WO2002003048A8 - Methylene blue diagnostic agent and diagnostic methods for detection of epithelial cancer - Google Patents

Methylene blue diagnostic agent and diagnostic methods for detection of epithelial cancer

Info

Publication number
WO2002003048A8
WO2002003048A8 PCT/US2000/018161 US0018161W WO0203048A8 WO 2002003048 A8 WO2002003048 A8 WO 2002003048A8 US 0018161 W US0018161 W US 0018161W WO 0203048 A8 WO0203048 A8 WO 0203048A8
Authority
WO
WIPO (PCT)
Prior art keywords
methylene blue
diagnostic
detection
epithelial cancer
methods
Prior art date
Application number
PCT/US2000/018161
Other languages
French (fr)
Other versions
WO2002003048A1 (en
Inventor
Douglas D Burkett
Original Assignee
Zila Inc
Douglas D Burkett
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002383194A priority Critical patent/CA2383194A1/en
Priority to IL14834200A priority patent/IL148342A0/en
Priority to MXPA02002183A priority patent/MXPA02002183A/en
Priority to BR0013635-2A priority patent/BR0013635A/en
Priority to AU35549/02A priority patent/AU781042B2/en
Priority to PCT/US2000/018161 priority patent/WO2002003048A1/en
Application filed by Zila Inc, Douglas D Burkett filed Critical Zila Inc
Priority to EP00948557A priority patent/EP1212600A4/en
Priority to CN00812317.9A priority patent/CN1372637A/en
Priority to JP2002508061A priority patent/JP2004502704A/en
Publication of WO2002003048A1 publication Critical patent/WO2002003048A1/en
Priority to NO20020959A priority patent/NO20020959L/en
Publication of WO2002003048A8 publication Critical patent/WO2002003048A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery

Abstract

Methylene blue dye compositions and methods for detecting and/or delineating cancerous and precancerous epithelial tissue are presented.
PCT/US2000/018161 2000-06-30 2000-06-30 Methylene blue diagnostic agent and diagnostic methods for detection of epithelial cancer WO2002003048A1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IL14834200A IL148342A0 (en) 2000-06-30 2000-06-30 Methylenen blue diagnostic agent and diagnostic methods for detection of epithelial cancer
MXPA02002183A MXPA02002183A (en) 2000-06-30 2000-06-30 Methylene blue diagnostic agent and diagnostic methods for detection of epithelial cancer.
BR0013635-2A BR0013635A (en) 2000-06-30 2000-06-30 Use of a dye composition for in vivo detection of lesions and pre-malignant epithelial carcinomas
AU35549/02A AU781042B2 (en) 2000-06-30 2000-06-30 Methylene blue diagnostic agent and diagnostic methods for detection of epithelial cancer
PCT/US2000/018161 WO2002003048A1 (en) 2000-06-30 2000-06-30 Methylene blue diagnostic agent and diagnostic methods for detection of epithelial cancer
CA002383194A CA2383194A1 (en) 2000-06-30 2000-06-30 Methylene blue diagnostic agent and diagnostic methods for detection of epithelial cancer
EP00948557A EP1212600A4 (en) 2000-06-30 2000-06-30 Methylene blue diagnostic agent and diagnostic methods for detection of epithelial cancer
CN00812317.9A CN1372637A (en) 2000-06-30 2000-06-30 Methylene blue diagnostic agent and diagnostic methods for detection of epithelita cancer
JP2002508061A JP2004502704A (en) 2000-06-30 2000-06-30 Methylene blue diagnostic agent and diagnostic method for detecting epithelial cancer
NO20020959A NO20020959L (en) 2000-06-30 2002-02-27 Methylene blue diagnostic agent and diagnostic methods for the detection of epithelial cancer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/018161 WO2002003048A1 (en) 2000-06-30 2000-06-30 Methylene blue diagnostic agent and diagnostic methods for detection of epithelial cancer

Publications (2)

Publication Number Publication Date
WO2002003048A1 WO2002003048A1 (en) 2002-01-10
WO2002003048A8 true WO2002003048A8 (en) 2002-07-25

Family

ID=21741552

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/018161 WO2002003048A1 (en) 2000-06-30 2000-06-30 Methylene blue diagnostic agent and diagnostic methods for detection of epithelial cancer

Country Status (9)

Country Link
EP (1) EP1212600A4 (en)
JP (1) JP2004502704A (en)
CN (1) CN1372637A (en)
AU (1) AU781042B2 (en)
CA (1) CA2383194A1 (en)
IL (1) IL148342A0 (en)
MX (1) MXPA02002183A (en)
NO (1) NO20020959L (en)
WO (1) WO2002003048A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2547556A1 (en) * 2003-11-28 2005-06-16 Photopharmica Limited Developments in biologically active methylene blue derivatives (2)
MX2007003777A (en) * 2004-09-30 2007-05-24 Zila Biotechnology Inc Light-directed method for detecting and aiding further evaluation of abnormal mucosal tissue.
CN101374912B (en) * 2006-01-18 2013-06-05 爱科来株式会社 Liquid reagent of color former and method of stabilizing the same
ITUD20080073A1 (en) * 2008-04-04 2009-10-05 Giuseppe Augusto Scigliano PHARMACEUTICAL COMPOSITION AND ITS DIAGNOSTIC AND THERAPEUTIC USE
CN103748396B (en) 2011-08-26 2016-03-09 沃特世科技公司 For pipeline being attached to the reusable accessory of port
CN105510321A (en) * 2011-12-29 2016-04-20 闫文广 Detection agent composition for epithelial tissue tumor cells and preparing method thereof
PT106082A (en) * 2012-01-04 2013-07-04 Fernando Jorge Neves Ferreira FIXING COMPOSITION FOR CYTOLOGY, CELL FITTING METHOD AND ITS APPLICATIONS
CN104483473B (en) * 2014-12-31 2016-03-02 广州市微米生物科技有限公司 For detection reagent and the preparation and determination methods method of epithelial neoplasms cell
WO2018126107A1 (en) * 2016-12-29 2018-07-05 Board Of Regents, The University Of Texas System Methylene blue solution for the treatment of oral lesions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321251A (en) * 1979-12-19 1982-03-23 The United States Of America As Represented By The Department Of Health And Human Services Detection of malignant lesions of the oral cavity utilizing toluidine blue rinse
US5485527A (en) * 1985-11-04 1996-01-16 Becton Dickinson And Company Apparatus and method for analyses of biological specimens
JPH028720A (en) * 1988-06-27 1990-01-12 Toagosei Chem Ind Co Ltd Temperature detection body
AU661727B2 (en) * 1991-10-31 1995-08-03 Zila Biotechnology, Inc. Biological stain composition, method of preparation and method of use for delineation of epitheleal cancer
US5301688A (en) * 1992-08-07 1994-04-12 Physion S.R.L. Method for localization and therapy of occult bladder cancer
DK0814847T3 (en) * 1996-01-16 2004-03-15 Zila Inc Methods and compositions for in vivo determination of oral cancers and precancerous conditions
US6376516B1 (en) * 1997-08-19 2002-04-23 Emory University Noscapine and noscapine derivatives, useful as anticancer agents

Also Published As

Publication number Publication date
WO2002003048A1 (en) 2002-01-10
EP1212600A1 (en) 2002-06-12
AU3554902A (en) 2002-04-22
NO20020959L (en) 2002-04-24
EP1212600A4 (en) 2007-10-10
AU781042B2 (en) 2005-05-05
IL148342A0 (en) 2002-09-12
CN1372637A (en) 2002-10-02
NO20020959D0 (en) 2002-02-27
MXPA02002183A (en) 2002-09-30
JP2004502704A (en) 2004-01-29
CA2383194A1 (en) 2002-01-10

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