WO2001081298A2 - Cyclic carboxylic acids as integrin antagonists - Google Patents
Cyclic carboxylic acids as integrin antagonists Download PDFInfo
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- WO2001081298A2 WO2001081298A2 PCT/EP2001/004043 EP0104043W WO0181298A2 WO 2001081298 A2 WO2001081298 A2 WO 2001081298A2 EP 0104043 W EP0104043 W EP 0104043W WO 0181298 A2 WO0181298 A2 WO 0181298A2
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- HMJVASYVASMMDG-MFOYZWKCSA-N CCOC(c1cc(NOC)cc(NC(/C(/NC(OC(C)(C)C)=O)=C/C(C)C)=O)c1)=O Chemical compound CCOC(c1cc(NOC)cc(NC(/C(/NC(OC(C)(C)C)=O)=C/C(C)C)=O)c1)=O HMJVASYVASMMDG-MFOYZWKCSA-N 0.000 description 1
- GQIHFIQMGCJUNB-UHFFFAOYSA-N Cc(cc1)ccc1NC(Nc1c(C)cccc1)=O Chemical compound Cc(cc1)ccc1NC(Nc1c(C)cccc1)=O GQIHFIQMGCJUNB-UHFFFAOYSA-N 0.000 description 1
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- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- C07C271/06—Esters of carbamic acids
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- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
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- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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Definitions
- the present invention relates to compounds of formula (I),
- compositions as integrin antagonists especially as ⁇ 4 ⁇ i and/or ⁇ 4 ⁇ 7 and/or ⁇ i integrin antagonists and in particular for the production of pharmaceutical compositions suitable for the inhibition or the pre- vention of cell adhesion and cell-adhesion mediated disorders.
- integrin antagonists especially as ⁇ 4 ⁇ i and/or ⁇ 4 ⁇ 7 and/or ⁇ i integrin antagonists and in particular for the production of pharmaceutical compositions suitable for the inhibition or the pre- vention of cell adhesion and cell-adhesion mediated disorders.
- COPD chronic obstructive pulmonary disease
- allergies diabetes
- inflammatory bowel disease multiple sclerosis
- myocardial ischemia myocardial ischemia
- rheumatoid arthritis transplant rejection and other inflammatory, autoimmune and immune disorders.
- Leukocyte recruitment to sites of inflammation occurs in a stepwise fashion begin- ning with leukocyte tethering to the endothelial cells lining the blood vessels. This is followed by leukocyte rolling, activation, firm adhesion, and transmigration.
- a number of cell adhesion molecules involved in those four recruitment steps have been identified and characterized to date. Among them, the interaction between vascular cell adhesion molecule 1 (NCAM-1) and very late antigen 4 (NLA-4, ⁇ 4 ⁇ integrin), as well as the interaction between mucosal addressin cell adhesion molecule 1
- NCAM-1 is a member of immunoglobulin (Ig) superfamily and is one of the key regulators of leukocyte trafficking to sites of inflammation.
- Ig immunoglobulin
- NCAM-1 along with intracellular adhesion molecule 1 (ICAM-1) and E-selectin, is expressed on inflamed endothelium activated by such cytokines as interleukin 1 (IL-1) and tumor necrosis factor ⁇ (T ⁇ F- ⁇ ), as well as by lipopolysaccharide (LPS), via nuclear factor KB ( ⁇ F- KB) dependent pathway.
- IL-1 interleukin 1
- T ⁇ F- ⁇ tumor necrosis factor ⁇
- LPS lipopolysaccharide
- ⁇ F- KB nuclear factor KB
- NCAM-1 may be involved in numerous physiological and pathological processes including myogenesis, hematopoiesis, inflammatory reactions, and the development of autoimmune disorders. Integrins NLA- 4 and ⁇ 4 ⁇ 7 both function as leukocyte receptors for NCAM-1.
- the integrin ⁇ 4 ⁇ t is a heterodimeric protein expressed in substantial levels on all circulating leukocytes except mature neutrophils. It regulates cell migration into tis- sues during inflammatory responses and normal lymphocyte trafficking.
- NLA-4 binds to different primary sequence determinants, such as a QTDSP motif of VCAM- 1 and an ILDNP sequence of the major cell type-specific adhesion site of the alternatively spliced type III connecting segment domain (CS-1) of fibronectin.
- the compounds of the present invention may also be used as ⁇ 4 ⁇ 7 or integrin antagonists.
- An object of the present invention is to provide new, alternative, aminobenzoic acids or aminocycloalkylcarboxylic acids or homologues thereof or heterocyclic analogues thereof derived integrin antagonists for the treatment of inflammatory, autoimmune and immune diseases.
- the present invention therefore relates to compounds of the general formula (I):
- R 1 represents a 4- to 9-membered saturated, unsaturated or aromatic cyclic residue
- cyclic residue R 1 can be annulated with a 4- to 8-mem- bered saturated, unsaturated or aromatic cyclic residue, which can contain 0 to 2 heteroatoms selected independently from the group N, S and O, and wherein the cyclic residue R 1 and/or a ring annulated to the cyclic residue R 1 is substituted by 1 to 2 substituents -R ⁇ R ⁇ -R ⁇ -Z, wherein
- R 1"1 represents a bond, -O-, -S-, NR 1"4 , Ci-Cio alkyl, C 2 -C 10 alkenyl, C 2 -C 1 o alkynyl, C 6 or Cio aryl, C -C 7 cycloalkyl or a 4-9-membered saturated or unsaturated heterocyclic residue containing up to 3 heteroatoms selected from the group oxygen, nitrogen or sulfur,
- R 1"1 can optionally be substituted by 1 to 2 substituents selected from the group R 1"5 ,
- R 1"5 represents hydrogen, Ci-do alkyl, C 2 -do alkenyl, C 2 -do alkynyl, C 6 or do aryl, C 3 -C cycloalkyl or a 4-9-membered saturated or unsaturated heterocyclic residue containing up to 3 heteroatoms selected from the group oxygen, nitrogen or sulfur,
- R 1"5 can optionally be substituted by 1 to 3 substituents se- lected from the group d-C 4 alkyl, d-C 4 alkyloxy, phenyl, C 3 -C 6 cycloalkyl, halogen, nitro, cyano, oxo,
- R 1"2 represents a bond, -O-, -S-, NR 1"4 , d-C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl,
- R 1"2 can optionally be substituted by d-do alkyl, C 2 -do alkenyl, C 2 - C 10 alkynyl or R 1"6 ,
- R 1"6 represents hydrogen, d-do alkyl, C 2 -do alkenyl, C 2 -C 10 alkynyl, C 6 or C 10 aryl, C -C 7 cycloalkyl or a 4-9-membered saturated or unsaturated heterocyclic residue containing up to 3 heteroatoms selected from the group oxygen, nitrogen or sulfur,
- R 1"6 can optionally be substituted by 1 to 3 substituents se- lected from the group d-C 4 alkyl, C ⁇ -C alkyloxy, phenyl, C 3 -C 6 cycloalkyl, halogen, nitro, cyano, oxo,
- R 1"4 can optionally be hydrogen, d-do alkyl, C2-C10 alkenyl or C 2 -C 10 alkynyl,
- R 1"3 represents a bond, d-do alkyl, C 2 -do alkenyl, C 2 -C ⁇ o alkynyl,
- R 1"3 can optionally be substituted by C ⁇ -C 10 alkyl, C 2 -do alkenyl, C 2 -do alkynyl or R 1- " 7 ,
- R 1"7 represents hydrogen, d-do alkyl, C 2 -do alkenyl, C 2 -do alkynyl, C 6 or do aryl, C -C 7 cycloalkyl or a 4-9-membered saturated or unsaturated heterocyclic residue containing up to 3 heteroatoms selected from the group oxygen, nitrogen or sulfur,
- R 1"7 can optionally be substituted by 1 to 3 substituents selected from the group d-C alkyl, d-C 4 alkyloxy, phenyl, C -C 6 cycloalkyl, halogen, nitro, cyano, oxo,
- R 1"3 is a bond
- R 1"2 is not a heteroatom
- Z represents -C ⁇ OR 2"1 , -C(O)NR z"2 R z"3 , -SO 2 NR z"2 R z"3 , -SO(OR z"1 ), -SO 2 (OR z"1 ), -P(O)R z"1 (OR z"3 ), -PO(OR z"1 )(OR z"3 ) or 5-tetrazolyl,
- R z"2 is hydrogen, C1-C4 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, C 6 or C 10 aryl, -C(O)R z"4 or-SO 2 R z_4 ,
- R 2"4 is C1-C4 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, C 6 or do aryl,
- R z"4 can optionally be substituted by 1 to 3 substituents selected from the group halogen, nitro, cyano, oxo,
- R z_1 and R z"3 are identical or different and represent hydrogen, C 1 -C 4 alkyl,
- R Z_I and R z"3 can optionally be substituted by 1 to 3 substitu- ents selected from the group d-C 4 alkyl, d-C alkyloxy, halogen, nitro, cyano,
- R can optionally be substituted by 0 to 2 substituents R " , halogen, nitro, amino, cyano and oxo,
- R " can independently be selected from the group of C 1 -C 4 alkyl, Cj-C 4 alkyloxy, phenyl, phenoxy, phenylamino, C 3 -C 6 cycloalkyl, and R 2 represents hydrogen, d-do alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, C 6 or do aryl, C 3 -C 7 cycloalkyl or a 4-9-membered saturated or unsaturated heterocyclic residue containing up to 2 heteroatoms selected from the group oxygen, nitrogen or sulfur,
- R 2"1 represents CM alkyl, trifluormethyl, trifluormethoxy, -OR 2"2 , -SR 2"2 , NR 2"3 R 2"4 , -C(O)R 2"2 , S(O)R 2"2 , -SO 2 R 2"2 , -CO 2 R 2"2 , -OC(O)R 2"2 , -C(O)NR 2"3 R 2"4 , -NR 2"2 C(O)R 2"3 , -SO 2 NR 2"3 R 2"4 , NR 2"2 SO 2 R 2"3 , -NR 2""
- R " represents hydrogen, C 1 -C 4 alkyl, C 3 - C 6 cycloalkyl, C 6 or o aryl
- R " and R " are identical or different and represent hydrogen, d-C 4 alkyl, C 3 -C 6 cycloalkyl, C 6 or do aryl,
- R 2"3 and R 2"4 together form a 4-7-membered ring, which includes the nitrogen atom to which R 2"3 and R 2"4 are bonded and which contains up to 2 additional heteroatoms selected from the group oxygen, nitrogen or sulfur and which contains up to 2 double bonds,
- R 2 represents alkyl, R 2 together with the cyclic residue R 1 and D can form a ring
- R 3 represents hydrogen, d-Cio alkyl, C -C 1 o alkenyl, C 2 -C 1 o alkynyl, C 6 or do aryl, C 3 -C 7 cycloalkyl or a 4-9-membered saturated or unsaturated heterocyclic residue containing up to 2 heteroatoms selected from the group oxygen, nitrogen or sulfur,
- R 3 can optionally be substituted by 1 to 3 radicals R 3"1 ,
- R 3 can furthermore be single-foldedly substituted by C 3 -C 7 cycloalkyl, C 6 or do .
- R 3"1 represents d-C 4 alkyl, trifluormethyl, trifluormethoxy, -OR 3"2 , -SR 3"2 , NR 3"3 R 3'4 , -C(O)R 3"2 , S(O)R 3"2 , -SO 2 R 3"2 , -OC(O)R 3"2 , ⁇ -NRr>3 J - " 2 / C(OY)RD3'- " 3- 5 , - ⁇ NNRR 3J""2 CC((OO))NNRR 3J"""3J RR 3J""4 , --NNRE J"z C(O)OR J J , -OC(O)NR 3"3 R 3"4 , -CO 2 R 3"5 , halogen, cyano, nitro or oxo,
- R 3"2 represents hydrogen, d-C 4 alkyl, C 3 -C 6 cycloalkyl, C 6 or C 10 aryl
- R 3"3 and R 3"4 are identical or different and represent hydrogen, C1-C 4 alkyl, C 3 -C 6 cycloalkyl, C 6 or do aryl, benzyl or 9-fluorenylmethyl,
- R 3"3 and R 3"4 together form a 4-7-membered ring, which includes the nitrogen atom to which R 3"3 and R 3"4 are bonded and which contains up to 2 additional heteroatoms selected from the group oxygen, nitrogen or sulfur and which contains up to 2 double bonds,
- R 3"5 represents d-C 4 alkyl, C -C 6 cycloalkyl, C or C 10 aryl
- R 4 represents hydrogen, d-do alkyl, C -do alkenyl, C -do alkynyl, C 6 or Cio aryl, C 3 -C 7 cycloalkyl or a 4-9-membered saturated or unsaturated heterocyclic residue containing up to 2 heteroatoms selected from the group oxygen, nitrogen or sulfur,
- R 4"1 represents d - C 4 alkyl, trifluormethyl, trifluormethoxy, -OR 4"2 , -SR 4"2 , NR 4"3 R 4"4 , -C(O)R 4"2 , S(O)R 4"2 , -SO 2 R 4"2 , -OC(O)R 4"2 , -C(O)NR 4"3 R 4"4 , -NR 4"2 C(O)R 4"3 , -SO 2 NR 4"3 R 4"4 , NR 4"2 SO 2 R 4"3 , -NR 4"2 C(O)NR 4"3 R 4"4 , -NR 4"2 C(O)OR 4"3 , -OC ⁇ NR ⁇ R 4"4 , -CO 2 R 4"5 , halogen, cyano, nitro or oxo,
- R 4"2 represents hydrogen, Ci - C 4 alkyl, C 3 - C 6 cycloalkyl, C 6 or do aryl which can optionally be substituted by 1 substituent selected from the group C 1 -C 4 alkyl, C 1 -C 4 alkyloxy, phenyl, C 3 -C 6 cycloalkyl, halogen, nitro, cyano,
- R 4"3 and R 4"4 are identical or different and represent hydrogen, CM alkyl, C 3 -C 6 cycloalkyl, C 6 or do aryl,
- R 4"3 and R 4"4 together form a 4-7-membered ring, which includes the nitrogen atom to which R 4"3 and R 4"4 are bonded and which contains up to 2 additional heteroatoms selected from the group oxygen, nitrogen or sulfur and which contains up to 2 double bonds,
- R 4"5 represents d - C 4 alkyl, C - C 6 cycloalkyl, C 6 or do aryl
- R 5 represents hydrogen, d-do alkyl, C 2 -do alkenyl, C 2 -C 1 o alkynyl, C 6 or do aryl, C 3 -C- 7 cycloalkyl or a 4-9-membered saturated or unsaturated heterocyclic residue containing up to 2 heteroatoms selected from the group oxygen, nitrogen or sulfur,
- C 3 -C cycloalkyl C 6 or do aryl, C 4 -C 9 heteroaryl or a heterocyclic residue containing up to 2 heteroatoms selected from the group oxygen, nitrogen or sulfur,
- R 5"1 represents C 1 -C 4 alkyl, trifluormethyl, trifluormethoxy, -OR 5"2 , -SR 5"2 , NR 5"3 R 5'4 , -C(O)R 5"2 , S(O)R 5"2 , -SO 2 R 5"2 , -CO 2 R 5"2 , -OC(O)R 5"2 ,
- R 5"2 represents hydrogen, C ⁇ -C 4 alkyl, C 3 -C 6 cycloalkyl, C 6 or do aryl
- R 5"3 and R 5"4 are identical or different and represent hydrogen
- R 5"3 and R 5"4 together form a 4-7-membered ring, which includes the nitrogen atom to which R 5"3 and R 5"4 are bonded and which contains up to 2 additional heteroatoms selected from the group oxygen, nitrogen or sulfur and which contains up to 2 double bonds,
- R 6 represents phenyl or a 5- to 6-membered aromatic heterocyclic residue containing up to 3 heteroatoms independently selected from the group oxygen, nitrogen or sulfur,
- R 6"1 represents C ⁇ -C alkyl, trifluormefhyl, trifluormethoxy, -OR 6"4 , -SR 6"2 , NR 6"3 R 6"4 , -C(O)R 6"2 , S(O)R 6"2 , -SO 2 R 6"2 , -CO 2 R 6"2 , -OC(O)R 6"2 , -C(O)NR 6"3 R 6"4 , -NR 6"2 C(O)R 6"2 , -SO 2 NR 6"3 R 6"4 , -NR 6"2 SO 2 R 6"2 , -NR 6"2 C(O)NR 6"3 R 6"4 , -NR 6"2 C(O)OR 6"4 , -OC(O)NR 6"3 R 6"4 , halogen, cyano, nitro or oxo,
- R " represents hydrogen, d-C 4 alkyl, C 3 - C 6 cycloalkyl, C 6 or C 10 aryl
- R 6"3 and R 6"4 are identical or different and represent hydrogen, d-C 4 alkyl, C 3 -C 6 cycloalkyl, C 6 or do aryl or a 4-9-membered saturated or unsaturated heterocyclic residue containing up to 2 heteroatoms selected from the group oxygen, nitrogen or sulfur,
- R “3 and R 6"4 together form a 4-7-membered ring, which includes the nitrogen atom to which R 6"3 and R 6"4 are bonded and which contains up to 2 additional heteroatoms selected from the group oxygen, nitrogen or sulfur and which contains up to 2 double bonds, which can optionally be substituted by 1 to 2 substituents selected from the group d-C 4 alkyl, phenyl, benzyl, C 3 -C 7 cycloalkyl, d-C 4 alkyloxy, halogen, nitro, cyano, oxo,
- R 1 represents a 3-amino benzoic acid derivative
- R 6"1 represents -OR 6"4 , -C(O)NR 6"3 R 6"4 or -NR 6"2 C(O)R 6"4
- R 6"4 represents C 6 or do aryl or a 4-9-membered saturated or unsaturated heterocyclic residue containing up to 2 heteroatoms selected from the group oxygen, nitrogen or sulfur
- R 6 " 3 and R 6 " 4 can optionally be substituted by 1 to 2 substituents selected from the group d-C 4 alkyl, phenyl, C 3 -C 7 cycloalkyl, d-C 4 alkyloxy, halogen, nitro, cyano,
- R 3 and R 4 or R 4 and R 5 together form a 4-7-membered saturated or unsaturated ring containing up to 2 heteroatoms selected from the group oxygen, nitrogen or sulfur, which can optionally be substituted by 1 to
- substituents selected from the group d-C 4 alkyl, phenyl, benzyl, C 3 -C 7 cycloalkyl, d-C 4 alkyloxy, halogen, nitro, cyano, oxo and which can be fused with a 3-7 membered homocyclic or heterocyclic, saturated, unsaturated or aromatic ring,
- ring systems can optionally be substituted by d-C 4 alkyl, d-C 4 alkoxy, halogen, nitro, amino, cyano,
- X represents -CR X"] R X"2 -
- R x_1 and R x"2 can be independently selected from the group hydrogen, C1-C4 alkyl, C 2 - C 4 alkenyl, C2-C4 alkynyl,
- R together with R form a 4-7-membered ring, which can contain up to 2 heteroatoms independently selected from the group oxygen, nitrogen or sulfur and containing up to 2 double bonds, which can optionally be substituted by 1 to 2 substituents selected from the group C1-C4 alkyl, phenyl, benzyl, C3-C7 cycloalkyl, d-C 4 alkyloxy, halogen, nitro, cyano, oxo, Y represents bond, -C(O)-, -S(O)-, -SO 2 -, -O-, -S-, -CR ⁇ R ⁇ 2 -, or
- R ⁇ _1 , R ⁇ "2 , R ⁇ "3 can be independently selected from the group bond, hydrogen, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl,
- D represents N or CR 0"1 ,
- R 0"1 can be independently selected from the group bond, hydrogen, C1-C4 alkyl, C -C 4 alkenyl, C 2 -C 4 alkynyl,
- R 0"1 can optionally be substituted by 1 to 2 substituents independently selected from the group C1-C4 alkyl, phenyl, benzyl, C3-C7 cycloalkyl, Ci -C4 alkyloxy, halogen, nitro, cyano, oxo,
- the present invention relates to compounds of general formula (I), wherein
- R 1 represents a 4- to 6-membered saturated, unsaturated or aromatic cyclic residue
- cyclic residue R 1 can be annulated with a 5- to 6-membered saturated, unsaturated or aromatic cyclic residue, which can contain 0 to 2 heteroatoms selected independently from the group N, S and O,
- R 1"1 represents a bond, d-C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or C 6 aryl,
- R 1"1 can optionally be substituted by 1 substituent selected from the group R 1"5 , wherein R 1"5 represents hydrogen, d-C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 7 cycloalkyl or C 6 aryl,
- R 1"2 represents a bond, d-C 6 alkyl, C -C 6 alkenyl, C 2 -C 6 alkynyl
- R 1"3 represents a bond, d-C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl represents -C(O)OR z"1 , -C(O)NR z"2 R z"3 or 5-tetrazolyl,
- R 2"1 , R z"2 and R z"3 are identical or different and represent hydrogen, d-C 4 alkyl, C -C 6 alkenyl, C -C 6 alkynyl or benzyl,
- the cyclic residue R 1 and or a ring annulated to the cyclic residue formed by R 1 can optionally be substituted by 0 to 2 substituents R 1"8 , halogen, nitro, amino, cyano and oxo,
- R 1"8 can independently be selected from the group of d-C 4 alkyl, C 1 -C 4 alkyloxy, phenyl, phenoxy, phenylamino,
- R represents hydrogen, d-C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 6 aryl, C 5 -C 6 cycloalkyl,
- R 2 if R 2 is alkyl, R 2 together with the cyclic residue R 1 and D can form a 5- to 6-membered ring,
- R represents hydrogen, d-C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 6 aryl, C 5 -C 6 cycloalkyl or a 5 -6-membered saturated or unsaturated heterocyclic residue containing up to 2 heteroatoms selected from the group oxygen, nitrogen or sulfur,
- R 3"1 which can optionally be substituted by 1 radical R 3"1 , and wherein R 3 can furthermore be single-foldedly substituted by C 3 -C cycloalkyl, C 6 aryl, C 4 -C 9 heteroaryl or a heterocyclic residue containing up to 2 heteroatoms selected from the group oxygen, nitrogen or sulfur, which can be annulated with a phenyl ring, wherein R 3"1 represents trifluormethyl, trifluormethoxy, -OR 3"2 , -SR 3"2 , NR 3"3 R 3"4 , -NR 3"2 C(O)OR 3"3 , -CO 2 R 3"5 , halogen, cyano, nitro or oxo,
- R " represents hydrogen or d-C 4 alkyl
- R 3"3 and R 3"4 are identical or different and represent hydrogen, d-C 4 alkyl or benzyl or 9-fluorenylmethyl,
- R 3"5 represents d -C 4 alkyl
- R 4 represents hydrogen, d-C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 or C 6 aryl,
- R 5 represents hydrogen, C]-C 6 alkyl, C -C 6 alkenyl, C -C 6 alkynyl or C 6 aryl,
- R " represents trifluormethyl, t ⁇ fluormethoxy, -OR “ , -SR “ , NR 5"3 R 5"4 , halogen, cyano, nitro or oxo,
- R 5"2 , R 5"3 and R 5"4 are identical or different and represent hydrogen or d-C 4 alkyl
- R 6 represents phenyl or a 5- to 6-membered aromatic heterocyclic residue containing up to 3 heteroatoms independently selected from the group oxygen, nitrogen or sulfur,
- R 6"1 represents -NR 6"2 C(O)NR 6"3 R 6"4 , wherein R 6"2 and R 6"3 are identical or different and represent hydrogen or d-C 4 alkyl,
- R 6"4 represents C 6 aryl
- R 3 and R 4 or R 4 and R 5 together form a 5-6-membered saturated or unsaturated ring containing up to 2 nitrogen atoms,
- A represents -C(O)-, -SO-, -SO 2 -,
- X represents -CR X_1 R X"2 ,
- Y represents -C(O)-
- the present invention relates to compounds of general formula (I), wherein
- R 1 represents a 5- to 6-membered saturated, unsaturated or aromatic cyclic residue, which can contain 0 to 3 heteroatoms selected independently from the group N and S,
- cyclic residue R 1 can be annulated with a 5-membered unsaturated or aromatic cyclic residue, which contains 1 nitrogen atom,
- R 1"1 represents a bond or alkyl
- R 1"1 can optionally be substituted by cyclopentyl
- R 1"2 represents a bond
- R 1"3 represents a bond
- Z represents -C(O)OR z_1 or 5-tetrazolyl
- R 2"1 represents hydrogen, d-C 2 alkyl or benzyl
- R 1"8 can independently be selected from the group of d-C alkyloxy, phenoxy and phenylamino, R 2 represents hydrogen or C1-C 3 alkyl,
- R 2 if R 2 is alkyl, R 2 together with the cyclic residue R 1 and D can form a piperidine ring,
- R represents hydrogen or d-C 4 alkyl
- R 3"1 represents NR 3"3 R 3"4 or -NR 3"2 C(O)OR 3"3 ,
- R 3"2 and R 3"4 represent hydrogen
- R 3"3 represents hydrogen, benzyl or 9-fluorenylmethyl
- R 4 represents hydrogen
- R 5 represents hydrogen or C 3 alkyl
- R 5"1 represents -OR 5"2 ,
- R 5"2 represents Ci alkyl
- R 6 represents phenyl
- R 6"1 represents -NR 6"2 C(O)NR 6"3 R 6"4 ,
- R 6"2 represents hydrogen
- R 6"4 represents C 6 aryl
- A represents -C(O)-
- X represents -CR ⁇ R ⁇ 2 -
- R x_1 and R x"2 represent hydrogen
- Y represents -C(O)-
- the present invention relates to compounds of gen- eral formula (I), wherein
- R 1 represents phenyl
- R 1" represents a bond or C ⁇ alkyl
- R , 1- " 2 represents a bond
- R 1"3 represents a bond
- the present invention relates to compounds of general formula (I), wherein
- R z_1 represents hydrogen, d-C alkyl or benzyl
- R 2 represents hydrogen
- R 3 represents hydrogen, d-C 6 alkyl, C -C 6 alkenyl, C 2 -C 6 alkynyl, C 6 aryl, C 5 -C 6 cycloalkyl or a 5-6-membered saturated or unsaturated heterocyclic residue containing up to 2 heteroatoms selected from the group oxygen, nitrogen or sulfur,
- R 3 can furthermore be single-foldedly substituted by C 3 -C 7 cycloalkyl, C 6 aryl, C 4 -C 9 heteroaryl or a heterocyclic residue containing up to 2 heteroatoms selected from the group oxygen, nitrogen or sulfur, which can be annulated with a phenyl ring, wherein R 3"1 represents trifluormethyl, trifluormethoxy, -OR 3"2 , -SR 3"2 , -NR 3"3 R 3"4 , -NR 3"2 C(O)OR 3"3 , -CO 2 R 3"5 , halogen, cyano, nitro or oxo,
- R 3"2 represents hydrogen or d-C 4 alkyl
- R 3"3 and R 3"4 are identical or different and represent hydrogen, d-C 4 alkyl or benzyl or 9-fluorenylmethyl,
- R ,3- " 5 represents C 1 -C 4 alkyl
- R 4 represents hydrogen
- R represents hydrogen
- R 6 represents phenyl
- R 6"1 represents -NR 6"2 C(O)NR 6"3 R 6"4 ,
- R represents hydrogen
- R 6"4 represents C 6 aryl
- R 3 and R 4 or R 4 and R 5 together form a 5-6-membered saturated or a un- saturated ring containing up to 2 nitrogen atoms,
- A represents -C(O)-,
- X represents -CR X"! R X"2 -
- R x_1 and R x"2 represent hydrogen
- Y represents -C(O)-
- the present invention relates to compounds of general formula (I),
- R 1 represents phenyl
- wliich is 1,4-substituted by a substituent -R ⁇ -R 1"2 -R 1 3 -Z,
- R 1"1 , R 1"2 and R 1"3 represent bonds.
- the present invention relates to compounds of general formula (I), wherein
- R 1 represents phenyl, which is 1,3-substituted by a substituent -R ⁇ -R 1"2 ⁇ 1"3 ⁇ ,
- R 1"1 represents -CH 2 -
- R 1"2 and R 1"3 represent bonds.
- the present invention relates to compounds of general formula (I), wherein
- R 1 represents a 5-membered heterocycle.
- the present invention relates to compounds of general formula (I), wherein
- R 1 represents a cyclohexyl ring.
- the present invention relates to compounds of general formula (I),
- alkyl stands for a straight-chain or branched alkyl residue, such as methyl, ethyl, n-propyl, iso-propyl, n-pentyl. If not stated otherwise, preferred is d-Cio alkyl, very preferred is d-C 6 alkyl.
- Alkenyl and alkinyl stand for straight-chain or branched residues containing one or more double or triple bonds, e.g. vinyl, allyl, isopropinyl, ethinyl. If not stated otherwise, preferred is d-do alkenyl or alkinyl, very preferred is d-C 6 alkenyl or alkinyl.
- Cycloalkyl stands for a cyclic alkyl group such as cyclopropyl, cyclobutyl, cyclo- pentyl, cyclohexyl or cycloheptyl. Preferred is C 3 -C 7 cycloalkyl.
- Halogen in the context of the present invention stands for fluorine, chlorine, bromine or iodine. If not specified otherwise, chlorine or fluorine are preferred.
- Heteroaryl stands for a monocyclic heteroaromatic system containing 4 to 9 ring atoms, which can be attached via a carbon atom or eventually via a nitrogen atom within the ring, for example, furan-2-yl, furan-3-yl, pyrrol- 1-yl, pyrrol-2-yl, pyrrol-3- yl, thienyl, thiazolyl, oxazolyl, imidazolyl, triazolyl, tetrazolyl, pyridyl, pyrimidyl or pyridazinyl.
- C 4 -C 9 heteroaryl also stands for a 4 to 9-membered ring, wherein one or more of the carbon atoms are replaced by heteroatoms.
- a saturated or unsaturated heterocyclic residue stands for a heterocyclic system con- taining 4 to 9 ring atoms, which can contain one or more double bonds and which can be attached via a ring carbon atom or eventually via a nitrogen atom, e.g. tetra- hydrofur-2-yl, pyrrolidine-1-yl, piperidine-1-yl, piperidine-2-yl, , piperidine-3-yl, piperidine-4-yl, piperazine-1-yl, piperazine-2-yl morpholine-1-yl, 1,4-diazepine-l-yl or 1,4-dihydropyridine-l-yl.
- heteroatom stands preferably for O, S, N or P.
- Annulated describes 1,1- or 1,2-fused ring systems, e.g. spiro systems or systems with a [0]-bridge. If not stated otherwise, substituents described for the "parent" ring system (the ring to which the annulated ring is attached) can be also present on the annulated ring.
- Derivative stands for a compound that is derived from the parent compound by ex- change of one or more hydrogen atoms by other functional groups.
- the compounds of the present invention show good integrin antagonistic activity. They are therefore suitable especially as ⁇ 4 ⁇ t and/or ⁇ 4 ⁇ and/or a$ ⁇ integrin antagonists and in particular for the production of pharmaceutical compositions for the inhibition or the prevention of cell adhesion and cell-adhesion mediated disorders.
- Examples are the treatment and the prophylaxis of atherosclerosis, asthma, chronic obstructive pulmonary disease (COPD), allergies, diabetes, inflammatory bowel disease, multiple sclerosis, myocardial ischemia, rheumatoid arthritis, transplant rejection and other inflammatory, autoimmune and immune disorders.
- COPD chronic obstructive pulmonary disease
- integrin antagonists of the invention are useful not only for treatment of the physiological conditions discussed above, but are also useful in such activities as purification of integrins and testing for activity.
- the compounds according to the invention can exhibit non-systemic or systemic activity, wherein the latter is preferred.
- the active compounds can be administered, among other things, orally or parenterally, wherein oral administration is preferred.
- parenteral administration forms of administration to the mucous membranes (i.e. buccal, lingual, sublingual, rectal, nasal, pulmonary, conjunctival or intravaginal) or into the interior of the body are particularly suitable.
- Administration can be carried out by avoiding absorption (i.e. intracardiac, intra-arterial, intravenous, intraspinal or intralumbar administration) or by including absorption (i.e. intracutaneous, subcutaneous, percutaneous, intramuscular or intraperitoneal admimstration).
- the active compounds can be administered per se or in administration forms.
- Suitable administration forms for oral administration are, inter alia, normal and en- teric-coated tablets, capsules, coated tablets, pills, granules, pellets, powders, solid and liquid aerosols, syrups, emulsions, suspensions and solutions.
- Suitable administration forms for parenteral administration are injection and infusion solutions.
- the active compound can be present in the administration forms in concentrations of from 0.001 - 100 % by weight; preferably the concentration of the active compound should be 0.5 - 90% by weight, i.e. quantities wliich are sufficient to allow the specified range of dosage.
- the active compounds can be converted in the known manner into the abovemen- tioned admimstration forms using inert non-toxic pharmaceutically suitable auxiliaries, such as for example excipients, solvents, vehicles, emulsifiers and/or disper- sants.
- auxiliaries can be mentioned as examples: water, solid excipients such as ground natural or synthetic minerals (e.g. talcum or silicates), sugar (e.g. lactose), non-toxic organic solvents such as paraffins, vegetable oils (e.g. sesame oil), alcohols (e.g. ethanol, glycerol), glycols (e.g. polyethylene glycol), emulsifying agents, dis- persants (e.g. polyvinylpyrrolidone) and lubricants (e.g. magnesium sulphate).
- ground natural or synthetic minerals e.g. talcum or silicates
- sugar e.g. lactose
- non-toxic organic solvents such as paraffins, vegetable oils (e.g. sesame oil), alcohols (e.g. ethanol, glycerol), glycols (e.g. polyethylene glycol), emulsifying agents, dis- persants (e.g. polyvinylpyrrolidon
- oral admimstration tablets can of course also contain additives such as sodium citrate as well as additives such as starch, gelatin and the like.
- Flavour enhancers or colorants can also be added to aqueous preparations for oral admimstration.
- Suitable pharmaceutically acceptable salts of the compounds of the present invention that contain an acidic moiety include addition salts formed with organic or inorganic bases.
- the salt forming ion derived from such bases can be metal ions, e.g., aluminum, alkali metal ions, such as sodium of potassium, alkaline earth metal ions such as calcium or magnesium, or an amine salt ion, of which a number are known for this purpose.
- Examples include ammonium salts, arylalkylamines such as dibenzylamine and N,N-dibenzylethylenediamine, lower alkylamines such as methylamine, t- butylamine, procaine, lower alkylpiperidines such as N-ethylpiperidine, cycloalkyl- amines such as cyclohexylamine or dicyclohexylamine, 1-adamantylamine, benza- thine, or salts derived from amino acids like arginine, lysine or the like.
- the physiologically acceptable salts such as the sodium or potassium salts and the amino acid salts can be used medicinally as described above and are preferred.
- Suitable pharmaceutically acceptable salts of the compounds of the present invention that contain a basic moiety include addition salts formed with organic or inorganic acids.
- the salt forming ion derived from such acids can be halide ions or ions of natural or unnatural carboxylic or sulfonic acids, of wliich a number are known for this purpose. Examples include chlorides, acetates, trifluoroacetates, tartrates, or salts derived from amino acids like glycine or the like.
- the physiologically acceptable salts such as the chloride salts, the trifluoroacetic acid salts and the amino acid salts can be used medicinally as described below and are preferred.
- salts which are not necessarily physiologically acceptable are useful in isolating or purifying a product acceptable for the purposes described below.
- the salts are produced by reacting the acid form of the invention compound with an equivalent of the base supplying the desired basic ion or the basic form of the invention compound with an equivalent of the acid supplying the desired acid ion in a medium in which the salt precipitates or in aqueous medium and then lyophilizing.
- the free acid or basic form of the invention compounds can be obtained from the salt by conventional neutralization techniques, e.g., with potassium bisulfate, hydrochloric acid, sodium hydroxide, sodium bicarbonate, etc.
- the compounds according to the invention can form non covalent addition compounds such as adducts or inclusion compounds like hydrates or clafhrates. This is known to the artisan and such compounds are also object of the present invention.
- the compounds according to the invention can exist in different stereoisomeric forms, which relate to each other in an enantiomeric way (image and mirror image) or in a diastereomeric way (image different from mirror image).
- the invention relates to the enantiomers and the diastereomers as well as their mixtures. They can be separated according to customary methods.
- the compounds according to the invention can exist in tautomeric forms. This is known to the artisan and such compounds are also object of the present invention.
- DCC dicyclohexyl- carbodiimid
- EDCI l-ethyl-3-(3'-dimethylaminopropyl)carbodiimidexHCl
- PG 1 stands for a suitable protecting group of the amino group that is stable under the respective reaction conditions.
- Protecting groups of this type are known to the person skilled in the art and are described in detail in T. W. Greene, P. G. Wuts, Protective Groups in Organic Synthesis, 3 rd ed., John Wiley, New York, 1999.
- the amino group is preferably protected by carbamates, PG 1 being for example tert-butyloxycarbonyl (Boc), 9-fluorenylmefhyloxycarbonyl (FMOC) or benzyloxycarbonyl (Cbz- / Z-) or other oxycarbonyl derivatives.
- PG 2 stands for a suitable protecting group of the carboxyl group or COOPG stands for the carboxylic group attached to a polymeric resin suitable for solid phase synthesis.
- Protecting groups of this type are known to the person skilled in the art and are described in detail in T. W. Greene, P. G. Wuts, Protective Groups in Organic Synthesis, 3 rd ed., John Wiley, New York, 1999.
- the carboxyl group is preferably esterified, PG 2 being d- 6 -alkyl such as, for example, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, t-butyl, pentyl, isopentyl, neopentyl, hexyl, a C 3 - 7 - cycloalkyl such as, for example, cyclopropyl, cyclopropylmethyl, cyclobutyl, cyclo- pentyl, cyclohexyl, an aryl such as, for example, phenyl, benzyl, tolyl or a substituted derivative thereof.
- PG 2 being d- 6 -alkyl such as, for example, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, t-butyl, pentyl, isopentyl, ne
- Formation of the amides (IN) can take place by reacting an activated form of the respective carboxylic acid (JJ), such as a ⁇ -carboxyanhydride or an t-r ⁇ -butylcarbonate with the desired amine (III) or an acceptable salt thereof.
- JJ carboxylic acid
- III t-r ⁇ -butylcarbonate
- ⁇ -carboxyanhydrides of (II) are commercially available or can be prepared for example by the reaction of the Bis-( ⁇ -tert-butyloxycarbonyl) protected derivative of (JJ) with thionylchloride and pyridine in dimethylformamide or by the reaction of the free amino acid of (II) with phosgene or with phosgene equivalents such as diphos- gene, triphosgene or methylchloroformate. /-. ⁇ -butylcarbonates can be prepared in situ by reaction of the N-protected amino acid (II) with w ⁇ -butylchloroformate as described below.
- Activated derivatives of the acids (II) such as other anhydrides, halides, esters e.g. succinyl or pentafluorophenyl esters or activated carboxylic acids obtained by the reaction with coupling agents such as, for example dicyclohexyl- carbodiimid (DCC), l-ethyl-3-(3'-dimethylaminopropyl)carbodiimidexHCl (EDCI),
- DCC dicyclohexyl- carbodiimid
- EDCI l-ethyl-3-(3'-dimethylaminopropyl)carbodiimidexHCl
- 2-(7-aza-3 -oxido- IH- 1 ,2,3-benzotriazol- 1 -yl)- 1 , 1 ,3,3-tetramethyluronium hexafluorophosphate may also be employed.
- amides of type (IN) can be prepared as follows:
- these carboxylic acid derivatives can have substituents such as described under R 3 and R 4 , for example, hydrogen, a Cj-do- alkyl, a C 3 -C 7 -cycloalkyl, an aryl, an alkenyl residue, or an alkinyl residue.
- the alkyl, alkenyl and cycloalkyl residues and the benzyl residue can be introduced by reaction of the ester of the starting compounds with the appropriate alkyl, alkenyl, cycloalkyl or benzyl halides in basic medium, if the corresponding derivatives are not commercially available.
- the alkinyl residue can be introduced, for example, by reaction of the bromo ester of the present starting compound with an appropriate acet- ylide anion.
- the starting materials used are preferably the corresponding ⁇ -phenyl- ⁇ -aminocarboxylic acid derivatives and, if necessary, the other substituents at the ⁇ -C atom to the terminal carboxyl group are introduced via the appropriate alkyl halide.
- substituents themselves should be substituted, e.g. by R', appropriate reactive groups should be present in the substituent to allow further functionalization. These reactive groups should be inert to the reaction conditions of the previous step.
- the substituent can also be unsaturated to allow further functionalization such as palladium catalyzed C-C-coupling reactions (e.g. Heck-reaction or Sonoga- shira-reaction), eventually followed by hydrogenation (scheme 2):
- PG ⁇ stands for a protecting group of the carboxyl group as described under PG ⁇
- hal stands for a leaving group such as a halogen, tosyl, mesyl or triflate
- [Pd] stands for a Palladium(O) or Palladium(II) moiety
- PG 3 stands for a protecting group of the amino group such as described under PG ⁇ . Protecting groups of this type are known to the person skilled in the art and are described in detail in T. W. Greene, P. G. Wuts, Protective Groups in Organic Synthesis, 3 rd ed., John Wiley, New York, 1999.
- the carbon chain can be elongated by Arndt-Eistert-reaction and optionally be derivatized by common methods for ⁇ - derivatization of carboxylic acids such as nucleophilic substitution.
- Y and D form an sulfinamide, or sulfonamide
- they may be prepared by reacting the respective sulfinylchlorides or sulfonylchlorides with the desired amine (III) or an acceptable salt thereof.
- O-C or S-C- bonds are formed via alkylation of the corresponding alcohols or thiols with alkylating agents such as alkyl halides, alkyl tosylates and the like.
- alkylating agents such as alkyl halides, alkyl tosylates and the like.
- the thioether can be converted into the corresponding sulfoxides or sulfones by oxidation with reagents like mCPBA or hydrogen peroxide.
- Y and D form a carbon-nitrogen-bond or a nitrogen-carbon-bond
- the bond is established by reductive animation via the corresponding aldehyde or ketone and the corresponding amine in the presence of a reducing agent such as sodium cyanoboro- hydride.
- the amine group -Y- ⁇ R 2 H can be coupled to the aromatic ring by an Buchwald reaction employing an halogen or triflate substituted aromatic residue and a suitable catalyst such as, for example Pd(0) or Pd(II) with phospine ligands such as triphenylphosphine, 2,2'-bis-(diphenylphosphino)-l,l'-bi- naphthyle (BINAP) or l, -bis-(diphenylphosphino)ferrocene (dppf) together with an appropriate base such as, for example cesium carbonate or cesium fluoride.
- a suitable catalyst such as, for example Pd(0) or Pd(II) with phospine ligands such as triphenylphosphine, 2,2'-bis-(diphenylphosphino)-l,l'-bi- naphthyle (BINAP) or l, -bis-(diphenylpho
- the bond may be established by Wittig reaction of the corresponding ketone or aldehyde and the corresponding phospho- nium ylide followed by reduction of the double bond, e.g. by catalytic hydrogenation.
- the bond may be formed by a
- the removal of protecting group PG 1 can be performed, depending on the nature of PG 1 , either by an acid such as trifluoroacetic acid (for example in the case PG 1 is tert- butyloxycarbonyl (Boc)), a base such as piperidine (for example in the case PG 1 is 9- fluorenylmethyloxycarbonyl (FMOC)) or by catalytic hydrogenation (for example in the case PG 1 is benzyloxycarbonyl (Cbz- / Z-)).
- an acid such as trifluoroacetic acid
- a base such as piperidine
- FMOC 9- fluorenylmethyloxycarbonyl
- catalytic hydrogenation for example in the case PG 1 is benzyloxycarbonyl (Cbz- / Z-)
- Formation of the amides (Nil) can take place by reacting the respective carboxylic acids (NT) - activated by a coupling agent such as DCC and HOBt; EDCI and HOBt or HATU - with the desired amines (V) or an acceptable salt thereof.
- a coupling agent such as DCC and HOBt; EDCI and HOBt or HATU - with the desired amines (V) or an acceptable salt thereof.
- Activated derivatives of the acids (VI) such as anhydrides, halides, and esters e.g. succinyl or pentafluorophenyl esters may also be employed.
- amides can be prepared as follows:
- a solution of carboxylic acid, HOBt and EDCI in an inert solvent is stirred at r.t.
- a non-nucleophilic base such as ethylisopropylamine stirring is continued at r.t. or elevated temperature.
- the reaction mixture is poured into water and worked up by standard procedures.
- biphenyl substituted acetic acid derivatives can be prepared by means of an aryl-aryl coupling of the respective phenyl acetic acid derivatives and a suitable phenyl system.
- Possible coupling reactions are, for example, the reaction of two unsubstituted phenyl groups in the presence of A1C1 3 and an acid (Scholl reaction), the coupling of the two phenyl iodides in the presence of copper (Ullmann reaction), the reaction of the unsubstituted carboxylic acid derivative with a phenyldiazonium compound under basic conditions (Gomberg-Bachmann reaction) or coupling with participation of organometallic reagents such as coupling of a phenyl halide with an organometallic phenyl compound in the presence of a palladium compound, for example a Pd(0), a Pd(II) or a Pd(JN) compound, and of a phosphane such as triphenylphosphane (e.g.
- Bisarylureas can be prepared by coupling of an amino phenyl acetic acid derivative and a phenylisocyanate.
- Bisarylamides can be prepared by coupling of an amino phenyl acetic acid and an activated benzoic acid derivative such as described under Step A.
- Bisarylcarbamates can be prepared by coupling of an isocyanato phenyl acetic acid ester and a phenol derivative followed by saponification as described in Step D.
- sulfinamide sulfonamide
- they may be prepared as described under Step A.
- Oxalic amides can be prepared by the same means as the amides described above.
- Phosphinic acid amides and phosphonic acid amides can be prepared by coupling of activated phosphinic/phosphonic acids with amines (N).
- the respective compounds (IV) can be prepared by nucleophilic substitution of the respective fluorosubstituted systems with a suitable amine (N).
- the removal of the protecting group PG can be performed either by an acid such as trifluoroacetic acid or an base such as potassium hydroxide or lithium hydroxide, depending on the nature of PG .
- Reactions are earned out in aqueous, inert organic solvents such as alcohols e.g. methanol or ethanol, ethers e.g. tetrahydrofurane or dioxane or polar aprotic solvents e.g. dimethylformamide. If necessary, mixtures of the above solvents may be used.
- NLA-4 very late antigen 4 ( ⁇ 4 ⁇ ! integrin)
- VCAM-1 extracellular domains 1-3
- cDNA Complementary DNA encoding 7-domain form of VCAM-1 (GenBank accession #M60335) was obtained using Rapid-ScreenTM cDNA library panels (OriGene Technologies, fric) at Takara Gene Analysis Center (Shiga, Japan).
- the primers used were 5'-CCA AGG CAG AGT ACG CAA AC-3' (sense) and 5'-TGG CAG GTA TTA TTA AGG AG-3' (antisense).
- NCAM-1 cD ⁇ A was perform using Pfu D ⁇ A polymerase (Stratagene) with the following sets of primers: (U-VCAMdl-3) 5'-CCA TAT GGT ACC TGA TCA ATT TAA AAT CGA GAC CAC CCC AGA A-3'j (L-VCAMdl-3) 5'-CCA TAT AGC AAT CCT AGG TCC AGG GGA GAT CTC AAC AGT AAA-3'.
- PCR cycle was 94 °C for 45 sec, 55 °C for 45 sec, 72 °C for 2 min, repeating 15 cycles. After the purification of the PCR product, the fragment was digested with Kpnl-Avrll.
- the digested fragment was ligated into pBluescript IISK(-) (Strategene), which was linearized by digesting with Kpnl-Xhol. The ligation was followed by transformation to a Dam/Dcm methylase-free E. coli strain SCSI 10 (Strategene) to create the donor plasmid ⁇ HH7.
- VCAM-1 coding sequence was fused to signal peptide sequence of honeybee melittin. The resulting melittin-VCAM fusion was placed in correct orientation to the baculovirus polyhedrin promoter.
- Baculovirus transfer vector containing first 3-domain form VCAM-1 was constructed by ligation of 0.9 kb fragment from Avrll/Klenow/Bcll digests of pH7 into SallTiaenow/ ⁇ ainHI digests of pMelBacB
- Recombinant baculovirus was generated by using Bac- ⁇ -BlueTM Trans- fection kit (Invitrogen) according to the manufacture's instruction.
- the recombinant virus was amplified by infection to High-FiveTM insect cells for 5 - 6 days, and virus titer was determined by plaque assay.
- the cells were pelleted again and washed once in fresh Express FiveTM serum free medium.
- the cells were pelleted again and finally, resuspended in 200 ml of fresh Express Five TM medium, transferred to a 1,000 ml shaker flask, and incubated in a shaker at 27 °C, 130 rpm, for 48 hours before the culture supernatant was collected.
- the purification of 3-domain form of VCAM-1 from the culture supernatant was performed by one-step anion exchange chromatography. Protein concentration was determined by using Coomassie protein assay reagent
- Recombinant human VCAM-1 (extracellular domains 1-3) was dissolved at 1.0 ⁇ g/ml in PBS.
- Each well of the microtiter plates ( ⁇ alge ⁇ unc International, Fluoro- nunc Cert, 437958) was coated with 100 ⁇ l of substrate or for background control with buffer alone for 15 hours at 4 C. After discarding the substrate solution, the wells were blocked using 150 ⁇ l per well of block solution (Kirkegaard Perry Labo- ratories, 50-61-01) for 90 minutes. The plate was washed with wash buffer containing 24 mM Tris-HCl (pH 7.4), 137 mM ⁇ aCl, 27 mM KC1 and 2 mM MnCl 2 just before addition of the assay.
- Jurkat cells (American Type Culture Collection, Clone E6-1, ATCC TIB-152) were cultured in RPMI 1640 medium ( ⁇ ikken Bio Medical Laboratory, CM1101) supplemented with 10% fetal bovine serum (Hyclone, A-1119-L), 100 U/ml pemcilin (Gibco BRL, 15140-122) and 100 ⁇ g/ml streptomycin (Gibco BRL, 15140-122) in a humidified incubator at 37 °C with 5% CO 2 .
- Jurkat cells were incubated with phosphate balanced solution (PBS, Nissui, 05913) containing 25 ⁇ M of 5(-and -6)-carboxyfluorescein diacetate, succinimidyle ester (CFSE, Dojindo Laboratories, 345-06441) for 20 min at room temperature while gently swirling every 5 min. After centrifugation at 1000 rpm for 5 min, the cell pellet was resuspended with adhesion assay buffer at a cell density of 4 x 10 6 cells/ml.
- PBS phosphate balanced solution
- CFSE succinimidyle ester
- the adhesion assay buffer was composed of 24 mM Tris-HCl (pH 7.4), 137 mM NaCl, 27 mM KC1, 4 mM glucose, 0.1 % bovine serum albumin (BSA, Sigma, A9647) and 2 mM MnCl 2 .
- the assay solution containing each test compounds was transferred to the VCAM-1 coated plates.
- the final concentration of each test compounds was 5 ⁇ M, 10 ⁇ M or various concentrations ranging from 0.0001 ⁇ M to 10 ⁇ M using a standard 5-point serial dilution.
- the assay solution containing the labeled Jurkat cells was transferred to the VCAM-1 coated plates at a cell density of 2 x 10 5 cells per well and incubated for 1 hour at 37 C. The non-adherent cells were removed by washing the plates 3 times with wash buffer. The adherent cells were broken by addition of 1 % Triton X- 100 (Nacalai Tesque, 355-01). Released CFSC was quantified fluorescence measurement in a fluorometer (Wallac, ARVO 1420 multilabel counter).
- Ramos cells (American Type Culture Collection, Clone CRL-1596) were cultured in RPMI 1640 medium (Nikken Bio Medical Laboratory, CM1101) supplemented with
- Ramos cells were incubated with phosphate balanced solution (PBS, Nissui, 05913) containing 25 ⁇ M of 5(-and -6)-carboxyfluorescein diacetate, succinimidyle ester (CFSE, Dojindo Laboratories, 345-06441) for 20 min at room temperature while gently swirling every 5 min. After centrifugation at 1000 rpm for 5 min, the cell pellet was resuspended with adhesion assay buffer at a cell density of 4 x 10 6 cells/ml.
- the adhesion assay buffer was composed of 24 mM Tris-HCl (pH 7.4), 137 mM
- the assay solution containing each test compounds or 5 ⁇ g/ml anti-CD49d monoclonal antibody (Immunotech, 0764) was transferred to the VCAM-1 coated plates.
- the final concentration of each test compounds was 5 ⁇ M, 10 ⁇ M or various concentrations ranging from 0.0001 ⁇ M to 10 ⁇ M using a standard 5-point serial dilu- tion.
- the assay solution containing the labeled Ramos cells was transferred to the
- NCAM-1 coated plates at a cell density of 2 x 10 5 cells per well and incubated for 1 hour at 37 C.
- the non-adherent cells were removed by washing the plates 3 times with wash buffer.
- the adherent cells were broken by addition of 1 % Triton X-100 ( ⁇ acalai Tesque, 355-01). Released CFSC was quantified fluorescence measurement in a fluorometer (Wallac, ARNO 1420 multilabel counter).
- the adhesion of Ramos cells to NCAM-1 was analyzed by percent binding calculated by the formula:
- FTB the total fluores- cent intensity from NCAM-1 coated wells without test compound
- FBG the fluorescent intensity from wells with anti-CD49d monoclonal antibody
- FTS the fluorescent intensity from wells containing the test compound of this invention.
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Abstract
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Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
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JP2001578395A JP2003531189A (en) | 2000-04-20 | 2001-04-09 | Cyclic carboxylic acids as integrin antagonists |
US10/258,079 US20030232868A1 (en) | 2000-04-20 | 2001-04-09 | Cyclic carboxylic acids as integrin antagonists |
AU2001265866A AU2001265866A1 (en) | 2000-04-20 | 2001-04-09 | Cyclic carboxylic acids as integrin antagonists |
EP01943235A EP1276714A2 (en) | 2000-04-20 | 2001-04-09 | Cyclic carboxylic acids as integrin antagonists |
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Application Number | Priority Date | Filing Date | Title |
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DE10019755.8 | 2000-04-20 | ||
DE10019755A DE10019755A1 (en) | 2000-04-20 | 2000-04-20 | New cyclic carboxylic acids are integrin antagonists, useful for treating inflammatory diseases, autoimmune and immune disorders, e.g. atherosclerosis, asthma and diabetes |
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WO2001081298A2 true WO2001081298A2 (en) | 2001-11-01 |
WO2001081298A3 WO2001081298A3 (en) | 2002-05-02 |
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PCT/EP2001/004043 WO2001081298A2 (en) | 2000-04-20 | 2001-04-09 | Cyclic carboxylic acids as integrin antagonists |
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US (1) | US20030232868A1 (en) |
EP (1) | EP1276714A2 (en) |
JP (1) | JP2003531189A (en) |
AU (1) | AU2001265866A1 (en) |
DE (1) | DE10019755A1 (en) |
WO (1) | WO2001081298A2 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003030889A1 (en) * | 2001-10-03 | 2003-04-17 | Bayer Healthcare Ag | Para-amino benzoic acids as integrin antagonists |
US6969728B2 (en) | 2000-05-12 | 2005-11-29 | Genzyme Corporation | Modulators of TNF-α signaling |
EP1658072A1 (en) * | 2003-08-21 | 2006-05-24 | Pfizer Products Inc. | Compounds for the treatment of neurodegenerative disorders |
US7064229B2 (en) | 2001-07-06 | 2006-06-20 | Bayer Healthcare Ag | Succinic acid derivatives |
EP1781287A2 (en) * | 2004-08-13 | 2007-05-09 | Genentech, Inc. | Thiazole based inhibitors of atp-utilizing enyzmes |
US7342118B2 (en) | 2004-03-23 | 2008-03-11 | Pfizer Inc | Imidazole compounds for the treatment of neurodegenerative disorders |
US7781435B2 (en) | 2005-09-22 | 2010-08-24 | Pfizer Inc | Imidazole compounds for the treatment of neurological disorders |
US11377425B1 (en) | 2018-12-19 | 2022-07-05 | Leo Pharma A/S | Small molecule modulators of IL-17 |
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WO1996022966A1 (en) * | 1995-01-23 | 1996-08-01 | Biogen, Inc. | Cell adhesion inhibitors |
WO1999033789A1 (en) * | 1997-12-23 | 1999-07-08 | Aventis Pharma Limited | SUBSTITUTED β-ALANINES |
WO1999037605A1 (en) * | 1998-01-23 | 1999-07-29 | Novartis Ag | Vla-4 antagonists |
Family Cites Families (1)
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US6686350B1 (en) * | 1996-07-25 | 2004-02-03 | Biogen, Inc. | Cell adhesion inhibitors |
-
2000
- 2000-04-20 DE DE10019755A patent/DE10019755A1/en not_active Withdrawn
-
2001
- 2001-04-09 EP EP01943235A patent/EP1276714A2/en not_active Withdrawn
- 2001-04-09 AU AU2001265866A patent/AU2001265866A1/en not_active Abandoned
- 2001-04-09 JP JP2001578395A patent/JP2003531189A/en active Pending
- 2001-04-09 WO PCT/EP2001/004043 patent/WO2001081298A2/en active Application Filing
- 2001-04-09 US US10/258,079 patent/US20030232868A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996022966A1 (en) * | 1995-01-23 | 1996-08-01 | Biogen, Inc. | Cell adhesion inhibitors |
WO1999033789A1 (en) * | 1997-12-23 | 1999-07-08 | Aventis Pharma Limited | SUBSTITUTED β-ALANINES |
WO1999037605A1 (en) * | 1998-01-23 | 1999-07-29 | Novartis Ag | Vla-4 antagonists |
Cited By (21)
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US9579325B2 (en) | 2000-05-12 | 2017-02-28 | Genzyme Corporation | Modulators of TNF-α signaling |
US6969728B2 (en) | 2000-05-12 | 2005-11-29 | Genzyme Corporation | Modulators of TNF-α signaling |
US7034031B2 (en) | 2000-05-12 | 2006-04-25 | Genzyme Corporation | Modulators of TNF-α signaling |
US8518999B2 (en) | 2000-05-12 | 2013-08-27 | Genzyme Corporation | Modulators of TNF-αsignaling |
US8921547B2 (en) | 2000-05-12 | 2014-12-30 | Genzyme Corporation | Modulators of TNF-α signaling |
US7064229B2 (en) | 2001-07-06 | 2006-06-20 | Bayer Healthcare Ag | Succinic acid derivatives |
WO2003030889A1 (en) * | 2001-10-03 | 2003-04-17 | Bayer Healthcare Ag | Para-amino benzoic acids as integrin antagonists |
EP1658072A1 (en) * | 2003-08-21 | 2006-05-24 | Pfizer Products Inc. | Compounds for the treatment of neurodegenerative disorders |
US7253195B2 (en) * | 2003-08-21 | 2007-08-07 | Pfizer Inc | Compounds for the treatment of neurodegenerative disorders |
US7408068B2 (en) | 2003-08-21 | 2008-08-05 | Pfizer Inc. | Compounds for the treatment of neurodegenerative disorders |
EP1658072A4 (en) * | 2003-08-21 | 2009-03-25 | Pfizer Prod Inc | Compounds for the treatment of neurodegenerative disorders |
US7342118B2 (en) | 2004-03-23 | 2008-03-11 | Pfizer Inc | Imidazole compounds for the treatment of neurodegenerative disorders |
US7795447B2 (en) | 2004-03-23 | 2010-09-14 | Pfizer Inc | Imidazole compounds for the treatment of neurodegenerative disorders |
US7951958B2 (en) | 2004-03-23 | 2011-05-31 | Pfizer Inc. | Imidazole compounds for the treatment of neurodegenerative disorders |
EP1781287A2 (en) * | 2004-08-13 | 2007-05-09 | Genentech, Inc. | Thiazole based inhibitors of atp-utilizing enyzmes |
US7795290B2 (en) | 2004-08-13 | 2010-09-14 | Genentech, Inc. | 2-amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
US7410988B2 (en) | 2004-08-13 | 2008-08-12 | Genentech, Inc. | 2-Amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
JP2008509923A (en) * | 2004-08-13 | 2008-04-03 | ジェネンテック・インコーポレーテッド | Thiazole-based inhibitors of ATP-utilizing enzymes |
EP1781287A4 (en) * | 2004-08-13 | 2008-02-27 | Genentech Inc | Thiazole based inhibitors of atp-utilizing enyzmes |
US7781435B2 (en) | 2005-09-22 | 2010-08-24 | Pfizer Inc | Imidazole compounds for the treatment of neurological disorders |
US11377425B1 (en) | 2018-12-19 | 2022-07-05 | Leo Pharma A/S | Small molecule modulators of IL-17 |
Also Published As
Publication number | Publication date |
---|---|
AU2001265866A1 (en) | 2001-11-07 |
WO2001081298A3 (en) | 2002-05-02 |
DE10019755A1 (en) | 2001-11-08 |
EP1276714A2 (en) | 2003-01-22 |
JP2003531189A (en) | 2003-10-21 |
US20030232868A1 (en) | 2003-12-18 |
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