WO2001078641A2 - Intraocular lenses - Google Patents
Intraocular lenses Download PDFInfo
- Publication number
- WO2001078641A2 WO2001078641A2 PCT/US2001/010434 US0110434W WO0178641A2 WO 2001078641 A2 WO2001078641 A2 WO 2001078641A2 US 0110434 W US0110434 W US 0110434W WO 0178641 A2 WO0178641 A2 WO 0178641A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- eye
- lens
- intraocular lens
- haptic
- optical axis
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1602—Corrective lenses for use in addition to the natural lenses of the eyes or for pseudo-phakic eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
- A61F2002/1683—Intraocular lenses having supporting structure for lens, e.g. haptics having filiform haptics
Definitions
- the present invention relates to intraocular lenses (lOLs) and a method for making and using the same. More particularly, the present invention relates to lOLs designed primarily for refractive correction in phakic eyes where the eye's natural lens remains intact.
- Visual acuity deficiencies such as myopia (nearsightedness), hyperopia (farsightedness), presbyopia (age-related farsightedness), aphakia (absence of the crystalline lens of the eye) and astigmatism (irregular conformation of the cornea of the eye) are typically corrected through the use of refractive lenses such as spectacles or contact lenses.
- refractive lenses such as spectacles or contact lenses.
- IOL implants have been used for years in the anterior or posterior chamber of aphakic eyes as replacements for diseased natural crystalline lenses that have been surgically removed from the eyes.
- Many different IOL designs have been developed over past years and proven successful for use in aphakic eyes.
- the successful IOL designs to date primarily include an optic portion with supports therefor, called haptics, connected to and surrounding at least part of the optic portion.
- the haptic portions of an IOL are designed to support the optic portion of the IOL in the lens capsule, anterior chamber or posterior chamber of an eye once implanted.
- lOLs have been made from a variety of biocompatible materials, ranging from more rigid materials such as polymethylmethacrylate (PMMA) to softer, more flexible materials capable of being folded or compressed such as silicones, certain acrylics, and hydrogels.
- PMMA polymethylmethacrylate
- Haptic portions of the lOLs have been formed separately from the optic portion and later connected thereto through processes such as heat, physical staking and/or chemical bonding. Haptics have also been formed as an integral part of the optic portion in what is commonly referred to as "single-piece" lOLs.
- Softer, more flexible lOLs have gained in popularity in recent years due to their ability to be compressed, folded, rolled or otherwise deformed.
- Such softer lOLs may be deformed prior to insertion thereof through an incision in the cornea of an eye. Following insertion of the IOL in an eye, the IOL returns to its original pre-deformed shape due to the memory characteristics of the soft material.
- Softer, more flexible lOLs as just described may be implanted into an eye through an incision that is much smaller, i.e., 2.8 to 3.2 mm, than that necessary for more rigid lOLs, i.e., 4.8 to 6.0 mm.
- a larger incision is necessary for more rigid lOLs because the lens must be inserted through an incision in the cornea slightly larger than that of the diameter of the inflexible IOL optic portion. Accordingly, more rigid lOLs have become less popular in the market since larger incisions have been found to be associated with an increased incidence of postoperative complications, such as induced astigmatism.
- both softer and more rigid lOLs are subject to compressive forces exerted on the outer edges thereof, which typically occur when an individual squints or rubs the eye. This is particularly true of lOLs implanted in the anterior chamber of an eye. Such compressive forces on an IOL may result in tissue damage, decentration of the IOL and/or distortion of the visual image. Compressive forces exerted on an IOL also tend to cause movement of the IOL haptics and axial displacement of the IOL along the optical axis of an eye.
- Haptic movement and broad haptic contact in the angle of the anterior chamber of an eye has the potential to cause damage to delicate structures within the eye such as the peripheral corneal endothelium, the trabecular meshwork and/or the iris. Movement of an IOL along the optical axis of an eye has the potential to cause the IOL to contact and damage the delicate corneal endothelial cell layer of the eye. Also, lOLs of current designs, whether formed of either softer or more rigid materials, tend to deflect along the optical axis of an eye when the haptics are compressed. IOL manufacturers provide a wide range of IOL sizes to more precisely fit lOLs to each particular patient's eye size. Providing a wide range of IOL sizes is an attempt to minimize the potential for haptic compression and the associated axial displacement of the IOL optic along the optical axis of an eye.
- An anterior chamber intraocular lens (IOL) made in accordance with the present invention has an optic portion with an outer peripheral edge and two or more but preferably three or four haptic elements for supporting the optic portion in a patient's eye. Three or four haptic elements are preferred in the present invention to provide a balance between IOL stability and minimized haptic contact in the angle of the anterior chamber.
- a lens having three haptic elements is balanced or stabilized by having two spaced haptic elements formed on one edge of the optic and the third haptic element formed on an opposite edge of the optic or alternatively stabilized by having each of the three haptic elements spaced on the edge of the optic with an equal distance therebetween.
- a lens having four haptic elements is balanced or stabilized by having two spaced haptic elements formed on one edge of the optic and two spaced haptic elements formed on an opposite edge of the optic or alternatively stabilized by having each of the four haptic elements spaced on the edge of the optic with an equal distance therebetween.
- Each of the haptic elements is of like form to achieve a rotational effect for ease of implantation, turning and centering of the IOL and to achieve the desired rotation and flexure functions described in greater detail below.
- Each of the haptic elements also has an inner portion and an outer portion with the inner portion being connected to the outer peripheral edge of the optic portion.
- Each haptic element includes a contact button or small knob on the outer portion thereof. The contact buttons are designed to minimally engage inner surfaces of a patient's eye.
- Each haptic element also has a central portion that extends between the contact button and the inner portion. Within this central portion, each haptic element is designed to have greater resistance to bending in a plane generally parallel to the optical axis of an eye than in a plane generally perpendicular to the optical axis of an eye.
- the flexibility characteristic of the subject haptic elements relative to the optic portion eliminates unacceptable axial displacement of the optic portion along the optical axis of an eye when compressive forces are exerted against the haptic elements of the IOL. In the present IOL, compressive forces are not dispersed through axial displacement of the optic portion, but rather through planar, rotational movement of the optic portion.
- Another object of the present invention is to provide intraocular lenses for use in phakic eyes. Another object of the present invention is to provide intraocular lenses for use in phakic eyes, which fit a variety of eye sizes.
- Another object of the present invention is to provide intraocular lenses for use in phakic eyes, which minimize axial displacement of the optic portions of the lenses along the optical axis of the eyes.
- Another object of the present invention is to provide intraocular lenses that allow for increased ease of implantation, turning and centering of the same.
- Another object of the present invention is to provide intraocular lenses for use in phakic eyes, which minimize damage to tissues in the interior of the eyes.
- Still another object of the present invention is to provide intraocular lenses, which are resistant to decentration within the eyes.
- FIGURE 1 is a schematic representation of the interior of a human eye including a natural lens and a refractive IOL implanted in the anterior chamber of the eye;
- FIGURE 2 is a plan view of an IOL with three haptics made in accordance with the present invention
- FIGURE 3 is a perspective view of the IOL of Figure 2;
- FIGURE 4 is a side cross sectional view of the IOL of Figure 2 taken along line 4-4;
- FIGURE 5 is a side view of a haptic element of Figure 2 with sharper edges;
- FIGURE 6 is a side view of a haptic element of Figure 2 with rounder edges;
- FIGURE 7 is a side cross sectional view of a haptic element of Figure 5 taken along line 7-7 with a stiffening element;
- FIGURE 8 is a side view of the contact button on the haptic of the IOL of Figure 2;
- FIGURE 9 is a plan view of an IOL with four haptics made in accordance with the present invention.
- FIGURE 10 is a side cross sectional view of the IOL of Figure 9 taken along line 10-10;
- FIGURE 11 is a side view of the contact button on the haptic of the IOL of Figure 9.
- Figure 1 illustrates a simplified diagram of an eye 10 showing landmark structures relevant to the implantation of an intraocular lens of the present invention.
- Eye 10 includes an optically clear cornea 12 and an iris 14.
- a natural crystalline lens 16 and a retina 18 are located behind the iris 14 of eye 10.
- Eye 10 also includes anterior chamber 6 located in front of iris 14 and a posterior chamber 8 located between iris 14 and natural lens 16.
- An IOL 26, such as that of the present invention, is preferably implanted in anterior chamber 6 to correct refractive errors while healthy natural lens 16 remains in place (phakic application).
- lOLs of the present invention may also be implanted in posterior chamber 8 or lens capsule 7 for use in aphakic eyes.
- Eye 10 When used in aphakic eyes, lOLs serve as replacements for surgically removed diseased natural lenses 16, such as for example following cataract surgeries.
- Eye 10 also includes an optical axis OA-OA that is an imaginary line that passes through the optical center 20 of anterior surface 22 and posterior surface 24 of lens 16.
- Optical axis OA-OA in the human eye 10 is generally perpendicular to a portion of cornea 12, natural lens 16 and retina 18.
- the IOL of the present invention is designed for implantation preferably in anterior chamber 6 of a patient's eye 10.
- IOL 26 may likewise be implanted in posterior chamber 8 or in the case of an aphakic eye, in lens capsule 7.
- IOL 26 has an optic portion 28 with an outer peripheral edge 30.
- Preferably integrally formed on peripheral edge 30 of optic portion 28 are two or more but preferably three or four separate haptic elements 32, each of like form to achieve a rotational design for ease in turning and centering IOL 26 upon implantation thereof within an eye and to achieve the desired rotation and flexure functions as described further herein.
- Each haptic element 32 is manufactured to have an inner portion 34 and an outer portion 36.
- Inner portions 34 of haptic elements 32 are preferably integrally formed with and permanently connected to outer peripheral edge 30 of optic portion 28. Alternatively however, inner portions 34 of haptic elements 32 may be attached to optic portion 28 by staking, chemical polymerization or other methods known to those skilled in the art.
- Each haptic element 32 also includes at outer portion 36, a radially protruding contact button 38 designed to preferably engage inner surfaces 40 in anterior chamber 6. However, contact buttons 38 are also suitable to engage inner surfaces 42 in posterior chamber 8 or inner surfaces 43 in lens capsule 7 of an aphakic eye 10.
- haptic elements 32 are designed so that when IOL 26 is implanted in a patient's phakic or aphakic eye 10 and held in place through compressive forces exerted by inner surfaces 40, 42 or 43 on contact buttons 38 of haptic elements 32, haptic elements 32 flex so that contact buttons 38 do not slide or move along surfaces 40, 42 or 43 in the eye 10. Sliding and movement of contact buttons 38 is avoided in the subject IOL 26 to minimize tissue damage. Accordingly, haptic elements 32 are designed to flex in a plane generally parallel to that of optic portion 28 of IOL 26 and generally perpendicular to that of optical axis OA-OA of eye 10.
- IOL 26 achieves significantly minimized axial displacement of optic portion 28 to protect the corneal endothelium 4 of eye 10 from damage when compressive forces are applied to eye 10. By minimizing axial displacement of IOL 26, harmful contact with corneal endothelium 4 is also minimized.
- IOL 26 has haptic elements 32 formed with a central portion 44 adjacent to inner portion 34 permanently connected to outer peripheral edge 30 of optic portion 28.
- central portion 44 has a dimension in plane 46-46, generally parallel to optical axis OA-OA, equal to or greater than the same in plane 48-48 generally perpendicular to optical axis OA-OA best depicted in Figures 2 and 9.
- a transition portion 50 of significantly decreasing size in dimension in plane 46-46 extends from central portion 44 to contact button 38.
- Contact buttons 38 are relatively small radially protruding knobs as best illustrated in Figures 8 and 11.
- the outer portions 36 which support contact buttons 38 may be formed with either rounded edges 52 depicted in Figure 6 for a smoother more contoured appearance or formed with more defined, sharper edges 54 as depicted in Figure 5.
- the subject IOL 26 is preferably produced having an optic portion 28 approximately 4.5 to 9.0 mm, but preferably approximately 5.0 to 6.0 mm and most preferably 5.5 mm in diameter and approximately 0.5 mm to 1.0 mm, but preferably approximately 0.6 to 0.8 mm and most preferably 0.7 mm in thickness at peripheral edge 30.
- Haptic elements 32 extend in a curved configuration and will increase or decrease in length depending upon the diameter of optic portion 28. As the diameter of optic portion 28 increases, the length of haptic elements 32 decrease. Likewise, as the diameter of optic portion 28 decreases, the length of haptic elements 32 increase.
- haptic elements 32 are formed to be approximately 2.6 to 6.0 mm, but preferably approximately 3.4 to 5.0 mm and most preferably approximately 4.2 mm in length measuring from the center of inner portion 34 to the center of outer portion 36.
- Haptic elements 32 are preferred to have curved configurations of like form as illustrated in Figures 2 and 9 to rotationally disperse compressive forces while outer portions 36 and contact buttons 38 remain stationary.
- the curved shape of haptic element 32 i.e., the beam curve shape, relative to the width to thickness ratio, i.e., the aspect ratio, of haptic element 32 as described herein is critical to achieve suitable rotation and flexure functions.
- Central portion 44 of haptic element 32 is approximately 0.5 to 2.5 mm, but preferably approximately 1.0 to 2.0 mm and most preferably 1.6 mm in length; approximately 0.2 to1.0 mm, but preferably approximately 0.3 to 0.7 mm and most preferably approximately 0.46 mm in thickness in plane 46-46 and approximately 0.2 to 0.7 mm, but preferably approximately 0.3 to 0.6 and most preferably approximately 0.43 mm in width in plane 48-48.
- Transition portion 50 is approximately 0.4 to 1.1 mm, but preferably approximately 0.5 to 1.0 mm and most preferably approximately 0.8 mm in length.
- Contact buttons 38 are approximately 0.2 to 1.0 mm, but preferably approximately 0.4 to 0.6 mm and most preferably approximately 0.5 mm in diameter and approximately 0.05 to 0.5 mm, but preferably approximately 0.1 to 0.4 mm and most preferably approximately 0.3 mm in thickness.
- Contact buttons 38 illustrated in Figures 2, 3, 8, 9 and 11 are relatively small, thin radially protruding knobs to minimize the area of contact and movement in the angle 19 of the anterior chamber 6.
- haptic elements 32 gradually change from being relatively thin in plane 46-46 at outer portion 36 to being relatively thick at inner portion 34 and optic portion 28, with central portion exhibiting a thicker dimension in plane 46-46 than that of the width in plane 48-48.
- Haptic elements 32 of the subject design tend to flex with rotational movement of optic portion 28 when a compression force is exerted against contact buttons 38.
- axial displacement along optical axis OA-OA is minimized and movement of haptic elements 32 is minimized.
- IOL 26 may likewise be achieved or enhanced by incorporating a stiffening element 60, in the shape of a ribbon, in one or more haptic elements 32, as illustrated in Figure 7.
- Stiffening element 60 may be positioned in haptic element 32 so that flat face 62 is oriented parallel to the dimension 46-46.
- Stiffening element 60 functions in a manner similar to that of an I-beam in construction to prevent axial displacement along optical axis OA-OA when compressive force is applied to contact buttons 38.
- Stiffening element 60 is formed of a less flexible material than that of IOL 26. Suitable materials for stiffening element 60 include but are not limited to polyimides, polyolefins, high-density polyethylenes, polyesters, nylons, metals or any biocompatible material with suitable stiffening characteristics. Stiffening element 60 may be used in conjunction with haptic elements 32 described above or in cases where a thinner haptic design is desired while still achieving the desired rotation and flexure characteristics.
- Suitable materials for the production of the subject IOL 26 include but are not limited to foldable or compressible materials, such as silicone polymers, hydrocarbon and fluorocarbon polymers, hydrogels, soft acrylic polymers, polyesters, polyamides, polyurethane, silicone polymers with hydrophilic monomer units, fluorine-containing polysiloxane elastomers and combinations thereof.
- the preferred material for the production of IOL 26 of the present invention is a hydrogel made from 2-hydroxyethyl methacrylate (HEMA) and 6-hydroxyhexyl methacrylate (HOHEXMA), i.e., poly(HEMA-co- HOHEXMA).
- Poly(HEMA-co-HOHEXMA) is the preferred material for the manufacture of IOL26 due to its equilibrium water content of approximately 18 percent by weight, and high refractive index of approximately 1.474, which is greater than that of the aqueous humor of the eye, i.e., 1.33.
- a high refractive index is a desirable feature in the production of lOLs to impart high optical power with a minimum of optic thickness.
- visual acuity deficiencies may be corrected using a thinner IOL.
- a thin IOL, such as that of IOL 26, is particularly desirable in phakic applications to minimize potentially harmful contact between the IOL and the iris 14 and the corneal endothelium 4.
- Poly(HEMA-co-HOHEXMA) is also a desirable material in the production of lOLs 26 due to its mechanical strength, which is suitable to withstand considerable physical manipulation.
- Poly(HEMA-co-HOHEXMA) also has desirable memory properties suitable for IOL use.
- lOLs manufactured from a material possessing good memory properties such as those of poly(HEMA-co- HOHEXMA) unfold in a controlled manner in an eye, rather than explosively, to its predetermined shape. Explosive unfolding of lOLs is undesirable due to potential damage to delicate tissues within the eye.
- Poly(HEMA-co- HOHEXMA) also has dimensional stability in the eye.
- the teachings of the present invention are preferably applied to soft or foldable lOLs formed of a foldable or compressible material, the same may also be applied to harder, less flexible lenses formed of a relatively rigid material such as polymethylmethacrylate (PMMA) having flexible haptics formed either of the same or a different material.
- PMMA polymethylmethacrylate
- Optic portion 28 of IOL 26 can be a positive powered lens from 0 to approximately +40 diopters or a negative powered lens from 0 to approximately -30 diopters.
- Optic portion 28 may be biconvex, planoconvex, plano-concave, biconcave or concave-convex (meniscus), depending upon the power required to achieve the appropriate central and peripheral thickness for efficient handling.
- Optic portion 28 of the subject IOL 26 may optionally be formed with a glare reduction zone 56 of approximately 0.25 to 0.75 mm but more preferably approximately 0.3 to 0.6 mm and most preferably 0.5 mm in width adjacent to the outer peripheral edge 30 for reducing glare when outer peripheral edge 30 of IOL 26 is struck by light entering eye10 during high light or at other times when pupil 58 is dilated.
- Glare reduction zone 56 is typically fabricated of the same material as optic portion 28, but may be opaque, colored or patterned in a conventional manner to block or diffuse light in plane with optical axis OA-OA.
- Subject IOL 26 may be molded using a removable mold as known to those skilled in the art or may be manufactured by first producing discs from a material of choice as described in U.S. Patent Nos. 5,217,491 and 5,326,506 each incorporated herein in its entirety by reference. IOL 26 may then be machined from the material discs in a conventional manner. Once machined, IOL 26 may be polished, cleaned, sterilized and packaged by a conventional method known to those skilled in the art.
- Subject IOL 26 is used in eye 10 by creating an incision in cornea 12, inserting IOL 26 in either anterior chamber 6 or posterior chamber 8 and closing the incision in accordance with methods known to those skilled in the art.
- IOL 26 may be used in eye 10 by creating an incision in cornea 12 and capsule 7, removing natural lens 16, inserting IOL 26 in capsule 7 and closing the incision in accordance with methods known to those skilled in the art.
- IOL 26 of the present invention provides for a refractive lens suitable for use in lens capsule 7 or posterior chamber 8, but most preferably for use in anterior chamber 6 of eye 10.
- IOL 26 has haptic elements 32 of like form with rotation and flexure characteristics that minimize axial displacement along optical axis OA-OA of eye 10 thereby preventing decentration of IOL 26, distortion of vision and damage to delicate eye tissues such as the natural lens 16, trabecular meshwork 17, the corneal endothelium 4 and the iris 14.
- IOL 26, having the rotation and flexure characteristics described herein is also advantageous because one or a few lens sizes suitably fit eyes 10 of most sizes. By providing a "universal" lens such as that of the present invention, clinical risks to patients due to improperly sized lenses are minimized.
- Such clinical risks minimized include pupil ovalization, corneal endothelium damage and poor fixation.
- manufacturers' need to produce lOLs of many sizes to fit eyes of many sizes is eliminated, thus reducing production and inventory costs associated therewith.
- Ophthalmologists also benefit from subject IOL 26 in that time is saved by eliminating the need to determine each patient's eye size and costs associated with maintaining large inventories of varying sized lenses.
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2001249716A AU2001249716A1 (en) | 2000-04-12 | 2001-04-02 | Intraocular lenses |
CA002405344A CA2405344A1 (en) | 2000-04-12 | 2001-04-02 | Intraocular lenses |
MXPA02010003A MXPA02010003A (en) | 2000-04-12 | 2001-04-02 | Intraocular lenses. |
JP2001575944A JP2003530202A (en) | 2000-04-12 | 2001-04-02 | Intraocular lens |
BR0110292-3A BR0110292A (en) | 2000-04-12 | 2001-04-02 | Intraocular Lenses and Methods for Manufacturing and Using |
EP01922974A EP1272129A2 (en) | 2000-04-12 | 2001-04-02 | Intraocular lenses |
HK03104829.6A HK1054181A1 (en) | 2000-04-12 | 2003-07-07 | Intraocular lenses |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/548,137 US6398809B1 (en) | 2000-04-12 | 2000-04-12 | Intraocular lens |
US09/548,137 | 2000-04-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001078641A2 true WO2001078641A2 (en) | 2001-10-25 |
WO2001078641A3 WO2001078641A3 (en) | 2002-05-16 |
Family
ID=24187573
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/010434 WO2001078641A2 (en) | 2000-04-12 | 2001-04-02 | Intraocular lenses |
Country Status (11)
Country | Link |
---|---|
US (1) | US6398809B1 (en) |
EP (1) | EP1272129A2 (en) |
JP (1) | JP2003530202A (en) |
CN (1) | CN1430493A (en) |
AR (1) | AR032878A1 (en) |
AU (1) | AU2001249716A1 (en) |
BR (1) | BR0110292A (en) |
CA (1) | CA2405344A1 (en) |
HK (1) | HK1054181A1 (en) |
MX (1) | MXPA02010003A (en) |
WO (1) | WO2001078641A2 (en) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8679089B2 (en) * | 2001-05-21 | 2014-03-25 | Michael S. Berlin | Glaucoma surgery methods and systems |
ATE377404T1 (en) | 2000-05-19 | 2007-11-15 | Michael S Berlin | LASER APPLICATION SYSTEM AND METHOD FOR USE IN THE EYE |
US9603741B2 (en) | 2000-05-19 | 2017-03-28 | Michael S. Berlin | Delivery system and method of use for the eye |
US6482229B1 (en) * | 2000-11-21 | 2002-11-19 | Advanced Medical Optics, Inc. | Anterior chamber intraocular lens having fixation members attached to the cornea and methods of implantation |
US6558420B2 (en) * | 2000-12-12 | 2003-05-06 | Bausch & Lomb Incorporated | Durable flexible attachment components for accommodating intraocular lens |
US6827738B2 (en) * | 2001-01-30 | 2004-12-07 | Timothy R. Willis | Refractive intraocular implant lens and method |
US8486140B2 (en) * | 2001-01-30 | 2013-07-16 | Timothy R. Willis | Refractive intraocular implant lens and method |
US7018410B1 (en) * | 2002-08-05 | 2006-03-28 | Mehdi Vazeen | Accommodating intraocular lens |
US7025781B2 (en) * | 2003-01-31 | 2006-04-11 | Delary Alberto Kahn | Artificial iris diaphragm implant |
CN1856281A (en) * | 2003-09-30 | 2006-11-01 | 博士伦公司 | Intraocular lens for inhibiting pco and aco |
JP4842835B2 (en) * | 2003-12-09 | 2011-12-21 | アボット・メディカル・オプティクス・インコーポレイテッド | Foldable intraocular lens and manufacturing method thereof |
US7615073B2 (en) | 2003-12-09 | 2009-11-10 | Advanced Medical Optics, Inc. | Foldable intraocular lens and method of making |
US20050187621A1 (en) * | 2004-02-24 | 2005-08-25 | Brady Daniel G. | Foldable unitary intraocular lens |
US7569073B2 (en) * | 2004-12-29 | 2009-08-04 | Bausch & Lomb Incorporated | Small incision intraocular lens with anti-PCO feature |
US7284685B1 (en) * | 2006-07-27 | 2007-10-23 | Black & Decker Inc. | Pusher bearing and pusher block for magazine feeder |
EP2095175A1 (en) * | 2006-12-19 | 2009-09-02 | Novartis AG | Premium vision ophthalmic lenses |
US20170360609A9 (en) | 2007-09-24 | 2017-12-21 | Ivantis, Inc. | Methods and devices for increasing aqueous humor outflow |
EP2259833A1 (en) | 2008-03-05 | 2010-12-15 | Ivantis, INC. | Methods and apparatus for treating glaucoma |
US8685087B2 (en) * | 2008-12-11 | 2014-04-01 | Bausch & Lomb Incorporated | Intraocular lens and method of making an intraocular lens |
CA2766192C (en) | 2009-07-09 | 2017-10-24 | Ivantis, Inc. | Ocular implants for residing partially in schlemm's canal |
WO2011006078A1 (en) | 2009-07-09 | 2011-01-13 | Ivantis, Inc. | Single operator device for delivering an ocular implant |
US9220590B2 (en) | 2010-06-10 | 2015-12-29 | Z Lens, Llc | Accommodative intraocular lens and method of improving accommodation |
US20120283557A1 (en) | 2011-05-05 | 2012-11-08 | Berlin Michael S | Methods and Apparatuses for the Treatment of Glaucoma using visible and infrared ultrashort laser pulses |
US8657776B2 (en) | 2011-06-14 | 2014-02-25 | Ivantis, Inc. | Ocular implants for delivery into the eye |
US8663150B2 (en) | 2011-12-19 | 2014-03-04 | Ivantis, Inc. | Delivering ocular implants into the eye |
US9358156B2 (en) | 2012-04-18 | 2016-06-07 | Invantis, Inc. | Ocular implants for delivery into an anterior chamber of the eye |
US9364318B2 (en) | 2012-05-10 | 2016-06-14 | Z Lens, Llc | Accommodative-disaccommodative intraocular lens |
WO2014085450A1 (en) | 2012-11-28 | 2014-06-05 | Ivantis, Inc. | Apparatus for delivering ocular implants into an anterior chamber of the eye |
WO2016011056A1 (en) | 2014-07-14 | 2016-01-21 | Ivantis, Inc. | Ocular implant delivery system and method |
US10881504B2 (en) | 2016-03-09 | 2021-01-05 | Staar Surgical Company | Ophthalmic implants with extended depth of field and enhanced distance visual acuity |
CN107072779B (en) | 2014-09-09 | 2020-01-14 | 斯塔尔外科有限公司 | Ocular implant with extended depth of field and enhanced distance vision |
JP2018524045A (en) * | 2015-05-26 | 2018-08-30 | スター サージカル カンパニー | Axial movement controlled posterior chamber type fake kick intraocular lens |
CN107920888A (en) * | 2015-05-26 | 2018-04-17 | 斯塔尔外科有限公司 | Controlled axial displacement back room Phakic intraocular lens |
US10695166B2 (en) | 2015-08-14 | 2020-06-30 | Timothy R. Willis | Intraocular lenses (IOLs) and related assemblies and intraocular attachment methods |
CN108135470B (en) | 2015-08-14 | 2021-03-09 | 伊万提斯公司 | Ocular implant with pressure sensor and delivery system |
US11938058B2 (en) | 2015-12-15 | 2024-03-26 | Alcon Inc. | Ocular implant and delivery system |
EP3503843B1 (en) | 2016-08-24 | 2023-11-15 | Carl Zeiss Meditec AG | Dual mode accommodative-disacommodative intraocular lens |
TW201927263A (en) * | 2017-12-18 | 2019-07-16 | 瑞士商諾華公司 | Intraocular lens platform having improved haptic force distribution |
AU2019223946B2 (en) | 2018-02-22 | 2021-05-20 | Alcon Inc. | Ocular implant and delivery system |
ES2956033T3 (en) | 2018-08-17 | 2023-12-12 | Staar Surgical Co | Polymeric composition exhibiting refractive index nanogradient |
US11759309B2 (en) | 2020-04-29 | 2023-09-19 | Long Bridge Medical, Inc. | Devices to support and position an intraocular lens within the eye and methods of use |
EP4274529A1 (en) | 2021-01-11 | 2023-11-15 | Alcon Inc. | Systems and methods for viscoelastic delivery |
DE102022122962A1 (en) * | 2022-09-09 | 2024-03-14 | Carl Zeiss Meditec Ag | INTRAOCULAR LENS HAVING A FIRST HAPTIC AND A SECOND HAPTIC HAVING TWO ARMS |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998056315A1 (en) * | 1997-06-13 | 1998-12-17 | Chiron Vision Corporation | Intraocular lens |
US5888122A (en) * | 1997-04-10 | 1999-03-30 | Prism Ophthalmics, L.L.C. | Method for manufacturing an intraocular lens |
WO1999056672A1 (en) * | 1998-05-01 | 1999-11-11 | Benz Research And Development Corporation | Intraocular lens |
WO2000027314A1 (en) * | 1998-11-05 | 2000-05-18 | Bausch & Lomb Surgical, Inc. | Flexible intraocular lens |
Family Cites Families (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1103399A (en) | 1953-12-22 | 1955-11-02 | Microttica | Lenses intended for application in the anterior chamber of the eye |
US3639524A (en) | 1969-07-28 | 1972-02-01 | Maurice Seiderman | Hydrophilic gel polymer insoluble in water from polyvinylpyrrolidone with n-vinyl-2-pyrrolidone and methacrylic modifier |
GB1463301A (en) | 1973-07-18 | 1977-02-02 | Highgate D J | Polymer properties |
USRE31640E (en) | 1976-03-15 | 1984-08-07 | .[.Neutral.]. Buoyancy intraocular lens device | |
US4073015A (en) | 1976-05-07 | 1978-02-14 | Peyman Gholam A | Artificial intraocular lens attachment |
DE2717706A1 (en) | 1977-04-21 | 1978-10-26 | Leonhard Klein | Eye implant lens after cataract operation - has three equally spaced synthetic rubber centering rings around periphery |
US4254509A (en) | 1979-04-09 | 1981-03-10 | Tennant Jerald L | Accommodating intraocular implant |
US4254510A (en) | 1979-06-18 | 1981-03-10 | Tennant Jerald L | Implant lens with biarcuate fixation |
US4242762A (en) | 1979-07-25 | 1981-01-06 | Tennant Jerald L | Posterior encapsuled implant lens |
US4261065A (en) | 1979-07-27 | 1981-04-14 | Tennant Jerald L | Artificial intraocular lens with forward-positioned optics |
US4316293A (en) | 1979-08-27 | 1982-02-23 | Bayers Jon Herbert | Flexible intraocular lens |
US4315336A (en) | 1980-01-21 | 1982-02-16 | Stanley Poler | Intraocular lens |
US4277852A (en) | 1980-01-21 | 1981-07-14 | Stanley Poler | Intraocular lens with astigmatism correction |
US4249272A (en) | 1980-03-05 | 1981-02-10 | Stanley Poler | Intraocular lens |
USRE32525F1 (en) | 1980-04-01 | 1989-05-09 | Universal intraocular lens and a method of measuring an eye chamber size | |
US4377873A (en) | 1980-10-30 | 1983-03-29 | Reichert Jr Henry L | Intraocular lens |
US4642113A (en) | 1981-01-30 | 1987-02-10 | Seymour Dubroff | Intraocular lenses |
US4575878A (en) | 1981-01-30 | 1986-03-18 | Seymour Dubroff | Intraocular lenses |
DE3119002A1 (en) | 1981-05-13 | 1982-12-02 | INPROHOLD Establishment, 9490 Vaduz | REAR CHAMBER IMPLANTATION LENS |
US4403353A (en) | 1981-06-25 | 1983-09-13 | Tennant Jerald L | Anterior chamber implant lens |
US4446581A (en) | 1981-09-02 | 1984-05-08 | Blake L W | Intraocular lens with free-ended sizing prong |
US4573998A (en) | 1982-02-05 | 1986-03-04 | Staar Surgical Co. | Methods for implantation of deformable intraocular lenses |
US4476591A (en) | 1982-10-07 | 1984-10-16 | Arnott Eric J | Lens implants for insertion in the human eye |
EP0118985A3 (en) | 1983-02-10 | 1985-07-31 | Kelman, Charles D. | Intraocular lens |
US4575374A (en) | 1983-02-16 | 1986-03-11 | Anis Aziz Y | Flexible anterior chamber lens |
DE3431224A1 (en) | 1983-08-04 | 1986-03-06 | Steven B Siepser | Artificial intraocular lens |
US4556998A (en) | 1983-08-04 | 1985-12-10 | Siepser Steven B | Artificial intraocular lenses and method for their surgical implantation |
FR2550922A1 (en) | 1983-08-26 | 1985-03-01 | Creusot Loire | PROCESS AND PLANT FOR PREPARING A CHOCOLATE PASTE |
EP0391452B1 (en) | 1983-08-30 | 1994-01-05 | Ezekiel Nominees Pty.Ltd. | Intraocular lens implants |
US4664666A (en) | 1983-08-30 | 1987-05-12 | Ezekiel Nominees Pty. Ltd. | Intraocular lens implants |
CS246966B1 (en) | 1983-12-12 | 1986-11-13 | Otto Wichterle | Soft and elastic intracamera lens and method and apparatus for its production |
US4585456A (en) | 1984-03-12 | 1986-04-29 | Ioptex Inc. | Corrective lens for the natural lens of the eye |
US4605409A (en) | 1984-05-21 | 1986-08-12 | Kelman Charles D | Intraocular lens with miniature optic having expandable and contractible glare-reducing means |
US4629460A (en) | 1984-06-25 | 1986-12-16 | Dyer Robert L | Intraocular lens |
US4787904A (en) | 1984-07-06 | 1988-11-29 | Severin Sanford L | Hydrophillic intraocular lens |
US4629462A (en) | 1984-07-13 | 1986-12-16 | Feaster Fred T | Intraocular lens with coiled haptics |
US4615702A (en) | 1984-09-10 | 1986-10-07 | Koziol Jeffrey E | Intraocular lens and method of forming the lens |
SU1311063A1 (en) | 1984-09-27 | 1988-01-30 | Московский научно-исследовательский институт микрохирургии глаза | Eye artificial lens |
DE3439551A1 (en) | 1984-10-29 | 1986-04-30 | Inprohold Establishment, Vaduz | ONE-PIECE IMPLANTING LENS |
US4642116A (en) | 1985-03-19 | 1987-02-10 | Henry Clayman | Buoyant posterior chamber intraocular lens implant |
US4634441A (en) | 1985-04-26 | 1987-01-06 | Henry Clayman | Posterior chamber intra-ocular lens with the lens body within a carrier |
US4781717A (en) | 1985-07-24 | 1988-11-01 | Grendahl Dennis T | Intraocular lens |
US4676791A (en) | 1985-08-01 | 1987-06-30 | Surgidev Corporation | Intraocular lens and method for making same |
US4687485A (en) | 1985-08-23 | 1987-08-18 | Barnes-Hind, Inc. | Intraocular lens with leg means having compressible regions and/or color |
US4666445A (en) | 1985-10-01 | 1987-05-19 | Tillay Michael J | Intraocular lens with shape memory alloy haptic/optic and method of use |
US4718904A (en) | 1986-01-15 | 1988-01-12 | Eye Technology, Inc. | Intraocular lens for capsular bag implantation |
US4718906A (en) | 1986-03-11 | 1988-01-12 | Mackool Richard J | Intraocular lens |
DE3610833A1 (en) | 1986-04-01 | 1987-10-08 | Inprohold Ets | INTRAOCULAR IMPLANTATION LENS |
US4725277A (en) | 1986-05-14 | 1988-02-16 | Precision-Cosmet Co., Inc. | Intraocular lens with tapered haptics |
US4676792A (en) | 1986-08-26 | 1987-06-30 | Donald Praeger | Method and artificial intraocular lens device for the phakic treatment of myopia |
US5002568A (en) | 1986-10-06 | 1991-03-26 | Surgidev Corporation | Intraocular lens |
US4769035A (en) | 1987-06-02 | 1988-09-06 | Kelman Charles D | Artificial lens and the method for implanting such lens |
US5047052A (en) | 1987-11-06 | 1991-09-10 | Seymour Dubroff | Anterior chamber intraocular lens with four point fixation |
FR2631228B1 (en) | 1988-05-11 | 1990-08-10 | Domilens Laboratoires | INTRA-EYE IMPLANT OF PREVIOUS CHAMBER |
US4932970A (en) | 1988-05-17 | 1990-06-12 | Allergan, Inc. | Ophthalmic lens |
US5092880A (en) | 1988-10-21 | 1992-03-03 | Genjiro Ohmi | Method of determining the astigmatic power and the power for an intraocular lens, for a toric intraocular lens |
GB8829819D0 (en) | 1988-12-21 | 1989-02-15 | Freeman Michael H | Lenses and mirrors |
US5211662A (en) | 1989-05-04 | 1993-05-18 | Alcon Laboratories, Inc. | Bicomposite intraocular lenses |
US4997442A (en) | 1989-05-04 | 1991-03-05 | Alcon Laboratories, Inc. | Bicomposite intraocular lenses |
US5078742A (en) | 1989-08-28 | 1992-01-07 | Elie Dahan | Posterior chamber lens implant |
US5476514A (en) | 1990-04-27 | 1995-12-19 | Cumming; J. Stuart | Accommodating intraocular lens |
US5171266A (en) | 1990-09-04 | 1992-12-15 | Wiley Robert G | Variable power intraocular lens with astigmatism correction |
US5203788A (en) | 1991-03-14 | 1993-04-20 | Wiley Robert G | Micromotor actuated adjustable focus lens |
US5108429A (en) | 1991-03-11 | 1992-04-28 | Wiley Robert G | Micromotor actuated adjustable focus lens |
US5066301A (en) | 1990-10-09 | 1991-11-19 | Wiley Robert G | Variable focus lens |
US5258025A (en) | 1990-11-21 | 1993-11-02 | Fedorov Svjatoslav N | Corrective intraocular lens |
US5217491A (en) | 1990-12-27 | 1993-06-08 | American Cyanamid Company | Composite intraocular lens |
US5133749A (en) | 1991-05-13 | 1992-07-28 | Nordan Lee T | Centrating haptics |
US5147395A (en) | 1991-07-16 | 1992-09-15 | Allergan Inc. | Small incision endocapsulator IOL |
US5222981A (en) | 1991-08-15 | 1993-06-29 | Werblin Research & Development Corp. | Multi-component intraocular lens |
US5196026A (en) | 1991-09-16 | 1993-03-23 | Chiron Ophthalmics, Inc. | Method of implanting corneal inlay lenses smaller than the optic zone |
US5203790A (en) | 1991-11-12 | 1993-04-20 | Henry H. McDonald | Foldable plastic optical lens with reduced thickness light blocking segments, and anchoring means |
US5197981A (en) | 1992-04-23 | 1993-03-30 | Alcon Surgical, Inc. | Intraocular lens having haptic of specific curvature and proportion |
US5716403A (en) | 1995-12-06 | 1998-02-10 | Alcon Laboratories, Inc. | Single piece foldable intraocular lens |
-
2000
- 2000-04-12 US US09/548,137 patent/US6398809B1/en not_active Expired - Fee Related
-
2001
- 2001-04-02 JP JP2001575944A patent/JP2003530202A/en not_active Withdrawn
- 2001-04-02 MX MXPA02010003A patent/MXPA02010003A/en unknown
- 2001-04-02 EP EP01922974A patent/EP1272129A2/en not_active Withdrawn
- 2001-04-02 WO PCT/US2001/010434 patent/WO2001078641A2/en not_active Application Discontinuation
- 2001-04-02 AU AU2001249716A patent/AU2001249716A1/en not_active Abandoned
- 2001-04-02 CN CN01807870A patent/CN1430493A/en active Pending
- 2001-04-02 BR BR0110292-3A patent/BR0110292A/en not_active Application Discontinuation
- 2001-04-02 CA CA002405344A patent/CA2405344A1/en not_active Abandoned
- 2001-04-10 AR ARP010101695A patent/AR032878A1/en unknown
-
2003
- 2003-07-07 HK HK03104829.6A patent/HK1054181A1/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5888122A (en) * | 1997-04-10 | 1999-03-30 | Prism Ophthalmics, L.L.C. | Method for manufacturing an intraocular lens |
WO1998056315A1 (en) * | 1997-06-13 | 1998-12-17 | Chiron Vision Corporation | Intraocular lens |
WO1999056672A1 (en) * | 1998-05-01 | 1999-11-11 | Benz Research And Development Corporation | Intraocular lens |
WO2000027314A1 (en) * | 1998-11-05 | 2000-05-18 | Bausch & Lomb Surgical, Inc. | Flexible intraocular lens |
Also Published As
Publication number | Publication date |
---|---|
EP1272129A2 (en) | 2003-01-08 |
HK1054181A1 (en) | 2003-11-21 |
US6398809B1 (en) | 2002-06-04 |
CA2405344A1 (en) | 2001-10-25 |
AU2001249716A1 (en) | 2001-10-30 |
WO2001078641A3 (en) | 2002-05-16 |
CN1430493A (en) | 2003-07-16 |
JP2003530202A (en) | 2003-10-14 |
AR032878A1 (en) | 2003-12-03 |
BR0110292A (en) | 2003-12-30 |
MXPA02010003A (en) | 2004-08-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6398809B1 (en) | Intraocular lens | |
US6461384B1 (en) | Intraocular lenses | |
AU754658B2 (en) | Flexible intraocular lens | |
CA2407432C (en) | Foldable iris fixated intraocular lenses | |
US20020087210A1 (en) | Intraocular | |
US6190410B1 (en) | Intraocular lenses | |
US6200344B1 (en) | Inraocular lenses | |
CA2430005C (en) | Iris fixated intraocular lenses | |
AU2001259541A1 (en) | Injectable iris fixated intraocular lenses | |
US20030055499A1 (en) | Low profile intraocular lenses |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2001922974 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2405344 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2001249716 Country of ref document: AU |
|
ENP | Entry into the national phase |
Ref document number: 2001 575944 Country of ref document: JP Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2002/010003 Country of ref document: MX Ref document number: 018078702 Country of ref document: CN |
|
WWP | Wipo information: published in national office |
Ref document number: 2001922974 Country of ref document: EP |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 2001922974 Country of ref document: EP |