WO2001087820A1 - Biocidal composition which is an aqueous solution of hydroxymethylaminoacetate - Google Patents

Biocidal composition which is an aqueous solution of hydroxymethylaminoacetate Download PDF

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Publication number
WO2001087820A1
WO2001087820A1 PCT/US2001/011995 US0111995W WO0187820A1 WO 2001087820 A1 WO2001087820 A1 WO 2001087820A1 US 0111995 W US0111995 W US 0111995W WO 0187820 A1 WO0187820 A1 WO 0187820A1
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WO
WIPO (PCT)
Prior art keywords
glycine
reaction
formaldehyde
composition
composition according
Prior art date
Application number
PCT/US2001/011995
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French (fr)
Inventor
John J. Merianos
Original Assignee
Isp Investments Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isp Investments Inc. filed Critical Isp Investments Inc.
Priority to EP01924982.0A priority Critical patent/EP1282593B1/en
Priority to AU2001251586A priority patent/AU2001251586A1/en
Priority to CA002409052A priority patent/CA2409052A1/en
Publication of WO2001087820A1 publication Critical patent/WO2001087820A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/50—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids the nitrogen atom being doubly bound to the carbon skeleton

Definitions

  • This invention relates to preservative compositions, and, more particularly, to high purity, clear, light stable, formaldehyde-free preservative compositions containing a compound formed by the reaction of excess glycine and formaldehyde at low temperatures.
  • a high purity, clear, light stable, formaldehyde-free, non-toxic composition for inhibiting growth in a substance requiring microbial inhibition comprising about 40-60% by weight of an aqueous solution of hydroxymethyl aminoacetate in the form of its alkali metal salt which is formed by the reaction of excess glycine, a lower alkyl substituted glycinate, or salts thereof, with formaldehyde, in an aqueous medium, at a pH of about 10.5-12.5, characterized by carrying out the reaction at a molar ratio of glycine to formaldehyde necessary to maintain a molar excess of glycine in the medium and to leave a predetermined amount of residual glycine present in the composition at the conclusion of the reaction, and sufficient to preclude the presence of any detectable free formaldehyde as methylene diol in the resultant composition.
  • the reaction between excess glycine and formaldehyde is carried out with a molar excess of glycine of 0.5 to 10% over a 1 :1 molar ratio of glycine to formaldehyde; so that no free or residual formaldehyde as methylene diol can remain in the composition at the conclusion of the reaction.
  • the residual excess glycine level in the composition is 750-35,000 ppm, preferably 1000-3000 ppm.
  • the reaction is carried out at a temperature of ⁇ 40°C, most preferably 10°-25°C, whereat no unwanted by-products can form during the reaction.
  • Equation (A) The overall chemistry of the reaction herein is given in Equation (A) below:
  • reaction product can also undergo a dehydration reaction (B) to produce a Schiff base:
  • the Schiff base is a reactive species which can undergo various side reaction which produce unwanted by-products, such as cyclization reactions to form the corresponding lactones, as well as hexahydro-triazines, and polymeric products thereof. These side reactions are minimized herein because the main reaction is carried out at a low temperature, i.e. below 40°C and preferably at about 10-25°C. At such low temperatures, formation of the Schiff base in reaction (B) is minimized. Thereby, the resultant reaction composition contains only a minimum amount of undesirable reaction byproducts.
  • Example 1 The procedure of Example 1 was followed using excess glycine in predetermined amounts over a 1:1 molar ratio glycine to formaldehyde, with similar results. Examples 1-5 are summarized in the Table below:
  • a solution of 75 g (1.00 mole) of glycine in 100 g (1.00 mole) of 40 wt. % aqueous sodium hydroxide was treated with 82 g (1.00 mole) of 37 wt. % formaldehyde, a 1:1 molar ratio of glycine at 48°C.
  • the final solution pH was 11.4.
  • the resultant solution contained 281 ppm of residual methylene diol (i.e. free formaldehyde), a small amount of residual glycine, and some reaction by-products.

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

A high purity, water-white, clear, light stable, non-toxic, formaldehyde-free composition for inhibiting growth in a substance requiring microbial inhibition comprising about 40-60 % by weight of an aqueous solution of hydroxymethylaminoacetate in the form of its alkali metal salt which is formed by the reaction of a salt of glycine, with formaldehyde, in an aqueous medium, at a pH of about 10.5-12.5, characterized by carrying out the reaction at a molar ratio of glycine to formaldehyde sufficient to maintain a molar excess of glycine in the medium and to leave a predetermined amount of residual glycine present in the composition at the conclusion of the reaction, and to preclude the presence of any detectable free formaldehyde as methylene diol in said composition.

Description

HIGH PURITY. CLEAR. LIGHT STABLE.
FORMALDEHYDE-FREE PRESERVATIVE COMPOSITIONS
CONTAINING A COMPOUND FORMED BY THE REACTION OF
EXCESS GLYCINE AND FORMALDEHYDE AT LOW TEMPERATURES
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to preservative compositions, and, more particularly, to high purity, clear, light stable, formaldehyde-free preservative compositions containing a compound formed by the reaction of excess glycine and formaldehyde at low temperatures.
2. Description of the Prior Art
P. Berke et al, in U.S. Pat. 4,337,269, described a biocidal composition containing the crystalline product obtained from the reaction of glycine and formaldehyde, at a 1 :1 molar ratio of reactants. Under these reaction conditions, the product obtained included considerable amounts of free formaldehyde.
Accordingly, it is an object of this invention to provide a high purity, clear, light stable, formaldehyde-free biocidal composition of the reaction product of glycine and formaldehyde, with predetermined amounts of residual glycine therein and substantially no unwanted by-products of the reaction. These and other objects and features of the invention will be made apparent from the following more detailed description hereinafter.
SUMMARY OF THE INVENTION
What is described herein is a high purity, clear, light stable, formaldehyde-free, non-toxic composition for inhibiting growth in a substance requiring microbial inhibition comprising about 40-60% by weight of an aqueous solution of hydroxymethyl aminoacetate in the form of its alkali metal salt which is formed by the reaction of excess glycine, a lower alkyl substituted glycinate, or salts thereof, with formaldehyde, in an aqueous medium, at a pH of about 10.5-12.5, characterized by carrying out the reaction at a molar ratio of glycine to formaldehyde necessary to maintain a molar excess of glycine in the medium and to leave a predetermined amount of residual glycine present in the composition at the conclusion of the reaction, and sufficient to preclude the presence of any detectable free formaldehyde as methylene diol in the resultant composition.
In suitable embodiments of the invention, the reaction between excess glycine and formaldehyde is carried out with a molar excess of glycine of 0.5 to 10% over a 1 :1 molar ratio of glycine to formaldehyde; so that no free or residual formaldehyde as methylene diol can remain in the composition at the conclusion of the reaction. The residual excess glycine level in the composition is 750-35,000 ppm, preferably 1000-3000 ppm.
Preferably, the reaction is carried out at a temperature of <40°C, most preferably 10°-25°C, whereat no unwanted by-products can form during the reaction. DETAILED DESCRIPTION OF THE INVENTION
The overall chemistry of the reaction herein is given in Equation (A) below:
(A) NH2CH2COONa + CH2O → HOCH2NHCH2COONa sodium glycinate formaldehyde sodium salt of hydroxymethyl glycinate
However, the reaction product can also undergo a dehydration reaction (B) to produce a Schiff base:
(B) HOCH2NHCH2COONa «■> H2C=NCH2COONa + H2O sodium salt of hydroxy methyl glycinate Schiff base
The Schiff base is a reactive species which can undergo various side reaction which produce unwanted by-products, such as cyclization reactions to form the corresponding lactones, as well as hexahydro-triazines, and polymeric products thereof. These side reactions are minimized herein because the main reaction is carried out at a low temperature, i.e. below 40°C and preferably at about 10-25°C. At such low temperatures, formation of the Schiff base in reaction (B) is minimized. Thereby, the resultant reaction composition contains only a minimum amount of undesirable reaction byproducts.
The invention will now be described with reference to the following examples. INVENTION EXAMPLE 1
Glycine (82.5 g, 1.1 mole) was charged into a reactor and 40% aqueous sodium hydroxide (110 g, 1.1 mole) was added slowly with cooling below 15°C. Then a 37 wt% formaldehyde aqueous solution (81.0 g, 1.0 mole) was added slowly with cooling to keep the temperature below 40°C, optimally at 10°-25°C. The pH of the resultant solution was 12.5 and it was adjusted to 11.5 with phosphoric acid. The final composition was a high purity, water-white, clear, light stable solution containing about 50% by wt. of hydroxymethyl glycinate sodium and no free formaldehyde, i.e. below the detectable limit of analytical equipment (<90 ppm). Substantially no reaction by-products were evident in the composition. The product was an effective biocide and without skin irritation in use in personal care formulations.
INVENTION EXAMPLES 2-5
The procedure of Example 1 was followed using excess glycine in predetermined amounts over a 1:1 molar ratio glycine to formaldehyde, with similar results. Examples 1-5 are summarized in the Table below:
TABLE
Figure imgf000005_0001
Invention Examples 1-5 above produced preservative compositions having no detectable residual methylene diol therein. Residual sodium glycinate was present in the compositions its amount increasing with the wt. % excess glycine used in the reactant mixture. Suitabley, in Example 1 , 750 ppm of residual glycinate remained, and up to 34,000 ppm was present (Example 5). The Examples 4 and 5, with 1 and 2 wt. % excess glycine reactant provided residual glycine amounts of about 2000 and 2500 ppm, respectively in the composition. Substantially no reaction by-products were evident in any of the examples.
COMPARATIVE EXAMPLE (Berke. P. Ex. 1)
A solution of 75 g (1.00 mole) of glycine in 100 g (1.00 mole) of 40 wt. % aqueous sodium hydroxide was treated with 82 g (1.00 mole) of 37 wt. % formaldehyde, a 1:1 molar ratio of glycine at 48°C. The final solution pH was 11.4. The resultant solution contained 281 ppm of residual methylene diol (i.e. free formaldehyde), a small amount of residual glycine, and some reaction by-products.
While the invention has been described with particular reference to certain embodiments thereof, it will be understood that changes and modifications may be made which are within the skill of the art. Accordingly, it is intended to be bound only by the following claims, in which:

Claims

WHAT IS CLAIMED IS:
1. A high purity, water-white, clear, light stable, non-toxic, formaldehyde-free composition for inhibiting growth in a substance requiring microbial inhibition comprising about 40-60% by weight of an aqueous solution of hydroxymethylaminoacetate in the form of its alkali metal salt which is formed by the reaction of a salt of glycine, with formaldehyde, in an aqueous medium, at a pH of about 10.5-12.5, characterized by carrying out the reaction at a molar ratio of glycine to formaldehyde sufficient to maintain a molar excess of glycine in the medium and to leave a predetermined amount of residual glycine present in the composition at the conclusion of the reaction, and to preclude the presence of any detectable free formaldehyde as methylene diol in said composition.
2. A composition according to claim 1 wherein the reaction is carried out at a temperature of <40°C so that substantially no reaction by-products can form during the reaction.
3. A composition according to claim 2 wherein the reaction temperature is about 15-25°C.
4. A composition according to claim 1 wherein said molar excess of glycine is 0.5 to 10% molar excess over a 1:1 molar ratio of glycine to formaldehyde.
5. A composition according to claim 4 wherein said molar excess is 1 to 2%.
6. A composition according to claim 1 which is about 48-52 wt.% aqueous solution of hydroxymethylaminoacetate.
7. A composition according to claim 1 wherein said residual glycine level is 750-35,000 ppm.
8. A composition according to claim 7 wherein said residual glycine level is about 1000-3000 ppm.
9. A product including the composition of claim 1.
PCT/US2001/011995 2000-05-17 2001-04-12 Biocidal composition which is an aqueous solution of hydroxymethylaminoacetate WO2001087820A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01924982.0A EP1282593B1 (en) 2000-05-17 2001-04-12 Biocidal composition which is an aqueous solution of hydroxymethylaminoacetate
AU2001251586A AU2001251586A1 (en) 2000-05-17 2001-04-12 Biocidal composition which is an aqueous solution of hydroxymethylaminoacetate
CA002409052A CA2409052A1 (en) 2000-05-17 2001-04-12 Biocidal composition which is an aqueous solution of hydroxymethylaminoacetate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/572,517 2000-05-17
US09/572,517 US6340707B1 (en) 2000-05-17 2000-05-17 High purity, clear, light stable, formaldehyde-free preservative compositions containing a compound formed by the reaction of excess glycine and formaldehyde at low temperatures

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EP (1) EP1282593B1 (en)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI642810B (en) * 2016-06-07 2018-12-01 美商卡博特微電子公司 Chemical-mechanical processing slurry and methods for processing a nickel substrate surface

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113956171B (en) * 2021-11-10 2023-12-15 广东派特埃尔生物科技有限公司 Continuous flow synthesis process of N-hydroxymethyl sodium glycine

Citations (2)

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Publication number Priority date Publication date Assignee Title
US4337269A (en) * 1979-07-23 1982-06-29 Sutton Laboratories, Inc. Preservative compositions
WO2000069423A1 (en) * 1999-05-19 2000-11-23 The Procter & Gamble Company Inverse phase emulsions having a preservative system with low evaporative water loss

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4337269A (en) * 1979-07-23 1982-06-29 Sutton Laboratories, Inc. Preservative compositions
WO2000069423A1 (en) * 1999-05-19 2000-11-23 The Procter & Gamble Company Inverse phase emulsions having a preservative system with low evaporative water loss

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS [online] 23 November 2000 (2000-11-23), BERG R.W. ET AL.: "Inverse phase emulsions having a preservative system with low evaporative water loss", XP002943291, Database accession no. 2000:824094 *
DATABASE CAPLUS 1997, AIXI H. ET AL.: "Determination of sodium hydroxymethyl aminoacetate as preservative", XP002943292 *
RIYONG HUAXUE GONGYE, vol. 2, no. 2, pages 44 - 45 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI642810B (en) * 2016-06-07 2018-12-01 美商卡博特微電子公司 Chemical-mechanical processing slurry and methods for processing a nickel substrate surface

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EP1282593A4 (en) 2005-01-19
AU2001251586A1 (en) 2001-11-26
CA2409052A1 (en) 2001-11-22
US6340707B1 (en) 2002-01-22
EP1282593B1 (en) 2016-06-08
EP1282593A1 (en) 2003-02-12

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