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Diagnosis of diseases associated with dna replication by assessing dna methylation

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Publication number
WO2001077377A3
WO2001077377A3 PCT/EP2001/003971 EP0103971W WO2001077377A3 WO 2001077377 A3 WO2001077377 A3 WO 2001077377A3 EP 0103971 W EP0103971 W EP 0103971W WO 2001077377 A3 WO2001077377 A3 WO 2001077377A3
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WO
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Application
Patent type
Prior art keywords
dna
replication
associated
genes
methylation
Prior art date
Application number
PCT/EP2001/003971
Other languages
French (fr)
Other versions
WO2001077377A8 (en )
WO2001077377A2 (en )
Inventor
Alexander Olek
Christian Piepenbrock
Kurt Berlin
Original Assignee
Epigenomics Ag
Alexander Olek
Christian Piepenbrock
Kurt Berlin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Hybridisation probes
    • C12Q1/6883Hybridisation probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82Translation products from oncogenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Hybridisation probes
    • C12Q1/6883Hybridisation probes for diseases caused by alterations of genetic material
    • C12Q1/6886Hybridisation probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Abstract

The present invention relates to the chemically modified genomic sequences of genes associated with DNA replication, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genes associated with DNA replication which are directed against the sequence, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes associated with DNA replication.
PCT/EP2001/003971 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna replication by assessing dna methylation WO2001077377A3 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE2000119058 DE10019058A1 (en) 2000-04-06 2000-04-06 Designing primers and probes for analyzing diseases associated with cytosine methylation state e.g. arthritis, cancer, aging, arteriosclerosis comprising fragments of chemically modified genes associated with cell cycle
DE10019058.8 2000-04-06
DE10019173.8 2000-04-07
DE10019173 2000-04-07
DE2000132529 DE10032529A1 (en) 2000-06-30 2000-06-30 Diagnosis of important genetic parameters within the major histocompatibility complex (MHC)
DE10032529.7 2000-06-30
DE10043826 2000-09-01
DE10043826.1 2000-09-01

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10240708 US20050282157A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna replication
EP20010953145 EP1278893A2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna replication

Publications (3)

Publication Number Publication Date
WO2001077377A2 true WO2001077377A2 (en) 2001-10-18
WO2001077377A8 true WO2001077377A8 (en) 2002-02-28
WO2001077377A3 true true WO2001077377A3 (en) 2002-07-11

Family

ID=27437807

Family Applications (8)

Application Number Title Priority Date Filing Date
PCT/EP2001/004016 WO2001076451A3 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with metabolism
PCT/EP2001/003972 WO2001081622A3 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna repair
PCT/EP2001/003968 WO2001077375A8 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with gene regulation
PCT/EP2001/003970 WO2001077376A3 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with metastasis
PCT/EP2001/004015 WO2001077378A3 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna adducts
PCT/EP2001/003969 WO2001077164A3 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with apoptosis by means of assessing the methylation status of genes associated with apoptosis
PCT/EP2001/003973 WO2001092565A3 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated dna transcription by means of assessing the methylation status of genes associated with dna transcription
PCT/EP2001/003971 WO2001077377A3 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna replication by assessing dna methylation

Family Applications Before (7)

Application Number Title Priority Date Filing Date
PCT/EP2001/004016 WO2001076451A3 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with metabolism
PCT/EP2001/003972 WO2001081622A3 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna repair
PCT/EP2001/003968 WO2001077375A8 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with gene regulation
PCT/EP2001/003970 WO2001077376A3 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with metastasis
PCT/EP2001/004015 WO2001077378A3 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna adducts
PCT/EP2001/003969 WO2001077164A3 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with apoptosis by means of assessing the methylation status of genes associated with apoptosis
PCT/EP2001/003973 WO2001092565A3 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated dna transcription by means of assessing the methylation status of genes associated with dna transcription

Country Status (5)

Country Link
US (7) US20030148327A1 (en)
JP (3) JP2003531589A (en)
DE (2) DE60126593D1 (en)
EP (9) EP1268861A2 (en)
WO (8) WO2001076451A3 (en)

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