WO2001064950A3 - Device and method for preparing a sample for analysis - Google Patents

Device and method for preparing a sample for analysis

Info

Publication number
WO2001064950A3
WO2001064950A3 PCT/US2001/006118 US0106118W WO2001064950A3 WO 2001064950 A3 WO2001064950 A3 WO 2001064950A3 US 0106118 W US0106118 W US 0106118W WO 2001064950 A3 WO2001064950 A3 WO 2001064950A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
sample
channel
valves
channels
fractionation
Prior art date
Application number
PCT/US2001/006118
Other languages
French (fr)
Other versions
WO2001064950A2 (en )
Inventor
Stanley N Lapidus
Walker M Sloan Iii
Original Assignee
Exact Sciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02Burettes; Pipettes
    • B01L3/0241Drop counters; Drop formers
    • B01L3/0265Drop counters; Drop formers using valves to interrupt or meter fluid flow, e.g. using solenoids or metering valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0605Metering of fluids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178Special arrangements of analysers
    • G01N2035/00237Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G01N2035/00247Microvalves

Abstract

The invention provides apparatus and methods for dividing a sample, into a plurality of subsamples without the need for pipetting or for other manual operations. Sample is placed, via inlet (2) into sample reservoir (4) in fluid communication with a main charging channel (1) which, in turn, is in fluid communication with a plurality of fractionation channels (5), with valves and vents and terminal purge channel (9). Prior to its use, the plate described above is mated with a receptacle plate, for receiving subsample via fractionation channel valves (6), and to a lid which seals the channels against leakage. The sealed device is subjected to centrifugation in order to distribute sample.
PCT/US2001/006118 2000-02-28 2001-02-27 Device and method for preparing a sample for analysis WO2001064950A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US51455900 true 2000-02-28 2000-02-28
US09/514,559 2000-02-28

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20010914503 EP1261739A2 (en) 2000-02-28 2001-02-27 Device and method for preparing a sample for analysis
CA 2401819 CA2401819A1 (en) 2000-02-28 2001-02-27 Device and method for preparing a sample for analysis

Publications (2)

Publication Number Publication Date
WO2001064950A2 true WO2001064950A2 (en) 2001-09-07
WO2001064950A3 true true WO2001064950A3 (en) 2002-01-24

Family

ID=24047724

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/006118 WO2001064950A3 (en) 2000-02-28 2001-02-27 Device and method for preparing a sample for analysis

Country Status (3)

Country Link
EP (1) EP1261739A2 (en)
CA (1) CA2401819A1 (en)
WO (1) WO2001064950A3 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7981612B2 (en) 1999-12-07 2011-07-19 Mayo Foundation For Medical Education And Research Methods of screening for supracolonic neoplasms based on stool samples containing a nucleic acid marker indicative of a neoplasm

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818404B2 (en) 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
WO2002041995A1 (en) * 2000-11-27 2002-05-30 Pyrosequencing Ab Microfluidic flow control
US6911308B2 (en) 2001-01-05 2005-06-28 Exact Sciences Corporation Methods for detecting, grading or monitoring an H. pylori infection
WO2006047787A3 (en) 2004-10-27 2006-06-01 Exact Sciences Corp Method for monitoring disease progression or recurrence
WO2007044071A3 (en) 2005-04-21 2008-01-24 Exact Sciences Corp Analysis of heterogeneous nucleic acid samples

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338666A (en) * 1991-01-23 1994-08-16 Becton, Dickinson And Company Method for distributing a liquid sample into a multiple aliquot device
EP0803288A2 (en) * 1996-04-26 1997-10-29 Kyoto Daiichi Kagaku Co., Ltd. Device and method for analyzing a sample
US5798215A (en) * 1993-02-18 1998-08-25 Biocircuits Corporation Device for use in analyte detection assays
WO1999058245A1 (en) * 1998-05-08 1999-11-18 Gyros Ab Microfluidic device
WO1999060397A1 (en) * 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338666A (en) * 1991-01-23 1994-08-16 Becton, Dickinson And Company Method for distributing a liquid sample into a multiple aliquot device
US5798215A (en) * 1993-02-18 1998-08-25 Biocircuits Corporation Device for use in analyte detection assays
EP0803288A2 (en) * 1996-04-26 1997-10-29 Kyoto Daiichi Kagaku Co., Ltd. Device and method for analyzing a sample
WO1999058245A1 (en) * 1998-05-08 1999-11-18 Gyros Ab Microfluidic device
WO1999060397A1 (en) * 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7981612B2 (en) 1999-12-07 2011-07-19 Mayo Foundation For Medical Education And Research Methods of screening for supracolonic neoplasms based on stool samples containing a nucleic acid marker indicative of a neoplasm

Also Published As

Publication number Publication date Type
CA2401819A1 (en) 2001-09-07 application
EP1261739A2 (en) 2002-12-04 application
WO2001064950A2 (en) 2001-09-07 application

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