kinase inhibitors |
WO2017187156A1 (en) | 2016-04-26 | 2017-11-02 | Big Dna Ltd | Combination therapy |
US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
WO2018022992A1 (en) | 2016-07-29 | 2018-02-01 | Flx Bio, Inc. | Chemokine receptor modulators and uses thereof |
US10544106B2 (en) | 2016-08-15 | 2020-01-28 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
EP4006035A1 (en) | 2016-08-15 | 2022-06-01 | Neupharma, Inc. | Quinazoline derivatives as tyrosine kinase inhibitors for the treatment of cancer |
US11208388B2 (en) | 2016-08-15 | 2021-12-28 | Neupharma, Inc | Certain chemical entities, compositions, and methods |
WO2018035061A1 (en) | 2016-08-15 | 2018-02-22 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
WO2018055402A1 (en) | 2016-09-22 | 2018-03-29 | Cancer Research Technology Limited | Preparation and uses of pyrimidinone derivatives |
WO2018065787A1 (en) | 2016-10-07 | 2018-04-12 | Cancer Research Technology Limited | Deuterated n-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-fluorophenyl)-2-((4-ethylpiperazin-1 -yl)methyl)quinoline-6-carboxamide |
WO2018106606A1 (en) | 2016-12-05 | 2018-06-14 | Apros Therapeutics, Inc. | Pyrimidine compounds containing acidic groups |
US10786502B2 (en) | 2016-12-05 | 2020-09-29 | Apros Therapeutics, Inc. | Substituted pyrimidines containing acidic groups as TLR7 modulators |
US10287253B2 (en) | 2016-12-05 | 2019-05-14 | Apros Therapeutics, Inc. | Substituted pyrimidines containing acidic groups as TLR7 modulators |
US11173157B2 (en) | 2016-12-05 | 2021-11-16 | Apros Therapeutics, Inc. | Substituted pyrimidines containing acidic groups as TLR7 modulators |
US11111245B2 (en) | 2017-02-01 | 2021-09-07 | Aucentra Therapeutics Pty Ltd | Derivatives of N-cycloalkyl/heterocycloalkyl-4-(imidazo[1,2-a]pyridine)pyrimidin-2-amine as therapeutic agents |
WO2018141002A2 (en) | 2017-02-01 | 2018-08-09 | University Of South Australia | DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO [1,2-a]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS |
US10703723B2 (en) | 2017-03-09 | 2020-07-07 | Truly Translational Sweden Ab | Prodrugs of sulfasalazine, pharmaceutical compositions thereof and their use in the treatment of autoimmune disease |
WO2018162625A1 (en) | 2017-03-09 | 2018-09-13 | Truly Translational Sweden Ab | Prodrugs of sulfasalazine, pharmaceutical compositions thereof and their use in the treatment of autoimmune disease |
WO2018167276A1 (en) | 2017-03-17 | 2018-09-20 | Argonaut Therapeutics Limited | Tricyclic compounds for use in treatment of proliferative disorders |
WO2018189553A1 (en) | 2017-04-13 | 2018-10-18 | Cancer Research Technology Limited | Compounds useful as ret inhibitors |
EP4105219A1 (en) | 2017-04-13 | 2022-12-21 | Cancer Research Technology Limited | Pyrazolopyrimidine compounds useful as ret inhibitors |
US11932650B2 (en) | 2017-05-11 | 2024-03-19 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
WO2018210246A1 (en) | 2017-05-15 | 2018-11-22 | 朱程刚 | Triazine compound and pharmaceutically acceptable salt thereof |
WO2018215798A1 (en) | 2017-05-26 | 2018-11-29 | Cancer Research Technology Limited | 2-quinolone derived inhibitors of bcl6 |
WO2018220101A1 (en) | 2017-05-31 | 2018-12-06 | Truly Translational Sweden Ab | A pharmaceutical composition comprising a combination of methotrexate and novobiocin, and the use of said composition in therapy |
US11883405B2 (en) | 2017-05-31 | 2024-01-30 | Amplio Pharma Ab | Pharmaceutical composition comprising a combination of methotrexate and novobiocin, and the use of said composition in therapy |
WO2019007447A1 (en) | 2017-07-05 | 2019-01-10 | E.P.O.S Iasis Research And Development Limited | Multifunctional conjugates |
WO2019025099A1 (en) | 2017-08-01 | 2019-02-07 | Merck Patent Gmbh | Thiazolopyridine derivatives as adenosine receptor antagonists |
WO2019034890A1 (en) | 2017-08-18 | 2019-02-21 | Cancer Research Technology Limited | Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer |
WO2019038215A1 (en) | 2017-08-21 | 2019-02-28 | Merck Patent Gmbh | Bezimidazole derivatives as adenosine receptor antagonists |
WO2019038214A1 (en) | 2017-08-21 | 2019-02-28 | Merck Patent Gmbh | Quinoxaline derivatives as adenosine receptor antagonists |
WO2019070167A1 (en) | 2017-10-06 | 2019-04-11 | Закрытое Акционерное Общество "Биокад" | Epidermal growth factor receptor inhibitors |
US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
WO2019083365A1 (en) | 2017-10-25 | 2019-05-02 | Universiteit Leiden | Delivery vectors |
WO2019090272A1 (en) | 2017-11-06 | 2019-05-09 | Flx Bio, Inc. | Chemokine receptor modulators for treatment of epstein barr virus positive cancer |
WO2019101903A1 (en) | 2017-11-23 | 2019-05-31 | Medac Gesellschaft für klinische Spezialpräparate mbH | Sulfasalazine salts, production processes and uses |
US11304936B2 (en) | 2017-11-23 | 2022-04-19 | Medac Gesellschaft Fuer Klinische Spezialpraeparate Mbh | Sulfasalazine salts, production processes and uses |
WO2019101904A1 (en) | 2017-11-23 | 2019-05-31 | Medac Gesellschaft für klinische Spezialpräparate mbH | Pharmaceutical composition for oral administration containing sulfasalazine and / or a sulfasalazine organic salt, production process and use |
EP3489222A1 (en) | 2017-11-23 | 2019-05-29 | medac Gesellschaft für klinische Spezialpräparate mbH | Sulfasalazine salts, production processes and uses |
EP3488868A1 (en) | 2017-11-23 | 2019-05-29 | medac Gesellschaft für klinische Spezialpräparate mbH | Pharmaceutical composition for oral administration containing sulfasalazine and / or a sulfasalazine organic salt, production process and use |
US11690857B2 (en) | 2017-11-23 | 2023-07-04 | Medac Gesellschaft Fuer Klinische Spezialpraeparate Mbh | Pharmaceutical composition for oral administration containing sulfasalazine and/or a sulfasalazine organic salt, production process and use |
WO2019136514A1 (en) | 2018-01-15 | 2019-07-18 | University Of South Australia | 5-(pyrimidin-4-yl)thiazol-2-yl urea derivatives as therapeutic agents |
WO2019145718A1 (en) | 2018-01-24 | 2019-08-01 | Oxford University Innovation Limited | Compounds |
WO2019147862A1 (en) | 2018-01-26 | 2019-08-01 | Flx Bio, Inc. | Chemokine receptor modulators and uses thereof |
WO2019157225A2 (en) | 2018-02-08 | 2019-08-15 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US11465975B2 (en) | 2018-02-08 | 2022-10-11 | Neupharma, Inc | Certain chemical entities, compositions, and methods |
WO2019175093A1 (en) | 2018-03-12 | 2019-09-19 | Astrazeneca Ab | Method for treating lung cancer |
EP4201939A1 (en) | 2018-04-13 | 2023-06-28 | Cancer Research Technology Limited | Bcl6 inhibitors |
US11304950B2 (en) | 2018-04-27 | 2022-04-19 | Spruce Biosciences, Inc. | Methods for treating testicular and ovarian adrenal rest tumors |
US10857153B2 (en) | 2018-06-04 | 2020-12-08 | Apros Therapeutics, Inc. | Pyrimidine compounds containing acidic groups |
WO2019234405A1 (en) | 2018-06-04 | 2019-12-12 | Oxford University Innovation Limited | Compounds useful in the treatment of disorders associated with mutant ras |
WO2019236496A1 (en) | 2018-06-04 | 2019-12-12 | Apros Therapeutics, Inc. | Pyrimidine compounds containing acidic groups useful to treat diseases connected to the modulation of tlr7 |
WO2019236631A1 (en) | 2018-06-05 | 2019-12-12 | Rapt Therapeutics, Inc. | Pyrazolo-pyrimidin-amino-cycloalkyl compounds and their therapeutic uses |
EP4335439A2 (en) | 2018-06-20 | 2024-03-13 | Ctxt Pty Ltd | Compounds |
WO2020002587A1 (en) | 2018-06-28 | 2020-01-02 | Ctxt Pty Limited | Compounds |
EP4360713A2 (en) | 2018-09-18 | 2024-05-01 | F. Hoffmann-La Roche AG | Quinazoline derivatives as antitumor agents |
WO2020068600A1 (en) | 2018-09-24 | 2020-04-02 | Rapt Therapeutics, Inc. | Ubiquitin-specific-processing protease 7 (usp7) modulators and uses thereof |
WO2020083856A1 (en) | 2018-10-25 | 2020-04-30 | Merck Patent Gmbh | 5-azaindazole derivatives as adenosine receptor antagonists |
WO2020083878A1 (en) | 2018-10-25 | 2020-04-30 | Merck Patent Gmbh | 5-azaindazole derivatives as adenosine receptor antagonists |
WO2020104820A1 (en) | 2018-11-23 | 2020-05-28 | Cancer Research Technology Limited | Substituted benzimidazolones as anti-cancer agents |
WO2020132844A1 (en) | 2018-12-25 | 2020-07-02 | 中国医学科学院基础医学研究所 | Small rna medicament for prevention and treatment of inflammation-related diseases and combination thereof |
WO2020152132A1 (en) | 2019-01-22 | 2020-07-30 | Merck Patent Gmbh | Thiazolopyridine derivatives as adenosine receptor antagonists |
US11033547B2 (en) | 2019-03-07 | 2021-06-15 | Merck Patent Gmbh | Carboxamide-pyrimidine derivatives as SHP2 antagonists |
WO2020181283A1 (en) | 2019-03-07 | 2020-09-10 | Merck Patent Gmbh | Carboxamide-pyrimidine derivatives as shp2 antagonists |
US11696916B2 (en) | 2019-03-07 | 2023-07-11 | Merck Patent Gmbh | Carboxamide-pyrimidine derivatives as SHP2 antagonists |
WO2020200158A1 (en) | 2019-03-29 | 2020-10-08 | 深圳福沃药业有限公司 | N-heteroaromatic amide derivatives for treatment of cancer |
WO2020201773A1 (en) | 2019-04-05 | 2020-10-08 | Storm Therapeutics Ltd | Mettl3 inhibitory compounds |
WO2020210384A1 (en) | 2019-04-08 | 2020-10-15 | Merck Patent Gmbh | Pyrimidinone derivatives as shp2 antagonists |
US11001561B2 (en) | 2019-04-08 | 2021-05-11 | Merck Patent Gmbh | Pyrimidinone derivatives as SHP2 antagonists |
US11702392B2 (en) | 2019-04-08 | 2023-07-18 | Merck Patent Gmbh | Pyrimidinone derivatives as SHP2 antagonists |
WO2020212697A1 (en) | 2019-04-15 | 2020-10-22 | Azeria Therapeutics Limited | Inhibitor compounds |
WO2020247054A1 (en) | 2019-06-05 | 2020-12-10 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
US11535634B2 (en) | 2019-06-05 | 2022-12-27 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
WO2020254831A1 (en) | 2019-06-20 | 2020-12-24 | Storm Therapeutics Ltd | Bicyclic heterocyclic compounds as inhibitors ofbcdin3d activity |
WO2021037219A1 (en) | 2019-08-31 | 2021-03-04 | 上海奕拓医药科技有限责任公司 | Pyrazole derivative for fgfr inhibitor and preparation method therefor |
WO2021055744A1 (en) | 2019-09-20 | 2021-03-25 | Ideaya Biosciences, Inc. | 4-substituted indole and indazole sulfonamido derivatives as parg inhibitors |
WO2021058974A1 (en) | 2019-09-27 | 2021-04-01 | Celleron Therapeutics Limited | Novel treatment |
WO2021074620A1 (en) | 2019-10-14 | 2021-04-22 | Cancer Research Technology Limited | [1,4]oxazepino[2,3-c]qui noli none derivatives as blc6 inhibitors |
WO2021084264A1 (en) | 2019-10-31 | 2021-05-06 | Cancer Research Technology Limited | Isoquinoline derivatives as sik2 inhibitors |
WO2021084266A1 (en) | 2019-10-31 | 2021-05-06 | Cancer Research Technology Limited | Bicyclic nitrogen containing heterocycles as inhibitors of salt-inuced kinase sik2 |
WO2021084265A1 (en) | 2019-10-31 | 2021-05-06 | Cancer Research Technology Limited | Isoquinoline derivatives as sik2 inhibitors |
WO2021111124A1 (en) | 2019-12-02 | 2021-06-10 | Storm Therapeutics Limited | Polyheterocyclic compounds as mettl3 inhibitors |
WO2021198709A1 (en) | 2020-04-03 | 2021-10-07 | Kinsensus Limited | Naphthyridine compounds as inhibitors of mer tyrosine kinase and axl tyrosine kinase |
WO2021245405A1 (en) | 2020-06-01 | 2021-12-09 | Neophore Limited | Inhibitors of mlh1 and/or pms2 for cancer treatment |
WO2022034313A1 (en) | 2020-08-11 | 2022-02-17 | University Of Huddersfield | Novel compounds and therapeutic uses thereof |
WO2022038356A1 (en) | 2020-08-19 | 2022-02-24 | University Of Oxford | Lmo2 protein inhibitors |
WO2022074379A1 (en) | 2020-10-06 | 2022-04-14 | Storm Therapeutics Limited | Mettl3 inhibitory compounds |
WO2022074391A1 (en) | 2020-10-08 | 2022-04-14 | Storm Therapeutics Limited | Compounds inhibitors of mettl3 |
WO2022185041A1 (en) | 2021-03-01 | 2022-09-09 | Cambridge Enterprise Limited | Benzo[c][2,6]naphthyridine derivatives, compositions and therapeutic uses thereof |
WO2022197641A1 (en) | 2021-03-15 | 2022-09-22 | Rapt Therapeutics, Inc. | 1h-pyrazolo[3,4-d]pyrimidin-6-yl-amine derivatives as hematopoietic progenitor kinase 1 (hpk1) modulators and/or inhibitors for the treatment of cancer and other diseases |
WO2022233718A2 (en) | 2021-05-03 | 2022-11-10 | Merck Patent Gmbh | Her2 targeting fc antigen binding fragment-drug conjugates |
WO2022245061A1 (en) | 2021-05-17 | 2022-11-24 | 에이치케이이노엔 주식회사 | Benzamide derivative, method for preparing same, and pharmaceutical composition for prevention or treatment of cancer containing same as active ingredient |
WO2022248380A1 (en) | 2021-05-25 | 2022-12-01 | Merck Patent Gmbh | Egfr targeting fc antigen binding fragment-drug conjugates |
WO2022254216A1 (en) | 2021-06-02 | 2022-12-08 | Storm Therapeutics Ltd | Combination therapies comprising a mettl3 inhibitor and a further anticancer agent |
WO2022258986A1 (en) | 2021-06-11 | 2022-12-15 | Argonaut Therapeutics Limited | Compounds useful in the treatment or prevention of a prmt5-mediated disorder |
WO2023002165A1 (en) | 2021-07-19 | 2023-01-26 | Neophore Limited | Inhibitor compounds |
WO2023057394A1 (en) | 2021-10-04 | 2023-04-13 | Forx Therapeutics Ag | N,n-dimethyl-4-(7-(n-(1-methylcyclopropyl)sulfamoyl)-imidazo[1,5-a]pyridin-5-yl)piperazine-1-carboxamide derivatives and the corresponding pyrazolo[1,5-a]pyridine derivatives as parg inhibitors for the treatment of cancer |
WO2023057389A1 (en) | 2021-10-04 | 2023-04-13 | Forx Therapeutics Ag | Parg inhibitory compounds |
WO2023094834A1 (en) | 2021-11-29 | 2023-06-01 | Neophore Limited | Isoindolines as pms2 inhibitors |
WO2023094833A1 (en) | 2021-11-29 | 2023-06-01 | Neophore Limited | Indolines as protac compounds |
WO2023131690A1 (en) | 2022-01-10 | 2023-07-13 | Merck Patent Gmbh | Substituted heterocycles as hset inhibitors |
WO2023156775A1 (en) | 2022-02-15 | 2023-08-24 | The Chancellor, Masters And Scholars Of The University Of Oxford | Anti-cancer treatment with a radioactive parp inhibitor |
WO2023156791A1 (en) | 2022-02-18 | 2023-08-24 | Cancer Research Technology Limited | Heterocyclic compounds useful for treating a erk5-mediated disease |
WO2023175185A1 (en) | 2022-03-17 | 2023-09-21 | Forx Therapeutics Ag | 2,4-dioxo-1,4-dihydroquinazoline derivatives as parg inhibitors for the treatment of cancer |
WO2023175184A1 (en) | 2022-03-17 | 2023-09-21 | Forx Therapeutics Ag | 2,4-dioxo-1,4-dihydroquinazoline derivatives as parg inhibitors for the treatment of cancer |
WO2023194414A1 (en) | 2022-04-04 | 2023-10-12 | Cambridge Enterprise Limited | Polydopamine co-polymer nanoparticles |
WO2023196432A1 (en) | 2022-04-06 | 2023-10-12 | Rapt Therapeutics, Inc. | Chemokine receptor modulators and uses thereof |
WO2023218201A1 (en) | 2022-05-11 | 2023-11-16 | Cancer Research Technology Limited | Ikk inhibitors |
WO2024003533A1 (en) | 2022-06-27 | 2024-01-04 | University College Cardiff Consultants Limited | Protacs for targeted degradation of kat2a and kat2b for the treatment of cancer |
WO2024030825A1 (en) | 2022-08-01 | 2024-02-08 | Neupharma, Inc | Crystalline salts of crystalline salts of (3s,5r,8r,9s,10s,13r,14s,17r)-14-hydroxy-10,13-dimethyl-17-(2- oxo-2h-pyran-5-yl)hexadecahydro-1h-cyclopenta[a]phenanthren-3-yl piperazine-1-carboxylate |
WO2024052693A1 (en) | 2022-09-08 | 2024-03-14 | Cambridge Enterprise Limited | Prodrugs |
WO2024052701A1 (en) | 2022-09-08 | 2024-03-14 | Cambridge Enterprise Limited | Novel compounds, compositions and therapeutic uses thereof |
WO2024052702A1 (en) | 2022-09-08 | 2024-03-14 | Cambridge Enterprise Limited | Novel compounds as ck2 inhibitors |
WO2024052690A1 (en) | 2022-09-08 | 2024-03-14 | Cambridge Enterprise Limited | Novel compounds, compositions and therapeutic uses thereof |
WO2024052692A1 (en) | 2022-09-08 | 2024-03-14 | Cambridge Enterprise Limited | Novel compounds as ck2 inhibitors |
WO2024074497A1 (en) | 2022-10-03 | 2024-04-11 | Forx Therapeutics Ag | Parg inhibitory compound |
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