New! View global litigation for patent families

WO2002000281A2 - Medicament inhaler - Google Patents

Medicament inhaler

Info

Publication number
WO2002000281A2
WO2002000281A2 PCT/US2001/020098 US0120098W WO2002000281A2 WO 2002000281 A2 WO2002000281 A2 WO 2002000281A2 US 0120098 W US0120098 W US 0120098W WO 2002000281 A2 WO2002000281 A2 WO 2002000281A2
Authority
WO
Grant status
Application
Patent type
Prior art keywords
inhaler
cup
port
medicament
yoke
Prior art date
Application number
PCT/US2001/020098
Other languages
French (fr)
Other versions
WO2002000281A3 (en )
Inventor
Lawrence Keane
David O'leary
Original Assignee
Ivax Corporation
Norton Healthcare Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0001Details of inhalators; Constructional features thereof
    • A61M15/0005Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A61M15/0006Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means
    • A61M15/0008Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means rotating by airflow
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • A61M15/0068Indicating or counting the number of dispensed doses or of remaining doses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • A61M15/0068Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007Mechanical counters
    • A61M15/0071Mechanical counters having a display or indicator
    • A61M15/0078Mechanical counters having a display or indicator on a strip
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0086Inhalation chambers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0091Inhalators mechanically breath-triggered
    • A61M15/0093Inhalators mechanically breath-triggered without arming or cocking, e.g. acting directly on the delivery valve
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0091Inhalators mechanically breath-triggered
    • A61M15/0096Hindering inhalation before activation of the dispenser
    • GPHYSICS
    • G06COMPUTING; CALCULATING; COUNTING
    • G06MCOUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00Design features of general application
    • G06M1/04Design features of general application for driving the stage of lowest order
    • GPHYSICS
    • G06COMPUTING; CALCULATING; COUNTING
    • G06MCOUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00Design features of general application
    • G06M1/22Design features of general application for visual indication of the result of count on counting mechanisms, e.g. by window with magnifying lens
    • G06M1/24Drums; Dials; Pointers
    • G06M1/246Bands; Sheets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0091Inhalators mechanically breath-triggered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00Characteristics of a physical parameter; associated device therefor
    • A61M2206/10Flow characteristics
    • A61M2206/16Rotating swirling helical flow, e.g. by tangential inflows

Abstract

A new and improved inhaler includes an accurate and consistent mechanical dose metering system that dispenses dry powdered medicament in discrete amounts or doses for patient inhalation, a pressure relief system that manages pressure within a medicament reservoir of the inhaler to ensure consistently dispensed doses, and a dose counting system indicating the number of doses remaining in the inhaler.

Description

MEDICAMENT INHALER

Cross-Reference to Related Applications

The present application claims priority to co-pending provisional U.S. patent application serial no. 60/213,668, filed June 23, 2000 (entitled "Breath-Actuated Dry Powder Inlialer"), and co-pending provisional U.S. patent application serial no. 60/213,382, filed June 23, 2000 (entitled "De-Agglomerator for Breath- Actuated Dry Powder Inlialer"). Each of these co-pending applications is assigned to the assignee of the present disclosure and incorporated herein by reference.

Field of the Disclosure

The present disclosure relates to an apparatus and method for administering medicament for inhalation by a patient and, more particularly, to a dry powdered medicament inhaler.

Background of the Disclosure

Metered dose medicament inhalers are well known for dispensing medicament to the lungs of a patient, for treating asthma for example. Existing types of medicament dispensing inhalers include pressurized propellant inhalers, aqueous solution inhalers, and dry-powdered inhalers.

U.S. Patent No. 5,503,144 to Bacon, for example, shows a dry powdered inhaler.

The inhaler includes a reservoir for containing a dry powdered medicament, a metering chamber for removal of the powdered medicament from the reservoir in discrete amounts, and an air inlet for entraining the removed powdered medicament through a mouthpiece upon patient inhalation.

Another example is U.S. Patent No. 5,971,951 to Ruskewicz, which shows an inhaler including a motor driven cam mechanism for extruding aqueous medicament through a porous membrane to form a medicament aerosol for inhalation by a patient. The inhaler also includes sensors, circuitry and a microprocessor that determines the rate of patient inhalation and operates the extrusion mechanism only upon adequate inhalation levels.

A pressurized propellant, or "aerosol" inhaler is shown in U.S. Patent No. 5,447,150 to Bacon, which also discloses a simple, mechanical actuation assembly for ensuring that medicament is dispensed from the inhaler only upon adequate inhalation by a patient. The actuation assembly works by applying a pre-load to a valve of the aerosol container sufficient to cause a dose release, but prevents the release by applying a pneumatic resisting force. The dose of medicament is then released upon a patient inhalation strong enough to move a door within the assembly, which in turn releases the pneumatic resisting force.

What is still desired, however, is a new and improved inhaler for administering medicament for patient inhalation. Preferably, the new and improved inhaler can be used with dry powdered medicament. In addition, the new and improved inhaler will preferably include mechanical assemblies for metering doses of medicament, managing medicament reservoir pressure, and counting the number of doses remaining in the inhaler.

Summary of the Disclosure

The present disclosure, therefore, provides a new and improved medicament inhaler having a unique dose metering system. The inlialer includes a mouthpiece for patient inhalation, a delivery passageway for directing an inhalation induced air flow through the mouthpiece, a channel extending from the delivery passageway, and a reservoir for containing medicament, with the reservoir having a dispenser port connected to the channel. In a preferred form, the dose metering system includes a cup received in the channel, which is movable between the dispenser port and the delivery passageway, a cup spring biasing the cup towards one of the dispenser port and the passageway, and a yoke movable between at least two positions. The yoke includes a ratchet engaging the cup and preventing movement of the cup when the yoke is in one of the positions, and allowing movement of the cup when the yoke is in another of the positions. The present disclosure also provides a medicament inhaler having a unique reservoir pressure system. The inhaler includes a sealed reservoir having a dispenser port, and a channel communicating with the dispenser port, and a cup assembly movably received in the channel. In a preferred form, the pressure system includes a pressure relief port in the channel, and a conduit providing fluid communication between an interior of the sealed reservoir and the pressure relief port of the channel. The cup assembly includes a recess adapted to receive medicament when aligned with the dispenser port, a first sealing surface adapted to seal the dispenser port when the recess is unaligned with the dispenser port, and a second sealing surface adapted to seal the pressure relief port when the recess is aligned with the dispenser port and unseal the pressure relief port when the recess is unaligned with the dispenser port.

The present disclosure additionally provides a medicament inhaler having a unique dose counter. The inhaler includes a mouthpiece for patient inhalation, a dose metering system including a pawl movable along a predetermined path during the metering of a dose of medicament to the mouthpiece by the dose metering system, and a dose counter. In a preferred form, the dose counter includes a bobbin, a rotatable spool, and a rolled ribbon received on the bobbin, rotatable about an axis of the bobbin. The ribbon has indicia thereon successively extending between a first end of the ribbon secured to the spool and a second end of the ribbon positioned on the bobbin. The dose counter also includes teeth extending radially outwardly from the spool into the predetermined path of the pawl so that the spool is rotated by the pawl and the ribbon advanced onto the spool during the metering of a dose to the mouthpiece.

Thus, the present disclosure provides a new and improved inhaler including a simple, accurate and consistent mechanical dose metering system that dispenses dry powdered medicament in discrete amounts or doses for patient inhalation, a reservoir pressure system that ensures consistently dispensed doses, and a dose counter indicating the number of doses remaining in the inhaler. Further features and advantages of the presently disclosed inhaler will become more readily apparent to those having ordinary skill in the art to which the present disclosure relates from the drawings and the detailed description.

Brief Description of the Drawings

So that those having ordinary skill in the art will more readily understand how to construct a dry powdered medicament inhaler in accordance with the present disclosure, a preferred embodiment is described below with reference to the drawing figures wherein:

FIG. 1 is a first side isometric view of a dry powdered medicament inhaler according to the present disclosure;

FIG. 2 is an exploded, second side isometric view of the inhaler of FIG. 1;

FIG. 3 is a second side isometric view of a main assembly of the inhaler of FIG. 1;

FIG. 4 is a second side isometric view of the main assembly of the inhaler of FIG. 1, shown with a yoke removed;

FIG. 5 is an exploded first side isometric view of the main assembly of the inhaler of FIG. 1;

FIG. 6 is an exploded enlarged isometric view of a medicament cup of the inhaler of FIG. 1;

FIG. 7 is an exploded first side isometric view of a hopper and a de-agglomerator of the inhaler of FIG. 1;

FIG. 8 is an exploded second side isometric view of the hopper and a swirl chamber roof of the de-agglomerator of the inhaler of FIG. 1;

FIG. 9 is an exploded first side isometric view of a case, cams and a mouthpiece cover of the inhaler of FIG. 1; FIG. 10 is an enlarged side isometric view of one of the cams of the inhaler of FIG. l;

FIG. 11 is a second side isometric view of the yoke of the inhaler of FIG. 1 ;

FIG. 12 is a first side isometric view of the yoke of the inhaler of FIG. 1, showing a ratchet and a push bar of the yoke;

FIG. 13 is a schematic illustration of lateral movement of a boss of the medicament cup in response to longitudinal movement of the ratchet and the push bar of the yoke of the inhaler of FIG. 1;

FIG. 14 is an enlarged isometric view of a dose counter of the inhaler of FIG. 1;

FIG. 15 is an exploded enlarged isometric view of the dose counter of the inhaler of FIG. l; and

FIG. 16 is an enlarged isometric view, partially in section, of a portion of the inlialer of FIG. 1 illustrating medicament inhalation through the inhaler.

Like reference characters designate identical or corresponding components and units throughout the several views.

Detailed Description of the Preferred Embodiments

Referring to FIGS. 1 through 16, the present disclosure provides a new and improved inhaler 10 for dispensing a dry-powdered medicament in metered doses for patient inhalation. The inhaler 10 of the present disclosure provides many beneficial features including but not limited to a dose metering system that dispenses dry powdered medicament in discrete amounts or doses for patient inhalation, a medicament reservoir pressure system for managing pressure within the reservoir, and a dose counting system indicating the number of doses remaining in the inhaler 10.

The inhaler 10 generally includes a housing 18, and an assembly 12 received in the housing (see FIG. 2). The housing 18 includes a case 20 having an open end 22 and a mouthpiece 24 for patient inhalation, a cap 26 secured to and closing the open end 22 of the case 20, and a cover 28 pivotally mounted to the case 20 for covering the mouthpiece 24 (see FIGS. 1, 2 and 9). The housing 18 is preferably manufactured from a plastic such as polypropylene, acetal or moulded polystyrene, but may be manufactured from metal or another suitable material.

The internal assembly 12 includes a reservoir 14 for containing dry powered medicament in bulk form, a de-agglomerator 32 that breaks down the medicament between a delivery passageway 34 and the mouthpiece 24, and a spacer 38 connecting the reservoir to the de-agglomerator.

Reservoir

The reservoir 14 is generally made up of a collapsible bellows 40 and a hopper 42 having an dispenser port 44 (see FIGS. 2-5 and 7-8) for dispensing medicament upon the bellows 40 being at least partially collapsed to reduce the internal volume of the reservoir. The hopper 42 is for holding the dry powder medicament in bulk form and has an open end 46 closed by the flexible accordion-like bellows 40 in a substantially air-tight manner. An air filter 48 covers the open end 46 of the hopper 42 and prevents dry powder medicament from leaking from the hopper 42 (see FIG. 7).

Spacer

A base 50 of the hopper 42 is secured to a spacer 38, which is in turn secured to the de-agglomerator 32 (see FIGS. 3-5 and 7-8). The hopper 42, the spacer 38, and the de- agglomerator 32 are preferably manufactured from a plastic such as polypropylene, acetal or moulded polystyrene, but may be manufactured from metal or another suitable material. The hopper 42, the spacer 38 and the de-agglomerator 32 are connected in a manner that provides an air tight seal between the parts. For this purpose heat or cold sealing, laser welding or ultrasonic welding could be used, for example.

The spacer 38 and the hopper 42 together define the medicament delivery passageway 34, which preferably includes a venturi 36 (see FIG. 16) for creating an entraining air flow. The spacer 38 defines a slide channel 52 communicating with the dispenser port 44 of the hopper 42, and a chimney 54 providing fluid communication between the medicament delivery passageway 34 and a supply port 56 of the de- agglomerator 32 (see FIGS. 7 and 8). The slide channel 52 extends generally normal with respect to the axis "A" of the inhaler 10.

De-Agglomerator

As its name implies, the de-agglomerator 32 breaks down agglomerates of dry powder medicament before the dry powder leaves the inhaler 10 through the mouthpiece 24. The de-agglomerator includes a swirl chamber 58 extending from the supply port 56 to an outlet port 60 connected to the mouthpiece 24 (see FIG. 16). The de-agglomerator 32 also includes two diametrically opposed inlet ports 62 that extend substantially tangential to the circular cross-section of the swirl chamber. Radial vanes 64 are positioned at the top of the swirl chamber and are sized such that at least a portion of breath-actuated air streams entering through the diametrically opposed inlet ports 62 collide with the vanes.

The inhaler 10 preferably includes a de-agglomerator of the type disclosed in co- pending provisional U.S. patent application serial no. 60/213,382, filed June 23, 2000 (entitled "De-Agglomerator for Breath- Actuated Dry Powder Inhaler 10"), which has been incorporated herein by reference. It should be understood that although the inhaler 10 of the present disclosure is shown with a particular de-agglomerator 32, the inlialer 10 is not limited to use with the de-agglomerator shown and can be used with other types of de- agglomerators or a simple swirl chamber.

Dose Metering System

The dose metering system includes a first yoke 66 and a second yoke 68 mounted on the internal assembly 12 within the housing 18, and movable in a linear direction parallel with an axis "A" of the inhaler 10 (see FIG. 2). An actuation spring 69 is positioned between the cap 26 of the housing 18 and the first yoke 66 for biasing the yokes in a first direction towards the mouthpiece 24. In particular, the actuation spring 69 biases the first yoke 66 against the bellows 40 and the second yoke 68 against cams 70 mounted on the mouthpiece cover 28 (see FIG. 9).

The first yoke 66 includes an opening 72 that receives and retains a crown 74 of the bellows 40 such that the first yoke 66 pulls and expands the bellows 40 when moved towards the cap 26, i.e., against the actuation spring 69 (see FIG. 2). The second yoke 68 includes a belt 76, which receives the first yoke 66, and two cam followers 78 extending from the belt in a direction opposite the first yoke 66 (see FIGS. 3, 11 and 12), towards the cams 70 of the mouthpiece cover 28.

The dose metering system also includes the two cams 70 mounted on the mouthpiece cover 28 (see FIGS. 9 and 10), and movable with the cover 28 between open and closed positions. The cams 70 each include an opening 80 for allowing outwardly extending hinges 82 of the case 20 to pass therethrough and be received in first recesses 84 of the cover 28. The cams 70 also include bosses 86 extending outwardly and received in second recesses 88 of the cover 28, such that the cover 28 pivots about the hinges 82 and the cams 70 move with the cover 28 about the hinges.

Each cam 70 also includes first, second and third cam surfaces 90, 92, 94, and the cam followers 78 of the second yoke 68 are biased against the cam surfaces by the actuation spring 69. The cam surfaces 90, 92, 94 are arranged such the cam followers 78 successively engage the first cam surfaces 90 when the cover 28 is closed, the second cam surfaces 92 when the cover 28 is partially opened, and the third cam surfaces 94 when the cover 28 is fully opened. The first cam surfaces 90 are spaced further from the hinges 82 than the second and the third cam surfaces, while the second cam surfaces 92 are spaced further from the hinges 82 than the third cam surfaces 94. The cams 70, therefore, allow the yokes 66, 68 to be moved by the actuation spring 69 parallel with the axis "A" of the inhaler 10 in the first direction (towards the mouthpiece 24) tlirough first, second and third positions as the cover 28 is opened. The cams 70 also push the yokes 66, 68 in a second direction parallel with the axis "A" (against the actuation spring 69 and towards the cap 26 of the housing 18) through the third, the second and the first positions as the cover 28 is closed. The dose metering system further includes a cup assembly 96 movable between the dispenser port 44 of the reservoir 14 and the delivery passageway 34. The cup assembly 96 includes a medicament cup 98 mounted in a sled 100 slidably received in the slide channel 52 of the spacer 38 below the hopper 42 (see FIGS. 5 and 6). The medicament cup 98 includes a recess 102 adapted to receive medicament from the dispenser port 44 of the reservoir 14 and sized to hold a predetermined dose of dry powdered medicament when filled. The cup sled 100 is biased along the slide channel 52 from the dispenser port 44 of the hopper 42 towards the delivery passageway 34 by a cup spring 104, which is secured on the hopper 42 (see FIGS. 4 and 5).

The dose metering system also includes a ratchet 106 and a push bar 108 on one of the cam followers 78 of the second yoke 68 that engage a boss 110 of the cup sled 100 (see FIGS. 5, 11 and 12). The ratchet 106 is mounted on a flexible flap 112 and is shaped to allow the boss 110 of the sled 100 to depress and pass over the ratchet 106, when the boss 110 is engaged by the push bar 108. Operation of the dose metering system is discussed below.

Reservoir Pressure System

The reservoir pressure system includes a pressure relief conduit 114 in fluid communication with the interior of the reservoir 14 (see FIGS. 7 and 8), and a pressure relief port 116 in a wall of the slide channel 52 (see FIGS. 5 and 8) providing fluid communication with the pressure relief conduit 114 of the hopper 42.

The medicament cup assembly 96 includes a first sealing surface 118 adapted to seal the dispenser port 44 upon the cup assembly being moved to the delivery passageway 34 (see FIGS. 5 and 6). A sealing spring 120 is provided between the sled 100 and the cup 98 for biasing the medicament cup 98 against a bottom surface of the hopper 42 to seal the dispenser port 44 of the reservoir 14. The cup 98 includes clips 122 that allow the cup to be biased against the reservoir, yet retain the cup in the sled 100.

The sled 100 includes a second sealing surface 124 adapted to seal the pressure relief port 116 when the recess 102 of the cup 98 is aligned with the dispenser port 44, and an indentation 126 (see FIG. 6) adapted to unseal the pressure relief port 116 when the first sealing surface 118 is aligned with the dispenser port 44. Operation of the pressure system is discussed below.

Dose Counting System

The dose counting system 16 is mounted to the hopper 42 and includes a ribbon

128, having successive numbers or other suitable indicia printed thereon, in alignment with a transparent window 130 provided in the housing 18 (see FIG. 2). The dose counting system 16 includes a rotatable bobbin 132, an indexing spool 134 rotatable in a single direction, and the ribbon 128 rolled and received on the bobbin 132 and having a first end 127 secured to the spool 134, wherein the ribbon 128 unrolls from the bobbin 132 so that the indicia is successively displayed as the spool 134 is rotated or advanced.

The spool 134 is arranged to rotate upon movement of the yokes 66, 68 to effect delivery of a dose of medicament from the reservoir 14 into the delivery passageway 34, such that the number on the ribbon 128 is advanced to indicate that another dose has been dispensed by the inhaler 10. The ribbon 128 can be arranged such that the numbers, or other suitable indicia, increase or decrease upon rotation of the spool 134. For example, the ribbon 128 can be arranged such that the numbers, or other suitable indicia, decrease upon rotation of the spool 134 to indicate the number of doses remaining in the inhaler 10. Alternatively, the ribbon 128 can be arranged such that the numbers, or other suitable indicia, increase upon rotation of the spool 134 to indicate the number of doses dispensed by the inhaler 10.

The indexing spool 134 preferably includes radially extending teeth 136, which are engaged by a pawl 138 extending from one of the cam followers 78 (see FIGS. 3 and 11) of the second yoke 68 upon movement of the yoke to rotate, or advance, the indexing spool 134. More particularly, the pawl 138 is shaped and arranged such that it engages the teeth 136 and advances the indexing spool 134 only upon the mouthpiece 24 cover 28 being closed and the yokes 66, 68 moved back towards the cap 26 of the housing 18. The dose counting system 16 also includes a chassis 140 that secures the dose counting system to the hopper 42 and includes shafts 142, 144 for receiving the bobbin 132 and the indexing spool 134. The bobbin shaft 142 is preferably forked and includes radially nubs 146 for creating a resilient resistance to rotation of the bobbin 132 on the shaft 142. A clutch spring 148 is received on the end of the indexing spool 134 and locked to the chassis 140 to allow rotation of the spool 134 in only a single direction (counterclockwise as shown in FIG. 14). Operation of the dose counting system 16 is discussed below.

Operation

FIG. 13 illustrates the relative movements of the boss 110 of the cup sled 100, and the ratchet 106 and the push bar 108 of the second yoke 68 as the mouthpiece cover 28 is opened and closed. In the first position of the yokes 66, 68 (wherein the cover 28 is closed and the cam followers 78 are in contact with the first cam surfaces 90 of the cams 70), the ratchet 106 prevents the cup spring 104 from moving the cup sled 100 to the delivery passageway 34. The dose metering system is arranged such that when the yokes are in the first position, the recess 102 of the medicament cup 98 is directly aligned with the dispenser port 44 of the reservoir 14 and the pressure relief port 116 of the spacer 38 is sealed by the second sealing surface 124 of the cup sled 100.

Upon the cover 28 being partially opened such that the second cam surfaces 92 of the cams 70 engage the cam followers 78, the actuator spring 69 is allowed to move the yokes 66, 68 linearly towards the mouthpiece 24 to the second position and partially collapse the bellows 40 of the medicament reservoir 14. The partially collapsed bellows 40 pressurizes the interior of the reservoir 14 and ensures medicament dispensed from the dispenser port 44 of the reservoir fills the recess 102 of the medicament cup 98 such that a predetermined dose is provided. In the second position, however, the ratchet 106 prevents the cup sled 100 from being moved to the delivery passageway 34, such that the recess 102 of the medicament cup 98 remains aligned with the dispenser port 44 of the reservoir 14 and the pressure relief port 116 of the spacer 38 remains sealed by the second sealing surface 124 of the cup assembly 96. Upon the cover 28 being fully opened such that the third cam surfaces 94 engage the cam followers 78, the actuator spring 69 is allowed to move the yokes 66, 68 further towards the mouthpiece 24 to the third position. When moved to the third position, the ratchet 106 disengages, or falls below the boss 110 of the cup sled 100 and allows the cup sled 100 to be moved by the cup spring 104, such that the filled recess 102 of the cup 98 is position in the venturi 36 of the delivery passageway 34 and the dispenser port 44 of the reservoir 14 is sealed by the first sealing surface 118 of the cup assembly 96. In addition, the pressure relief port 116 is uncovered by the indentation 126 in the side surface of the sled 100 to release pressure from the reservoir 14 and allow the bellows 40 to further collapse and accommodate the movement of the yokes 66, 68 to the third position. The inhaler 10 is then ready for inhalation by a patient of the dose of medicament placed in the delivery passageway 34.

As shown in FIG. 16, a breath-induced air stream 150 diverted through the delivery passageway 34 passes through the venturi 36, entrains the medicament and carries the medicament into the de-agglomerator 32 of the inhaler 10. Two other breath-induced air streams 152 (only one shown) enter the de-agglomerator 32 through the diametrically opposed inlet ports 62 and combine with the medicament entrained air stream 150 from the delivery passageway 34. The combined flows 154 and entrained dry powder medicament then travel to the outlet port 60 of the de-agglomerator and pass through the mouthpiece 24 for patient inhalation.

Once inhalation is completed, the mouthpiece cover 28 can be closed. When the cover 28 is closed, the trigger cams 70 force the yokes 66, 68 upwardly such that the first yoke 66 expands the bellows 40, and the pawl 138 of the second yoke 68 advances the indexing spool 134 of the dose counting system 16 to provide a visual indication of a dose having been dispensed. In addition, the cup assembly 96 is forced back to the first position by the pusher bar 108 of the upwardly moving second yoke 68 (see FIG. 13) such that the boss 110 of the cup sled 100 is engaged and retained by the ratchet 106 of the second yoke 68. It should be understood that the foregoing detailed description and preferred embodiment are only illustrative of inhalers constructed in accordance with the present disclosure. Various alternatives and modifications to the presently disclosed inhalers can be devised by those skilled in the art without departing from the spirit and scope of the present disclosure. For example, the medicament cup could be provided on a rotary sled, advanced by movement of the yokes. In addition, the outlet port of the pressure relief could be provided in other locations than the side wall of the slide channel. Furthermore, the dose counting system could be adapted to provide an audible indications in addition to a visual indication of a dispensed dose. Accordingly, the present disclosure is intended to embrace all such alternatives and modifications that fall within the spirit and scope of an inlialer as recited in the appended claims.

Claims

What is claimed is:
1. An inhaler comprising: a sealed reservoir including a dispensing port; a channel communicating with the dispensing port and including a pressure relief port; a conduit providing fluid communication between an interior of the sealed reservoir and the pressure relief port of the channel; a cup assembly movably received in the channel and including, a recess adapted to receive medicament when aligned with the dispensing port, a first sealing surface adapted to seal the dispensing port when the recess is unaligned with the dispensing port, and a second sealing surface adapted to sealing the pressure relief port when the recess is aligned with the dispensing port and unseal the pressure relief port when the recess is unaligned with the dispensing port.
2. An inhaler according to claim 1, wherein the cup assembly includes a sealing spring biasing the first sealing surface against the reservoir.
3. An inhaler according to claim 1, wherein the reservoir includes a collapsible bellows adapted to increase pressure within the interior of the reservoir upon being collapsed, when the pressure relief port is sealed.
4. An inhaler according to claim 1, wherein the cup assembly includes a cup received in a cup sled movable within the channel, the cup defining the recess and the first sealing surface, and the sled defining the second sealing surface.
5. An inhaler according to claim 4, wherein the sled defines an indentation adapted to align with and unseal the pressure relief port when the first sealing surface is aligned with the dispenser port.
6. An inhaler according to claim 4, wherein the cup assembly includes a sealing spring between the cup and the cup sled, biasing the first sealing surface of the cup against the reservoir.
7. An inhaler according to claim 1, wherein the channel extends linearly and the cup assembly is movable in opposing directions within the channel.
8. An inhaler according to claim 1, further comprising: a cup spring biasing the cup assembly along the channel; and a yoke movable between at least two positions and including a ratchet engaging the cup assembly and preventing movement of the cup assembly when the yoke is in one of the positions and allowing movement of the cup when the yoke is in another of the positions.
9. An inlialer according to claim 8, wherein the cup spring biases the cup assembly to a position wherein the recess is unaligned with the dispensing port of the reservoir.
10. An inhaler according to claim 9, wherein the yoke further includes a push bar adapted to align the recess of the cup assembly with the dispensing port upon movement of the yoke to one of the positions.
11. An inhaler according to claim 9, further comprising: at least one movable cam including at least two successive cam surfaces; and a spring biasing the yoke against the cam such that movement of the cam causes the yoke to successively engage the cam surfaces and move the yoke between the at least two positions of the yoke.
12. An inhaler according to claim 11, wherein the cam includes three successive cam surfaces for moving the yoke between three positions, wherein the ratchet is adapted to hold the recess unaligned with the dispensing port when the yoke is in a first and a second of the three positions, and allow movement of the cup assembly when the yoke is in a third of the three positions.
13. An inhaler according to claim 12, further comprising a collapsible bellows adapted to increase pressure within the interior of the reservoir upon being collapsed, and wherein the yoke is arranged to collapse the bellows when the yoke is in the first and the second positions.
14. An inhaler according to claim 11, further comprising: a mouthpiece for patient inhalation; and a cover movable to open and close the mouthpiece, wherein the at least one cam is secured to the cover for movement therewith, whereby opening and closing the mouthpiece causes the yoke to move between the three positions of the yoke.
15. An inhaler according to claim 14, wherein the cam is movable by rotation.
16. An inlialer according to claim 1, wherein the reservoir includes a volume of dry powdered medicament.
17. An inhaler according to claim 1, further comprising: a pawl movable along a predetermined path upon movement of the recess of the cup assembly from the dispensing port; and a dose counter including, a bobbin, a rotatable spool, a rolled ribbon received on the bobbin and rotatable about an axis of the bobbin, the ribbon having indicia thereon successively extending between a first end of the ribbon secured to the spool and a second end of the ribbon positioned on the bobbin, and teeth extending radially outwardly from the spool into the predetermined path of the pawl so that the spool is rotated by the pawl and the ribbon is advanced onto the spool during the metering of a dose.
18. A medicament inlialer comprising :
a mouthpiece for patient inhalation; a dose meter including a pawl movable along a predetermined path during 85 the metering of a dose of medicament to the mouthpiece; a dose counter including, a bobbin, a rotatable spool, a rolled ribbon received on the bobbin and rotatable about an axis of 90 the bobbin, the ribbon having indicia thereon successively extending between a first end of the ribbon secured to the spool and a second end of the ribbon positioned on the bobbin, and teeth extending radially outwardly from the spool into the predetermined path of the pawl so that the spool is rotated by the pawl and the ribbon is 95 advanced onto the spool during the metering of a dose.
19. An inhaler according to claim 18, wherein the spool rotates in a single direction.
20. An inhaler according to claim 18, wherein the dose counter includes a clutch spring secured to the spool and allowing rotation of the spool in a single direction.
100 21. An inhaler according to claim 1 , wherein the indicia comprises numbers.
22. An inlialer according to claim 18, wherein the indicia are provided on a radially outwardly facing surface of the rolled ribbon.
23. An inhaler according to claim 18, wherein the predetermined path of the pawl is linear.
105 24. An inhaler according to claim 18, wherein the pawl moves in first and second directions along the predetermined path and is adapted to engage the teeth and advance the spool upon movement in the second direction.
25. An inhaler according to claim 18, further comprising a housing containing the dose counter and include a transparent window over the indicia of the ribbon.
110 26. An inhaler according to claim 18, further comprising a medicament reservoir including a dispensing port, and the dose meter meters a dose of medicament from the dispensing port to the mouthpiece.
27. An inhaler according to claim 26, wherein the reservoir is adapted to contain dry powdered medicament in bulk form.
115 28. An inlialer according to claim 18, wherein the indicia comprises numbers arranged to successively decrease as the ribbon is advanced onto the spool.
29. A medicament inhaler comprising:
a mouthpiece for patient inhalation; a delivery passageway for directing an inhalation induced air flow tlirough 120 the mouthpiece; a chamiel extending from the delivery passageway; a reservoir for containing medicament, the reservoir having a dispensing port connected to the channel; a cup received in the channel and movable between the dispensing port and 125 the delivery passageway; a cup spring biasing the cup towards one of the dispensing port and the passageway; and a yoke movable between at least two positions and including a ratchet engaging the cup and preventing movement of the cup when the yoke is in one of the 130 positions and allowing movement of the cup when the yoke is in another of the positions.
30. An inhaler according to claim 29, wherein the cup spring biases the cup towards the delivery passageway.
31. An inhaler according to claim 2, wherein the yoke further includes a push bar adapted to return the cup to the dispensing port of the reservoir upon movement of the
135 yoke to one of the positions .
32. An inhaler according to claim 3, further comprising: at least one movable cam including at least two successive cam surfaces; and a spring biasing the yoke against the cam such that movement of the cam 140 causes the yoke to successively engage the cam surfaces and move the yoke between the at least two positions of the yoke.
33. An inhaler according to claim 4, wherein the cam includes three successive cam surfaces for moving the yoke between three positions, wherein the ratchet is adapted to prevent movement of the cup to the passageway when the yoke is in two of 145 the three positions and allow movement of the cup when the yoke is in a third of the three positions, and the push bar is adapted to return the cup to the dispensing port of the reservoir upon movement of the yoke to a first of the positions.
34. An inhaler according to claim 5, further comprising a cover movable to open and close the mouthpiece, wherein the at least one cam is secured to the cover for
150 movement therewith, whereby opening and closing the mouthpiece causes the yoke to move between the three positions of the yoke.
35. An inhaler according to claim 4, wherein the cam is movable by rotation.
36. An inhaler according to claim 29, wherein the reservoir includes a volume of dry powdered medicament.
155 37. An inhaler according to claim 29, further comprising a de-agglomerator between the delivery passageway and the mouthpiece.
160 38. An inhaler according to claim 29, further comprising: a pawl extending from the yoke; a dose counter including, a bobbin, a rotatable spool, 165 a rolled ribbon received on the bobbin and rotatable about an axis of the bobbin, the ribbon having indicia thereon successively extending between a first end of the ribbon secured to the spool and a second end of the ribbon positioned on the bobbin, and teeth extending radially outwardly from the spool into a 170 predetermined path of the pawl during movement of the yoke between the at least two positions, so that the spool is rotated by the pawl and the ribbon is advanced onto the spool during movement of the cup.
39. An inhaler according to claim 29, wherein:
the channel includes a pressure relief port; 175 a conduit provides fluid communication between an interior of the reservoir and the pressure relief port; and the cup includes, a recess adapted to receive medicament when aligned with the dispensing port of the reservoir, 180 a first sealing surface adapted to seal the dispensing port when the recess is unaligned with the dispensing port, and a second sealing surface adapted to seal the pressure relief port of the channel when the recess is aligned with the dispensing port and unseal the pressure relief port when the recess is unaligned with the dispensing port.
PCT/US2001/020098 2000-06-23 2001-06-23 Medicament inhaler WO2002000281A3 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US21366800 true 2000-06-23 2000-06-23
US21338200 true 2000-06-23 2000-06-23
US60/213,668 2000-06-23
US60/213,382 2000-06-23

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DE2001607107 DE60107107D1 (en) 2000-06-23 2001-06-23 inhaler
CA 2407262 CA2407262C (en) 2000-06-23 2001-06-23 Medicament inhaler
KR20027016057A KR100517900B1 (en) 2000-06-23 2001-06-23 Medicament inhaler
DE2001607107 DE60107107T2 (en) 2000-06-23 2001-06-23 inhaler
EP20010948661 EP1330280B1 (en) 2000-06-23 2001-06-23 Medicament inhaler
DK01948661T DK1330280T3 (en) 2001-06-23 2001-06-23 drug inhaler
JP2002505061A JP4015943B2 (en) 2000-06-23 2001-06-23 Drug inhaler

Publications (2)

Publication Number Publication Date
WO2002000281A2 true true WO2002000281A2 (en) 2002-01-03
WO2002000281A3 true WO2002000281A3 (en) 2003-01-03

Family

ID=26908022

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/020098 WO2002000281A3 (en) 2000-06-23 2001-06-23 Medicament inhaler

Country Status (10)

Country Link
US (4) US6701917B2 (en)
EP (3) EP1486227B1 (en)
JP (3) JP4015943B2 (en)
KR (3) KR100518721B1 (en)
CA (2) CA2552468C (en)
DE (2) DE60107107D1 (en)
DK (2) DK2314336T3 (en)
ES (3) ES2233659T3 (en)
GB (3) GB2366208B (en)
WO (1) WO2002000281A3 (en)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002068030A2 (en) * 2001-02-26 2002-09-06 Optinose As Nasal devices
WO2004050153A1 (en) * 2002-11-07 2004-06-17 Glaxo Group Limited Holder for a dispensing container system
FR2854973A1 (en) * 2003-05-15 2004-11-19 Valois Sas Dose meter for liquid product dispenser, includes flexible metering tape which is fed from feeding ring to receiving ring each time the meter is activated, and carrying figures or symbols for indicating amount of dispensed product
JP2006505313A (en) * 2002-11-07 2006-02-16 グラクソ グループ リミテッドGlaxo Group Limited container
WO2006062448A1 (en) * 2004-12-10 2006-06-15 Ernst Hörlins Ingenjörsbyrå Ab Dose inhaler with a dose counter
WO2006110080A1 (en) * 2005-04-14 2006-10-19 Astrazeneca Ab Inhaler device counter
US7617822B2 (en) 2003-06-16 2009-11-17 Rijksuniversiteit Groningen Dry powder inhaler and method for pulmonary inhalation of dry powder
EP2436414A3 (en) * 2010-05-18 2012-08-08 Ivax Pharmaceuticals Ireland Dose counters for inhalers, inhalers and shafts thereof
US8851069B2 (en) 2004-04-21 2014-10-07 Innovata Biomed Limited Inhaler
WO2014174036A1 (en) * 2013-04-26 2014-10-30 Sanofi Sa Mechanism for a drug delivery device
WO2015086278A1 (en) * 2013-12-09 2015-06-18 Pharmachemie B.V. Inhalable medicaments
US9066957B2 (en) 2013-10-07 2015-06-30 Teva Branded Pharmaceutical Products R&D, Inc. Dry powder inhaler
WO2015191259A1 (en) 2014-06-13 2015-12-17 Microdose Therapeutx Inc. Medical device communication
WO2016033419A1 (en) 2014-08-28 2016-03-03 Microdose Therapeutx, Inc. Compliance monitoring module for a breath-actuated inhaler
WO2016090260A1 (en) 2014-12-04 2016-06-09 Microdose Therapeutx, Inc. Inhalation monitoring system and method
US9415008B2 (en) 2015-01-20 2016-08-16 Teva Branded Pharmaceutical Products R&D, Inc. Dry powder inhaler
WO2016196974A1 (en) 2015-06-03 2016-12-08 Microdose Therapeutx, Inc. Medical device notification system

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1047467B1 (en) 1998-01-16 2004-06-23 1263152 Ontario Inc. Indicating device for use with a dispensing device
US6082358A (en) * 1998-05-05 2000-07-04 1263152 Ontario Inc. Indicating device for aerosol container
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
GB9920839D0 (en) 1999-09-04 1999-11-10 Innovata Biomed Ltd Inhaler
ES2233659T3 (en) * 2000-06-23 2005-06-16 Norton Healthcare Limited Inhaler drugs.
GB0128148D0 (en) 2001-11-23 2002-01-16 Innovata Biomed Ltd Assembly
EP1894591B1 (en) 2002-03-20 2013-06-26 MannKind Corporation Cartridge for an inhalation apparatus
US7004164B2 (en) * 2002-03-21 2006-02-28 Trudell Medical International Indicating device for aerosol container
WO2003080161A1 (en) * 2002-03-22 2003-10-02 Clinical Designs Limited Can fixture
DK1386630T3 (en) * 2002-07-31 2006-09-11 Chiesi Farma Spa powder inhaler
US7322352B2 (en) * 2002-09-21 2008-01-29 Aventis Pharma Limited Inhaler
US6883517B2 (en) * 2002-09-30 2005-04-26 Asaf Halamish Downdraft nebulizer
CA2694183C (en) * 2002-10-11 2013-06-25 Otsuka Techno Corporation Powder inhalator
ES2299760T3 (en) * 2002-11-04 2008-06-01 BANG & OLUFSEN MEDICOM A/S Dispensing device.
US20040177848A1 (en) * 2003-03-12 2004-09-16 Alley Kenneth A. Multi-compartment inhaler
US7703454B2 (en) * 2003-07-14 2010-04-27 Vortran Medical Technology Inhaler with breath actuated dose counter
US7600512B2 (en) * 2003-07-14 2009-10-13 Vortran Medical Technology 1, Inc. Inhaler with breath actuated dose counter
GB0323085D0 (en) * 2003-10-02 2003-11-05 Norton Healthcare Ltd Dry powder inhalation apparatus
US7621273B2 (en) 2003-10-28 2009-11-24 Trudell Medical International Indicating device with warning dosage indicator
US7100530B2 (en) * 2003-12-15 2006-09-05 Trudell Medical International, Inc. Dose indicating device
CA2555347A1 (en) 2004-02-16 2005-09-01 Stephen Edward Augustyn Counter for use with a medicament dispenser
US8397714B2 (en) 2004-03-10 2013-03-19 Glaxo Group Limited Dispensing device
GB0409197D0 (en) * 2004-04-24 2004-05-26 Innovata Biomed Ltd Device
DE202004007115U1 (en) * 2004-05-03 2004-07-08 Altana Pharma Ag Blindungsvorrichtung
US7709639B2 (en) 2004-08-20 2010-05-04 Mannkind Corporation Catalysis of diketopiperazine synthesis
JP4990142B2 (en) 2004-08-23 2012-08-01 マンカインド コーポレイション Diketopiperazine salts for drug delivery, diketomorpholine salt or diketodioxanes salt,
US7543582B2 (en) * 2004-09-20 2009-06-09 Trudell Medical International Dose indicating device with display elements attached to container
GB0427028D0 (en) 2004-12-09 2005-01-12 Cambridge Consultants Dry powder inhalers
JP5189369B2 (en) 2005-01-20 2013-04-24 トルーデル メディカル インターナショナル Dispensing device
GB0507100D0 (en) * 2005-04-08 2005-05-11 Team Holdings Uk Ltd Improvements in or relating to inhalers
US7219664B2 (en) * 2005-04-28 2007-05-22 Kos Life Sciences, Inc. Breath actuated inhaler
JP4500280B2 (en) * 2005-06-08 2010-07-14 日立オートモティブシステムズ株式会社 Powder medicine administering device
GB0518355D0 (en) * 2005-09-08 2005-10-19 Glaxo Group Ltd An inhaler
KR20120060245A (en) 2005-09-14 2012-06-11 맨카인드 코포레이션 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
GB0519151D0 (en) 2005-09-20 2005-10-26 Aventis Pharma Ltd Inhaler
CA2643464A1 (en) 2006-02-22 2007-08-30 Mannkind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
EP1991295B1 (en) * 2006-03-03 2016-02-10 3M Innovative Properties Company Apparatus for metered dosed dispensing
GB0605150D0 (en) 2006-03-14 2006-04-26 Glaxo Group Ltd Counter For Use With A Medicament Dispenser
US20070295329A1 (en) * 2006-06-13 2007-12-27 Lieberman Eric A Dose indicator
US8141550B2 (en) * 2006-08-01 2012-03-27 Trudell Medical International Dispensing device
DK2063940T3 (en) * 2006-12-22 2012-05-07 Almirall Sa Inhalation device for drugs in powder form
US8225790B2 (en) 2007-01-02 2012-07-24 Astrazeneca Ab Inhaler 624
DE102007056263A1 (en) * 2007-11-22 2009-05-28 Siegfried Generics International Ag Dosing device for inhalation of a powdery substance
CA2709071C (en) 2007-12-14 2016-11-15 Labogroup S.A.S. Delivering aerosolizable food products
GB0800457D0 (en) * 2008-01-11 2008-02-20 Innovata Biomed Ltd Improvements in or relating to inhalers
US8082873B2 (en) 2008-05-05 2011-12-27 Trudell Medical International Drive mechanism for an indicating device
JP5681622B2 (en) * 2008-05-07 2015-03-11 マップ・ファーマシューティカルズ・インコーポレイテッド Dose counter and lock-out mechanism
US8181591B1 (en) 2008-05-23 2012-05-22 Trudell Medical International Domed actuator for indicating device
CN104689432A (en) 2008-06-13 2015-06-10 曼金德公司 A dry powder inhaler and system for drug delivery
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
EP2609954A3 (en) 2008-06-20 2018-01-10 MannKind Corporation An interactive apparatus and method for real-time profiling of inhalation efforts
US8596265B2 (en) * 2008-10-22 2013-12-03 Trudell Medical International Modular aerosol delivery system
US8381719B1 (en) 2008-12-22 2013-02-26 Trudell Medical International Medicament delivery system with dose indicator and oversleeve actuator
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
DE202008017185U1 (en) * 2008-12-30 2010-05-12 Siegfried Generics International Ag metering
GB0904040D0 (en) 2009-03-10 2009-04-22 Euro Celtique Sa Counter
GB0908584D0 (en) * 2009-05-19 2009-06-24 Burnup Alexander Adjusting device
US8551528B2 (en) 2009-06-12 2013-10-08 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
GB0910537D0 (en) 2009-06-18 2009-07-29 Ivax Pharmaceuticals Ireland Inhaler
WO2011008662A9 (en) * 2009-07-13 2011-06-16 Meadwestvaco Calmar Gmbh Powder delivery devices and methods of using the same
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
GB0919465D0 (en) * 2009-11-06 2009-12-23 Norton Healthcare Ltd Airflow adaptor for a breath-actuated dry powder inhaler
EP2582421A1 (en) 2010-06-21 2013-04-24 MannKind Corporation Dry powder drug delivery system and methods
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
WO2013045996A1 (en) 2011-09-26 2013-04-04 Trudell Medical International Dose counter and medication delivery device
CN103945859A (en) 2011-10-24 2014-07-23 曼金德公司 Methods and compositions for treating pain
EP2872205B1 (en) 2012-07-12 2017-02-08 MannKind Corporation Dry powder drug delivery systems
GB201304784D0 (en) * 2013-03-15 2013-05-01 Euro Celtique Sa Dispenser
USD783805S1 (en) * 2013-07-10 2017-04-11 Teva Pharmaceutical Industries Limited Respiratory apparatus
CA2918369A1 (en) 2013-07-18 2015-01-22 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
USD783150S1 (en) * 2013-10-07 2017-04-04 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD782650S1 (en) * 2013-10-07 2017-03-28 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD783807S1 (en) * 2013-10-07 2017-04-11 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD782651S1 (en) * 2013-10-07 2017-03-28 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD783806S1 (en) * 2013-10-07 2017-04-11 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD783159S1 (en) * 2013-10-07 2017-04-04 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD783151S1 (en) * 2013-10-07 2017-04-04 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD783152S1 (en) * 2013-10-08 2017-04-04 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD782652S1 (en) * 2013-10-08 2017-03-28 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD783147S1 (en) * 2013-10-08 2017-04-04 Teva Pharmaceutical Industries Limited Respiratory appartus
USD783149S1 (en) * 2013-10-08 2017-04-04 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD783154S1 (en) * 2013-10-08 2017-04-04 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD783148S1 (en) * 2013-10-08 2017-04-04 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD783156S1 (en) * 2013-10-08 2017-04-04 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD783157S1 (en) * 2013-10-08 2017-04-04 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD783153S1 (en) * 2013-10-08 2017-04-04 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD783158S1 (en) * 2013-10-08 2017-04-04 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD782653S1 (en) * 2013-10-08 2017-03-28 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD783155S1 (en) * 2013-10-08 2017-04-04 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD782648S1 (en) * 2013-10-08 2017-03-28 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD783804S1 (en) * 2013-10-08 2017-04-11 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD782647S1 (en) * 2013-10-08 2017-03-28 Teva Pharmaceutical Industries Limited Respiratory apparatus
USD782649S1 (en) * 2013-10-08 2017-03-28 Teva Pharmaceutical Industries Limited Respiratory apparatus
GB201319265D0 (en) * 2013-10-31 2013-12-18 Norton Waterford Ltd Medicament inhaler
USD769437S1 (en) * 2013-11-29 2016-10-18 Norton (Waterford) Limited Respiratory apparatus
USD769436S1 (en) * 2013-11-29 2016-10-18 Norton (Waterford) Limited Respiratory apparatus
GB201321712D0 (en) * 2013-12-09 2014-01-22 Pharmachemie Bv Dry Powder Inhaler
DE102013021718B4 (en) * 2013-12-20 2017-03-02 Gerresheimer Regensburg Gmbh Capsule for use as reservoir for pharmaceutical, preferably powdered formulation in an inhaler and the inhaler for
USD752204S1 (en) * 2014-03-10 2016-03-22 Civitas Therapeutics, Inc. Indicator for an inhaler
USD752734S1 (en) 2014-03-10 2016-03-29 Civitas Therapeutics, Inc. Inhaler grip
USD755367S1 (en) * 2014-03-10 2016-05-03 Civitas Therapeutics, Inc. Indicator for an inhaler
DE102014017065B3 (en) * 2014-11-20 2015-11-19 Klaus-Dieter Beller Powder container for powder inhalers
US20160375202A1 (en) 2015-06-24 2016-12-29 Ethicon, Inc. Hemostatic Powder Delivery Devices and Methods

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447150A (en) 1990-12-01 1995-09-05 Norton Healthcare Limited Medicament dispensing device
US5503144A (en) 1990-12-15 1996-04-02 Norton Healthcare Limited Powdered medicament dispensing device
US5971951A (en) 1997-08-20 1999-10-26 Aradigm Corp. Aerosol extrusion mechanism

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8630100D0 (en) 1986-12-17 1987-01-28 Weston T E Pressurised metering dispenser
US5119806A (en) * 1987-05-12 1992-06-09 Glaxo Inc. Inhalation device
GB8917775D0 (en) * 1989-08-03 1989-09-20 Atomic Energy Authority Uk Aerosol inhaler
ES2044365T3 (en) * 1989-10-27 1994-01-01 Miat Spa Multidose inhaler for powdered medications.
US5201308A (en) * 1990-02-14 1993-04-13 Newhouse Michael T Powder inhaler
US5113855A (en) * 1990-02-14 1992-05-19 Newhouse Michael T Powder inhaler
US5020527A (en) * 1990-02-20 1991-06-04 Texax-Glynn Corporation Inhaler device with counter/timer means
GB9004781D0 (en) * 1990-03-02 1990-04-25 Glaxo Group Ltd Device
GB9015522D0 (en) 1990-07-13 1990-08-29 Braithwaite Philip W Inhaler
GB9025705D0 (en) * 1990-11-27 1991-01-09 Britains Petite Ltd Powder inhaler
WO1992017231A1 (en) * 1991-03-28 1992-10-15 Innomed, Inc. Microelectronic inhaler having a counter and timer
US6029661A (en) * 1991-08-26 2000-02-29 3M Innovative Properties Company Powder dispenser
DE69325722T2 (en) 1992-05-05 2000-02-10 Astra Ab Soedertaelje Metered dose inhaler with both lights / disconnection device
GB9218937D0 (en) * 1992-09-08 1992-10-21 Norton Healthcare Ltd Medicament dispensing device
WO1994005360A1 (en) 1992-09-08 1994-03-17 Norton Healthcare Limited Medicament dispensing device
DE69323897D1 (en) * 1992-12-18 1999-04-15 Schering Corp An inhaler for powdered medications
FR2701653B1 (en) * 1993-02-18 1995-04-07 Valois A metering device for dry powder inhalation.
GB9314614D0 (en) * 1993-07-14 1993-08-25 Minnesota Mining & Mfg Dry powder inhalers
FI942196A (en) * 1994-05-11 1995-11-12 Orion Yhtymae Oy The powder inhaler
FR2721106B1 (en) * 1994-06-10 1996-09-13 Step Dose counter for inhalers.
CA2199858A1 (en) 1994-09-16 1996-03-21 Alain Emile Edward Schaeffer Inhalation device
US5544647A (en) * 1994-11-29 1996-08-13 Iep Group, Inc. Metered dose inhalator
US6029659A (en) * 1995-04-17 2000-02-29 Solar Shield Corporation Inhalation device with counter
CN1181896C (en) * 1995-06-21 2004-12-29 索福泰克两合公司 Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments
FI102875B1 (en) * 1995-11-10 1999-03-15 Orion Yhtymae Oy The powder inhaler
US6182655B1 (en) * 1995-12-07 2001-02-06 Jago Research Ag Inhaler for multiple dosed administration of a pharmacological dry powder
US5833066A (en) * 1996-01-02 1998-11-10 Inhalermate, Llc Carrying case for oral and nasal inhalation devices with counting mechanism
RU2195965C2 (en) * 1996-02-21 2003-01-10 Шеринг Корпорейшн Device for inhaling powder
GB9626538D0 (en) * 1996-12-20 1997-02-05 Norton Healthcare Ltd Inhaler dose counter
GB9700226D0 (en) 1997-01-08 1997-02-26 Glaxo Group Ltd Inhalation device
US6142145A (en) * 1997-03-14 2000-11-07 Astra Aktiebolag Inhalation device
CA2290684A1 (en) * 1997-05-23 1998-11-26 David John Hearne Inhaler mechanism
JP3487865B2 (en) * 1997-06-10 2004-01-19 グラクソ、グループ、リミテッド Dispenser with a dose counter
US6142339A (en) * 1998-01-16 2000-11-07 1263152 Ontario Inc. Aerosol dispensing device
GB9807558D0 (en) * 1998-04-09 1998-06-10 Bason Neil P An indicator device
US6082358A (en) * 1998-05-05 2000-07-04 1263152 Ontario Inc. Indicating device for aerosol container
WO2000001612A3 (en) * 1998-07-06 2008-04-03 Iep Group Inc Counter for fluid dispenser
US6336453B1 (en) * 1999-04-30 2002-01-08 Trudell Medical International Indicating device for aerosol container
ES2233659T3 (en) * 2000-06-23 2005-06-16 Norton Healthcare Limited Inhaler drugs.
FR2811576B1 (en) * 2000-07-13 2003-01-24 Henri Bocquee Disposits or delivery devices produced assets pulverurents the drug type or vaccines, pulmonary

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447150A (en) 1990-12-01 1995-09-05 Norton Healthcare Limited Medicament dispensing device
US5503144A (en) 1990-12-15 1996-04-02 Norton Healthcare Limited Powdered medicament dispensing device
US5971951A (en) 1997-08-20 1999-10-26 Aradigm Corp. Aerosol extrusion mechanism

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8522778B2 (en) 2001-02-26 2013-09-03 Optinose As Nasal devices
WO2002068030A3 (en) * 2001-02-26 2003-02-06 Optinose As Nasal devices
WO2002068030A2 (en) * 2001-02-26 2002-09-06 Optinose As Nasal devices
US7740014B2 (en) 2001-02-26 2010-06-22 Optinose As Nasal devices
WO2004050153A1 (en) * 2002-11-07 2004-06-17 Glaxo Group Limited Holder for a dispensing container system
JP2006505313A (en) * 2002-11-07 2006-02-16 グラクソ グループ リミテッドGlaxo Group Limited container
FR2854973A1 (en) * 2003-05-15 2004-11-19 Valois Sas Dose meter for liquid product dispenser, includes flexible metering tape which is fed from feeding ring to receiving ring each time the meter is activated, and carrying figures or symbols for indicating amount of dispensed product
US7617822B2 (en) 2003-06-16 2009-11-17 Rijksuniversiteit Groningen Dry powder inhaler and method for pulmonary inhalation of dry powder
US8851069B2 (en) 2004-04-21 2014-10-07 Innovata Biomed Limited Inhaler
WO2006062448A1 (en) * 2004-12-10 2006-06-15 Ernst Hörlins Ingenjörsbyrå Ab Dose inhaler with a dose counter
US7587988B2 (en) 2005-04-14 2009-09-15 Astrazeneca Ab Inhaler device counter
US7819075B2 (en) 2005-04-14 2010-10-26 Astrazeneca Ab Inhaler device counter
WO2006110080A1 (en) * 2005-04-14 2006-10-19 Astrazeneca Ab Inhaler device counter
EP2436414A3 (en) * 2010-05-18 2012-08-08 Ivax Pharmaceuticals Ireland Dose counters for inhalers, inhalers and shafts thereof
CN102892448A (en) * 2010-05-18 2013-01-23 艾瓦克斯医药爱尔兰公司 Dose counters for inhalers, inhalers and shafts thereof
US9731087B2 (en) 2010-05-18 2017-08-15 Ivax Pharmaceuticals Ireland Dose counter for inhaler having a bore and shaft arrangement
EP2987523A1 (en) * 2010-05-18 2016-02-24 Ivax Pharmaceuticals Ireland Dose counters for inhalers
US9808587B2 (en) 2010-05-18 2017-11-07 Ivax Pharmaceuticals Ireland Dose counter for inhaler having an anti-reverse rotation actuator
WO2014174036A1 (en) * 2013-04-26 2014-10-30 Sanofi Sa Mechanism for a drug delivery device
US9066957B2 (en) 2013-10-07 2015-06-30 Teva Branded Pharmaceutical Products R&D, Inc. Dry powder inhaler
WO2015054124A3 (en) * 2013-10-07 2015-09-03 Teva Branded Pharmaceutical Products R&D, Inc. Dry powder inhaler
WO2015086278A1 (en) * 2013-12-09 2015-06-18 Pharmachemie B.V. Inhalable medicaments
WO2015191259A1 (en) 2014-06-13 2015-12-17 Microdose Therapeutx Inc. Medical device communication
EP3097937A1 (en) 2014-08-28 2016-11-30 MicroDose Therapeutx, Inc. Compliance monitoring module for a breath-actuated inhaler
WO2016033419A1 (en) 2014-08-28 2016-03-03 Microdose Therapeutx, Inc. Compliance monitoring module for a breath-actuated inhaler
WO2016090260A1 (en) 2014-12-04 2016-06-09 Microdose Therapeutx, Inc. Inhalation monitoring system and method
US9415008B2 (en) 2015-01-20 2016-08-16 Teva Branded Pharmaceutical Products R&D, Inc. Dry powder inhaler
WO2016196974A1 (en) 2015-06-03 2016-12-08 Microdose Therapeutx, Inc. Medical device notification system

Also Published As

Publication number Publication date Type
GB0115518D0 (en) 2001-08-15 grant
GB2366208A (en) 2002-03-06 application
KR20050048687A (en) 2005-05-24 application
CA2407262A1 (en) 2002-01-03 application
EP1330280A2 (en) 2003-07-30 application
KR100517900B1 (en) 2005-10-04 grant
DE60107107D1 (en) 2004-12-16 grant
GB2365778B (en) 2004-10-13 grant
US8006690B2 (en) 2011-08-30 grant
GB0115519D0 (en) 2001-08-15 grant
EP2314336A2 (en) 2011-04-27 application
JP2007289716A (en) 2007-11-08 application
JP4897570B2 (en) 2012-03-14 grant
GB2365779B (en) 2004-09-29 grant
JP4897569B2 (en) 2012-03-14 grant
KR20030066328A (en) 2003-08-09 application
ES2520966T3 (en) 2014-11-12 grant
EP1486227A3 (en) 2007-02-21 application
EP1486227B1 (en) 2012-03-07 grant
KR100518721B1 (en) 2005-10-05 grant
EP2314336B1 (en) 2014-08-20 grant
ES2233659T3 (en) 2005-06-16 grant
CA2552468C (en) 2008-02-19 grant
JP2007252946A (en) 2007-10-04 application
US20020078950A1 (en) 2002-06-27 application
DK2314336T3 (en) 2014-11-03 grant
EP1330280B1 (en) 2004-11-10 grant
KR20050039884A (en) 2005-04-29 application
US20020073996A1 (en) 2002-06-20 application
EP2314336A3 (en) 2013-07-10 application
GB2365778A (en) 2002-02-27 application
GB2365779A (en) 2002-02-27 application
JP4015943B2 (en) 2007-11-28 grant
CA2552468A1 (en) 2002-01-03 application
GB0115525D0 (en) 2001-08-15 grant
GB2366208B (en) 2004-10-13 grant
US6701917B2 (en) 2004-03-09 grant
CA2407262C (en) 2007-08-28 grant
JP2004501685A (en) 2004-01-22 application
US7540282B2 (en) 2009-06-02 grant
DK1486227T3 (en) 2012-04-02 grant
KR100518723B1 (en) 2005-10-05 grant
EP1486227A2 (en) 2004-12-15 application
DE60107107T2 (en) 2005-11-03 grant
US20020078949A1 (en) 2002-06-27 application
ES2382734T3 (en) 2012-06-13 grant
US6718972B2 (en) 2004-04-13 grant
WO2002000281A3 (en) 2003-01-03 application
US20090178678A1 (en) 2009-07-16 application

Similar Documents

Publication Publication Date Title
US5349945A (en) Aerosol dispenser comprising an indicator assembly
US5447150A (en) Medicament dispensing device
US6029662A (en) Compressed-air powder inhaler
US5408994A (en) Inhalation device
US6405727B1 (en) Inhaler mechanism
US5657749A (en) Inhalation device
US20040149773A1 (en) Dosage counting devices
US7100530B2 (en) Dose indicating device
US6591832B1 (en) Dry powder dispenser
US7219664B2 (en) Breath actuated inhaler
US7107988B2 (en) Powder inhaler
EP0488609A1 (en) Powder inhaler
US5301666A (en) Powder inhaler
US5069204A (en) Inhaler
US20060254581A1 (en) Dose counting in metered dose inhaler
US6029661A (en) Powder dispenser
US5857457A (en) Powder inhaler with remnant mover and chamber
US20050183718A1 (en) Nebulizer
US20040144798A1 (en) Dosage counting devices
US6769601B2 (en) Inhaler with a dose counter
WO2005037353A1 (en) Inhaler
US5623920A (en) Valve assemblies
US7171965B2 (en) Breath actuated dry powder inhaler and tape dose strip
US20060150971A1 (en) Inhaler with breath actuated dose counter
US5582162A (en) Inhaler for multiple use

Legal Events

Date Code Title Description
AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2407262

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 1020027016057

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 2001270113

Country of ref document: AU

ENP Entry into the national phase in:

Ref country code: JP

Ref document number: 2002 505061

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 2001948661

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 2001948661

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1020027016057

Country of ref document: KR

WWG Wipo information: grant in national office

Ref document number: 2001948661

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 2001270113

Country of ref document: AU

WWG Wipo information: grant in national office

Ref document number: 1020027016057

Country of ref document: KR