WO2001074818A1 - Chlorins with fused rings for use in photodynamic therapy - Google Patents

Chlorins with fused rings for use in photodynamic therapy Download PDF

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Publication number
WO2001074818A1
WO2001074818A1 PCT/US2001/010563 US0110563W WO0174818A1 WO 2001074818 A1 WO2001074818 A1 WO 2001074818A1 US 0110563 W US0110563 W US 0110563W WO 0174818 A1 WO0174818 A1 WO 0174818A1
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WO
WIPO (PCT)
Prior art keywords
independently selected
hydrogen
formula
compound
aryl
Prior art date
Application number
PCT/US2001/010563
Other languages
English (en)
French (fr)
Inventor
Bryon C. Robinson
Dipanjan Sengupta
Avinash S. Phadke
Original Assignee
Miravant Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miravant Pharmaceuticals, Inc. filed Critical Miravant Pharmaceuticals, Inc.
Priority to AU2001289273A priority Critical patent/AU2001289273A1/en
Publication of WO2001074818A1 publication Critical patent/WO2001074818A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PCT/US2001/010563 2000-03-30 2001-03-30 Chlorins with fused rings for use in photodynamic therapy WO2001074818A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001289273A AU2001289273A1 (en) 2000-03-30 2001-03-30 Chlorins with fused rings for use in photodynamic therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/538,980 2000-03-30
US09/538,980 US6794505B1 (en) 2000-03-30 2000-03-30 Chlorins possessing fused ring systems useful as photoselective compounds for photodynamic therapy

Publications (1)

Publication Number Publication Date
WO2001074818A1 true WO2001074818A1 (en) 2001-10-11

Family

ID=24149245

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/010563 WO2001074818A1 (en) 2000-03-30 2001-03-30 Chlorins with fused rings for use in photodynamic therapy

Country Status (2)

Country Link
US (3) US6794505B1 (US07521551-20090421-C00042.png)
WO (1) WO2001074818A1 (US07521551-20090421-C00042.png)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1834955A1 (en) 2006-03-10 2007-09-19 Humboldt Universität zu Berlin Porphyrin derivates and their use as photosensitizers in photodynamic therapy

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794505B1 (en) * 2000-03-30 2004-09-21 Miravant Pharmaceuticals, Inc. Chlorins possessing fused ring systems useful as photoselective compounds for photodynamic therapy
US20050163821A1 (en) * 2002-08-02 2005-07-28 Hsing-Wen Sung Drug-eluting Biodegradable Stent and Delivery Means
US7297154B2 (en) * 2003-02-24 2007-11-20 Maxwell Sensors Inc. Optical apparatus for detecting and treating vulnerable plaque
WO2006089122A2 (en) * 2005-02-18 2006-08-24 North Carolina State University De novo synthesis of bacteriochlorins
WO2007064841A2 (en) * 2005-11-30 2007-06-07 North Carolina State University Porphyrinic compounds for use in flow cytometry

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4649151A (en) 1982-09-27 1987-03-10 Health Research, Inc. Drugs comprising porphyrins
US5283255A (en) 1987-01-20 1994-02-01 The University Of British Columbia Wavelength-specific cytotoxic agents
US5171749A (en) 1987-01-20 1992-12-15 University Of British Columbia Wavelength-specific cytotoxic agents
US5002962A (en) 1988-07-20 1991-03-26 Health Research, Inc. Photosensitizing agents
US5198460A (en) 1988-07-20 1993-03-30 Health Research Inc. Pyropheophorbides and their use in photodynamic therapy
US5177073A (en) 1988-09-30 1993-01-05 Baylor Research Institute Therapeutic compositions derived from photoactive compounds
FR2677030B1 (fr) * 1991-05-27 1994-05-06 Chemoxal Sa Procede d'obtention de cyclodextrines ou autres composes susceptibles de former des clathrates avec un gaz.
CA2221912A1 (en) 1997-11-21 1999-05-21 David Dolphin Photosensitizers with improved biodistribution and light-absorbing properties
US6794505B1 (en) * 2000-03-30 2004-09-21 Miravant Pharmaceuticals, Inc. Chlorins possessing fused ring systems useful as photoselective compounds for photodynamic therapy

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BARLOY, LAURENT ET AL: "Anomalous Double Cyclization Reactions of.beta.-Formylporphyrins", J. ORG. CHEM. (1994), 59(26), 7976-85, XP002174649 *
FAUSTINO, M.A. ET AL: "New Naphthochlorins from the intramoldecular Cyclization of beta-vinyl-meso-tetraarylporphyrins", TETRAHEDRON LETTERS, vol. 36, no. 33, 1995, pages 5977 - 8, XP004027515 *
ISHKOV, YU. V. ET AL: "Porphyrins and their derivatives. XVII. Intramolecular cyclization of 2-formyl-5,10,15,20-tetraphenylporphyrin complexes", ZH. ORG. KHIM. (1995), 31(1), 136-9, XP002174648 *
KRATTINGER, B.; NURCO, D.J.; SMITH K.M.: "Novel synthesis and new chemistry of naphthochlorins", CHEMICAL COMMUNICATIONS, 1998, pages 757 - 8, XP002174601 *
SHINODA S ET AL: "Energy and Electron Transfer Properties of Methyl Pheophorbide-a in Zinc Porphyrin-Pheophorbide Dyads", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 53, no. 40, 6 October 1997 (1997-10-06), pages 13657 - 13666, XP004106245, ISSN: 0040-4020 *
ZHANG, XIAO-XIANG ET AL: "Synthesis and Triiron Complexes of PDK, a New Porphyrin-Linked Dicarboxylate Ligand", J. AM. CHEM. SOC. (1998), 120(39), 10260-10261, XP002175461 *
ZHILIN, Z. I. ET AL: "A new product of intramolecular cyclization of the copper 2-formyl-5,10,15,20-tetraphenylporphyrin complex", DOPOV. NATS. AKAD. NAUK UKR. (2000), (4), 147-150, XP002174647 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1834955A1 (en) 2006-03-10 2007-09-19 Humboldt Universität zu Berlin Porphyrin derivates and their use as photosensitizers in photodynamic therapy

Also Published As

Publication number Publication date
US20050020560A1 (en) 2005-01-27
US6794505B1 (en) 2004-09-21
US7521551B2 (en) 2009-04-21
US20080275232A1 (en) 2008-11-06

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