WO2002003860A1 - Regulation de pression destinee a stabiliser la pression du liquide cephalo-rachidien - Google Patents

Regulation de pression destinee a stabiliser la pression du liquide cephalo-rachidien Download PDF

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Publication number
WO2002003860A1
WO2002003860A1 PCT/EP2001/006955 EP0106955W WO0203860A1 WO 2002003860 A1 WO2002003860 A1 WO 2002003860A1 EP 0106955 W EP0106955 W EP 0106955W WO 0203860 A1 WO0203860 A1 WO 0203860A1
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WO
WIPO (PCT)
Prior art keywords
pressure
measuring
pressure sensor
sensor
thin tube
Prior art date
Application number
PCT/EP2001/006955
Other languages
German (de)
English (en)
Inventor
Wolfgang Barnikol
Original Assignee
Glukomeditech Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glukomeditech Ag filed Critical Glukomeditech Ag
Priority to AU2001272492A priority Critical patent/AU2001272492A1/en
Publication of WO2002003860A1 publication Critical patent/WO2002003860A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/03—Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs
    • A61B5/031—Intracranial pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M2025/0001—Catheters; Hollow probes for pressure measurement
    • A61M2025/0002—Catheters; Hollow probes for pressure measurement with a pressure sensor at the distal end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
    • A61M27/006—Cerebrospinal drainage; Accessories therefor, e.g. valves

Definitions

  • Device for measuring and regulating pressure in the human body, in particular for adjusting and stabilizing the cerebrospinal fluid pressure for the therapy of hydrocephalus and for diagnostic purposes
  • the invention relates to a device for pressure measurement and regulation in the human body with the features of claim 1 for use in various medical applications.
  • One embodiment of the invention relates to a device in a totally implantable microtechnical embodiment, which can be an integral part of a liquor pressure ' drainage (so-called liquor "shunt") and with the help of which one is in the cerebrospiral liquor (brain water) in the therapy mode Pressure sensor by changing an artificial CSF drain resistance can keep a person's CSF pressure stable at a desired value and can determine a long-term profile of brain pressure in the diagnostic mode artificial respiration, cyclically discontinued.
  • liquor pressure ' drainage so-called liquor "shunt”
  • pressure sensor by changing an artificial CSF drain resistance can keep a person's CSF pressure stable at a desired value and can determine a long-term profile of brain pressure in the diagnostic mode artificial respiration, cyclically discontinued.
  • the liquor is in the pair, so-called.
  • the choroid plexus of the 1st and 2nd ventricles is formed and flows into the venous blood in various ways: via the arachnoid granulation and the interventricular foramina in the 3rd ventricle and further via the cerebral aqueduct in the 4th brain ventricle.
  • the formation and drainage of the brain water are usually coordinated so that there is a real overpressure in the brain water.
  • This so-called intracranial intracranial pressure also depends on the position and is physiologically 10 ⁇ 5mmHg in the lying adult.
  • the CSF flow amounts to about 350 ml per day.
  • Various disturbances can lead to pressure deviations from the norm, in particular to increases. These cause considerable complaints and (Cerebral) disorders for the wearer.
  • An ongoing increase in pressure also leads to the irreversible loss of nerve cells, especially in the cortex, ie to the debarking of the person concerned.
  • the reason for this is, among other things, that the cerebral perfusion pressure (ZPD) decreases, since this is the difference between the blood pressure and the cerebral pressure.
  • the cerebral perfusion pressure is the decisive driving force for the blood supply to the brain and thus for its supply.
  • cerebrospinal fluid pressure also increases due to a decrease in cerebrospinal fluid absorption (Hydrocephalus aresorptivus) after meningitis or encephalitis;
  • a thin tube with an outer diameter of approximately 2.5 mm is used a CSF drainage (so-called, cerebral "shunt").
  • the tube is located at one end in one of the two lateral and paired intracerebral CSF spaces (so-called brain ventricles) and leads out through the skull cap; it usually runs under the skin to the abdomen.
  • the targeted system for stabilizing the intracranial pressure is to be integrated into a cerebrospinal fluid drainage
  • only a micro pressure sensor can be used for pressure measurement, which is best integrated at the tip of the implanted catheter of the cerebrospinal fluid drainage in such a way that its pressure-sensitive surface is facing the cerebral cerebrospinal fluid space.
  • Stabilization should function properly for years; for this it is particularly important that the signal of the fully integrated and implanted pressure sensor remains stable for years - a problem that cannot be solved practically, even if the pressure sensors are constructed as stable as possible. Therefore, the fully implanted system must have a device by means of which the calibration of the pressure sensor can be checked and, if necessary, corrected.
  • Another embodiment of the invention relates to pressure measurement in other medical applications.
  • micro sensors to directly and continuously measure the pressure at the tip of a child's tube, which has an outer diameter of only 2.5 mm and less, in order to achieve this so-called endotracheal pressure during artificial ventilation of a child, so that a ventilator could also be controlled with this signal.
  • a ventilator could then control the signal of the tube sensor in such a way that on the one hand the ventilated lung does not experience any volumetric and / or baro-trauma and on the other hand it is adequately ventilated in order to supply the person concerned with sufficient oxygen.
  • a measurement mode diagnostic mode
  • a regulation mode therapeutic mode
  • a micro-pressure sensor is incorporated in a special way into the tip of a thin tube; the thin tube also serves for liquid conduction, for example into the abdomen.
  • the signal - wireless or wired - arrives at a controllable flow resistance, which is found in the CSF.
  • Discharge hose is located.
  • the resistance is adjusted so that the cerebrospinal fluid pressure stabilizes at a desired value.
  • the controllable flow resistance is followed by a flow sensor, which can measure the CSF flow quantitatively.
  • a miniaturized subcutaneous puncture system with a diaphragm is switched on in the liquor discharge tube, via which the intracranial one is connected with the help of a cannula to which an externally calibrated pressure sensor is connected via a tube (here: intraventricular) pressure can be checked and verified if necessary.
  • the controllable flow resistance is an important aid here: firstly, it can be used to check the flowability of the implanted drainage tube, and secondly, after closing the flow resistance, which in turn can be controlled via the downstream flow sensor, the signal of the pressure sensor located in the brain ventricle can be obtained.
  • the pressure signal passes from the pressure sensor at the tip of the tube to a ventilator, which ensures the desired ventilation.
  • a flow sensor is located in the connector of the children's tube, which allows the ventilation set by the ventilator to be determined.
  • Fig. 1 shows the scheme for the process of CSF pressure stabilization.
  • the pressure measuring device (1) consists of the sensor (1.1) and the measuring amplifier (1.2).
  • the sensor (1.1) is located in the 1st or 2nd brain ventricle.
  • the sensor (1.1) and the measuring amplifier (1.2) are electrically coupled to one another via the lines 1.6.
  • Number 5 identifies a hose route.
  • the sensor (1.1), the measuring amplifier (1.2) and the lines (1.6) are implanted, the measuring amplifier (1.2) is preferably directly subclavicular. From time to time, the electrical energy source (1.2.1) of the measuring amplifier (1.2) can be charged telemetrically via the non-implanted external device (3).
  • the implanted measuring amplifier (1.2) transmits the measuring signal to the non-implanted external registration, control and regulating device (4) by means of a transmitter (1.2.2).
  • the sensor (1.1) is located in a child's windpipe and part 5 identifies an airway. All other parts of the device are not implanted.
  • the external device (3) is omitted, the energy source (1.2.1) likewise, the measuring amplifier (1.2) can be supplied with electrical energy via lines.
  • the device (1, 3, 4 and 5) explained can work as a whole; in the case of cerebrospinal fluid, the intracranial pressure, in the case of the pediatric sensor tube, the endotracheal pressure is recorded continuously.
  • the actuating, calibrating and measuring device (2) can be implanted or replaced at any time in the application of the intracranial pressure measurement - preferably subclavicularly, i.e. directly below the clavicle - or switched and electrically connected. It includes a controllable flow resistance (2.1), a subcutaneous one
  • the actuating and measuring device (2) can also be supplied with electrical energy via the transmitter (3.1) of the external device (3) and the receiver (2.5) of the actuating and measuring device (2).
  • Via the subcutaneous puncture system (2.6) the pressure inside the liquor discharge tube (5) can be measured with the help of a cannula, which reaches the tip of the skin through the skin and the diaphragm (2.7) with the tip into the inner fluid of the liquor drain tube (5). measure directly.
  • the pressure measuring device (1) and the adjusting, calibrating and measuring device (2) can be used in two different function modes:
  • 1.Measurement mode In this mode, the liquor path (5) is determined with the help of the registration, control and regulating device (4) via the receiver (2.5) of the actuating, calibration and measuring device (2). closed by the controllable flow resistance (2.1), which can be controlled with the flow sensor (2.2): In this case, the signal of the flow sensor (2.2) must remain zero.
  • This mode allows the detection of a pressure profile in the 'cerebrospinal fluid, for example, over 24 hours, and permitted a characterization of the disease condition.
  • the external registration, control and regulating device (4) works as a controller with negative feedback: it sets the flow resistance via its transmitter (4.1)
  • Control and regulating device (4) is transmitted telemetrically by the transmitter (1.2.2) - a desired value preselected in the registration, control and regulating device (4) is the same.
  • the pressure sensor (1.1) can be checked and re-calibrated using the subcutaneous puncture system (2.6) as follows: A cannula is inserted into the puncture system (2.6) from the outside through the skin and the diaphragm (2.7), which is filled with a liquid Hose is connected to an external calibrated pressure sensor. Now the adjustable flow resistance (2.1) is completely closed. The flow sensor (2.2) must set its zero signal here: this is an indication that the CSF drain hose (5) is continuous. In the subcutaneous puncture system (2.6) there is - since there is no longer any flow in the discharge tube - pressure compensation with the pressure sensor (1.1), which is located in the brain ventricle.
  • part (2) represents a respirator with a fan (2.1) and a gas flow meter (2.2); In this case, the device (2.6) is omitted.
  • the doctor sets the ventilator (2.1) according to clinical experience and the flow sensor (2.2) quantitatively detects the ventilation.
  • the pressure sensor (1.1) continuously determines the endotracheal ventilation pressure, the signal of which is transmitted from the measuring amplifier (1.2) to the registration, control and regulating device (4).
  • the registration, control and regulating device (4) monitors the endotracheal pressure. If this does not have the desired course in the breathing cycle, which is defined in this device, the mode of operation of the fan (2.1) is changed accordingly.
  • the flow sensor (2.2) always provides the respiratory flow and thus the ventilation as a measurement.
  • Fig. 2 shows schematically an embodiment of the pressure sensor (1.1) at the tip of a thin tube (1.9) as a longitudinal section.
  • the thin hose (1.9) is roughly cut off at the end.
  • the micro-pressure sensor (1.1) is placed inside a bead (1.13).
  • the sensor (1.1) has a pressure-sensitive membrane (1.4) on the outside.
  • On the back of the sensor (1.1) begins a flat air shaft (1.5) in the hose wall, which runs lengthways in the hose wall.
  • the cable connections (1.6) of the micro pressure sensor are located in the flat shaft (1.5).
  • the pressure sensor can work, among other things, piezoelectric, resistive, inductive or capacitive.
  • the flat shaft (1.5) can also be filled with material.
  • a variant of this embodiment can include that the end of the hose is filled with solid material (1.8) and the thin hose (1.9) then necessarily has some lateral openings (1.7).
  • Fig. 3 shows a section along the line I of Fig. 2 again. Here the micro pressure sensor (1.1), the pressure sensitive membrane (1.4) and the flat channel (1.5) are shown.
  • Fig. 4 shows the cross section II of Fig. 2 again with the flat channel (1.5) and with the cable connections (1.6).
  • the hose in the wall can be provided with further hollow channels (1.10; 1.11).
  • FIG. 5 shows schematically in longitudinal section an embodiment of the controllable flow resistance (2.1) and FIG. 6 shows a cross section along line I of FIG. 5.
  • the hose (1.9) is located between the two legs (5.1) and (5.2) of a clamp (5.3).
  • the cross-section of the hose (1.9) can be reduced by the clamp (5.3), thus increasing its flow resistance.
  • the hose (1.9) is firmly connected to the legs (5.1; 5.2) at points (5.4) and (5.5). This means that the hose resistance can be safely reduced again.
  • the two legs (5.1; 5.2) of the clamp (5.3) can be moved against each other with a threaded rod (5.6).
  • the threaded rod (5.6) has two opposing threads (5.7) and (5.8), the transition (5.9) of which is located in the middle of the screw between the legs.
  • the threaded rod (5.6) can be moved, for example, with a motor (5.10), controllable in both directions of rotation and at different speeds.
  • the threaded rod (5.6) runs in two nuts (5.11) and (5.12) corresponding to the threads, which are articulated at the ends of the two legs (5.1) and (5.2).
  • the flow sensor (2.2) consists of a tubular constriction (6.1), which is equipped with two pressure measuring points (6.2) and (6.3) in the wall at a suitable distance. The difference in the pressures measured at the points gives a measure of the flow of the medium through the pipe.
  • the pressure measuring points can each consist of the pressure-sensitive membrane of a pressure microsensor. Then the difference between the two (electrical) signals is a measure of the flow.
  • the pressure measuring points can also be the end of pressure transmission lines (6.4) and (6.5), which lead to a differential pressure Guide sensor (6.6).
  • These lines can consist, for example, of liquid-filled tubes.
  • the signal from the differential pressure sensor (6.6) is a measure of the flow.
  • the inside of the tubular constriction is provided with an inert coating (6.7), which prevents interaction with molecules that are dissolved in the brain water, so that the flow resistance of the constriction (6.1) does not change.
  • a diamond-like carbon coating can preferably be used for this purpose.
  • the flow sensor can be made of metal or plastic, but in any case from a cell-compatible material.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

L'invention concerne un dispositif destiné à la mesure et à la régulation dans le corps humain, composé d'un tuyau (1.9) chanfreiné sur une de ses extrémités, comportant un capteur de pression miniaturisé (1.1) au niveau de sa pointe, les lignes électriques (1.6) transmettant les signaux de mesure du capteur de pression (1.1) étant disposées dans la paroi dudit capteur ; d'un amplificateur de mesure (1.2) recevant, amplifiant, et réacheminant les signaux de mesure du capteur de pression (1.1) ; d'un appareil d'enregistrement, de commande, et de régulation (4) recevant et traitant les signaux électriques de l'amplificateur de mesure (1.2) ; et d'un système de réglage, d'étalonnage, et de mesure (2) destiné à réguler l'amenée ou l'évacuation d'un courant gazeux ou liquide, comportant un capteur de flux (2.2). Le système de réglage, d'étalonnage, et de mesure (2) peut de préférence présenter un système de ponction (2.6) comportant un diaphragme (2.7), permettant d'effectuer l'étalonnage, le contrôle, et la correction des signaux du capteur de pression (1.1) au moyen d'une canule introduite au travers de la peau et d'un capteur de pression couplé à cette canule. Le dispositif selon l'invention peut de préférence être employé pour la mesure et régulation du liquide céphalo-rachidien et la respiration artificielle d'enfants.
PCT/EP2001/006955 2000-07-07 2001-06-20 Regulation de pression destinee a stabiliser la pression du liquide cephalo-rachidien WO2002003860A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001272492A AU2001272492A1 (en) 2000-07-07 2001-06-20 Pressure regulator for stabilizing cerebrospinal fluid pressure

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10033138A DE10033138A1 (de) 2000-07-07 2000-07-07 Vorrichtung zur Druck-Messung und -Regulierung im menschlichen Körper, insbesondere zur Einstellung und Stabilisation des Liquordruckes für die Therapie des Hydrocephalus und für diagnostische Zwecke
DE10033138.6 2000-07-07

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AU (1) AU2001272492A1 (fr)
DE (1) DE10033138A1 (fr)
WO (1) WO2002003860A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006091164A1 (fr) * 2005-02-28 2006-08-31 Jan Malm Procede et dispositif permettant de determiner les proprietes hydrodynamiques du systeme contenant le liquide cephalorachidien
JP2008048210A (ja) * 2006-08-17 2008-02-28 Konica Minolta Business Technologies Inc 認証サーバ、画像形成装置、画像形成認証システム及びプログラム
WO2011116393A1 (fr) * 2010-03-19 2011-09-22 University Of Washington Systèmes de drainage pour l'évacuation des fluides corporels en excédent
US8109899B2 (en) 2009-07-06 2012-02-07 Likvor Ab Fully automated method of measuring and regulating cerebrospinal fluid parameters using disposable tube-set
CN102525446A (zh) * 2012-01-10 2012-07-04 镇江恒生涓恩医疗器械有限公司 一次性使用颅内压动态监测仪
CN107496013A (zh) * 2017-09-01 2017-12-22 南昌大学 一种颅内ommaya囊穿刺引流针
CN107550537A (zh) * 2017-10-18 2018-01-09 孙永全 一种适用于慢性硬膜下血肿的密闭引流装置及密闭引流管
US10413710B2 (en) 2014-01-16 2019-09-17 University Of Washington Pressure reference assemblies for body fluid drainage systems and associated methods

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050043670A1 (en) * 2003-08-22 2005-02-24 Codman & Shurtleff, Inc. Intra-ventricular pressure sensing catheter
US20050055009A1 (en) * 2003-09-05 2005-03-10 Codman & Shurtleff, Inc. Method and apparatus for managing normal pressure hydrocephalus
WO2006073670A1 (fr) * 2004-12-30 2006-07-13 Cytyc Corporation Procede d’utilisation de la pression pour determiner la position d’un catheter dans un canal mammaire
DE102007007969B4 (de) * 2007-02-17 2020-07-09 Drägerwerk AG & Co. KGaA Patientenverbindung für die maschinelle Beatmung eines Patienten

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4593703A (en) * 1976-06-21 1986-06-10 Cosman Eric R Telemetric differential pressure sensor with the improvement of a conductive shorted loop tuning element and a resonant circuit
US5117836A (en) * 1990-10-22 1992-06-02 Millar Instruments, Inc. Method for measuring intracranial fluid characteristics
EP0982048A1 (fr) * 1998-03-12 2000-03-01 Leonhardt, Steffen, Dr.-Ing. Implant de drainage à commande de fluide cephalo-rachidien

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19654990A1 (de) * 1996-09-09 1998-06-18 Steffen Dr Ing Leonhardt Implantat zur kontrollierten Ableitung von Gehirnflüssigkeit

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4593703A (en) * 1976-06-21 1986-06-10 Cosman Eric R Telemetric differential pressure sensor with the improvement of a conductive shorted loop tuning element and a resonant circuit
US5117836A (en) * 1990-10-22 1992-06-02 Millar Instruments, Inc. Method for measuring intracranial fluid characteristics
EP0982048A1 (fr) * 1998-03-12 2000-03-01 Leonhardt, Steffen, Dr.-Ing. Implant de drainage à commande de fluide cephalo-rachidien

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8784331B2 (en) 2005-02-28 2014-07-22 Likvor Ab Method and device for determining the hydrodynamics of the cerebrospinal fluid system
WO2006091164A1 (fr) * 2005-02-28 2006-08-31 Jan Malm Procede et dispositif permettant de determiner les proprietes hydrodynamiques du systeme contenant le liquide cephalorachidien
JP2008048210A (ja) * 2006-08-17 2008-02-28 Konica Minolta Business Technologies Inc 認証サーバ、画像形成装置、画像形成認証システム及びプログラム
JP4501912B2 (ja) * 2006-08-17 2010-07-14 コニカミノルタビジネステクノロジーズ株式会社 画像形成認証システム
US8109899B2 (en) 2009-07-06 2012-02-07 Likvor Ab Fully automated method of measuring and regulating cerebrospinal fluid parameters using disposable tube-set
WO2011116393A1 (fr) * 2010-03-19 2011-09-22 University Of Washington Systèmes de drainage pour l'évacuation des fluides corporels en excédent
US9662478B2 (en) 2010-03-19 2017-05-30 University Of Washington Body fluid drainage system
US10166375B2 (en) 2010-03-19 2019-01-01 University Of Washington Body fluid drainage system
US11247030B2 (en) 2010-03-19 2022-02-15 University Of Washington Body fluid drainage system
CN102525446A (zh) * 2012-01-10 2012-07-04 镇江恒生涓恩医疗器械有限公司 一次性使用颅内压动态监测仪
US10413710B2 (en) 2014-01-16 2019-09-17 University Of Washington Pressure reference assemblies for body fluid drainage systems and associated methods
CN107496013A (zh) * 2017-09-01 2017-12-22 南昌大学 一种颅内ommaya囊穿刺引流针
CN107550537A (zh) * 2017-10-18 2018-01-09 孙永全 一种适用于慢性硬膜下血肿的密闭引流装置及密闭引流管

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DE10033138A1 (de) 2002-01-31

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