WO2002002585A3 - Low fluorescence nylon/glass composites for microdiagnostics - Google Patents

Low fluorescence nylon/glass composites for microdiagnostics Download PDF

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Publication number
WO2002002585A3
WO2002002585A3 PCT/US2001/021262 US0121262W WO0202585A3 WO 2002002585 A3 WO2002002585 A3 WO 2002002585A3 US 0121262 W US0121262 W US 0121262W WO 0202585 A3 WO0202585 A3 WO 0202585A3
Authority
WO
WIPO (PCT)
Prior art keywords
luminescent
substrate
cell
microdiagnostics
useful
Prior art date
Application number
PCT/US2001/021262
Other languages
French (fr)
Other versions
WO2002002585A2 (en
Inventor
Rita Andreoli
Murtaza Amin
Mark Myering
Richard Chesterton
Eugene Ostreicher
Original Assignee
Cuno Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cuno Inc filed Critical Cuno Inc
Priority to BR0106969-1A priority Critical patent/BR0106969A/en
Priority to EP01950882A priority patent/EP1297340A2/en
Priority to AU71835/01A priority patent/AU780441B2/en
Priority to JP2002507837A priority patent/JP2004502928A/en
Publication of WO2002002585A2 publication Critical patent/WO2002002585A2/en
Publication of WO2002002585A3 publication Critical patent/WO2002002585A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00576—Chemical means fluorophore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00644—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being present in discrete locations, e.g. gel pads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00657—One-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B01J2219/00662—Two-dimensional arrays within two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Abstract

An improved combination non-luminescent microporous membrane and solid support for use in micro-analytical diagnostic applications is disclosed. Specifically, a multi-cell non-luminescent substrate having a porous membrane formed by a phase inversion process effectively attached by covalent bonding through a surface treatment to a substrate that prepares the substrate to sufficiently, covalently bond to the non-luminescent microporous membrane formed by a phase inversion process such that the combination produced thereby is useful in microarray applications and wherein the porous non-luminescent nylon multi-cell substrate is covalently bonded to a solid base member, such as, for example, a glass or Mylar microscope slide, such that the combination produced thereby is useful in microarray aplications. Apparatus and methods for fabricating the non-luminescent multi-cell substrate are also disclosed.
PCT/US2001/021262 2000-07-05 2001-07-05 Low fluorescence nylon/glass composites for microdiagnostics WO2002002585A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
BR0106969-1A BR0106969A (en) 2000-07-05 2001-07-05 Method of manufacturing a multicellular substrate and multicellular substrate
EP01950882A EP1297340A2 (en) 2000-07-05 2001-07-05 Low fluorescence nylon/glass composites for microdagnostics
AU71835/01A AU780441B2 (en) 2000-07-05 2001-07-05 Improved low fluorescence nylon/glass composites for micro-analytical diagnostic applications
JP2002507837A JP2004502928A (en) 2000-07-05 2001-07-05 Improved low fluorescence nylon / glass composite for microanalysis identification applications

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US21622900P 2000-07-05 2000-07-05
US60/216,229 2000-07-05
US21639000P 2000-07-06 2000-07-06
US60/216,390 2000-07-06
US22414100P 2000-08-10 2000-08-10
US60/224,141 2000-08-10

Publications (2)

Publication Number Publication Date
WO2002002585A2 WO2002002585A2 (en) 2002-01-10
WO2002002585A3 true WO2002002585A3 (en) 2002-10-03

Family

ID=27396248

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/021262 WO2002002585A2 (en) 2000-07-05 2001-07-05 Low fluorescence nylon/glass composites for microdiagnostics

Country Status (6)

Country Link
US (2) US6734012B2 (en)
EP (1) EP1297340A2 (en)
JP (1) JP2004502928A (en)
AU (1) AU780441B2 (en)
BR (1) BR0106969A (en)
WO (1) WO2002002585A2 (en)

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US20030219816A1 (en) * 2001-07-02 2003-11-27 Keith Solomon Composite microarray slides
US6890483B2 (en) * 2000-07-05 2005-05-10 Cuno Incorporated Non-luminescent substrate
US20050164188A1 (en) * 2002-01-24 2005-07-28 Jeffrey Kane Analysis device
EP1520037A4 (en) * 2002-02-27 2006-06-07 Miragene Inc Improved substrate chemistry for protein immobilization on a rigid support
US7597936B2 (en) * 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
AU2003293015A1 (en) * 2002-11-26 2004-06-18 University Of Utah Research Foundation Microporous materials, methods, and articles for localizing and quantifying analytes
US20050218067A1 (en) * 2003-04-10 2005-10-06 Cuno Incorporated Ablated predetermined surface geometric shaped boundary formed on porous material mounted on a substrate and methods of making same
US20050064431A1 (en) * 2003-09-09 2005-03-24 Eastman Kodak Company Biological microarray comprising polymer particles and method of use
TWI246593B (en) * 2003-11-12 2006-01-01 Ind Tech Res Inst Method and substrate for biochips by using single-step manufacturing process
US20060088857A1 (en) * 2003-12-01 2006-04-27 Said Attiya Method for isolation of independent, parallel chemical micro-reactions using a porous filter
US20070056898A1 (en) * 2004-05-13 2007-03-15 Keith Wesner Ablated predetermined surface geometric shaped boundary formed on porous material mounted on a substrate and methods of making same
FR2860802B1 (en) * 2004-07-28 2008-02-22 Bertin Technologies Sa METHOD FOR ENABLING CHIMILUMINESCENCE READING OF A CHIP
US20060108287A1 (en) * 2004-09-21 2006-05-25 Arnold Todd E Discrete zoned microporous nylon coated glass platform for use in microwell plates and methods of making and using same
EP1841757B1 (en) * 2005-01-07 2010-06-30 Pfizer Products Incorporated Heteroaromatic quinoline compounds and their use as pde10 inhibitors
US20070023354A1 (en) * 2005-07-26 2007-02-01 Cuno Incorporated Methods and systems for dispersing ultrafine non-polar particles into a polymer/solvent/non-solvent solution and products formed thereby
CN101017174A (en) * 2005-10-04 2007-08-15 米利波尔公司 Protein microarray slide
US7923054B2 (en) 2006-04-19 2011-04-12 Gore Enterprise Holdings, Inc. Functional porous substrates for attaching biomolecules
US7501250B2 (en) * 2006-09-26 2009-03-10 Chung-Cheng Chang Blotting method for rapidly analyzing nucleic acid
DE102010001322A1 (en) * 2010-01-28 2011-08-18 Siemens Aktiengesellschaft, 80333 Arrangement and method for filtration of a liquid and use in microscopy
GB201002824D0 (en) 2010-02-19 2010-04-07 Temasek Polytechnic A method of preparing a substrate for immobilization of functional substances thereon and the substrate obtained therefrom
CN103189131A (en) * 2010-08-06 2013-07-03 台达电子工业股份有限公司 Process for manufacturing porous material
CN111603948B (en) * 2020-05-21 2023-06-30 杭州科百特科技有限公司 Nylon membrane and preparation method and application thereof
CN113244794B (en) * 2021-05-11 2022-04-19 燕山大学 Preparation method of nanofiltration membrane for intercepting nitrate and resource utilization of concentrated solution

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US5420047A (en) * 1992-11-13 1995-05-30 Bayer Aktiengesellschaft Method for carrying out immunodiagnostic tests

Also Published As

Publication number Publication date
EP1297340A2 (en) 2003-04-02
BR0106969A (en) 2004-07-13
WO2002002585A2 (en) 2002-01-10
US20020119559A1 (en) 2002-08-29
AU780441B2 (en) 2005-03-24
AU7183501A (en) 2002-01-14
JP2004502928A (en) 2004-01-29
US6734012B2 (en) 2004-05-11
US20040157320A1 (en) 2004-08-12

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