WO2001053538A3 - Method for functional mapping of an alzheimer's disease gene network and for identifying therapeutic agents for the treatment of alzheimer's disease - Google Patents

Method for functional mapping of an alzheimer's disease gene network and for identifying therapeutic agents for the treatment of alzheimer's disease Download PDF

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Publication number
WO2001053538A3
WO2001053538A3 PCT/US2001/002332 US0102332W WO0153538A3 WO 2001053538 A3 WO2001053538 A3 WO 2001053538A3 US 0102332 W US0102332 W US 0102332W WO 0153538 A3 WO0153538 A3 WO 0153538A3
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WO
WIPO (PCT)
Prior art keywords
alzheimer
disease
therapeutic agents
treatment
identifying therapeutic
Prior art date
Application number
PCT/US2001/002332
Other languages
French (fr)
Other versions
WO2001053538A2 (en
Inventor
Ralph J Greenspan
Gerald M Edelman
Original Assignee
Neurosciences Res Found
Ralph J Greenspan
Gerald M Edelman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosciences Res Found, Ralph J Greenspan, Gerald M Edelman filed Critical Neurosciences Res Found
Priority to US10/182,087 priority Critical patent/US20050241010A1/en
Priority to DE60141028T priority patent/DE60141028D1/en
Priority to CA002398243A priority patent/CA2398243A1/en
Priority to AT01942677T priority patent/ATE454466T1/en
Priority to EP01942677A priority patent/EP1309727B1/en
Priority to AU29751/01A priority patent/AU2975101A/en
Publication of WO2001053538A2 publication Critical patent/WO2001053538A2/en
Publication of WO2001053538A3 publication Critical patent/WO2001053538A3/en

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/033—Rearing or breeding invertebrates; New breeds of invertebrates
    • A01K67/0333—Genetically modified invertebrates, e.g. transgenic, polyploid
    • A01K67/0337—Genetically modified Arthropods
    • A01K67/0339—Genetically modified insects, e.g. Drosophila melanogaster, medfly
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/70—Invertebrates
    • A01K2227/706—Insects, e.g. Drosophila melanogaster, medfly
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Environmental Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention provides a novel genetic method for mapping a network of functional gene interactions relating to Alzheimer's disease. Further provided by the invention is a screening method for identifying therapeutic agents for treating Alzheimer's disease.
PCT/US2001/002332 2000-01-24 2001-01-23 Method for functional mapping of an alzheimer's disease gene network and for identifying therapeutic agents for the treatment of alzheimer's disease WO2001053538A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US10/182,087 US20050241010A1 (en) 2000-01-24 2001-01-23 Method for functional mapping of an alzheimer's disease gene network and for identifying therapeutic agents for the treatment of alzheimer' s disease
DE60141028T DE60141028D1 (en) 2000-01-24 2001-01-23 Method for functional mapping of the entire network of Alzheimer's disease
CA002398243A CA2398243A1 (en) 2000-01-24 2001-01-23 Method for functional mapping of an alzheimer's disease gene network and for identifying therapeutic agents for the treatment of alzheimer's disease
AT01942677T ATE454466T1 (en) 2000-01-24 2001-01-23 METHOD FOR FUNCTIONAL MAPPING OF THE ENTIRE NETWORK OF ALZHEIMER'S DISEASE
EP01942677A EP1309727B1 (en) 2000-01-24 2001-01-23 Method for functional mapping of the gene network of Alzheimer's disease
AU29751/01A AU2975101A (en) 2000-01-24 2001-01-23 Method for functional mapping of an alzheimer's disease gene network and for identifying therapeutic agents for the treatment of alzheimer's disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49024300A 2000-01-24 2000-01-24
US09/490,243 2000-01-24

Publications (2)

Publication Number Publication Date
WO2001053538A2 WO2001053538A2 (en) 2001-07-26
WO2001053538A3 true WO2001053538A3 (en) 2003-02-20

Family

ID=23947224

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/002332 WO2001053538A2 (en) 2000-01-24 2001-01-23 Method for functional mapping of an alzheimer's disease gene network and for identifying therapeutic agents for the treatment of alzheimer's disease

Country Status (7)

Country Link
US (1) US20050241010A1 (en)
EP (1) EP1309727B1 (en)
AT (1) ATE454466T1 (en)
AU (1) AU2975101A (en)
CA (1) CA2398243A1 (en)
DE (1) DE60141028D1 (en)
WO (1) WO2001053538A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120035855A1 (en) * 2008-12-08 2012-02-09 Tsinghua University Method of network-based identification for drug action and/or synergy effect of medicine combination
KR20180055091A (en) 2016-11-16 2018-05-25 한국수력원자력 주식회사 Method for mitigating condition of drosophila degenerative diseases using low-dose radiation
KR102034271B1 (en) * 2017-12-11 2019-10-18 연세대학교 산학협력단 Apparatus and method for constructing gene network
KR102002913B1 (en) * 2019-04-24 2019-07-23 한국수력원자력 주식회사 Method for mitigating condition of drosophila degenerative diseases using low-dose radiation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998017782A1 (en) * 1996-10-21 1998-04-30 University Of South Florida Method for producing transgenic animal models with modulated phenotype and animals produced therefrom
WO1999055906A2 (en) * 1998-04-27 1999-11-04 University Health Network Gene screening methods and related assays

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6489535B1 (en) * 1999-03-18 2002-12-03 The Board Of Trustees Of The Leland Stanford Junior University Non-mammalian transgenic animal having an adult onset neurodegenerative phenotype

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998017782A1 (en) * 1996-10-21 1998-04-30 University Of South Florida Method for producing transgenic animal models with modulated phenotype and animals produced therefrom
WO1999055906A2 (en) * 1998-04-27 1999-11-04 University Health Network Gene screening methods and related assays

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BRYANT ZEV ET AL: "Characterization of differentially expressed genes in purified Drosophila follicle cells: Toward a general strategy for cell type-specific developmental analysis.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 96, no. 10, 11 May 1999 (1999-05-11), May 11, 1999, pages 5559 - 5564, XP002214578, ISSN: 0027-8424 *
DATABASE EMBL [online] 29 July 1995 (1995-07-29), "olfactory receptor (clone HbA1)", XP002208318, Database accession no. S76957 *
GUO YIQUAN ET AL: "Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling.", JOURNAL OF NEUROSCIENCE, vol. 19, no. 19, 1 October 1999 (1999-10-01), pages 8435 - 8442, XP002196478, ISSN: 0270-6474 *
HOLCOMB L A ET AL: "BEHAVIORAL CHANGES IN TRANSGENIC MICE EXPRESSING BOTH AMYLOID PRECURSOR PROTEIN AND PRESENILIN-1 MUTATIONS: LACK OF ASSOCIATION WITH AMYLOID DEPOSITS", BEHAVIOR GENETICS, NEW YORK, NY, US, vol. 29, no. 3, May 1999 (1999-05-01), pages 177 - 185, XP000978983, ISSN: 0001-8244 *
PRICE D L ET AL: "GENETIC NEURODEGENERATIVE DISEASES: THE HUMAN ILLNESS AND TRANSGENIC MODELS", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 282, November 1998 (1998-11-01), pages 1079 - 1083, XP002929296, ISSN: 0036-8075 *

Also Published As

Publication number Publication date
ATE454466T1 (en) 2010-01-15
WO2001053538A2 (en) 2001-07-26
DE60141028D1 (en) 2010-02-25
US20050241010A1 (en) 2005-10-27
EP1309727B1 (en) 2010-01-06
EP1309727A2 (en) 2003-05-14
AU2975101A (en) 2001-07-31
CA2398243A1 (en) 2001-07-26

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