WO2001087849A3 - Modulators of tnf- alpha signaling - Google Patents

Modulators of tnf- alpha signaling Download PDF

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Publication number
WO2001087849A3
WO2001087849A3 PCT/US2001/015027 US0115027W WO0187849A3 WO 2001087849 A3 WO2001087849 A3 WO 2001087849A3 US 0115027 W US0115027 W US 0115027W WO 0187849 A3 WO0187849 A3 WO 0187849A3
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WO
WIPO (PCT)
Prior art keywords
tnf
modulators
alpha signaling
signaling
alpha
Prior art date
Application number
PCT/US2001/015027
Other languages
French (fr)
Other versions
WO2001087849A2 (en
Inventor
Scott F Sneddon
John L Kane
Bradford H Hirth
Fred Vinick
Shuang Qiao
Sharon R Nahill
Original Assignee
Genzyme Corp
Scott F Sneddon
John L Kane
Bradford H Hirth
Fred Vinick
Shuang Qiao
Sharon R Nahill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IL15245001A priority Critical patent/IL152450A0/en
Priority to AU2001259691A priority patent/AU2001259691B2/en
Priority to JP2001584245A priority patent/JP4960565B2/en
Priority to EP01933253.5A priority patent/EP1294699B1/en
Priority to AU5969101A priority patent/AU5969101A/en
Priority to BR0111158A priority patent/BR0111158A/en
Priority to CA2408408A priority patent/CA2408408C/en
Priority to MXPA02010993A priority patent/MXPA02010993A/en
Application filed by Genzyme Corp, Scott F Sneddon, John L Kane, Bradford H Hirth, Fred Vinick, Shuang Qiao, Sharon R Nahill filed Critical Genzyme Corp
Priority to KR1020027015152A priority patent/KR100840816B1/en
Publication of WO2001087849A2 publication Critical patent/WO2001087849A2/en
Publication of WO2001087849A3 publication Critical patent/WO2001087849A3/en
Priority to IL15245002A priority patent/IL152450A/en
Priority to NO20025405A priority patent/NO324693B1/en
Priority to HK03103293.5A priority patent/HK1051186A1/en

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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Abstract

The present invention provides compounds which are modulators of TNF-α signaling and methods of use thereof for treating a patient having a TNF-α mediated condition. The compounds can be represented by structural formulas (I), (II) and (III).
PCT/US2001/015027 2000-05-12 2001-05-10 Modulators of tnf- alpha signaling WO2001087849A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CA2408408A CA2408408C (en) 2000-05-12 2001-05-10 Modulators of tnf- alpha signaling
JP2001584245A JP4960565B2 (en) 2000-05-12 2001-05-10 Modulator of TNFα signaling
EP01933253.5A EP1294699B1 (en) 2000-05-12 2001-05-10 Modulators of tnf- alpha signalling
AU5969101A AU5969101A (en) 2000-05-12 2001-05-10 Modulators of tnf-alpha signaling
BR0111158A BR0111158A (en) 2000-05-12 2001-05-10 Compound and physiological salts thereof, method for treating a median condition by tnf-a in a patient
IL15245001A IL152450A0 (en) 2000-05-12 2001-05-10 COMPOUNDS HAVING TNF-alpha SIGNAL MODULATING ACTIVITY
MXPA02010993A MXPA02010993A (en) 2000-05-12 2001-05-10 MODULATORS OF TNF agr; SIGNALING.
AU2001259691A AU2001259691B2 (en) 2000-05-12 2001-05-10 Modulators of TNF-alpha signaling
KR1020027015152A KR100840816B1 (en) 2000-05-12 2001-05-10 MODULATORS OF TNF-¥áSIGNALING
IL15245002A IL152450A (en) 2000-05-12 2002-10-24 Compounds and compositions for use in treating tnf-?? mediated conditions
NO20025405A NO324693B1 (en) 2000-05-12 2002-11-11 2-acetamidoacetamide derivatives, use of such compounds for the preparation of compositions for the treatment of diseases and preparations comprising such compounds
HK03103293.5A HK1051186A1 (en) 2000-05-12 2003-05-12 Modulators of tnf-alpha signalling tnf-

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20378400P 2000-05-12 2000-05-12
US60/203,784 2000-05-12
US20521300P 2000-05-18 2000-05-18
US60/205,213 2000-05-18

Publications (2)

Publication Number Publication Date
WO2001087849A2 WO2001087849A2 (en) 2001-11-22
WO2001087849A3 true WO2001087849A3 (en) 2002-06-06

Family

ID=26898898

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/015027 WO2001087849A2 (en) 2000-05-12 2001-05-10 Modulators of tnf- alpha signaling

Country Status (13)

Country Link
US (5) US6969728B2 (en)
EP (1) EP1294699B1 (en)
JP (3) JP4960565B2 (en)
KR (1) KR100840816B1 (en)
CN (1) CN100494182C (en)
AU (2) AU5969101A (en)
BR (1) BR0111158A (en)
CA (3) CA2408408C (en)
HK (1) HK1051186A1 (en)
IL (2) IL152450A0 (en)
MX (1) MXPA02010993A (en)
NO (1) NO324693B1 (en)
WO (1) WO2001087849A2 (en)

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EP1765347A4 (en) * 2004-06-04 2008-10-01 Univ California Compounds having activity in increasing ion transport by mutant-cftr and uses thereof
KR20080089461A (en) * 2005-12-30 2008-10-06 랜박시 래보러터리스 리미티드 Muscarinic receptor antagonists
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