WO2001089699A1 - Improvements to microcontainers for clinical assays - Google Patents
Improvements to microcontainers for clinical assays Download PDFInfo
- Publication number
- WO2001089699A1 WO2001089699A1 PCT/ES2000/000339 ES0000339W WO0189699A1 WO 2001089699 A1 WO2001089699 A1 WO 2001089699A1 ES 0000339 W ES0000339 W ES 0000339W WO 0189699 A1 WO0189699 A1 WO 0189699A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- microrecipient
- retention
- microrecipients
- reagent
- retention body
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5082—Test tubes per se
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5082—Test tubes per se
- B01L3/50825—Closing or opening means, corks, bungs
Definitions
- the present invention is intended to disclose improvements in the microrecipients intended for clinical analysis especially of blood groups that provide remarkable characteristics of novelty and inventive activity to the function to which they are intended.
- the refinements object of the present invention are intended for microrecipients for clinical analysis in which a lower body of the reagent carrier vessel is disposed, possibly with a built-in gel for retention and filtration, being destined to subsequently receive the sample to be analyzed in the upper mouth of the container, whose sample must reach the reagent contained in the lower body after an appropriate centrifugation.
- the microrecipients form a set in the form of a "plate” or "card” that facilitates its manipulation.
- European Patent 194,212 disclosed micro-containers of substantially cylindrical shape in their upper part that are narrowly narrowed, after an intermediate conical zone.
- European Patent 305,337 also disclosed similar microrecipients provided with an optionally flattened side, adapted on a flat plate.
- All of the indicated microrecipients are open at the top when they are used for their specific function, both based on the fact that, in the case of a blood test, the red blood cells placed above the mixture of particles or gel embedded in the binder serum, they penetrate by centrifugation in the said layer formed by reagent and particles and, as they descend, they agglutinate if the reactive serum and the red blood cells are of the same specificity and, because of this agglutination, they produce lumps of larger size that cannot penetrate the granular mass and, therefore, remain visible above the granule or gel layer. When there is no reaction, the red blood cells, which are not agglutinated, are smaller than lumps and pass through the gel and particle layer to the bottom of the tube.
- microrecipients may have certain disadvantages due to the ineffective retention, with an unsafe location of the reagent in the cylindrical lower part of the microrecipient, so that in the practical use of microrecipient cards of this type they are presented with certain frequency of use situations in which, due to errors in the manipulation, card drop or others, the reagent can be partially or totally expelled outside the cylindrical body of the microrecipient, so that it is not in adequate conditions to perform its function at receive the sample to be analyzed, and may produce erroneous results, with the serious consequences that this may entail.
- the current applicant herself presented the Spanish Utility Model application No. Q 9900372, which provided for a controlled closing element arranged between the upper part of the microrecipient or receiving cavity and the lower part thereof, of so that the communication of said upper and lower parts should necessarily take place due to the centrifugation action, since the closing element interposed between both chambers left free some small cross-sectional steps that were sufficient for the centrifugation passage, but which prevented the free passage from the upper chamber to the lower chamber of the microrecipient as was the case in practice.
- Said invention already meant an important advance in providing for the provision of a intermediate stop body between the upper mouth of the microrecipient and the lower body containing the reagent, in order to prevent the sudden entry of the sample to be analyzed within the part of the body containing the reagent.
- the present invention constitutes a refinement of the application of the Spanish Utility Model No. Q 9900372 of the current applicant himself, since by the studies and investigations carried out by the inventor, although his invention consists in arranging a controlled closing body between the upper mouth of the microrecipient and the lower body of the same had clear positive effects, there was still the possibility that if, due to a bad maneuver by an unskilled operator, the carrier pipette of the sample to be analyzed with excessive analysis is introduced force and / or excessive depth, this action could report the partial elevation of the intermediate closing body, allowing the accidental passage of the pipette towards the bottom of the microrecipient, so that the reaction would not be seen, being able to give rise to a reading completely wrong, especially dangerous in the case of blood tests.
- the objective of the present invention is to obtain microrecipients for clinical analyzes that present not only sufficient characteristics of protection against an abrupt entry or against an erroneous placement of the sample to be analyzed, but also is avoided at the same time. the loss of efficiency of the intermediate stop body, avoiding the eventual detachment of the same.
- the present invention discloses microrecipients for clinical analyzes in which the intermediate body for controlled separation between the entrance mouth of the microrecipient and the lower body thereof, which contains the reagent, is retained by a specific structure. of the receiving seat of said intermediate body which, allowing the passage by centrifugation of the sample to be analyzed from the introduction mouth, through the narrow interstices controlled by said intermediate body, to the lower body containing the reagent, prevents the body from leaving intermediate of your seat, thus guaranteeing the desired efficiency.
- the retention of said intermediate body may preferably be carried out by means of the arrangement of longitudinal ribs in the seating area that determine support areas for the limitation body that prevent its accidental exit and that simultaneously determine interstices to allow the sample to pass through lower body of the microrecipient in which the reagent is found.
- the present improvements are characterized by the provision of axial retention means of the abutment body in its seat, constituted by mechanical interference between said restraint body and the seating area therein in the intermediate narrowing of the microrecipient, which they extend to limited areas of the periphery of the retention body to free interstices for centrifugal passage of the sample from the mouth of the microrecipient into the reagent carrier body.
- Such interference can be achieved, for example, by the constitution of housings on the frontal edges of longitudinal ribs arranged in the narrowing of the microrecipient, whose housings have a conjugate shape of the lateral surface of the retention body, allowing the introduction thereof by elasticity of the Microrecipient and / or the retention body, or also, according to another example, by the constitution of a prismatic housing in the narrowing of the microrecipient intended to receive a spherical or similar retention body with interference.
- Figures 1 and 2 are longitudinal sections of a microrecipient incorporating the present improvements according to planes perpendicular to each other.
- Figure 3 shows a plan view of the microrecipient itself.
- Figures 4 and 5 are sections similar to Figures 1 and 3 of an embodiment variant of the present invention.
- Figure 6 shows a plan view of the microrecipient shown in Figures 4 and 5.
- the present improvements are applicable to microrecipients in which a mouthpiece is available or upper body -1- and a lower body -2- intended to contain the reagent, both of which are separated by a narrower area -3- in which an intermediate body -4- is used as a stop to prevent the entry of the sample can take place with excessive speed or with an error of placement of the nozzle or dispensing pipette, producing a possible direct mixing with the reagent of the container -2-.
- the present improvements provide for the provision of means for axial retention of the body -4- in its housing.
- ribs or longitudinal partitions are constituted such as those represented with the numerals -5-, -6-, -7- and -8-, in variable number, which are characterized in that at its front edge it can be straight or it can have respective recesses -20- conjugated to the retention body -4-, that is, in an arcuate manner for the case in which said retention body is a spherical ball, such as It has been represented in the drawings.
- the mouthpiece -9- of the microrecipient will have a narrowing -10- whose transverse shape may be prismatic, for example, square prismatic sides -11-, -12-, -13- and -14-, intended to receive the retention body preferably in ball shape -15- that may be retained under pressure inside said prismatic housing, determining the edges of each step -16-, -17-, -18- and -19- for communication between the mouth of the upper part and the lower body of the microrecipient.
- the retention of the stop body inside the prismatic housing can be carried out by simple elasticity, both of the retention body and of the same container, or by the realization of areas of conjugate form destined to receive said retention body after its introduction. This form of retention will be equally applicable, as is evident, to the structure represented in Figures 1 to 3.
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU68439/00A AU6843900A (en) | 2000-05-26 | 2000-09-11 | Improvements to microcontainers for clinical assays |
JP2001585930A JP3474558B6 (en) | 2000-05-26 | 2000-09-11 | Improved microcontainer for clinical analysis |
EP00956535A EP1206968A1 (en) | 2000-05-26 | 2000-09-11 | Improvements to microcontainers for clinical assays |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200001336A ES2165322B1 (en) | 2000-05-26 | 2000-05-26 | IMPROVEMENTS IN MICRORRECIPIENTS FOR CLINICAL ANALYSIS. |
ESP200001336 | 2000-05-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001089699A1 true WO2001089699A1 (en) | 2001-11-29 |
Family
ID=8493671
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/ES2000/000339 WO2001089699A1 (en) | 2000-05-26 | 2000-09-11 | Improvements to microcontainers for clinical assays |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1206968A1 (en) |
AU (1) | AU6843900A (en) |
ES (1) | ES2165322B1 (en) |
WO (1) | WO2001089699A1 (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3935113A (en) * | 1974-02-27 | 1976-01-27 | Becton, Dickinson And Company | Serum/plasma separator with centrifugal valve |
US4417981A (en) * | 1981-05-04 | 1983-11-29 | Becton, Dickinson And Company | Blood phase separator device |
EP0875202A2 (en) * | 1997-04-30 | 1998-11-04 | Becton, Dickinson and Company | Evacuated sample collection tube with aqueous additive |
ES1042236U (en) * | 1999-02-12 | 1999-08-16 | Lucas Victor Grifols | Device for carrying out agglutination tests |
-
2000
- 2000-05-26 ES ES200001336A patent/ES2165322B1/en not_active Expired - Fee Related
- 2000-09-11 WO PCT/ES2000/000339 patent/WO2001089699A1/en not_active Application Discontinuation
- 2000-09-11 AU AU68439/00A patent/AU6843900A/en not_active Abandoned
- 2000-09-11 EP EP00956535A patent/EP1206968A1/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3935113A (en) * | 1974-02-27 | 1976-01-27 | Becton, Dickinson And Company | Serum/plasma separator with centrifugal valve |
US4417981A (en) * | 1981-05-04 | 1983-11-29 | Becton, Dickinson And Company | Blood phase separator device |
EP0875202A2 (en) * | 1997-04-30 | 1998-11-04 | Becton, Dickinson and Company | Evacuated sample collection tube with aqueous additive |
ES1042236U (en) * | 1999-02-12 | 1999-08-16 | Lucas Victor Grifols | Device for carrying out agglutination tests |
Also Published As
Publication number | Publication date |
---|---|
JP3474558B2 (en) | 2003-12-08 |
ES2165322A1 (en) | 2002-03-01 |
ES2165322B1 (en) | 2003-02-16 |
JP2004506875A (en) | 2004-03-04 |
AU6843900A (en) | 2001-12-03 |
EP1206968A1 (en) | 2002-05-22 |
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