WO2001057510A3 - Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations - Google Patents

Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations

Info

Publication number
WO2001057510A3
WO2001057510A3 PCT/US2001/002465 US0102465W WO2001057510A3 WO 2001057510 A3 WO2001057510 A3 WO 2001057510A3 US 0102465 W US0102465 W US 0102465W WO 2001057510 A3 WO2001057510 A3 WO 2001057510A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
analyte
determination
time
devices
concentration
Prior art date
Application number
PCT/US2001/002465
Other languages
French (fr)
Other versions
WO2001057510A2 (en )
Inventor
Timothy J Ohara
Mahyar Z Kermani
Original Assignee
Lifescan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • G01N27/30Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327Biochemical electrodes electrical and mechanical details of in vitro measurements
    • G01N27/3271Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3274Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration

Abstract

Methods and devices for determining the concentration of an analyte in a physiological sample are provided. In the subject methods, the physiological sample is introduced into an electrochemical cell having a working and reference electrode. A first electric potential is applied to the cell and the resultant cell current over a period of time is measured to determine a first time-current transient. A second electric potential of opposite polarity is then applied and a second time-current transient is determined. The preliminary concentration of the analyte is then calculated from the first and/or second time-current transient. This preliminary analyte concentration less a background value is then multiplied by a hematocrit correction factor to obtain the analyte concentration in the sample, where the hematocrit correction factor is a function of the preliminary analyte concentration and the variable η of the electrochemical cell. The subject methods and devices are suited for use in the determination of a wide variety of analytes in a wide variety of samples, and are particularly suited for the determination of analytes in whole blood or derivatives thereof, where an analyte of particular interest is glucose.
PCT/US2001/002465 2000-02-02 2001-01-25 Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations WO2001057510A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US09497304 US6475372B1 (en) 2000-02-02 2000-02-02 Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations
US09/497,304 2000-02-02

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001556308A JP2003521708A (en) 2000-02-02 2001-01-25 Electrochemical methods and apparatus used to measure the analyte concentration corrected for hematocrit
EP20010905055 EP1252514B1 (en) 2000-02-02 2001-01-25 Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations
DE2001616056 DE60116056T2 (en) 2000-02-02 2001-01-25 Electrochemical methods and devices for use in measuring analyte concentrations with corrected hematocrit
CA 2398203 CA2398203A1 (en) 2000-02-02 2001-01-25 Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations

Publications (2)

Publication Number Publication Date
WO2001057510A2 true WO2001057510A2 (en) 2001-08-09
WO2001057510A3 true true WO2001057510A3 (en) 2002-02-21

Family

ID=23976305

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/002465 WO2001057510A3 (en) 2000-02-02 2001-01-25 Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations

Country Status (10)

Country Link
US (3) US6475372B1 (en)
EP (2) EP1645876A3 (en)
JP (1) JP2003521708A (en)
CN (1) CN1193228C (en)
CA (1) CA2398203A1 (en)
DE (1) DE60116056T2 (en)
DK (1) DK1252514T3 (en)
ES (1) ES2254368T3 (en)
RU (2) RU2262890C2 (en)
WO (1) WO2001057510A3 (en)

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