WO2001090320A3 - A novel helicase family member and uses thereof - Google Patents

A novel helicase family member and uses thereof Download PDF

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Publication number
WO2001090320A3
WO2001090320A3 PCT/US2001/016014 US0116014W WO0190320A3 WO 2001090320 A3 WO2001090320 A3 WO 2001090320A3 US 0116014 W US0116014 W US 0116014W WO 0190320 A3 WO0190320 A3 WO 0190320A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid molecules
expression vectors
helicase family
family member
Prior art date
Application number
PCT/US2001/016014
Other languages
French (fr)
Other versions
WO2001090320A2 (en
Inventor
Maria Alexandria Glucksmann
Original Assignee
Millenium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millenium Pharmaceuticals Inc filed Critical Millenium Pharmaceuticals Inc
Priority to EP01937506A priority Critical patent/EP1297111A2/en
Priority to AU2001263234A priority patent/AU2001263234A1/en
Publication of WO2001090320A2 publication Critical patent/WO2001090320A2/en
Publication of WO2001090320A3 publication Critical patent/WO2001090320A3/en
Priority to US11/591,659 priority patent/US20070048784A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides isolated nucleic acids molecules, designated 58224 nucleic acid molecules, which encode novel helicase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 58224 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 58224 gene has been introduced or disrupted. The invention still further provides isolated 58224 proteins, fusion proteins, antigenic peptides and anti-58224 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
PCT/US2001/016014 2000-03-24 2001-05-18 A novel helicase family member and uses thereof WO2001090320A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01937506A EP1297111A2 (en) 2000-05-19 2001-05-18 A novel helicase family member and uses therefor
AU2001263234A AU2001263234A1 (en) 2000-05-19 2001-05-18 58224, a novel helicase family member and uses therefor
US11/591,659 US20070048784A1 (en) 2000-03-24 2006-11-01 Novel human hydrolase family members and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20544200P 2000-05-19 2000-05-19
US60/205,442 2000-05-19

Publications (2)

Publication Number Publication Date
WO2001090320A2 WO2001090320A2 (en) 2001-11-29
WO2001090320A3 true WO2001090320A3 (en) 2002-04-25

Family

ID=22762204

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/016014 WO2001090320A2 (en) 2000-03-24 2001-05-18 A novel helicase family member and uses thereof

Country Status (4)

Country Link
US (1) US20030186859A1 (en)
EP (1) EP1297111A2 (en)
AU (1) AU2001263234A1 (en)
WO (1) WO2001090320A2 (en)

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL EBI; 12 February 2000 (2000-02-12), ISOGAI, T AND OTSUKI, T: "Homo sapiens cDNA FLJ10339 fis, clone NT2RM2000740, weakly similar to POSSIBLE GLOBAL TRANSCRIPTION ACTIVATOR SNF2L", XP002189626 *
DATABASE GENEBANK NIH; 13 September 1996 (1996-09-13), MUEGGE, K: "Mus musculus lymphocyte specific helicase mRNA, complete cds.", XP002189664 *
EISEN ET AL: "Evoluton of the SNF2 family of proteins:", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 23, no. 14, 1995, pages 2715 - 2723, XP002056293, ISSN: 0305-1048 *
GEIMAN T M ET AL: "Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh).", GENOMICS, vol. 54, no. 3, 15 December 1998 (1998-12-15), pages 477 - 483, XP002189624, ISSN: 0888-7543 *
JARVIS C D ET AL: "A novel putative helicase produced in early murine lymphocytes.", GENE (AMSTERDAM), vol. 169, no. 2, 1996, pages 203 - 207, XP002189623, ISSN: 0378-1119 *
LEE DAVID W ET AL: "Proliferation-associated SNF2-like gene (PASG): A SNF2 family member altered in leukemia.", CANCER RESEARCH, vol. 60, no. 13, 1 July 2000 (2000-07-01), pages 3612 - 3622, XP002189625, ISSN: 0008-5472 *

Also Published As

Publication number Publication date
EP1297111A2 (en) 2003-04-02
WO2001090320A2 (en) 2001-11-29
US20030186859A1 (en) 2003-10-02
AU2001263234A1 (en) 2001-12-03

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