WO2001093855A1 - Compositions et aliments hydratants - Google Patents

Compositions et aliments hydratants Download PDF

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Publication number
WO2001093855A1
WO2001093855A1 PCT/JP2001/004764 JP0104764W WO0193855A1 WO 2001093855 A1 WO2001093855 A1 WO 2001093855A1 JP 0104764 W JP0104764 W JP 0104764W WO 0193855 A1 WO0193855 A1 WO 0193855A1
Authority
WO
WIPO (PCT)
Prior art keywords
skin
ceramide
food
theanine
moisturizing
Prior art date
Application number
PCT/JP2001/004764
Other languages
English (en)
Japanese (ja)
Inventor
Kenichi Okayama
Harumi Yoshida
Original Assignee
Otsuka Kagaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Kagaku Kabushiki Kaisha filed Critical Otsuka Kagaku Kabushiki Kaisha
Publication of WO2001093855A1 publication Critical patent/WO2001093855A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair

Definitions

  • the present invention relates to a composition for moisturizing the skin, which enhances the skin's moisturizing effect by enhancing the moisturizing effect of the skin, and more particularly to a food for moisturizing the skin, which improves the moisturizing effect by oral ingestion.
  • dry skin In recent years, the population of dry skin (so-called dry skin) has increased due to the effects of changes in the living environment. Dry skin is a phenomenon that was previously common in middle-aged and elderly people, but has recently become more common in young women who tend to pursue excessive degreasing due to a desire for purity. To deal with these dry skins, it is important to provide adequate moisture for drying and to keep the skin moist. It is said that moisturizing the skin requires preventing the evaporation of water by the outermost layer of skin, the stratum corneum, rather than the sebum on the surface. Among various factors, keratinocyte intercellular lipids (ceramide, etc.) are said to be the most important.
  • the present inventors have conducted intensive studies in order to further express the moisturizing effect of ceramide, and as a result, focused on theanine, which is a kind of amino acid.
  • This theanine is one of the delicious ingredients contained in green tea and the like, and is known to be effective for a relaxing effect.
  • the present inventors have found that by causing theanine to act simultaneously with the ceramide, the two substances exhibit a synergistic effect, and in particular, by simultaneously ingesting these substances orally, further enhance the moisturizing effect on the skin. And found that a beautiful skin effect can be achieved, and completed the present invention.
  • the present invention relates to a skin moisturizing composition containing ceramide and theanine as active ingredients.
  • the composition for moisturizing the skin can be used as a food and drink additive, a cosmetic ingredient, a skin external preparation ingredient, and the like.However, according to the study of the present inventors, it is absorbed from the body by oral ingestion and acts on the skin. It has been found that the moisturizing effect is more favorable. That is, the present invention relates to a food for moisturizing skin, wherein the food contains ceramide and theanine, and the theanine is contained at a weight ratio of 3 to 500 times that of the ceramide.
  • the skin moisturizer contains theanine and ceramide in food. Pertaining to food.
  • the food is preferably an oily food, and examples thereof include animal fats and oils, vegetable fats and oils, and foods obtained by processing them.
  • the ceramide used in the present invention has a structure in which sphingosine, a fatty acid and a sugar are bonded, and is a ceramide derived from nature, for example, extracted from wheat (ceramide-containing wheat extract), extracted from rice (Ceramic-containing rice germ extract), other so-called plant-derived ceramide extracts such as those extracted from soybean, millet, spinach, etc., or extracted from bovine brain, extracted from microorganisms such as yeast It can be obtained as a so-called animal-derived ceramide extract.
  • the ceramide (ceramide extract) can be obtained by a known method.
  • a method of extracting ceramide from a raw material such as wheat or rice bran with a polar solvent such as ethanol, acetone and water using a polar solvent such as ethanol, and recrystallizing the same in an organic solvent to obtain a ceramide extract is exemplified. be able to.
  • the mixing ratio of ceramide in the food can be in an arbitrary range depending on the type of the food to be mixed.
  • the amount of ceramide taken in a day is preferably 0.1 to 3 mg, more preferably 0.3 to 1.5 mg. Therefore, considering the daily intake of food containing ceramide, the amount of ceramide in the food is preferably 0.001 to 5% by weight, particularly 0.01 to 2% by weight.
  • theanine that can be used in the present invention those obtained as a natural product or a synthetic product can be used.
  • the natural theanine include a theanine extract extracted from green tea such as gyokuro, sencha, andnadoha.
  • the synthetic theanine include an organic synthesis method (Chem. Pharm. Bull., 19 (7) 1301-1307 (1971)), a fermentation method (Japanese Patent Application Laid-Open No. 05-69578, etc.), a plant cell culture method, and the like. (Japanese Patent Application Laid-Open No. 5-123166).
  • the mixing ratio of theanine in the food can be in an arbitrary range depending on the type of the food to be mixed.
  • the amount of theanine to be taken in a day is preferably 10 to 500 mg, more preferably 30 to 300 mg. Therefore, considering the daily intake of food containing theanine, the amount of theanine in the food is preferably 0.1 to 98% by weight, particularly preferably 1 to 50% by weight.
  • the combination ratio of ceramide and theanine in the food is determined by the amount of ceramide (parts by weight).
  • Theanine is preferably 3 to 500 times, more preferably 20 to 100 times, particularly preferably 100 to 500 times. If it is less than 3 times or more than 500 times, it is difficult to efficiently obtain a synergistic effect of ceramide and theanine, which is not preferable.
  • the form of the food for moisturizing the skin is not limited to a solid food, but may be a tablet, a capsule, a powder such as a powder, a liquid such as a beverage, and a jelly-like food. Any form is possible.
  • the food to be used is not particularly limited as long as it can mix ceramide and theanine, but oil-based foods are preferable in view of the good absorption efficiency of ceramide into the body. Examples of such oily foods include animal fats and oils such as butter and lard, and vegetable fats and oils such as margarine, salad oil and olive oil.
  • oily food can be processed into another form of oily food by specifically processing chocolate, cookies, ice cream, bread, curry roux and the like. Above all, chocolate is preferred, considering that it is easy to process and can be eaten while satisfying human tastes.
  • the composition for moisturizing the skin according to the present invention can be used as a food or drink additive, a cosmetic component, a skin external preparation component, a bath agent component, or a cleansing component such as a face wash.
  • a food or drink additive e.g., a cosmetic component, a skin external preparation component, a bath agent component, or a cleansing component such as a face wash.
  • ceramide and theanine can be ingested simultaneously, so that both can act synergistically.
  • the synergistic effect of ceramide and theanine can effectively improve the moisturizing effect of the skin.
  • by keeping the skin moisturized it also has a beautiful skin effect.
  • the present invention will be described in detail with reference to Examples and Comparative Examples. Note that the present invention is not limited to these examples.
  • chocolates of the examples were prepared by a conventional method. Commercial products other than ceramide and theanine were also used.
  • Theanine (manufactured by Taiyo Kagaku Co., Ltd.) 2. 55
  • the synergistic effect of Ceramide and Theanine allows the moisturizing effect of the skin to be more remarkably expressed and the skin to be moisturized. Is maintained, a beautiful skin effect can be obtained.
  • the food for moisturizing skin containing ceramide and theanine in the food it is possible to ingest both at the same time and according to taste simply by eating the food, so that a further synergistic effect is obtained. It is easy to be used and can have a skin moisturizing effect.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Confectionery (AREA)

Abstract

Avec le changement de l'environnement et du cadre de vie, le nombre de personnes souffrant de peau sèche a considérablement augmenté. On a remarqué ces dernières années que la peau sèche est souvent observé chez les jeunes femmes en quête de sensation de propreté qui ont tendance à éliminer de manière excessive le sébum. Pour traiter la peau sèche, il suffit d'hydrater la peau. Plus précisément, il est important de maintenir l'hydratation de la couche cornée en raison de la présence, entre autres, des lipides (céramides, etc.) parmi les cellules cornées. Cette invention fournit une méthode qui permet d'alimenter efficacement les céramides qui agissent comme principe actif, en particulier, en créant une synergie avec d'autres composants pour hydrater la peau de manière encore plus efficace. Pour ce faire, on utilise des compositions hydratantes qui renferment des céramides et de la théanine comme principes actifs.
PCT/JP2001/004764 2000-06-07 2001-06-06 Compositions et aliments hydratants WO2001093855A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000-170388 2000-06-07
JP2000170388A JP2004238285A (ja) 2000-06-07 2000-06-07 皮膚保湿用組成物および皮膚保湿用食品

Publications (1)

Publication Number Publication Date
WO2001093855A1 true WO2001093855A1 (fr) 2001-12-13

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ID=18673117

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/004764 WO2001093855A1 (fr) 2000-06-07 2001-06-06 Compositions et aliments hydratants

Country Status (2)

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JP (1) JP2004238285A (fr)
WO (1) WO2001093855A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4359205B2 (ja) * 2004-03-19 2009-11-04 花王株式会社 皮膚保湿用食品
JP4700313B2 (ja) * 2004-09-27 2011-06-15 サントリーホールディングス株式会社 プロアントシアニジン及びスフィンゴ脂質を含む組成物
JP5722282B2 (ja) * 2004-12-24 2015-05-20 株式会社明治 皮膚改善剤及び皮膚改善方法
JP5635221B2 (ja) * 2004-12-24 2014-12-03 株式会社明治 皮膚改善用及び／又は治療用の発酵乳とその製造方法
JP2006348027A (ja) * 2005-05-17 2006-12-28 Kobayashi Pharmaceut Co Ltd アトピー性皮膚炎の予防又は治療剤
CA2673714A1 (fr) * 2006-12-26 2008-07-03 Meiji Dairies Corporation Lait fermente destine a ameliorer et/ou a traiter la peau et son procede de production
KR20090064743A (ko) * 2007-12-17 2009-06-22 (주)아모레퍼시픽 데아닌을 함유하는 프롤린 리사이클링 촉진용 피부 외용제또는 미용 식품 조성물

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11113530A (ja) * 1997-10-21 1999-04-27 Nof Corp セラミドを含有する健康食品
JPH11137212A (ja) * 1997-11-14 1999-05-25 Sogo Pharmaceut Co Ltd 美容組成物
JP2001031554A (ja) * 1999-07-21 2001-02-06 Kose Corp 皮膚外用剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3395444B2 (ja) * 1995-03-27 2003-04-14 日本油脂株式会社 飲食品用セラミド含有水性組成物およびそれを含む飲食品

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11113530A (ja) * 1997-10-21 1999-04-27 Nof Corp セラミドを含有する健康食品
JPH11137212A (ja) * 1997-11-14 1999-05-25 Sogo Pharmaceut Co Ltd 美容組成物
JP2001031554A (ja) * 1999-07-21 2001-02-06 Kose Corp 皮膚外用剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ELIAN LATI: "Phytoceramides and their application", FRAGRANCE JOURNAL, January 1995 (1995-01-01), pages 81 - 89, XP002944703 *

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