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WO2001085094A3 - Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the bbb and cerebral blood flow - Google Patents

Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the bbb and cerebral blood flow

Info

Publication number
WO2001085094A3
WO2001085094A3 PCT/IL2001/000402 IL0100402W WO2001085094A3 WO 2001085094 A3 WO2001085094 A3 WO 2001085094A3 IL 0100402 W IL0100402 W IL 0100402W WO 2001085094 A3 WO2001085094 A3 WO 2001085094A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
patient
blood
spg
flow
ganglion
Prior art date
Application number
PCT/IL2001/000402
Other languages
French (fr)
Other versions
WO2001085094A2 (en )
Inventor
Alon Shalev
Yossi Gross
Original Assignee
Brainsgate Ltd
Alon Shalev
Yossi Gross
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/40Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076Diagnosing or monitoring particular conditions of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526Head electrodes
    • A61N1/0546Nasal electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026Measuring blood flow

Abstract

Apparatus for modifying a property of a brain of a patient is provided, including one or more electrodes (7), adapted to be applied to a site selected from a group of sites consisting of: a sphenopalatine ganglion (SPG) (6) of the patient and a neural tract originating in or leading to the SPG. A control unit (8) is adapted to drive the one or more electrodes to apply a current to the site capable of inducing (a) an increase in permeability of a blood-brain barrier (BBB) of the patient, (b) a change in cerebral blood flow of the patient, and/or (c) an inhibition of parasympathetic activity of the SPG.
PCT/IL2001/000402 2000-05-08 2001-05-07 Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the bbb and cerebral blood flow WO2001085094A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US20317200 true 2000-05-08 2000-05-08
US60/203,172 2000-05-08

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
CA 2408097 CA2408097A1 (en) 2000-05-08 2001-05-07 Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the bbb and cerebral blood flow
US10258714 US7120489B2 (en) 2000-05-08 2001-05-07 Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the BBB and cerebral blood flow
JP2001581749A JP4311904B2 (en) 2000-05-08 2001-05-07 Stimulation method and apparatus of the pterygopalatine ganglion in order to improve the properties of the blood-brain barrier and cerebral blood flow
EP20010929945 EP1286621A4 (en) 2000-05-08 2001-05-07 Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the bbb and cerebral blood flow
US10294310 US7146209B2 (en) 2000-05-08 2002-11-14 Stimulation for treating eye pathologies
US10753882 US7190998B2 (en) 2000-05-08 2004-01-09 Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the BBB and cerbral blood flow
US10783113 US7117033B2 (en) 2000-05-08 2004-02-20 Stimulation for acute conditions
US10952536 US20050159790A1 (en) 2000-05-08 2004-09-27 Stimulation for treating and diagnosing conditions
US10518322 US7640062B2 (en) 2000-05-08 2005-07-08 Methods and systems for management of alzheimer's disease
US11502790 US7729759B2 (en) 2000-05-08 2006-08-12 Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the BBB and cerebral blood flow
US11656808 US7877147B2 (en) 2000-05-08 2007-01-22 Stimulation of the sphenopalatine ganglion for treating depression
US13011061 US20110184494A1 (en) 2000-05-08 2011-01-21 Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the BBB and cerebral blood

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10258714 A-371-Of-International US7120489B2 (en) 2000-05-08 2001-05-07 Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the BBB and cerebral blood flow
US10753882 Continuation US7190998B2 (en) 2000-05-08 2004-01-09 Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the BBB and cerbral blood flow
US10783113 Continuation-In-Part US7117033B2 (en) 2000-05-08 2004-02-20 Stimulation for acute conditions

Publications (2)

Publication Number Publication Date
WO2001085094A2 true WO2001085094A2 (en) 2001-11-15
WO2001085094A3 true true WO2001085094A3 (en) 2002-03-28

Family

ID=22752807

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2001/000402 WO2001085094A3 (en) 2000-05-08 2001-05-07 Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the bbb and cerebral blood flow

Country Status (6)

Country Link
US (5) US7120489B2 (en)
EP (1) EP1286621A4 (en)
JP (1) JP4311904B2 (en)
CN (1) CN1440256A (en)
CA (1) CA2408097A1 (en)
WO (1) WO2001085094A3 (en)

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US7908000B2 (en) 2004-02-20 2011-03-15 Brainsgate Ltd. Transmucosal electrical stimulation
US8958881B2 (en) 2005-08-19 2015-02-17 Brainsgate Ltd. Neuroprotective electrical stimulation
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation

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US20070142875A1 (en) 2007-06-21 application
US7877147B2 (en) 2011-01-25 grant
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US7190998B2 (en) 2007-03-13 grant
US20110184494A1 (en) 2011-07-28 application
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US7729759B2 (en) 2010-06-01 grant
US7120489B2 (en) 2006-10-10 grant
EP1286621A2 (en) 2003-03-05 application
US20040015068A1 (en) 2004-01-22 application
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