WO2001070967A3 - Regulation of human serotonin-like g protein-coupled receptor - Google Patents

Regulation of human serotonin-like g protein-coupled receptor Download PDF

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Publication number
WO2001070967A3
WO2001070967A3 PCT/EP2001/003117 EP0103117W WO0170967A3 WO 2001070967 A3 WO2001070967 A3 WO 2001070967A3 EP 0103117 W EP0103117 W EP 0103117W WO 0170967 A3 WO0170967 A3 WO 0170967A3
Authority
WO
WIPO (PCT)
Prior art keywords
disorders
protein
coupled receptor
regulation
human serotonin
Prior art date
Application number
PCT/EP2001/003117
Other languages
French (fr)
Other versions
WO2001070967A2 (en
Inventor
Shyam Ramakrishnan
Original Assignee
Bayer Ag
Shyam Ramakrishnan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Shyam Ramakrishnan filed Critical Bayer Ag
Priority to EP01915376A priority Critical patent/EP1290163A2/en
Priority to AU2001242485A priority patent/AU2001242485A1/en
Publication of WO2001070967A2 publication Critical patent/WO2001070967A2/en
Publication of WO2001070967A3 publication Critical patent/WO2001070967A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Reagents which regulate human serotonin-like G protein-coupled receptor (5-HT-GPCR) and reagents which bind to human 5-HT-GPCR gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to disorders of both the central and the peripheral nervous system, for example in primary and secondary disorders after brain injury, disorders of mood, anxiety disorders, disorders of thought and volition, disorders of sleep and wakefulness, diseases of the motor unit like neurogenic and myopathic disorders, neurodegenerative disorders like Alzheimer's and Parkinson's disease, disorders leading to peripheral and chronic pain.
PCT/EP2001/003117 2000-03-20 2001-03-19 Regulation of human serotonin-like g protein-coupled receptor WO2001070967A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01915376A EP1290163A2 (en) 2000-03-20 2001-03-19 Regulation of human serotonin-like g protein-coupled receptor
AU2001242485A AU2001242485A1 (en) 2000-03-20 2001-03-19 Regulation of human serotonin-like g protein-coupled receptor

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US19010400P 2000-03-20 2000-03-20
US60/190,104 2000-03-20
US21097500P 2000-06-12 2000-06-12
US60/210,975 2000-06-12
US25511000P 2000-12-14 2000-12-14
US60/255,110 2000-12-14

Publications (2)

Publication Number Publication Date
WO2001070967A2 WO2001070967A2 (en) 2001-09-27
WO2001070967A3 true WO2001070967A3 (en) 2001-12-27

Family

ID=27392683

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/003117 WO2001070967A2 (en) 2000-03-20 2001-03-19 Regulation of human serotonin-like g protein-coupled receptor

Country Status (3)

Country Link
EP (1) EP1290163A2 (en)
AU (1) AU2001242485A1 (en)
WO (1) WO2001070967A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001081576A2 (en) * 2000-04-19 2001-11-01 Pharmacia & Upjohn Company Novel g protein-coupled receptor con-218
EP1158002A1 (en) * 2000-05-19 2001-11-28 Pfizer Limited Human G-protein coupled receptor
MXPA04004564A (en) * 2001-11-16 2004-08-13 Wyeth Corp Genes encoding g-protein coupled receptors and methods of use therefor.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996005302A1 (en) * 1994-08-11 1996-02-22 Takeda Chemical Industries, Ltd. G protein coupled receptor protein, production, and use thereof
US5780245A (en) * 1992-10-14 1998-07-14 Institut National De La Sante Et De La Recherche Medicale Polypeptides having a serotonin receptor activity, nucleic acids coding for these polypeptides and uses
WO1998046620A1 (en) * 1997-04-17 1998-10-22 Millennium Pharmaceuticals, Inc. A novel human g-protein coupled receptor
WO2001036471A2 (en) * 1999-11-17 2001-05-25 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human g protein-coupled receptors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780245A (en) * 1992-10-14 1998-07-14 Institut National De La Sante Et De La Recherche Medicale Polypeptides having a serotonin receptor activity, nucleic acids coding for these polypeptides and uses
WO1996005302A1 (en) * 1994-08-11 1996-02-22 Takeda Chemical Industries, Ltd. G protein coupled receptor protein, production, and use thereof
WO1998046620A1 (en) * 1997-04-17 1998-10-22 Millennium Pharmaceuticals, Inc. A novel human g-protein coupled receptor
WO2001036471A2 (en) * 1999-11-17 2001-05-25 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human g protein-coupled receptors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE EM_HTG [online] EMBL; 18 October 1999 (1999-10-18), BIRREN ET AL.: "Homo sapins, clone RP11-15H8", XP002178458, retrieved from EBI accession no. AC011780 Database accession no. AC011780 *
DATABASE EM_HTG [online] EMBL; 5 May 2000 (2000-05-05), WALLIS: "Human DNA sequence ..... from clone RP5-1160K1", XP002178459, retrieved from EBI accession no. AL355310 Database accession no. AL355310 *

Also Published As

Publication number Publication date
EP1290163A2 (en) 2003-03-12
AU2001242485A1 (en) 2001-10-03
WO2001070967A2 (en) 2001-09-27

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