WO2001074791A1 - Derives de diazepane ou sels desdits composes - Google Patents
Derives de diazepane ou sels desdits composes Download PDFInfo
- Publication number
- WO2001074791A1 WO2001074791A1 PCT/JP2001/002673 JP0102673W WO0174791A1 WO 2001074791 A1 WO2001074791 A1 WO 2001074791A1 JP 0102673 W JP0102673 W JP 0102673W WO 0174791 A1 WO0174791 A1 WO 0174791A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methyl
- salts
- derivatives
- blood
- diazepan
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01917634A EP1273575B1 (en) | 2000-03-31 | 2001-03-29 | Diazepane derivatives or salts thereof |
US10/148,544 US6642224B1 (en) | 2000-03-31 | 2001-03-29 | Diazepan derivatives or salts thereof |
DE60103390T DE60103390T2 (de) | 2000-03-31 | 2001-03-29 | Diazepinderivate oder deren salze |
AT01917634T ATE267178T1 (de) | 2000-03-31 | 2001-03-29 | Diazepinderivate oder deren salze |
AU2001244634A AU2001244634A1 (en) | 2000-03-31 | 2001-03-29 | Diazepane derivatives or salts thereof |
CA002395846A CA2395846C (en) | 2000-03-31 | 2001-03-29 | Diazepan derivatives or salts thereof |
JP2001572486A JP3788349B2 (ja) | 2000-03-31 | 2001-03-29 | ジアゼパン誘導体又はその塩 |
US10/656,129 US7307074B2 (en) | 2000-03-31 | 2003-09-08 | Diazepan derivatives or salts thereof |
US12/203,640 USRE43481E1 (en) | 2000-03-31 | 2008-09-03 | Diazepan derivatives or salts thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000-096858 | 2000-03-31 | ||
JP2000096858 | 2000-03-31 |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/148,544 A-371-Of-International US6642224B1 (en) | 2000-03-31 | 2001-03-29 | Diazepan derivatives or salts thereof |
US10148544 A-371-Of-International | 2001-03-29 | ||
US10/656,129 Division US7307074B2 (en) | 2000-03-31 | 2003-09-08 | Diazepan derivatives or salts thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001074791A1 true WO2001074791A1 (fr) | 2001-10-11 |
Family
ID=18611560
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2001/002673 WO2001074791A1 (fr) | 2000-03-31 | 2001-03-29 | Derives de diazepane ou sels desdits composes |
Country Status (21)
Country | Link |
---|---|
US (3) | US6642224B1 (ja) |
EP (2) | EP1273575B1 (ja) |
JP (1) | JP3788349B2 (ja) |
KR (1) | KR100739359B1 (ja) |
CN (1) | CN1226292C (ja) |
AR (1) | AR027985A1 (ja) |
AT (2) | ATE340166T1 (ja) |
AU (2) | AU776053B2 (ja) |
BR (1) | BR0101264A (ja) |
CA (1) | CA2395846C (ja) |
DE (2) | DE60103390T2 (ja) |
DK (1) | DK1273575T3 (ja) |
ES (2) | ES2271464T3 (ja) |
HU (1) | HUP0101333A3 (ja) |
MX (1) | MXPA01003279A (ja) |
PL (1) | PL207651B1 (ja) |
PT (1) | PT1273575E (ja) |
RU (1) | RU2257381C2 (ja) |
TR (1) | TR200401955T4 (ja) |
TW (1) | TW575569B (ja) |
WO (1) | WO2001074791A1 (ja) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002064567A2 (en) * | 2000-11-28 | 2002-08-22 | Eli Lilly And Company | Substituted carboxamides as inhibitors of factor xa |
WO2003050088A1 (en) * | 2001-12-07 | 2003-06-19 | Eli Lilly And Company | Substituted heterocyclic carboxamides with antithrombotic activity |
WO2003087057A1 (en) * | 2002-04-05 | 2003-10-23 | Astrazeneca Ab | Benzamide derivatives useful as histone deacetylase inhibitors |
JP2006527708A (ja) * | 2003-06-18 | 2006-12-07 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 血栓症の治療のための凝固因子XaおよびVIIaの阻害剤としての1−[(4−エチニルフェニル)]−2−[(フェニル)]−ピロリジン−1,2−ジカルボキサミド誘導体 |
US7160878B2 (en) | 2000-07-27 | 2007-01-09 | Eli Lilly And Company | Substituted heterocyclic amides |
WO2007055183A1 (ja) * | 2005-11-08 | 2007-05-18 | Astellas Pharma Inc. | ベンゼン誘導体又はその塩 |
US7390908B2 (en) | 2001-08-17 | 2008-06-24 | Astrazeneca Ab | Compounds effecting glucokinase |
WO2008123017A1 (ja) * | 2007-03-09 | 2008-10-16 | Daiichi Sankyo Company, Limited | 新規なジアミド誘導体 |
WO2010005087A1 (ja) | 2008-07-11 | 2010-01-14 | 味の素株式会社 | アミジン誘導体 |
WO2010038689A1 (ja) * | 2008-09-30 | 2010-04-08 | アステラス製薬株式会社 | 経口投与用医薬組成物 |
US8207202B2 (en) | 2005-10-19 | 2012-06-26 | Astrazeneca Ab | Benzamide compounds useful as histone deacetylase inhibitors |
US8227506B2 (en) | 2005-02-02 | 2012-07-24 | Ajinomoto., Inc. | Benzamidine compound |
WO2013161871A1 (ja) * | 2012-04-25 | 2013-10-31 | 興和株式会社 | Tlr阻害作用を有するチオフェン誘導体 |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6376515B2 (en) * | 2000-02-29 | 2002-04-23 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor Xa |
AU776053B2 (en) | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
PT1336605E (pt) * | 2000-11-22 | 2006-06-30 | Astellas Pharma Inc | Derivados de fenol substituidos ou seus sais como inibidores do factor x de coagulacao |
US7511066B2 (en) | 2003-09-30 | 2009-03-31 | Eli Lilly And Company | Antithrombotic aromatic ethers |
US7700628B2 (en) | 2004-11-24 | 2010-04-20 | Eli Lilly And Company | Aromatic ether derivatives useful as thrombin inhibitors |
ES2330461T3 (es) | 2004-11-29 | 2009-12-10 | Eli Lilly And Company | Diamidas antitromboticas. |
WO2008057972A1 (en) * | 2006-11-02 | 2008-05-15 | Millennium Pharmaceuticals, Inc. | Methods of synthesizing pharmaceutical salts of a factor xa inhibitor |
WO2012006475A1 (en) * | 2010-07-07 | 2012-01-12 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
JP5827328B2 (ja) | 2010-07-07 | 2015-12-02 | アーデリクス,インコーポレーテッド | リン酸輸送を阻害する化合物及び方法 |
JP5827327B2 (ja) | 2010-07-07 | 2015-12-02 | アーデリクス,インコーポレーテッド | リン酸輸送を阻害する化合物及び方法 |
WO2012054110A2 (en) | 2010-07-07 | 2012-04-26 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
JP5827326B2 (ja) | 2010-07-07 | 2015-12-02 | アーデリクス,インコーポレーテッド | リン酸輸送を阻害する化合物及び方法 |
WO2012059442A2 (en) * | 2010-11-01 | 2012-05-10 | Neurotune Ag | Neurotrypsin inhibitors |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999037643A1 (fr) * | 1998-01-26 | 1999-07-29 | Yamanouchi Pharmaceutical Co., Ltd. | Nouveaux derives heterocycliques a fusion benzenique ou sels de ceux-ci |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5417200A (en) * | 1994-01-25 | 1995-05-23 | Wasielewski; John J. | Lantern cooker |
JP3004362B2 (ja) | 1994-12-02 | 2000-01-31 | 山之内製薬株式会社 | 新規なアミジノナフチル誘導体又はその塩 |
ES2248911T3 (es) | 1997-06-26 | 2006-03-16 | Eli Lilly And Company | Agentes antitromboticos. |
AU8270298A (en) | 1997-06-26 | 1999-01-19 | Eli Lilly And Company | Antithrombotic agents |
IL133625A0 (en) | 1997-06-26 | 2001-04-30 | Lilly Co Eli | Antithrombotic agents |
IL133621A0 (en) * | 1997-06-26 | 2001-04-30 | Lilly Co Eli | Antithrombotic agents |
US6140351A (en) | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
SK9432000A3 (en) | 1997-12-19 | 2001-02-12 | Schering Ag | Ortho-anthranilamide derivatives as anti-coagulants, pharmaceutical composition containing such derivatives and use thereof |
JP2002533453A (ja) | 1998-12-23 | 2002-10-08 | イーライ・リリー・アンド・カンパニー | Xa因子のインヒビターとしてのヘテロ芳香族アミド |
WO2000039118A1 (en) | 1998-12-23 | 2000-07-06 | Eli Lilly And Company | Aromatic amides |
US6610704B1 (en) | 1998-12-23 | 2003-08-26 | Eli Lilly And Company | Antithrombotic amides |
JP4390024B2 (ja) * | 1999-04-23 | 2009-12-24 | アステラス製薬株式会社 | 新規なジアゼパン誘導体又はその塩 |
JP4744050B2 (ja) | 1999-09-17 | 2011-08-10 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | ベンズアミドおよび関連するXa因子阻害剤 |
US6632815B2 (en) | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
EP1216231A2 (en) | 1999-09-17 | 2002-06-26 | Millennium Pharmaceuticals, Inc. | INHIBITORS OF FACTOR Xa |
US6376515B2 (en) * | 2000-02-29 | 2002-04-23 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor Xa |
AU776053B2 (en) * | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
WO2002010154A2 (en) * | 2000-07-27 | 2002-02-07 | Eli Lilly And Company | Substituted heterocyclic amides |
WO2002064567A2 (en) * | 2000-11-28 | 2002-08-22 | Eli Lilly And Company | Substituted carboxamides as inhibitors of factor xa |
-
2001
- 2001-03-22 AU AU29827/01A patent/AU776053B2/en not_active Ceased
- 2001-03-28 PL PL346731A patent/PL207651B1/pl not_active IP Right Cessation
- 2001-03-29 DE DE60103390T patent/DE60103390T2/de not_active Expired - Lifetime
- 2001-03-29 MX MXPA01003279A patent/MXPA01003279A/es active IP Right Grant
- 2001-03-29 DE DE60123294T patent/DE60123294T2/de not_active Expired - Lifetime
- 2001-03-29 AR ARP010101497A patent/AR027985A1/es active IP Right Grant
- 2001-03-29 JP JP2001572486A patent/JP3788349B2/ja not_active Expired - Fee Related
- 2001-03-29 AT AT03029061T patent/ATE340166T1/de not_active IP Right Cessation
- 2001-03-29 EP EP01917634A patent/EP1273575B1/en not_active Expired - Lifetime
- 2001-03-29 AT AT01917634T patent/ATE267178T1/de active
- 2001-03-29 EP EP03029061A patent/EP1415990B1/en not_active Expired - Lifetime
- 2001-03-29 AU AU2001244634A patent/AU2001244634A1/en not_active Abandoned
- 2001-03-29 WO PCT/JP2001/002673 patent/WO2001074791A1/ja active IP Right Grant
- 2001-03-29 CA CA002395846A patent/CA2395846C/en not_active Expired - Fee Related
- 2001-03-29 ES ES03029061T patent/ES2271464T3/es not_active Expired - Lifetime
- 2001-03-29 DK DK01917634T patent/DK1273575T3/da active
- 2001-03-29 US US10/148,544 patent/US6642224B1/en not_active Expired - Fee Related
- 2001-03-29 TR TR2004/01955T patent/TR200401955T4/xx unknown
- 2001-03-29 ES ES01917634T patent/ES2217129T3/es not_active Expired - Lifetime
- 2001-03-29 PT PT01917634T patent/PT1273575E/pt unknown
- 2001-03-29 RU RU2001108494/04A patent/RU2257381C2/ru not_active IP Right Cessation
- 2001-03-30 TW TW90107761A patent/TW575569B/zh not_active IP Right Cessation
- 2001-03-30 BR BR0101264-9A patent/BR0101264A/pt not_active IP Right Cessation
- 2001-03-30 CN CNB011121904A patent/CN1226292C/zh not_active Expired - Fee Related
- 2001-03-30 KR KR1020010016952A patent/KR100739359B1/ko not_active IP Right Cessation
- 2001-03-30 HU HU0101333A patent/HUP0101333A3/hu unknown
-
2003
- 2003-09-08 US US10/656,129 patent/US7307074B2/en not_active Ceased
-
2008
- 2008-09-03 US US12/203,640 patent/USRE43481E1/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999037643A1 (fr) * | 1998-01-26 | 1999-07-29 | Yamanouchi Pharmaceutical Co., Ltd. | Nouveaux derives heterocycliques a fusion benzenique ou sels de ceux-ci |
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7160878B2 (en) | 2000-07-27 | 2007-01-09 | Eli Lilly And Company | Substituted heterocyclic amides |
WO2002064567A2 (en) * | 2000-11-28 | 2002-08-22 | Eli Lilly And Company | Substituted carboxamides as inhibitors of factor xa |
WO2002064567A3 (en) * | 2000-11-28 | 2003-11-06 | Lilly Co Eli | Substituted carboxamides as inhibitors of factor xa |
US7163938B2 (en) | 2000-11-28 | 2007-01-16 | Eli Lilly And Company | Substituted carboxamides |
US7390908B2 (en) | 2001-08-17 | 2008-06-24 | Astrazeneca Ab | Compounds effecting glucokinase |
US7449457B2 (en) | 2001-12-07 | 2008-11-11 | Eli Lilly And Company | Substituted heterocyclic carboxamides with antithrombotic activity |
WO2003050088A1 (en) * | 2001-12-07 | 2003-06-19 | Eli Lilly And Company | Substituted heterocyclic carboxamides with antithrombotic activity |
US8247562B2 (en) | 2002-04-05 | 2012-08-21 | Astrazeneca Ab | Benzamide derivatives useful as histone deacetylase inhibitors |
WO2003087057A1 (en) * | 2002-04-05 | 2003-10-23 | Astrazeneca Ab | Benzamide derivatives useful as histone deacetylase inhibitors |
JP2006527708A (ja) * | 2003-06-18 | 2006-12-07 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 血栓症の治療のための凝固因子XaおよびVIIaの阻害剤としての1−[(4−エチニルフェニル)]−2−[(フェニル)]−ピロリジン−1,2−ジカルボキサミド誘導体 |
US8227506B2 (en) | 2005-02-02 | 2012-07-24 | Ajinomoto., Inc. | Benzamidine compound |
US8207202B2 (en) | 2005-10-19 | 2012-06-26 | Astrazeneca Ab | Benzamide compounds useful as histone deacetylase inhibitors |
US8022208B2 (en) | 2005-11-08 | 2011-09-20 | Astellas Pharma Inc. | Benzene derivative or salt thereof |
JPWO2007055183A1 (ja) * | 2005-11-08 | 2009-04-30 | アステラス製薬株式会社 | ベンゼン誘導体又はその塩 |
WO2007055183A1 (ja) * | 2005-11-08 | 2007-05-18 | Astellas Pharma Inc. | ベンゼン誘導体又はその塩 |
JP5045442B2 (ja) * | 2005-11-08 | 2012-10-10 | アステラス製薬株式会社 | ベンゼン誘導体又はその塩 |
WO2008123017A1 (ja) * | 2007-03-09 | 2008-10-16 | Daiichi Sankyo Company, Limited | 新規なジアミド誘導体 |
WO2010005087A1 (ja) | 2008-07-11 | 2010-01-14 | 味の素株式会社 | アミジン誘導体 |
WO2010038689A1 (ja) * | 2008-09-30 | 2010-04-08 | アステラス製薬株式会社 | 経口投与用医薬組成物 |
JP4582263B2 (ja) * | 2008-09-30 | 2010-11-17 | アステラス製薬株式会社 | 経口投与用医薬組成物 |
CN102170885A (zh) * | 2008-09-30 | 2011-08-31 | 安斯泰来制药株式会社 | 口服用药物组合物 |
JPWO2010038689A1 (ja) * | 2008-09-30 | 2012-03-01 | アステラス製薬株式会社 | 経口投与用医薬組成物 |
WO2013161871A1 (ja) * | 2012-04-25 | 2013-10-31 | 興和株式会社 | Tlr阻害作用を有するチオフェン誘導体 |
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