WO2001081286A1 - Process for preparation of r-1-(aryloxy)propan-2-ol - Google Patents
Process for preparation of r-1-(aryloxy)propan-2-ol Download PDFInfo
- Publication number
- WO2001081286A1 WO2001081286A1 PCT/US2001/012792 US0112792W WO0181286A1 WO 2001081286 A1 WO2001081286 A1 WO 2001081286A1 US 0112792 W US0112792 W US 0112792W WO 0181286 A1 WO0181286 A1 WO 0181286A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- aryloxy
- trialkylsiloxypropane
- propan
- catalyst
- mixture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/02—Preparation of ethers from oxiranes
- C07C41/03—Preparation of ethers from oxiranes by reaction of oxirane rings with hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B51/00—Introduction of protecting groups or activating groups, not provided for in the preceding groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1884—Preparation; Treatments not provided for in C07F7/20 by dismutation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002406215A CA2406215A1 (en) | 2000-04-21 | 2001-04-20 | Process for preparation of r-1-(aryloxy)propan-2-ol |
KR1020027014109A KR20020097223A (en) | 2000-04-21 | 2001-04-20 | Process for preparation of R-1-(aryloxy)propan-2-ol |
EP01928673A EP1280753A1 (en) | 2000-04-21 | 2001-04-20 | Process for preparation of r-1-(aryloxy)propan-2-ol |
JP2001578384A JP2003531184A (en) | 2000-04-21 | 2001-04-20 | Method for producing (R) -1- (aryloxy) propan-2-ol |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19894200P | 2000-04-21 | 2000-04-21 | |
US60/198,942 | 2000-04-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001081286A1 true WO2001081286A1 (en) | 2001-11-01 |
Family
ID=22735535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/012792 WO2001081286A1 (en) | 2000-04-21 | 2001-04-20 | Process for preparation of r-1-(aryloxy)propan-2-ol |
Country Status (7)
Country | Link |
---|---|
US (1) | US6448449B2 (en) |
EP (1) | EP1280753A1 (en) |
JP (1) | JP2003531184A (en) |
KR (1) | KR20020097223A (en) |
CN (1) | CN1438981A (en) |
CA (1) | CA2406215A1 (en) |
WO (1) | WO2001081286A1 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20010635A1 (en) | 1999-10-08 | 2001-08-15 | Smithkline Beecham Corp | USEFUL FAB I INHIBITORS FOR THE TREATMENT OF BACTERIAL INFECTIONS |
WO2001097050A1 (en) * | 2000-06-14 | 2001-12-20 | Sleep Solutions, Inc. | Secure medical test and result delivery system |
ES2320984T3 (en) * | 2001-04-06 | 2009-06-01 | Affinium Pharmaceuticals, Inc. | FAB INHIBITORS I. |
ES2518316T3 (en) | 2002-12-06 | 2014-11-05 | Debiopharm International Sa | Heterocyclic compounds, their manufacturing methods and their use in therapy |
CA2519429C (en) | 2003-03-17 | 2013-08-06 | Affinium Pharmaceuticals, Inc. | Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics |
ES2515101T3 (en) | 2004-06-04 | 2014-10-29 | Debiopharm International Sa | Acrylamide derivatives as antibiotic agents |
KR20080075027A (en) * | 2005-12-05 | 2008-08-13 | 아피늄 파마슈티컬스, 인크. | Heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents |
EP2054422B1 (en) | 2006-07-20 | 2017-06-14 | Debiopharm International SA | Acrylamide derivatives as fab i inhibitors |
US8263613B2 (en) * | 2007-02-16 | 2012-09-11 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab I inhibitors |
KR101503745B1 (en) * | 2010-02-25 | 2015-03-19 | 에스케이이노베이션 주식회사 | Catalytic system of nitrate anions for carbon dioxide/epoxide copolymerization |
NZ702695A (en) | 2012-06-19 | 2015-10-30 | Debiopharm Int Sa | Prodrug derivatives of (e)-n-methyl-n-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide |
US10751351B2 (en) | 2016-02-26 | 2020-08-25 | Debiopharm International S.A. | Medicament for treatment of diabetic foot infections |
CN112079958A (en) * | 2019-06-12 | 2020-12-15 | 中国石化扬子石油化工有限公司 | Preparation method of carbon-five copolymerized petroleum resin |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5929232A (en) * | 1995-03-14 | 1999-07-27 | President And Fellows Of Harvard College | Stereoselective ring opening reactions |
US6172268B1 (en) * | 1998-03-25 | 2001-01-09 | Asahi Glass Company, Limited | Method for producing an optically active 1-substituted 2-propanol |
US6207847B1 (en) * | 1997-07-10 | 2001-03-27 | E. I. Du Pont De Nemours And Company | Manufacture of optically active halohydrin trialkylsilyl ethers |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8525953D0 (en) * | 1985-10-21 | 1985-11-27 | Mcneilab Inc | Preparation of galactopyranoside |
GB8525954D0 (en) * | 1985-10-21 | 1985-11-27 | Mcneilab Inc | Chlorination of carbohydrates &c alcohols |
JP2620290B2 (en) * | 1988-03-11 | 1997-06-11 | 旭電化工業株式会社 | Method for producing aryl ether compound having silyloxy group |
AU4376589A (en) * | 1988-11-07 | 1990-05-10 | Gist-Brocades N.V. | Optically active benzoxazines and benzothiazines |
US5637739A (en) | 1990-03-21 | 1997-06-10 | Research Corporation Technologies, Inc. | Chiral catalysts and catalytic epoxidation catalyzed thereby |
US5559222A (en) * | 1995-02-03 | 1996-09-24 | Eli Lilly And Company | Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose |
JPH11269131A (en) | 1998-03-20 | 1999-10-05 | Asahi Glass Co Ltd | Production of 1-acyloxy-2-propanol |
JP2000063314A (en) * | 1998-08-14 | 2000-02-29 | Asahi Glass Co Ltd | Production of optically active 1-substituted-2-propanol |
-
2001
- 2001-04-20 EP EP01928673A patent/EP1280753A1/en not_active Withdrawn
- 2001-04-20 WO PCT/US2001/012792 patent/WO2001081286A1/en not_active Application Discontinuation
- 2001-04-20 CN CN01808380A patent/CN1438981A/en active Pending
- 2001-04-20 JP JP2001578384A patent/JP2003531184A/en active Pending
- 2001-04-20 US US09/839,062 patent/US6448449B2/en not_active Expired - Fee Related
- 2001-04-20 KR KR1020027014109A patent/KR20020097223A/en not_active Application Discontinuation
- 2001-04-20 CA CA002406215A patent/CA2406215A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5929232A (en) * | 1995-03-14 | 1999-07-27 | President And Fellows Of Harvard College | Stereoselective ring opening reactions |
US6207847B1 (en) * | 1997-07-10 | 2001-03-27 | E. I. Du Pont De Nemours And Company | Manufacture of optically active halohydrin trialkylsilyl ethers |
US6172268B1 (en) * | 1998-03-25 | 2001-01-09 | Asahi Glass Company, Limited | Method for producing an optically active 1-substituted 2-propanol |
Also Published As
Publication number | Publication date |
---|---|
US20020007090A1 (en) | 2002-01-17 |
CN1438981A (en) | 2003-08-27 |
US6448449B2 (en) | 2002-09-10 |
CA2406215A1 (en) | 2001-11-01 |
JP2003531184A (en) | 2003-10-21 |
KR20020097223A (en) | 2002-12-31 |
EP1280753A1 (en) | 2003-02-05 |
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